WO2006084193A3 - System and methods for performing neurophysiologic assessments during spine surgery - Google Patents

System and methods for performing neurophysiologic assessments during spine surgery Download PDF

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Publication number
WO2006084193A3
WO2006084193A3 PCT/US2006/003966 US2006003966W WO2006084193A3 WO 2006084193 A3 WO2006084193 A3 WO 2006084193A3 US 2006003966 W US2006003966 W US 2006003966W WO 2006084193 A3 WO2006084193 A3 WO 2006084193A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
spine surgery
assessments during
during spine
neurophysiologic assessments
Prior art date
Application number
PCT/US2006/003966
Other languages
French (fr)
Other versions
WO2006084193A9 (en
WO2006084193A2 (en
Inventor
James Gharib
Allen Farquhar
Doug Layman
Jeff Balzer
Blair Calancie
Original Assignee
Nuvasive Inc
James Gharib
Allen Farquhar
Doug Layman
Jeff Balzer
Blair Calancie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36777993&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2006084193(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nuvasive Inc, James Gharib, Allen Farquhar, Doug Layman, Jeff Balzer, Blair Calancie filed Critical Nuvasive Inc
Priority to US11/883,709 priority Critical patent/US20090177112A1/en
Priority to EP06720282A priority patent/EP1846094B1/en
Priority to AT06720282T priority patent/ATE527017T1/en
Publication of WO2006084193A2 publication Critical patent/WO2006084193A2/en
Publication of WO2006084193A9 publication Critical patent/WO2006084193A9/en
Publication of WO2006084193A3 publication Critical patent/WO2006084193A3/en
Priority to US15/153,703 priority patent/US9700228B2/en
Priority to US15/645,605 priority patent/US10362957B2/en
Priority to US16/449,364 priority patent/US11033218B2/en
Priority to US17/320,317 priority patent/US11793447B2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/24Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316Modalities, i.e. specific diagnostic methods
    • A61B5/389Electromyography [EMG]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4029Detecting, measuring or recording for evaluating the nervous system for evaluating the peripheral nervous systems
    • A61B5/4041Evaluating nerves condition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/40Detecting, measuring or recording for evaluating the nervous system
    • A61B5/4058Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
    • A61B5/407Evaluating the spinal cord
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/45For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4504Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/48Other medical applications
    • A61B5/4887Locating particular structures in or on the body
    • A61B5/4893Nerves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/74Details of notification to user or communication with user or patient ; user input means
    • A61B5/7475User input or interface means, e.g. keyboard, pointing device, joystick
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/02Details
    • A61N1/04Electrodes
    • A61N1/05Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526Head electrodes
    • A61N1/0548Oral electrodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36003Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of motor muscles, e.g. for walking assistance
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372Arrangements in connection with the implantation of stimulators
    • A61N1/37211Means for communicating with stimulators
    • A61N1/37235Aspects of the external programmer
    • A61N1/37247User interfaces, e.g. input or presentation means

Abstract

A system and methods for performing neurophysiology assessments during surgery, such as assessing the health of the spinal cord via at least one of MEP and SSEP monitoring and assessing bone integrity, nerve proximity, neuromuscular pathway, and nerve pathology during spine surgery.
PCT/US2006/003966 2005-02-02 2006-02-02 System and methods for performing neurophysiologic assessments during spine surgery WO2006084193A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
US11/883,709 US20090177112A1 (en) 2005-02-02 2006-02-02 System and Methods for Performing Neurophysiologic Assessments During Spine Surgery
EP06720282A EP1846094B1 (en) 2005-02-02 2006-02-02 System for performing neurophysiologic assessments during surgery
AT06720282T ATE527017T1 (en) 2005-02-02 2006-02-02 SYSTEM FOR PERFORMING NEUROPHYSIOLOGICAL ASSESSMENTS DURING SURGERY
US15/153,703 US9700228B2 (en) 2005-02-02 2016-05-12 System and methods for performing neurophysiologic assessments during spine surgery
US15/645,605 US10362957B2 (en) 2005-02-02 2017-07-10 System and methods for performing neurophysiologic assessments during spine surgery
US16/449,364 US11033218B2 (en) 2005-02-02 2019-06-22 System and methods for performing neurophysiologic assessments during spine surgery
US17/320,317 US11793447B2 (en) 2005-02-02 2021-05-14 System and methods for performing neurophysiologic assessments during spine surgery

