WO2006096497A3 - Vaccines comprising oligonucleotides having immunostimulatory sequences (iss) wherein the iss are conjugated to antigens and stabilized by buffer conditions and further excipients - Google Patents
Vaccines comprising oligonucleotides having immunostimulatory sequences (iss) wherein the iss are conjugated to antigens and stabilized by buffer conditions and further excipients Download PDFInfo
- Publication number
- WO2006096497A3 WO2006096497A3 PCT/US2006/007571 US2006007571W WO2006096497A3 WO 2006096497 A3 WO2006096497 A3 WO 2006096497A3 US 2006007571 W US2006007571 W US 2006007571W WO 2006096497 A3 WO2006096497 A3 WO 2006096497A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- iss
- vaccines
- oligonucleotides
- antigens
- conjugated
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 108091034117 Oligonucleotide Proteins 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 230000003308 immunostimulating effect Effects 0.000 title 1
- 239000000546 pharmaceutical excipient Substances 0.000 title 1
- 229960005486 vaccine Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 3
- 244000036975 Ambrosia artemisiifolia Species 0.000 abstract 1
- 235000003129 Ambrosia artemisiifolia var elatior Nutrition 0.000 abstract 1
- 239000013566 allergen Substances 0.000 abstract 1
- 235000003484 annual ragweed Nutrition 0.000 abstract 1
- 235000006263 bur ragweed Nutrition 0.000 abstract 1
- 235000003488 common ragweed Nutrition 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 235000009736 ragweed Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6006—Cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6025—Nucleotides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2006220835A AU2006220835B2 (en) | 2005-03-04 | 2006-03-03 | Vaccines comprising oligonucleotides having immunostimulatory sequences (ISS) wherein the ISS are conjugated to antigens and stabilized by buffer conditions and further excipients |
CA002600036A CA2600036A1 (en) | 2005-03-04 | 2006-03-03 | Vaccines comprising oligonucleotides having immunostimulatory sequences (iss) wherein the iss are conjugated to antigens and stabilized by buffer conditions and further excipients |
NZ561144A NZ561144A (en) | 2005-03-04 | 2006-03-03 | Vaccines comprising oligonucleotides having immunostimulatory sequences (ISS) wherein the ISS are conjugated to antigens and stabilized by buffer conditions and further excipients |
JP2007558260A JP2008531722A (en) | 2005-03-04 | 2006-03-03 | Composition comprising a structurally stable conjugate molecule |
EP06736828A EP2007421A2 (en) | 2005-03-04 | 2006-03-03 | Vaccines comprising oligonucleotides having immunostimulatory sequences (iss) wherein the iss are conjugated to antigens and stabilized by buffer conditions and further excipients. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65894705P | 2005-03-04 | 2005-03-04 | |
US60/658,947 | 2005-03-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006096497A2 WO2006096497A2 (en) | 2006-09-14 |
WO2006096497A3 true WO2006096497A3 (en) | 2007-05-03 |
Family
ID=36953874
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/007571 WO2006096497A2 (en) | 2005-03-04 | 2006-03-03 | Vaccines comprising oligonucleotides having immunostimulatory sequences (iss) wherein the iss are conjugated to antigens and stabilized by buffer conditions and further excipients |
Country Status (10)
Country | Link |
---|---|
US (2) | US7718622B2 (en) |
EP (1) | EP2007421A2 (en) |
JP (1) | JP2008531722A (en) |
KR (1) | KR20070110901A (en) |
CN (1) | CN101171033A (en) |
AU (1) | AU2006220835B2 (en) |
CA (1) | CA2600036A1 (en) |
NZ (1) | NZ561144A (en) |
SG (1) | SG160336A1 (en) |
WO (1) | WO2006096497A2 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7935675B1 (en) | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
