WO2006083269A3 - Luminescent nanosensors - Google Patents

Luminescent nanosensors Download PDF

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Publication number
WO2006083269A3
WO2006083269A3 PCT/US2005/016818 US2005016818W WO2006083269A3 WO 2006083269 A3 WO2006083269 A3 WO 2006083269A3 US 2005016818 W US2005016818 W US 2005016818W WO 2006083269 A3 WO2006083269 A3 WO 2006083269A3
Authority
WO
WIPO (PCT)
Prior art keywords
luminescent
biomolecule
biosensor
specific
assembly
Prior art date
Application number
PCT/US2005/016818
Other languages
French (fr)
Other versions
WO2006083269A2 (en
Inventor
Rakesh Mogul
Original Assignee
Univ Florida Atlantic
Rakesh Mogul
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Florida Atlantic, Rakesh Mogul filed Critical Univ Florida Atlantic
Publication of WO2006083269A2 publication Critical patent/WO2006083269A2/en
Publication of WO2006083269A3 publication Critical patent/WO2006083269A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots

Abstract

A luminescent protein-quantum dot biosensor that can be tailor designed towards the specific detection of environmentally or medicinally important compounds. This biosensor utilizes a biomolecule-inorganic or organic nanometer-sized assembly that serves as a scaffold for a fluorescence competition assay. Specific and sensitive detection of chemical poisons, contaminants, and biotoxins can be realized by mediating the structures within the biomolecule-nanoparticle assembly, while maintaining the luminescent properties of the generalized probe. This versatile strategy of biosensing is applicable towards environmental analysis, medicinal diagnostics, and biodefense.
PCT/US2005/016818 2004-05-14 2005-05-13 Luminescent nanosensors WO2006083269A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57116004P 2004-05-14 2004-05-14
US60/571,160 2004-05-14

Publications (2)

Publication Number Publication Date
WO2006083269A2 WO2006083269A2 (en) 2006-08-10
WO2006083269A3 true WO2006083269A3 (en) 2007-02-22

Family

ID=36777635

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2005/016818 WO2006083269A2 (en) 2004-05-14 2005-05-13 Luminescent nanosensors

Country Status (1)