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US64972405P 2005-02-02 2005-02-02
US60/649,724 2005-02-02
US71989705P 2005-09-22 2005-09-22
US60/719,897 2005-09-22

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/883,709 A-371-Of-International US20090177112A1 (en) 2005-02-02 2006-02-02 System and Methods for Performing Neurophysiologic Assessments During Spine Surgery
US15/153,703 Continuation US9700228B2 (en) 2005-02-02 2016-05-12 System and methods for performing neurophysiologic assessments during spine surgery

Publications (3)

Publication Number Publication Date
WO2006084193A2 WO2006084193A2 (en) 2006-08-10
WO2006084193A9 WO2006084193A9 (en) 2006-10-12
WO2006084193A3 true WO2006084193A3 (en) 2007-01-11

Family

ID=36777993

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/003966 WO2006084193A2 (en) 2005-02-02 2006-02-02 System and methods for performing neurophysiologic assessments during spine surgery

Country Status (4)

Country Link
US (5) US20090177112A1 (en)
EP (2) EP1846094B1 (en)
AT (1) ATE527017T1 (en)
WO (1) WO2006084193A2 (en)

Families Citing this family (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8147421B2 (en) 2003-01-15 2012-04-03 Nuvasive, Inc. System and methods for determining nerve direction to a surgical instrument
US8313430B1 (en) 2006-01-11 2012-11-20 Nuvasive, Inc. Surgical access system and related methods
US10912712B2 (en) 2004-03-25 2021-02-09 The Feinstein Institutes For Medical Research Treatment of bleeding by non-invasive stimulation
US8538539B2 (en) 2004-10-07 2013-09-17 Nu Vasive, Inc. System and methods for assessing the neuromuscular pathway prior to nerve testing
US7887538B2 (en) 2005-10-15 2011-02-15 Baxano, Inc. Methods and apparatus for tissue modification
US9247952B2 (en) 2004-10-15 2016-02-02 Amendia, Inc. Devices and methods for tissue access
US8430881B2 (en) 2004-10-15 2013-04-30 Baxano, Inc. Mechanical tissue modification devices and methods
US9101386B2 (en) 2004-10-15 2015-08-11 Amendia, Inc. Devices and methods for treating tissue
US20110190772A1 (en) 2004-10-15 2011-08-04 Vahid Saadat Powered tissue modification devices and methods
US7857813B2 (en) 2006-08-29 2010-12-28 Baxano, Inc. Tissue access guidewire system and method
US8062300B2 (en) 2006-05-04 2011-11-22 Baxano, Inc. Tissue removal with at least partially flexible devices
US8613745B2 (en) 2004-10-15 2013-12-24 Baxano Surgical, Inc. Methods, systems and devices for carpal tunnel release
US7578819B2 (en) 2005-05-16 2009-08-25 Baxano, Inc. Spinal access and neural localization
US20080103504A1 (en) * 2006-10-30 2008-05-01 Schmitz Gregory P Percutaneous spinal stenosis treatment
JP5243034B2 (en) 2004-10-15 2013-07-24 バクサノ,インク. Tissue removal device
US20100331883A1 (en) 2004-10-15 2010-12-30 Schmitz Gregory P Access and tissue modification systems and methods
US8048080B2 (en) 2004-10-15 2011-11-01 Baxano, Inc. Flexible tissue rasp
US20100004654A1 (en) * 2008-07-01 2010-01-07 Schmitz Gregory P Access and tissue modification systems and methods
US7938830B2 (en) 2004-10-15 2011-05-10 Baxano, Inc. Powered tissue modification devices and methods
US8221397B2 (en) 2004-10-15 2012-07-17 Baxano, Inc. Devices and methods for tissue modification
US8257356B2 (en) 2004-10-15 2012-09-04 Baxano, Inc. Guidewire exchange systems to treat spinal stenosis
US11207518B2 (en) * 2004-12-27 2021-12-28 The Feinstein Institutes For Medical Research Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway
WO2006084193A2 (en) 2005-02-02 2006-08-10 Nuvasive, Inc. System and methods for performing neurophysiologic assessments during spine surgery