ES2487645T3 (en) * | 2001-06-21 | 2014-08-22 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of use thereof |
EP1551376A4 (en) * | 2002-08-12 | 2010-10-06 | Dynavax Tech Corp | Immunomodulatory compositions, methods of making, and methods of use thereof |
US8158768B2 (en) | 2002-12-23 | 2012-04-17 | Dynavax Technologies Corporation | Immunostimulatory sequence oligonucleotides and methods of using the same |
JP2008531722A (en) | 2005-03-04 | 2008-08-14 | ダイナバックス テクノロジーズ コーポレイション | Composition comprising a structurally stable conjugate molecule |
US8252757B2 (en) | 2006-11-09 | 2012-08-28 | Dynavax Technologies Corporation | Long term disease modification using immunostimulatory oligonucleotides |
US8815817B2 (en) | 2008-05-15 | 2014-08-26 | Dynavax Technologies Corporation | Long term disease modification using immunostimulatory oligonucleotides |
PL2153841T5 (en) * | 2008-08-15 | 2016-09-30 | Circassia Ltd | Vaccine comprising Amb a 1 peptides for use in the treatment of ragweed allergy |
GB0821806D0 (en) * | 2008-11-28 | 2009-01-07 | Circassia Ltd | Compositions with reduced dimer formation |
US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
DE102009034779A1 (en) | 2009-07-25 | 2011-02-03 | Emc Microcollections Gmbh | Synthetic analogues of bacterial lipopeptides and their application for the therapy and prophylaxis of allergic diseases |
CA2919268C (en) | 2013-07-25 | 2023-09-05 | Exicure, Inc. | Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use |
PL3164113T3 (en) | 2014-06-04 | 2019-09-30 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
CN104181309B (en) * | 2014-08-22 | 2016-03-02 | 山东博科生物产业有限公司 | A kind of highly sensitive Troponin I detection kit |
CA2968531A1 (en) | 2014-11-21 | 2016-05-26 | Northwestern University | The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
US11364304B2 (en) | 2016-08-25 | 2022-06-21 | Northwestern University | Crosslinked micellar spherical nucleic acids |
EP3295956A1 (en) | 2016-09-20 | 2018-03-21 | Biomay Ag | Polypeptide construct comprising fragments of allergens |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001015726A2 (en) * | 1999-08-27 | 2001-03-08 | Inex Pharmaceuticals Corp. | Compositions for stimulating cytokine secretion and inducing an immune response |
WO2001035991A2 (en) * | 1999-11-15 | 2001-05-25 | Dynavax Technologies Corporation | Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof |
US6251678B1 (en) * | 1999-02-05 | 2001-06-26 | Merck & Co., Inc. | Human papillomavirus vaccine formulations |
WO2003000922A2 (en) * | 2001-06-21 | 2003-01-03 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same |
WO2003106644A2 (en) * | 2002-06-14 | 2003-12-24 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (rsv) antibody formulations |
WO2004060396A2 (en) * | 2002-12-27 | 2004-07-22 | Chiron Corporation | Immunogenic compositions containing phospholpid |
Family Cites Families (69)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4705684A (en) | 1985-05-31 | 1987-11-10 | The University Of Tennessee Research Corporation | Synthetic M proteins - streptococci type 6 |
AU705889B2 (en) | 1993-08-26 | 1999-06-03 | Regents Of The University Of California, The | Method, compositions and devices for administration of naked polynucleotides which encode antigens and immunostimulatory peptides |
US5830877A (en) | 1993-08-26 | 1998-11-03 | The Regents Of The University Of California | Method, compositions and devices for administration of naked polynucleotides which encode antigens and immunostimulatory |
US5849719A (en) | 1993-08-26 | 1998-12-15 | The Regents Of The University Of California | Method for treating allergic lung disease |
