WO2006090389A3 - Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof - Google Patents

Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof Download PDF

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Publication number
WO2006090389A3
WO2006090389A3 PCT/IL2006/000251 IL2006000251W WO2006090389A3 WO 2006090389 A3 WO2006090389 A3 WO 2006090389A3 IL 2006000251 W IL2006000251 W IL 2006000251W WO 2006090389 A3 WO2006090389 A3 WO 2006090389A3
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WO
WIPO (PCT)
Prior art keywords
assays
methods
diagnostic markers
vivo imaging
novel diagnostic
Prior art date
Application number
PCT/IL2006/000251
Other languages
French (fr)
Other versions
WO2006090389A2 (en
Inventor
Sarah Pollock
Anat Cohen-Dayag
Osnat Sella-Tavor
Shirley Sameah-Greenwald
Shira Walach
Lily Bazak
Original Assignee
Compugen Ltd
Sarah Pollock
Anat Cohen-Dayag
Osnat Sella-Tavor
Shirley Sameah-Greenwald
Shira Walach
Lily Bazak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Compugen Ltd, Sarah Pollock, Anat Cohen-Dayag, Osnat Sella-Tavor, Shirley Sameah-Greenwald, Shira Walach, Lily Bazak filed Critical Compugen Ltd
Priority to EP06711233A priority Critical patent/EP1851543A2/en
Publication of WO2006090389A2 publication Critical patent/WO2006090389A2/en
Priority to IL185501A priority patent/IL185501A0/en
Publication of WO2006090389A3 publication Critical patent/WO2006090389A3/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21109Matriptase (3.4.21.109)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424Serine endopeptidases (3.4.21)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism

Abstract

Novel splice variants as diagnostic markers, preferably membrane-bound. The novel variants according to the present invention may optionally be used for diagnosis of Marker-detectable disease as described herein, optionally through immunohistochemistry.
PCT/IL2006/000251 2005-02-24 2006-02-23 Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof WO2006090389A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06711233A EP1851543A2 (en) 2005-02-24 2006-02-23 Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof
IL185501A IL185501A0 (en) 2005-02-24 2007-08-23 Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL16709105 2005-02-24
IL167091 2005-02-24

Publications (2)

Publication Number Publication Date
WO2006090389A2 WO2006090389A2 (en) 2006-08-31
WO2006090389A3 true WO2006090389A3 (en) 2007-11-29

Family

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Family Applications (1)

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PCT/IL2006/000251 WO2006090389A2 (en) 2005-02-24 2006-02-23 Novel diagnostic markers, especially for in vivo imaging, and assays and methods of use thereof

Country Status (4)

Country Link
US (3) US7488813B2 (en)
EP (1) EP1851543A2 (en)
IL (1) IL185501A0 (en)
WO (1) WO2006090389A2 (en)

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CA2740806C (en) 2008-12-09 2021-07-20 Bryan Irving Anti-pd-l1 antibodies and their use to enhance t-cell function
US8348856B1 (en) 2008-12-16 2013-01-08 Zanetta Malanowska-Stega Simultaneous multiple method out-patient uterus biopsy device and method
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US9536162B2 (en) * 2011-01-17 2017-01-03 Republic of Korea (National Forensic Service Director Ministry of Public Administration and Security) Method for detecting an invisible mark on a card
CN103826662A (en) * 2011-07-06 2014-05-28 美艾利尔圣地亚哥公司 Methods and compositions for assigning likelihood of acute kidney injury progression
US20140279712A1 (en) * 2013-03-15 2014-09-18 American Metering Services, Inc. Utility monitoring and billing systems, and methods
AR098523A1 (en) 2013-11-25 2016-06-01 Oxford Biotherapeutics Ltd DIRECTED ANTIBODIES AGAINST MATRIPTASE AND RELATED COMPOSITIONS
WO2015085398A1 (en) * 2013-12-09 2015-06-18 British Columbia Cancer Agency Branch Matriptase variants associated with tumors
CN110248609A (en) 2016-12-09 2019-09-17 扎内塔·马拉诺夫斯卡-斯蒂加 Brush biopsy device, tool set and method
CN107091730A (en) * 2017-06-08 2017-08-25 金华职业技术学院 Estimate the device of absolute light responsiveness of the photomultiplier under low light-intensity conditions
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CN112679617B (en) * 2021-01-15 2021-09-17 北京鼎成肽源生物技术有限公司 Mammal fusion protein display plasmid based on mesothelin anchoring, cell line and application
AU2022222688A1 (en) * 2021-02-16 2023-07-06 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Molecules that bind to mesothelin polypeptides

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Also Published As

Publication number Publication date
US20100189652A1 (en) 2010-07-29
EP1851543A2 (en) 2007-11-07
IL185501A0 (en) 2008-01-20
WO2006090389A2 (en) 2006-08-31
US20060257896A1 (en) 2006-11-16
US7741433B2 (en) 2010-06-22
US20090202991A1 (en) 2009-08-13
US7488813B2 (en) 2009-02-10

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