WO2006084194A2 (en) 2005-02-02 2006-08-10 Nuvasive, Inc. System and methods for monitoring during anterior surgery
US8740783B2 (en) 2005-07-20 2014-06-03 Nuvasive, Inc. System and methods for performing neurophysiologic assessments with pressure monitoring
US8206312B2 (en) 2005-09-22 2012-06-26 Nuvasive, Inc. Multi-channel stimulation threshold detection algorithm for use in neurophysiology monitoring
US8568317B1 (en) 2005-09-27 2013-10-29 Nuvasive, Inc. System and methods for nerve monitoring
US8062298B2 (en) 2005-10-15 2011-11-22 Baxano, Inc. Flexible tissue removal devices and methods
US8092456B2 (en) 2005-10-15 2012-01-10 Baxano, Inc. Multiple pathways for spinal nerve root decompression from a single access point
US8366712B2 (en) 2005-10-15 2013-02-05 Baxano, Inc. Multiple pathways for spinal nerve root decompression from a single access point
US7906239B2 (en) * 2006-03-06 2011-03-15 Sony Corporation Cathode active material, method for producing the same, and nonaqueous electrolyte secondary battery
US8255045B2 (en) * 2007-04-03 2012-08-28 Nuvasive, Inc. Neurophysiologic monitoring system
US8391970B2 (en) * 2007-08-27 2013-03-05 The Feinstein Institute For Medical Research Devices and methods for inhibiting granulocyte activation by neural stimulation
EP2194861A1 (en) 2007-09-06 2010-06-16 Baxano, Inc. Method, system and apparatus for neural localization
ES2332682B1 (en) * 2007-10-17 2011-01-17 Universitat Politecnica De Catalunya MOBILE INTRAOPERATIVE RADIOTHERAPY SYSTEM BY ELECTRONIC BEAM.
US8343079B2 (en) * 2007-10-18 2013-01-01 Innovative Surgical Solutions, Llc Neural monitoring sensor
AU2008317311B2 (en) 2007-10-24 2013-07-04 Nuvasive, Inc. Surgical trajectory monitoring system and related methods
US8192436B2 (en) 2007-12-07 2012-06-05 Baxano, Inc. Tissue modification devices
US9662490B2 (en) 2008-03-31 2017-05-30 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
WO2009146030A1 (en) 2008-03-31 2009-12-03 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation of t-cell activity
US8409206B2 (en) 2008-07-01 2013-04-02 Baxano, Inc. Tissue modification devices and methods
US8398641B2 (en) 2008-07-01 2013-03-19 Baxano, Inc. Tissue modification devices and methods
US9314253B2 (en) 2008-07-01 2016-04-19 Amendia, Inc. Tissue modification devices and methods
CA2730732A1 (en) 2008-07-14 2010-01-21 Baxano, Inc. Tissue modification devices
AU2015258176B2 (en) * 2008-10-15 2017-06-22 Nuvasive, Inc. Neurophysiologic monitoring system and related methods
US20120095360A1 (en) * 2008-10-15 2012-04-19 Kevin Runney Neurophysiologic Monitoring System and Related Methods
WO2010059617A2 (en) 2008-11-18 2010-05-27 Setpoint Medical Corporation Devices and methods for optimizing electrode placement for anti-inflamatory stimulation
US9084551B2 (en) 2008-12-08 2015-07-21 Medtronic Xomed, Inc. Method and system for monitoring a nerve
CA2749673A1 (en) 2009-03-13 2010-09-16 Baxano, Inc. Flexible neural localization devices and methods
US20110054569A1 (en) * 2009-09-01 2011-03-03 Zitnik Ralph J Prescription pad for treatment of inflammatory disorders
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US8996116B2 (en) * 2009-10-30 2015-03-31 Setpoint Medical Corporation Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
US9211074B2 (en) * 2009-06-09 2015-12-15 Safeop Surgical, Inc. System, method, apparatus, device and computer program product for automatically detecting positioning effect