US5985847A (en) | 1993-08-26 | 1999-11-16 | The Regents Of The University Of California | Devices for administration of naked polynucleotides which encode biologically active peptides |
US5679647A (en) | 1993-08-26 | 1997-10-21 | The Regents Of The University Of California | Methods and devices for immunizing a host against tumor-associated antigens through administration of naked polynucleotides which encode tumor-associated antigenic peptides |
US5804566A (en) | 1993-08-26 | 1998-09-08 | The Regents Of The University Of California | Methods and devices for immunizing a host through administration of naked polynucleotides with encode allergenic peptides |
US6270757B1 (en) | 1994-04-21 | 2001-08-07 | Genetics Institute, Inc. | Formulations for IL-11 |
US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US7935675B1 (en) * | 1994-07-15 | 2011-05-03 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6323201B1 (en) | 1994-12-29 | 2001-11-27 | The Regents Of The University Of California | Compounds for inhibition of ceramide-mediated signal transduction |
US5843943A (en) | 1994-12-29 | 1998-12-01 | The Regents Of The University Of California | Compounds for inhibition of ceramide-mediated signal transduction |
US5656730A (en) | 1995-04-07 | 1997-08-12 | Enzon, Inc. | Stabilized monomeric protein compositions |
US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
WO1997028259A1 (en) | 1996-01-30 | 1997-08-07 | The Regents Of The University Of California | Gene expression vectors which generate an antigen specific immune response and methods of using the same |
US5763401A (en) | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
ES2241042T3 (en) | 1996-10-11 | 2005-10-16 | The Regents Of The University Of California | IMMUNO STIMULATOR POLINUCLEOTIDE CONJUGATES / IMMUNOMODULATOR MOLECULA. |
US6797276B1 (en) | 1996-11-14 | 2004-09-28 | The United States Of America As Represented By The Secretary Of The Army | Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response |
US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
DE69840850D1 (en) | 1997-06-06 | 2009-07-09 | Dynavax Tech Corp | INHIBITORS OF IMMUNSTIMULATORY DNA SEQUENCE ACTIVITY |
US20040006034A1 (en) | 1998-06-05 | 2004-01-08 | Eyal Raz | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
US6589940B1 (en) * | 1997-06-06 | 2003-07-08 | Dynavax Technologies Corporation | Immunostimulatory oligonucleotides, compositions thereof and methods of use thereof |
AU757175B2 (en) * | 1997-09-05 | 2003-02-06 | Regents Of The University Of California, The | Use of immunostimulatory oligonucleotides for preventing or reducing antigen-stimulated, granulocyte-mediated inflammation |
US6562798B1 (en) | 1998-06-05 | 2003-05-13 | Dynavax Technologies Corp. | Immunostimulatory oligonucleotides with modified bases and methods of use thereof |
ATE326239T1 (en) | 1998-09-18 | 2006-06-15 | Dynavax Tech Corp | METHODS FOR TREATING IG-E ASSOCIATED DISEASES AND COMPOSITIONS FOR USE IN SUCH METHODS |
AU6425999A (en) | 1998-10-09 | 2000-05-01 | Dynavax Technologies Corporation | Anti hiv compositions comprising immunostimulatory polynucleotides and hiv antigens |
US6689600B1 (en) | 1998-11-16 | 2004-02-10 | Introgen Therapeutics, Inc. | Formulation of adenovirus for gene therapy |
FR2790955B1 (en) * | 1999-03-19 | 2003-01-17 | Assist Publ Hopitaux De Paris | USE OF STABILIZED OLIGONUCLEOTIDES AS ANTI-TUMOR ACTIVE INGREDIENT |
US6737066B1 (en) * | 1999-05-06 | 2004-05-18 | The Immune Response Corporation | HIV immunogenic compositions and methods |
US6930101B1 (en) | 1999-05-17 | 2005-08-16 | The Regents Of The University Of California | Thiazolopyrimidines useful as TNFα inhibitors |
US6514948B1 (en) * | 1999-07-02 | 2003-02-04 | The Regents Of The University Of California | Method for enhancing an immune response |
