WO2006096835A3 - Monitoring and manipulating cellular transmembrane potentials using nanostructures - Google Patents

Monitoring and manipulating cellular transmembrane potentials using nanostructures Download PDF

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Publication number
WO2006096835A3
WO2006096835A3 PCT/US2006/008560 US2006008560W WO2006096835A3 WO 2006096835 A3 WO2006096835 A3 WO 2006096835A3 US 2006008560 W US2006008560 W US 2006008560W WO 2006096835 A3 WO2006096835 A3 WO 2006096835A3
Authority
WO
WIPO (PCT)
Prior art keywords
nanostructures
monitoring
transmembrane potentials
cellular transmembrane
manipulating cellular
Prior art date
Application number
PCT/US2006/008560
Other languages
French (fr)
Other versions
WO2006096835A2 (en
Inventor
Michael J Ignatius
Elena Molokanova
Alex Savtchenko
Original Assignee
Molecular Probes Inc
Michael J Ignatius
Elena Molokanova
Alex Savtchenko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Molecular Probes Inc, Michael J Ignatius, Elena Molokanova, Alex Savtchenko filed Critical Molecular Probes Inc
Priority to JP2008500960A priority Critical patent/JP2008532522A/en
Priority to EP06748333.9A priority patent/EP1869451B1/en
Publication of WO2006096835A2 publication Critical patent/WO2006096835A2/en
Publication of WO2006096835A3 publication Critical patent/WO2006096835A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots

Abstract

The use of nanostructures to monitor or modulate changes in cellular membrane potentials is disclosed. Nanoparticles having phospholipid coatings were found to display improved responses relative to nanoparticles having other coatings that do not promote localization or attraction to membranes.
PCT/US2006/008560 2005-03-08 2006-03-08 Monitoring and manipulating cellular transmembrane potentials using nanostructures WO2006096835A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2008500960A JP2008532522A (en) 2005-03-08 2006-03-08 Monitoring and manipulating cell membrane potential differences using nanostructures
EP06748333.9A EP1869451B1 (en) 2005-03-08 2006-03-08 Monitoring and manipulating cellular transmembrane potentials using nanostructures

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US65997505P 2005-03-08 2005-03-08
US60/659,975 2005-03-08

Publications (2)

Publication Number Publication Date
WO2006096835A2 WO2006096835A2 (en) 2006-09-14
WO2006096835A3 true WO2006096835A3 (en) 2006-12-21

Family

ID=36954044

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/008560 WO2006096835A2 (en) 2005-03-08 2006-03-08 Monitoring and manipulating cellular transmembrane potentials using nanostructures

Country Status (4)

Country Link
US (3) US20100116664A1 (en)
EP (1) EP1869451B1 (en)
JP (1) JP2008532522A (en)
WO (1) WO2006096835A2 (en)

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US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
WO2006094263A2 (en) 2005-03-03 2006-09-08 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
US8562660B2 (en) 2005-08-05 2013-10-22 Gholam A. Peyman Methods to regulate polarization and enhance function of excitable cells
US8460351B2 (en) * 2005-08-05 2013-06-11 Gholam A. Peyman Methods to regulate polarization and enhance function of excitable cells
WO2008154645A1 (en) * 2007-06-12 2008-12-18 University Of Southern California Functional abiotic nanosystems
WO2009048039A1 (en) * 2007-10-12 2009-04-16 Konica Minolta Medical & Graphic, Inc. Molecule/cell imaging method and semiconductor nanoparticle
CN102119331A (en) * 2008-06-05 2011-07-06 生命科技公司 Activation and monitoring of cellular transmembrane potentials
JP5168092B2 (en) * 2008-11-10 2013-03-21 コニカミノルタエムジー株式会社 Semiconductor nanoparticle labeling agent
JP5492477B2 (en) * 2009-07-09 2014-05-14 株式会社リプロセル Culture solution for measuring membrane potential of cells, culture method using the same, and membrane potential measurement method
DE102011080772B3 (en) * 2011-08-10 2012-12-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Apparatus, system and method for detecting sensory perception
WO2014100283A1 (en) * 2012-12-19 2014-06-26 University Of Southern California Photoactivated molecules for light-induced modulation of the activity of electrically excitable cells and methods of using same
US11291931B2 (en) 2014-12-15 2022-04-05 Akadeum Life Sciences, Inc. Method and system for buoyant separation
US9763892B2 (en) * 2015-06-01 2017-09-19 Autotelic Llc Immediate release phospholipid-coated therapeutic agent nanoparticles and related methods
WO2017031380A1 (en) 2015-08-19 2017-02-23 University Of Southern California Photoactivated molecules for light-induced modulation of the activity of electrically excitable cells and methods of using
US10935512B2 (en) * 2015-09-24 2021-03-02 Roche Sequencing Solutions, Inc. Encoding state change of nanopore to reduce data size
US10102338B2 (en) 2015-09-24 2018-10-16 Genia Technologies, Inc. Adaptive compression and modification of nanopore measurement data
GB201806419D0 (en) * 2018-04-19 2018-06-06 Univ Warwick Detecting cell vitality

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Also Published As

Publication number Publication date
JP2008532522A (en) 2008-08-21
EP1869451A4 (en) 2009-03-25
US8290714B2 (en) 2012-10-16
US20100178665A1 (en) 2010-07-15
EP1869451A2 (en) 2007-12-26
EP1869451B1 (en) 2013-06-26
WO2006096835A2 (en) 2006-09-14
US20100116664A1 (en) 2010-05-13
US20130033252A1 (en) 2013-02-07
US9506930B2 (en) 2016-11-29

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