AU2010258792B2 (en) 2009-06-09 2015-07-02 Setpoint Medical Corporation Nerve cuff with pocket for leadless stimulator
US8394102B2 (en) 2009-06-25 2013-03-12 Baxano, Inc. Surgical tools for treatment of spinal stenosis
US9008781B2 (en) * 2009-10-22 2015-04-14 The Research Foundation Of The City University Of New York Method and system for treatment of mobility dysfunction
US9833621B2 (en) 2011-09-23 2017-12-05 Setpoint Medical Corporation Modulation of sirtuins by vagus nerve stimulation
US11051744B2 (en) 2009-11-17 2021-07-06 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
WO2011079309A2 (en) 2009-12-23 2011-06-30 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US20110230785A1 (en) * 2010-03-16 2011-09-22 ProNerve, LLC Somatosensory Evoked Potential (SSEP) Automated Alert System
US9392953B1 (en) * 2010-09-17 2016-07-19 Nuvasive, Inc. Neurophysiologic monitoring
US9155503B2 (en) 2010-10-27 2015-10-13 Cadwell Labs Apparatus, system, and method for mapping the location of a nerve
CN103619405B (en) 2011-05-09 2015-11-25 赛博恩特医疗器械公司 The individual pulse being used for the treatment of the cholinergic anti-inflammatory pathway of chronic inflammatory disease activates
WO2013067018A2 (en) * 2011-11-01 2013-05-10 Synthes Usa, Llc Intraoperative neurophysiological monitoring system
US9655505B1 (en) 2012-02-06 2017-05-23 Nuvasive, Inc. Systems and methods for performing neurophysiologic monitoring during spine surgery
US9066701B1 (en) 2012-02-06 2015-06-30 Nuvasive, Inc. Systems and methods for performing neurophysiologic monitoring during spine surgery
US9572983B2 (en) 2012-03-26 2017-02-21 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
CA3122358C (en) 2012-05-02 2023-10-03 Safeop Surgical Inc. System, method, and computer algorithm for characterization and classification of electrophysiological evoked potentials
WO2014063163A1 (en) 2012-10-19 2014-04-24 Block Jonathan D Systems and methods for nerve mapping and monitoring
US11259737B2 (en) 2012-11-06 2022-03-01 Nuvasive, Inc. Systems and methods for performing neurophysiologic monitoring during spine surgery
US11877860B2 (en) * 2012-11-06 2024-01-23 Nuvasive, Inc. Systems and methods for performing neurophysiologic monitoring during spine surgery
US9757067B1 (en) 2012-11-09 2017-09-12 Nuvasive, Inc. Systems and methods for performing neurophysiologic monitoring during spine surgery
US9295401B2 (en) * 2012-11-27 2016-03-29 Cadwell Laboratories, Inc. Neuromonitoring systems and methods
US9757072B1 (en) 2013-02-11 2017-09-12 Nuvasive, Inc. Waveform marker placement algorithm for use in neurophysiologic monitoring
US10098585B2 (en) 2013-03-15 2018-10-16 Cadwell Laboratories, Inc. Neuromonitoring systems and methods
FR3010628B1 (en) 2013-09-18 2015-10-16 Medicrea International METHOD FOR REALIZING THE IDEAL CURVATURE OF A ROD OF A VERTEBRAL OSTEOSYNTHESIS EQUIPMENT FOR STRENGTHENING THE VERTEBRAL COLUMN OF A PATIENT
FR3012030B1 (en) 2013-10-18 2015-12-25 Medicrea International METHOD FOR REALIZING THE IDEAL CURVATURE OF A ROD OF A VERTEBRAL OSTEOSYNTHESIS EQUIPMENT FOR STRENGTHENING THE VERTEBRAL COLUMN OF A PATIENT
WO2015069949A1 (en) 2013-11-07 2015-05-14 Safeop Surgical, Inc. Systems and methods for detecting nerve function
US10441207B2 (en) * 2014-04-07 2019-10-15 Cognisens Inc. Configurable system for evaluating stimulus sensitivity of a subject and method of use therefor
US10123731B2 (en) 2014-08-08 2018-11-13 Medtronic Xomed, Inc. Wireless sensors for nerve integrity monitoring systems
US10420480B1 (en) 2014-09-16 2019-09-24 Nuvasive, Inc. Systems and methods for performing neurophysiologic monitoring