ATE419869T1 (en) | 1999-08-19 | 2009-01-15 | Dynavax Tech Corp | METHOD FOR MODULATING AN IMMUNE RESPONSE USING IMMUNSTIMULATIVE SEQUENCES AND COMPOSITIONS THEREOF |
DK1221955T3 (en) * | 1999-09-25 | 2006-01-30 | Univ Iowa Res Found | Immune-stimulating nucleic acid |
ATE378348T1 (en) * | 2000-01-14 | 2007-11-15 | Us Health | OLIGODEOXYNUCLEOTIDES AND THEIR USE FOR INDUCING AN IMMUNE RESPONSE |
WO2001055341A2 (en) * | 2000-01-31 | 2001-08-02 | The Regents Of The University Of California | Immunomodulatory polynucleotides in treatment of an infection by an intracellular pathogen |
US7585847B2 (en) * | 2000-02-03 | 2009-09-08 | Coley Pharmaceutical Group, Inc. | Immunostimulatory nucleic acids for the treatment of asthma and allergy |
CA2399550A1 (en) * | 2000-02-23 | 2001-08-30 | The Regents Of The University Of California | Method for treating inflammatory bowel disease and other forms of gastrointestinal inflammation |
US7129222B2 (en) | 2000-03-10 | 2006-10-31 | Dynavax Technologies Corporation | Immunomodulatory formulations and methods for use thereof |
US7157437B2 (en) | 2000-03-10 | 2007-01-02 | Dynavax Technologies Corporation | Methods of ameliorating symptoms of herpes infection using immunomodulatory polynucleotide sequences |
US20020107212A1 (en) | 2000-03-10 | 2002-08-08 | Nest Gary Van | Methods of reducing papillomavirus infection using immunomodulatory polynucleotide sequences |
US20010046967A1 (en) | 2000-03-10 | 2001-11-29 | Gary Van Nest | Methods of preventing and treating respiratory viral infection using immunomodulatory polynucleotide |
US20020098199A1 (en) | 2000-03-10 | 2002-07-25 | Gary Van Nest | Methods of suppressing hepatitis virus infection using immunomodulatory polynucleotide sequences |
US20020028784A1 (en) | 2000-03-10 | 2002-03-07 | Nest Gary Van | Methods of preventing and treating viral infections using immunomodulatory polynucleotide sequences |
US20030129251A1 (en) * | 2000-03-10 | 2003-07-10 | Gary Van Nest | Biodegradable immunomodulatory formulations and methods for use thereof |
CA2404041A1 (en) * | 2000-03-28 | 2001-10-04 | The Regents Of The University Of California | Methods for increasing a cytotoxic t lymphocyte response in vivo |
US20020142978A1 (en) | 2000-04-07 | 2002-10-03 | Eyal Raz | Synergistic improvements to polynucleotide vaccines |
US6893821B2 (en) * | 2000-05-05 | 2005-05-17 | The Regents Of The University Of California | Agents that modulate DNA-PK activity and methods of use thereof |
US6689353B1 (en) | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
WO2002052002A2 (en) | 2000-12-27 | 2002-07-04 | Dynavax Technologies Corporation | Immunomodulatory polynucleotides and methods of using the same |
US7785610B2 (en) | 2001-06-21 | 2010-08-31 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same—III |
US20040132677A1 (en) | 2001-06-21 | 2004-07-08 | Fearon Karen L. | Chimeric immunomodulatory compounds and methods of using the same-IV |
EP1420829A4 (en) | 2001-08-07 | 2006-05-17 | Dynavax Tech Corp | Immunomodulatory compositions, formulations, and methods for use thereof |
WO2003027313A2 (en) * | 2001-09-24 | 2003-04-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | SUPPRESSORS OF CpG OLIGONUCLEOTIDES AND METHODS OF USE |
EP1455833A1 (en) * | 2001-12-04 | 2004-09-15 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES | Chimeric molecule for the treatment of th2-like cytokine mediated disorders |
US7615227B2 (en) * | 2001-12-20 | 2009-11-10 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Use of CpG oligodeoxynucleotides to induce angiogenesis |
US7605138B2 (en) * | 2002-07-03 | 2009-10-20 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US7569553B2 (en) * | 2002-07-03 | 2009-08-04 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
