WO2006086552A3 - Bioreactor for selectively controlling the molecular diffusion between fluids - Google Patents

Bioreactor for selectively controlling the molecular diffusion between fluids Download PDF

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Publication number
WO2006086552A3
WO2006086552A3 PCT/US2006/004578 US2006004578W WO2006086552A3 WO 2006086552 A3 WO2006086552 A3 WO 2006086552A3 US 2006004578 W US2006004578 W US 2006004578W WO 2006086552 A3 WO2006086552 A3 WO 2006086552A3
Authority
WO
WIPO (PCT)
Prior art keywords
bioreactor
microchannel
fluids
fluid
molecular diffusion
Prior art date
Application number
PCT/US2006/004578
Other languages
French (fr)
Other versions
WO2006086552A2 (en
Inventor
Emilio Barbera-Guillem
Original Assignee
Emilio Barbera-Guillem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Emilio Barbera-Guillem filed Critical Emilio Barbera-Guillem
Priority to AT06734653T priority Critical patent/ATE553182T1/en
Priority to EP06734653A priority patent/EP1855776B1/en
Publication of WO2006086552A2 publication Critical patent/WO2006086552A2/en
Publication of WO2006086552A3 publication Critical patent/WO2006086552A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0472—Diffusion
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0694—Valves, specific forms thereof vents used to stop and induce flow, backpressure valves

Abstract

A diffusion controlling bioreactor (50) that selectively controls the molecular diffusion between fluids through a microchannel (200) in fluid communication with a reaction reservoir (300). A length (230) and a cross-sectional area (250) are selected to obtain a predetermined rate of molecular diffusion between fluids. When the fluids are liquids, flow through the microchannel (200) is laminar and the capillary action of the microchannel (200) and fluid is such that the fluid does not flow into the reaction reservoir (300) unless the pressure of the fluid is increased by an external source, thereby minimizing contamination of the bioreactor (50). The instant invention may also utilize at least one microchannel and reagent reservoir to regulate, rather than prevent, the passage of various molecules into the bioreactor (50). A pressure equalizing vent (400) operating on similar principles to the microchannel (200) may have a structure configured to minimize the chances of fluid leakage from the bioreactor (50), even if the bioreactor (50) is turned in various directions.
PCT/US2006/004578 2005-02-11 2006-02-09 Bioreactor for selectively controlling the molecular diffusion between fluids WO2006086552A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT06734653T ATE553182T1 (en) 2005-02-11 2006-02-09 BIOREACTOR FOR SELECTIVE CONTROL OF MOLECULAR DIFFUSION BETWEEN FLUIDS
EP06734653A EP1855776B1 (en) 2005-02-11 2006-02-09 Bioreactor for selectively controlling the molecular diffusion between fluids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/056,725 US7514256B2 (en) 2005-02-11 2005-02-11 Bioreactor for selectively controlling the molecular diffusion between fluids
US11/056,725 2005-02-11

Publications (2)

Publication Number Publication Date
WO2006086552A2 WO2006086552A2 (en) 2006-08-17
WO2006086552A3 true WO2006086552A3 (en) 2008-06-19

Family

ID=36793713

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/004578 WO2006086552A2 (en) 2005-02-11 2006-02-09 Bioreactor for selectively controlling the molecular diffusion between fluids

Country Status (4)

Country Link
US (1) US7514256B2 (en)
EP (1) EP1855776B1 (en)
AT (1) ATE553182T1 (en)
WO (1) WO2006086552A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8232096B2 (en) * 2005-02-11 2012-07-31 Emilio Barbera-Guillem Bioreactor for selectively controlling the molecular diffusion between fluids
US20080206845A1 (en) * 2007-02-23 2008-08-28 Emilio Barbera-Guillem Bioreactor analysis system
WO2021071824A1 (en) * 2019-10-07 2021-04-15 The University Of Chicago Large lateral scale two-dimensional materials and other thin films, and associated systems and methods

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Also Published As

Publication number Publication date
US7514256B2 (en) 2009-04-07
WO2006086552A2 (en) 2006-08-17
EP1855776A4 (en) 2010-02-03
ATE553182T1 (en) 2012-04-15
US20060180529A1 (en) 2006-08-17
EP1855776A2 (en) 2007-11-21
EP1855776B1 (en) 2012-04-11

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