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
WO2016126807A1 (en) 2015-02-03 2016-08-11 Setpoint Medical Corporation Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
US10433793B1 (en) 2015-03-27 2019-10-08 Cadwell Laboratories, Inc. Methods and systems for simultaneous review of brain activity and physical manifestations of users
WO2016179191A1 (en) 2015-05-04 2016-11-10 Safeop Surgical, Inc. System, method, and computer algorithm for measuring, displaying, and accurately detecting changes in electrophysiological evoked potentials
US11278722B2 (en) 2015-08-27 2022-03-22 Hrl Laboratories, Llc System and method to cue specific memory recalls while awake
US10596372B2 (en) 2015-08-27 2020-03-24 Hrl Laboratories, Llc Targeted steerable transcranial intervention to accelerate memory consolidation
US10413724B2 (en) 2015-10-23 2019-09-17 Hrl Laboratories, Llc Method for low latency automated closed-loop synchronization of neurostimulation interventions to neurophysiological activity
US10744321B2 (en) 2015-10-23 2020-08-18 Hrl Laboratories, Llc Transcranial current stimulation system and virtual reality for treatment of PTSD or fears
US10918862B1 (en) 2015-10-23 2021-02-16 Hrl Laboratories, Llc Method for automated closed-loop neurostimulation for improving sleep quality
WO2017079655A2 (en) 2015-11-04 2017-05-11 Mcafee Paul C Methods and apparatus for spinal reconstructive surgery and measuring spinal length and intervertebral spacing, tension and rotation
US10596367B2 (en) 2016-01-13 2020-03-24 Setpoint Medical Corporation Systems and methods for establishing a nerve block
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
EP3405255A4 (en) 2016-01-20 2019-10-16 Setpoint Medical Corporation Implantable microstimulators and inductive charging systems
CN114904142A (en) 2016-01-20 2022-08-16 赛博恩特医疗器械公司 Control of vagal nerve stimulation
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
CA3022430A1 (en) * 2016-04-27 2017-11-02 Neux Technologies, Inc. Electrotherapeutic treatment
WO2018011439A1 (en) * 2016-07-11 2018-01-18 Jimenez-Carles Gil-Delgado Eduardo Intraoperative monitoring system
WO2018014007A1 (en) * 2016-07-14 2018-01-18 Sidewaystrategies Llc System and methods for improving diagnostic evoked potential studies for functional assessments of nerves and nerve pathways
US10849517B2 (en) * 2016-09-19 2020-12-01 Medtronic Xomed, Inc. Remote control module for instruments
EP3534792B1 (en) 2016-11-03 2021-05-19 EDGe Surgical, Inc. Surgical depth instrument having neuromonitoring capabilities
US11241297B2 (en) 2016-12-12 2022-02-08 Cadwell Laboratories, Inc. System and method for high density electrode management
WO2018109556A1 (en) 2016-12-12 2018-06-21 Medicrea International Systems and methods for patient-specific spinal implants
US9935395B1 (en) 2017-01-23 2018-04-03 Cadwell Laboratories, Inc. Mass connection plate for electrical connectors
US10939867B2 (en) * 2017-03-10 2021-03-09 Robert S. Bray Paralysis monitoring system
JP7187473B2 (en) 2017-03-22 2022-12-12 セーフオプ サージカル インコーポレイテッド Medical system and method for detecting changes in electrophysiological evoked potentials
EP4108201B1 (en) 2017-04-21 2024-03-27 Medicrea International A system for developing one or more patient-specific spinal implants
EP3618697A4 (en) * 2017-05-01 2021-03-03 HRL Laboratories, LLC A method for low latency automated closed-loop synchronization of neurostimulation interventions to neurophysiological activity
US10792080B2 (en) 2017-06-14 2020-10-06 Edge Surgical, Inc. Devices for minimally invasive procedures