US7576066B2 (en) * | 2002-07-03 | 2009-08-18 | Coley Pharmaceutical Group, Inc. | Nucleic acid compositions for stimulating immune responses |
EP1551376A4 (en) | 2002-08-12 | 2010-10-06 | Dynavax Tech Corp | Immunomodulatory compositions, methods of making, and methods of use thereof |
CN100536853C (en) * | 2002-09-13 | 2009-09-09 | 艾登尼科斯(开曼)有限公司 | Ss-l-2'-deoxynucleosides for the treatment of resistant HBV strains and combination therapies |
AU2003302743B2 (en) | 2002-12-23 | 2008-09-04 | Dynavax Technologies Corporation | Branched immunomodulatory compounds and methods of using the same |
ATE544772T1 (en) | 2002-12-23 | 2012-02-15 | Dynavax Tech Corp | IMMUNO-STIMULATING SEQUENCE OLIGONUCLEOTIDES AND METHOD OF USE THEREOF |
CA2536139A1 (en) * | 2003-09-25 | 2005-04-07 | Coley Pharmaceutical Group, Inc. | Nucleic acid-lipophilic conjugates |
NZ553581A (en) | 2004-09-01 | 2011-04-29 | Dynavax Tech Corp | Methods and compositions for inhibition of innate immune responses and autoimmunity using immunoregulatory polynucleotides with a TGC sequence |
MY159370A (en) * | 2004-10-20 | 2016-12-30 | Coley Pharm Group Inc | Semi-soft-class immunostimulatory oligonucleotides |
EP1836218A2 (en) | 2004-12-17 | 2007-09-26 | Dynavax Technologies Corporation | Methods and compositions for induction or promotion of immune tolerance |
JP2008531722A (en) * | 2005-03-04 | 2008-08-14 | ダイナバックス テクノロジーズ コーポレイション | Composition comprising a structurally stable conjugate molecule |
US8815817B2 (en) * | 2008-05-15 | 2014-08-26 | Dynavax Technologies Corporation | Long term disease modification using immunostimulatory oligonucleotides |
US20120177701A1 (en) * | 2010-12-31 | 2012-07-12 | Selecta Biosciences, Inc. | Compositions comprising immunostimulatory nucleic acids and related methods |
-
2006
- 2006-03-03 JP JP2007558260A patent/JP2008531722A/en active Pending
- 2006-03-03 US US11/367,661 patent/US7718622B2/en not_active Ceased
- 2006-03-03 SG SG201001247-4A patent/SG160336A1/en unknown
- 2006-03-03 AU AU2006220835A patent/AU2006220835B2/en not_active Ceased
- 2006-03-03 NZ NZ561144A patent/NZ561144A/en not_active IP Right Cessation
- 2006-03-03 CN CNA2006800151077A patent/CN101171033A/en active Pending
- 2006-03-03 WO PCT/US2006/007571 patent/WO2006096497A2/en active Application Filing
- 2006-03-03 EP EP06736828A patent/EP2007421A2/en not_active Withdrawn
- 2006-03-03 KR KR1020077022686A patent/KR20070110901A/en not_active Application Discontinuation
- 2006-03-03 CA CA002600036A patent/CA2600036A1/en not_active Abandoned
-
2012
- 2012-05-18 US US13/475,928 patent/USRE45196E1/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6251678B1 (en) * | 1999-02-05 | 2001-06-26 | Merck & Co., Inc. | Human papillomavirus vaccine formulations |
WO2001015726A2 (en) * | 1999-08-27 | 2001-03-08 | Inex Pharmaceuticals Corp. | Compositions for stimulating cytokine secretion and inducing an immune response |
WO2001035991A2 (en) * | 1999-11-15 | 2001-05-25 | Dynavax Technologies Corporation | Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof |
WO2003000922A2 (en) * | 2001-06-21 | 2003-01-03 | Dynavax Technologies Corporation | Chimeric immunomodulatory compounds and methods of using the same |
WO2003106644A2 (en) * | 2002-06-14 | 2003-12-24 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (rsv) antibody formulations |
WO2004060396A2 (en) * | 2002-12-27 | 2004-07-22 | Chiron Corporation | Immunogenic compositions containing phospholpid |
Non-Patent Citations (1)
Title |
---|
SIMONS ET AL: "Selective immune redirection in humans with ragweed allergy by injecting Amb a 1 linked to immunostimulatory DNA", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, MOSBY - YEARLY BOOK, INC, US, vol. 113, no. 6, June 2004 (2004-06-01), pages 1144 - 1151, XP005396559, ISSN: 0091-6749 * |