Country Link
WO (1) WO2006083269A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008018894A2 (en) * 2005-12-19 2008-02-14 The University Of Miami Chemosensors based on quantum dots and oxazine compounds
US8597959B2 (en) 2007-04-19 2013-12-03 3M Innovative Properties Company Methods of use of solid support material for binding biomolecules
EP2137533A2 (en) * 2007-04-19 2009-12-30 3M Innovative Properties Company Uses of water-dispersible silica nanoparticles for attaching biomolecules
JP2011530699A (en) * 2008-08-05 2011-12-22 エージェンシー フォー サイエンス， テクノロジー アンド リサーチ Methods, compositions and articles comprising stable gold nanoclusters
CN101782570A (en) * 2008-12-25 2010-07-21 国家纳米技术与工程研究院 Biomolecule competition analysis method and application thereof
CN102690349A (en) * 2011-03-24 2012-09-26 苏州工业园区晨健抗体组药物开发有限公司 Quantum dot nano-particle biological probe of hepatitis B surface antigen and its preparation method and use
CN102942935B (en) * 2012-09-28 2013-12-25 武汉大学 One-step method for synthesizing DNA functionalized Zn doped CdTe quantum dot
AU2013338039B2 (en) 2012-10-29 2019-08-15 University Of Utah Research Foundation Functionalized nanotube sensors and related methods
US9970950B1 (en) 2014-03-09 2018-05-15 Hound Labs, Inc. Method and apparatus for detecting acute use of target substance(s)
WO2015148622A1 (en) * 2014-03-26 2015-10-01 Virginia Commonwealth University Nanosensor for assessing thrombin inhibitors
US9726684B1 (en) 2015-01-18 2017-08-08 Hound Labs, Inc. Compositions for target substance detection and measurement
CN104880424B (en) * 2015-05-13 2017-12-01 福州市传染病医院 A kind of dual-functional nanometer probe, kit and method for being used to detect AMACR
US9933445B1 (en) 2016-05-16 2018-04-03 Hound Labs, Inc. System and method for target substance identification
US9921234B1 (en) 2016-06-17 2018-03-20 Hound Labs, Inc. Compositions and methods for detection of target constituent in exhaled breath
US11026596B1 (en) 2017-05-19 2021-06-08 Hound Labs, Inc. Detection and measurement of target substance in exhaled breath
CN107449761B (en) * 2017-08-09 2020-02-18 贵州大学 Double-channel fluorescence imaging detection of trace Cu in active cancer cells2+And Hg2+Method (2)
US11187711B1 (en) 2017-09-11 2021-11-30 Hound Labs, Inc. Analyte detection from breath samples
PL240252B1 (en) * 2017-10-10 2022-03-07 Univ Jagiellonski Nanosized mercury ions sensor and method for obtaining it and method for detection of Hg2+ ions
US11426097B1 (en) 2018-10-17 2022-08-30 Hound Labs, Inc. Rotary valve assemblies and methods of use for breath sample cartridge systems
US20200245898A1 (en) 2019-01-31 2020-08-06 Hound Labs, Inc. Single-use Microfluidic Cartridge for Detection of Target Chemical Presence in Human Breath
US11933731B1 (en) 2020-05-13 2024-03-19 Hound Labs, Inc. Systems and methods using Surface-Enhanced Raman Spectroscopy for detecting tetrahydrocannabinol
CN112201752B (en) * 2020-08-11 2023-11-10 苏州科技大学 Preparation method and application of flexible electric storage device
CN112526127B (en) * 2020-10-28 2022-12-06 四川大学华西医院 Detection method of tetanus antigen and application thereof
CN112480151A (en) * 2020-11-25 2021-03-12 辽宁大学 Novel fluorescent probe, preparation method thereof and application of novel fluorescent probe in detection of sulfadimidine in honey
US11806711B1 (en) 2021-01-12 2023-11-07 Hound Labs, Inc. Systems, devices, and methods for fluidic processing of biological or chemical samples using flexible fluidic circuits
WO2022222237A1 (en) * 2021-04-21 2022-10-27 苏州科技大学 Halogenated fluorescein spirocyclic lactone probe, preparation method therefor, and application thereof in metal ion detection
CN114113265B (en) * 2021-12-14 2023-08-08 郑州轻工业大学 Aptamer sensor and preparation method thereof
CN114487401B (en) * 2022-04-18 2022-06-21 中国农业大学 Double-aptamer functional nucleic acid constant-temperature micro-fluidic chip sensor for microbial detection

Citations (6)

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US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US5521289A (en) * 1994-07-29 1996-05-28 Nanoprobes, Inc. Small organometallic probes
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US5738453A (en) * 1993-12-30 1998-04-14 Canon Kabushiki Kaisha Sheet supplying apparatus
US6344337B1 (en) * 1999-02-19 2002-02-05 Board Of Trustees Of Michigan State University Antigen test to detect equine protozoal myeloencephalitis in horse serum and cerebrospinal fluid
US6468808B1 (en) * 1998-09-24 2002-10-22 Advanced Research And Technology Institute, Inc. Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) * 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US5738453A (en) * 1993-12-30 1998-04-14 Canon Kabushiki Kaisha Sheet supplying apparatus
US5521289A (en) * 1994-07-29 1996-05-28 Nanoprobes, Inc. Small organometallic probes
US5700646A (en) * 1995-09-15 1997-12-23 The United States Of America As Represented By The Secretary Of The Army Comprehensive identification scheme for pathogens
US6468808B1 (en) * 1998-09-24 2002-10-22 Advanced Research And Technology Institute, Inc. Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and method of use
US6344337B1 (en) * 1999-02-19 2002-02-05 Board Of Trustees Of Michigan State University Antigen test to detect equine protozoal myeloencephalitis in horse serum and cerebrospinal fluid

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MAXWELL D.J. ET AL.: "Self-Assembled Nanoparticle Probes for Recognition and Detection of Biomolecules", J. AM. CHEM. SOC., vol. 124, no. 32, 2002, pages 9606 - 9612, XP001179600 *
MEDINTZ I.L. ET AL.: "Self-assembled nanoscale biosensors based on quantum dot FRET donors", NATURE MATERIALS, vol. 2, 2 September 2003 (2003-09-02), pages 630 - 638, XP003005623 *

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