EP3760280A1 (en) 2017-06-16 2021-01-06 Alphatec Spine, Inc. Systems, methods, and devices for detecting the threshold of nerve-muscle response using variable frequency stimulation
EP3668402A4 (en) 2017-08-14 2021-05-19 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test
CN107468237B (en) * 2017-08-24 2024-02-13 郭铮蔚 Multifunctional nerve monitoring exploration system and implementation method thereof
US10918422B2 (en) 2017-12-01 2021-02-16 Medicrea International Method and apparatus for inhibiting proximal junctional failure
EP3761870B1 (en) 2018-03-05 2022-05-04 EDGe Surgical, Inc. Handheld devices for use in medical procedures
US11517239B2 (en) 2018-04-05 2022-12-06 Cadwell Laboratories, Inc. Systems and methods for processing and displaying electromyographic signals
US11285319B1 (en) 2018-04-06 2022-03-29 Hrl Laboratories, Llc Method and system for improving quality of life for the elderly through neurostimulation
US11285320B1 (en) 2018-04-06 2022-03-29 Hrl Laboratories, Llc Comprehensive second-language acquisition system leveraging sleep neuromodulation and neuroaugmented executive control
US11596337B2 (en) 2018-04-24 2023-03-07 Cadwell Laboratories, Inc Methods and systems for operating an intraoperative neurophysiological monitoring system in conjunction with electrocautery procedures
US11253182B2 (en) 2018-05-04 2022-02-22 Cadwell Laboratories, Inc. Apparatus and method for polyphasic multi-output constant-current and constant-voltage neurophysiological stimulation
US11443649B2 (en) 2018-06-29 2022-09-13 Cadwell Laboratories, Inc. Neurophysiological monitoring training simulator
US11185684B2 (en) 2018-09-18 2021-11-30 Cadwell Laboratories, Inc. Minimally invasive two-dimensional grid electrode
US11260229B2 (en) 2018-09-25 2022-03-01 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
US11517245B2 (en) 2018-10-30 2022-12-06 Cadwell Laboratories, Inc. Method and system for data synchronization
US11471087B2 (en) 2018-11-09 2022-10-18 Cadwell Laboratories, Inc. Integrity verification system for testing high channel count neuromonitoring recording equipment
US11317841B2 (en) 2018-11-14 2022-05-03 Cadwell Laboratories, Inc. Method and system for electrode verification
US11529107B2 (en) 2018-11-27 2022-12-20 Cadwell Laboratories, Inc. Methods for automatic generation of EEG montages
US11128076B2 (en) 2019-01-21 2021-09-21 Cadwell Laboratories, Inc. Connector receptacle
US11877801B2 (en) 2019-04-02 2024-01-23 Medicrea International Systems, methods, and devices for developing patient-specific spinal implants, treatments, operations, and/or procedures
US11925417B2 (en) 2019-04-02 2024-03-12 Medicrea International Systems, methods, and devices for developing patient-specific spinal implants, treatments, operations, and/or procedures
US11504539B2 (en) * 2019-08-15 2022-11-22 Boston Scientific Neuromodulation Corporation User interface for neural signal and biomarker visualization and assessment
US11769251B2 (en) 2019-12-26 2023-09-26 Medicrea International Systems and methods for medical image analysis
US11938324B2 (en) 2020-05-21 2024-03-26 The Feinstein Institutes For Medical Research Systems and methods for vagus nerve stimulation
KR102558032B1 (en) * 2021-07-19 2023-07-19 가톨릭대학교 산학협력단 Neuromonitoring apparatus and method
WO2023225111A1 (en) * 2022-05-19 2023-11-23 Alphatec Spine, Inc. Stimulation system
CN116212236A (en) * 2023-03-15 2023-06-06 马鞍山市人民医院 Steady state somatosensory evoked potential stimulation system and signal acquisition method