Also Published As
Publication number | Publication date |
---|---|
WO2006096497A2 (en) | 2006-09-14 |
SG160336A1 (en) | 2010-04-29 |
US20070036807A1 (en) | 2007-02-15 |
AU2006220835B2 (en) | 2012-01-19 |
CN101171033A (en) | 2008-04-30 |
EP2007421A2 (en) | 2008-12-31 |
USRE45196E1 (en) | 2014-10-14 |
AU2006220835A1 (en) | 2006-09-14 |
NZ561144A (en) | 2009-09-25 |
JP2008531722A (en) | 2008-08-14 |
CA2600036A1 (en) | 2006-09-14 |
US7718622B2 (en) | 2010-05-18 |
KR20070110901A (en) | 2007-11-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2006096497A3 (en) | Vaccines comprising oligonucleotides having immunostimulatory sequences (iss) wherein the iss are conjugated to antigens and stabilized by buffer conditions and further excipients | |
WO2006067632A3 (en) | Saccharide conjugate vaccines | |
WO2008021076A3 (en) | Protein matrix vaccines and methods of making and administering such vaccines | |
WO2001035991A3 (en) | Immunomodulatory compositions containing an immunostimulatory sequence linked to antigen and methods of use thereof | |
WO2000062800A3 (en) | Adjuvant composition comprising saponin and an immunostimulatory oligonucleotide | |
MA30066B1 (en) | VACCINE | |
WO2006116475A3 (en) | Immunostimulatory compositions | |
WO2004041157A3 (en) | Group b streptococcus vaccine | |
WO2005097211A3 (en) | Compositions as adjuvants to improve immune responses to vaccines and methods of use | |
DK2343320T3 (en) | ANTI-GITR ANTIBODIES AND APPLICATIONS THEREOF | |
WO2006034292A3 (en) | Antibodies against and methods for producing vaccines for respiratory syncytial virus | |
WO2005055950A3 (en) | Glycopegylated factor ix | |
WO2006031811A3 (en) | Glycopegylated interferon alpha | |
IL155283A0 (en) | Adjuvant composition comprising an immunostimulatory oligonucleotide and a tocol | |
SE0202110D0 (en) | Iscom preparation and use thereof | |
WO2010146598A3 (en) | Stable, dried rotavirus vaccine, compositions and process for preparation thereof | |
WO2007041216A3 (en) | Plasmodium liver stage antigens | |
WO2010141312A3 (en) | Flagellin fusion proteins and conjugates comprising pneumococcus antigens and methods of using the same | |
EP3381445A3 (en) | Aqueous formulation of antibody stablised by antioxidants for parenteral administration | |
WO2007116409A3 (en) | Improved vaccines comprising multimeric hsp60 peptide carriers | |
Gaertner et al. | Efficient orthogonal bioconjugation of dendrimers for synthesis of bioactive nanoparticles | |
WO2006105993A3 (en) | Method for shielding functional sites or epitopes on proteins | |
WO2003025119A3 (en) | Compositions comprising immunostimulatory oligonucleotides and uses thereof to enhance fc receptor-mediated immunotherapies | |
Demircan et al. | Biotin Functionalized Self‐Assembled Peptide Nanofiber as an Adjuvant for Immunomodulatory Response | |
WO2005007673A3 (en) | Immunogenic peptides |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200680015107.7 Country of ref document: CN |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006220835 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007558260 Country of ref document: JP Ref document number: 561144 Country of ref document: NZ |
|
ENP | Entry into the national phase |
Ref document number: 2600036 Country of ref document: CA |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2006220835 Country of ref document: AU Date of ref document: 20060303 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006736828 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: RU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020077022686 Country of ref document: KR |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 06736828 Country of ref document: EP Kind code of ref document: A2 |