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050004623A1 (en) * 2002-10-30 2005-01-06 Patrick Miles System and methods for performing percutaneous pedicle integrity assessments

Family Cites Families (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2736002A (en) * 1956-02-21 oriel
US3664329A (en) 1970-03-09 1972-05-23 Concept Nerve locator/stimulator
US3785368A (en) * 1971-08-23 1974-01-15 Carthy T Mc Abnormal nerve pressure locus detector and method
US4291705A (en) 1979-09-10 1981-09-29 The Regents Of The University Of California Neuromuscular block monitor
US4570640A (en) * 1981-08-06 1986-02-18 Barsa John E Sensory monitoring apparatus and method
US4545374A (en) * 1982-09-03 1985-10-08 Jacobson Robert E Method and instruments for performing a percutaneous lumbar diskectomy
US4744371A (en) 1987-04-27 1988-05-17 Cordis Leads, Inc. Multi-conductor lead assembly for temporary use
FR2615804B1 (en) 1987-05-27 1989-09-15 Peugeot Aciers Et Outillage ALIGNABLE POSITION HOLDING MECHANISM FOR SEAT BELT
US4962766A (en) * 1989-07-19 1990-10-16 Herzon Garrett D Nerve locator and stimulator
US5269785A (en) * 1990-06-28 1993-12-14 Bonutti Peter M Apparatus and method for tissue removal
US5212476A (en) * 1990-09-28 1993-05-18 Maloney Sean R Wireless intraoral controller disposed in oral cavity with electrodes to sense E.M.G. signals produced by contraction of the tongue
SE467561B (en) * 1990-12-04 1992-08-10 Dorsograf Ab DEVICE FOR SEATING TRANSPORT TIME OF NERV SIGNALS
US5284153A (en) * 1992-04-14 1994-02-08 Brigham And Women's Hospital Method for locating a nerve and for protecting nerves from injury during surgery
US5196015A (en) 1992-04-30 1993-03-23 Neubardt Seth L Procedure for spinal pedicle screw insertion
US5474558A (en) * 1992-04-30 1995-12-12 Neubardt; Seth L. Procedure and system for spinal pedicle screw insertion
US5549656A (en) 1993-08-16 1996-08-27 Med Serve Group, Inc. Combination neuromuscular stimulator and electromyograph system
US5575284A (en) * 1994-04-01 1996-11-19 University Of South Florida Portable pulse oximeter
US6038469A (en) * 1994-10-07 2000-03-14 Ortivus Ab Myocardial ischemia and infarction analysis and monitoring method and apparatus
US5601608A (en) * 1995-02-02 1997-02-11 Pacesetter, Inc. Methods and apparatus for applying charge-balanced antiarrhythmia shocks
AU5448496A (en) * 1995-04-10 1996-10-30 St. Luke's-Roosevelt Hospital Peripheral nerve stimulation device for unassisted nerve blo ckade
US5775331A (en) * 1995-06-07 1998-07-07 Uromed Corporation Apparatus and method for locating a nerve
US5806522A (en) * 1995-08-15 1998-09-15 Katims; Jefferson Jacob Digital automated current perception threshold (CPT) determination device and method
US5779642A (en) * 1996-01-16 1998-07-14 Nightengale; Christopher Interrogation device and method
US5792044A (en) * 1996-03-22 1998-08-11 Danek Medical, Inc. Devices and methods for percutaneous surgery
US5853373A (en) 1996-08-05 1998-12-29 Becton, Dickinson And Company Bi-level charge pulse apparatus to facilitate nerve location during peripheral nerve block procedures
US5810747A (en) * 1996-08-21 1998-09-22 Interactive Remote Site Technology, Inc. Remote site medical intervention system
US5830150A (en) * 1996-09-18 1998-11-03 Marquette Electronics, Inc. Method and apparatus for displaying data
US5928158A (en) * 1997-03-25 1999-07-27 Aristides; Arellano Medical instrument with nerve sensor
US6132387A (en) * 1997-07-01 2000-10-17 Neurometrix, Inc. Neuromuscular electrode
US7628761B2 (en) * 1997-07-01 2009-12-08 Neurometrix, Inc. Apparatus and method for performing nerve conduction studies with localization of evoked responses
US6132386A (en) * 1997-07-01 2000-10-17 Neurometrix, Inc. Methods for the assessment of neuromuscular function by F-wave latency
US5851191A (en) 1997-07-01 1998-12-22 Neurometrix, Inc. Apparatus and methods for assessment of neuromuscular function
US6306100B1 (en) * 1997-12-16 2001-10-23 Richard L. Prass Intraoperative neurophysiological monitoring system
US6027456A (en) * 1998-07-10 2000-02-22 Advanced Neuromodulation Systems, Inc. Apparatus and method for positioning spinal cord stimulation leads
US6366813B1 (en) * 1998-08-05 2002-04-02 Dilorenzo Daniel J. Apparatus and method for closed-loop intracranical stimulation for optimal control of neurological disease
US6292701B1 (en) * 1998-08-12 2001-09-18 Medtronic Xomed, Inc. Bipolar electrical stimulus probe with planar electrodes
US6104957A (en) * 1998-08-21 2000-08-15 Alo; Kenneth M. Epidural nerve root stimulation with lead placement method
US6451015B1 (en) * 1998-11-18 2002-09-17 Sherwood Services Ag Method and system for menu-driven two-dimensional display lesion generator
US6266558B1 (en) * 1998-12-01 2001-07-24 Neurometrix, Inc. Apparatus and method for nerve conduction measurements with automatic setting of stimulus intensity
US6564078B1 (en) * 1998-12-23 2003-05-13 Nuvasive, Inc. Nerve surveillance cannula systems
US6393325B1 (en) * 1999-01-07 2002-05-21 Advanced Bionics Corporation Directional programming for implantable electrode arrays
US6416480B1 (en) * 1999-03-29 2002-07-09 Valeriy Nenov Method and apparatus for automated acquisition of the glasgow coma score (AGCS)
US6224549B1 (en) * 1999-04-20 2001-05-01 Nicolet Biomedical, Inc. Medical signal monitoring and display
US6259945B1 (en) * 1999-04-30 2001-07-10 Uromed Corporation Method and device for locating a nerve
US6901928B2 (en) * 1999-05-04 2005-06-07 Paul G. Loubser Superglottic and peri-laryngeal apparatus for supraglottic airway insertion
US6516227B1 (en) * 1999-07-27 2003-02-04 Advanced Bionics Corporation Rechargeable spinal cord stimulator system
US6334068B1 (en) * 1999-09-14 2001-12-25 Medtronic Xomed, Inc. Intraoperative neuroelectrophysiological monitor
US6466817B1 (en) * 1999-11-24 2002-10-15 Nuvasive, Inc. Nerve proximity and status detection system and method
EP1237472A4 (en) * 1999-11-24 2008-04-30 Nuvasive Inc Electromyography system
US6760616B2 (en) 2000-05-18 2004-07-06 Nu Vasive, Inc. Tissue discrimination and applications in medical procedures
WO2001093748A2 (en) * 2000-06-08 2001-12-13 Nuvasive, Inc. Relative nerve movement and status detection system and method
US7305268B2 (en) * 2000-07-13 2007-12-04 Northstar Neurscience, Inc. Systems and methods for automatically optimizing stimulus parameters and electrode configurations for neuro-stimulators
US7089059B1 (en) * 2000-11-03 2006-08-08 Pless Benjamin D Predicting susceptibility to neurological dysfunction based on measured neural electrophysiology
WO2003005887A2 (en) 2001-07-11 2003-01-23 Nuvasive, Inc. System and methods for determining nerve proximity, direction, and pathology during surgery
US6926728B2 (en) * 2001-07-18 2005-08-09 St. Francis Medical Technologies, Inc. Curved dilator and method
EP2481338A3 (en) 2001-09-25 2012-09-05 Nuvasive, Inc. System for performing surgical procedures and assessments
US8771149B2 (en) * 2001-10-01 2014-07-08 The Nemours Foundation Compliance monitor and method for a medical device
JP4340153B2 (en) 2001-10-30 2009-10-07 ヌバシブ, インコーポレイテッド System and method for performing percutaneous stem integrity assessment
US7216001B2 (en) * 2003-01-22 2007-05-08 Medtronic Xomed, Inc. Apparatus for intraoperative neural monitoring
US6830051B1 (en) * 2003-04-29 2004-12-14 Dental Concepts Llc Interocclusal appliance
JP4436836B2 (en) 2003-08-05 2010-03-24 ヌヴァシヴ インコーポレイテッド System and method for performing dynamic pedicle integrity assessment
US7905840B2 (en) * 2003-10-17 2011-03-15 Nuvasive, Inc. Surgical access system and related methods
WO2005030318A1 (en) * 2003-09-25 2005-04-07 Nuvasive, Inc. Surgical access system and related methods
US7783355B2 (en) * 2004-01-21 2010-08-24 Medtronic, Inc. Dynamic adjustment of capture management “safety margin”
US7493567B2 (en) 2004-01-28 2009-02-17 Microsoft Corporation Method and system for pinning contacts and items
US8538539B2 (en) * 2004-10-07 2013-09-17 Nu Vasive, Inc. System and methods for assessing the neuromuscular pathway prior to nerve testing
WO2006084193A2 (en) 2005-02-02 2006-08-10 Nuvasive, Inc. System and methods for performing neurophysiologic assessments during spine surgery
US8206312B2 (en) * 2005-09-22 2012-06-26 Nuvasive, Inc. Multi-channel stimulation threshold detection algorithm for use in neurophysiology monitoring

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050004623A1 (en) * 2002-10-30 2005-01-06 Patrick Miles System and methods for performing percutaneous pedicle integrity assessments

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