WO2006098772A3 - Systems and methods for measurement optimization - Google Patents
Systems and methods for measurement optimization Download PDFInfo
- Publication number
- WO2006098772A3 WO2006098772A3 PCT/US2005/037092 US2005037092W WO2006098772A3 WO 2006098772 A3 WO2006098772 A3 WO 2006098772A3 US 2005037092 W US2005037092 W US 2005037092W WO 2006098772 A3 WO2006098772 A3 WO 2006098772A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- systems
- methods
- measurement optimization
- optimization
- measurement
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000005259 measurement Methods 0.000 title 1
- 238000005457 optimization Methods 0.000 title 1
- 230000003287 optical effect Effects 0.000 abstract 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0654—Lenses; Optical fibres
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/087—Multiple sequential chambers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/16—Surface properties and coatings
- B01L2300/168—Specific optical properties, e.g. reflective coatings
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N2021/0346—Capillary cells; Microcells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N21/03—Cuvette constructions
- G01N21/05—Flow-through cuvettes
- G01N2021/058—Flat flow cell
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6469—Cavity, e.g. ellipsoid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6463—Optics
- G01N2021/6478—Special lenses
Abstract
The invention relates to methods and systems for detecting and or analyzing an agent in a sample with a chip having optical components incorporated therein.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61845304P | 2004-10-13 | 2004-10-13 | |
US60/618,453 | 2004-10-13 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006098772A2 WO2006098772A2 (en) | 2006-09-21 |
WO2006098772A3 true WO2006098772A3 (en) | 2007-11-22 |
Family
ID=36992165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/037092 WO2006098772A2 (en) | 2004-10-13 | 2005-10-13 | Systems and methods for measurement optimization |
Country Status (2)
Country | Link |
---|---|
US (2) | US7262859B2 (en) |
WO (1) | WO2006098772A2 (en) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6696022B1 (en) * | 1999-08-13 | 2004-02-24 | U.S. Genomics, Inc. | Methods and apparatuses for stretching polymers |
JP2005504275A (en) * | 2001-09-18 | 2005-02-10 | ユー.エス. ジェノミクス, インコーポレイテッド | Differential tagging of polymers for high-resolution linear analysis |
WO2003091455A1 (en) * | 2002-04-23 | 2003-11-06 | U.S.Genomics, Inc. | Compositions and methods related to two-arm nucleic acid probes |
US7282330B2 (en) * | 2002-05-28 | 2007-10-16 | U.S. Genomics, Inc. | Methods and apparati using single polymer analysis |
JP2005527220A (en) * | 2002-05-28 | 2005-09-15 | ユー.エス. ジェノミクス, インコーポレイテッド | Method and apparatus using single polymer analysis |
WO2004007692A2 (en) * | 2002-07-17 | 2004-01-22 | U.S.Genomics, Inc. | Methods and compositions for analyzing polymers using chimeric tags |
WO2004066185A1 (en) * | 2003-01-23 | 2004-08-05 | U.S. Genomics, Inc. | Methods for analyzing polymer populations |
EP1620203A2 (en) * | 2003-04-10 | 2006-02-01 | U.S. Genomics, Inc. | Manipulation of polymers in a microchannel |
JP2007501003A (en) * | 2003-08-01 | 2007-01-25 | ユー.エス. ジェノミクス, インコーポレイテッド | Methods and compositions related to the use of sequence-specific endonucleases for analyzing nucleic acids under non-cleaving conditions |
WO2005067692A2 (en) * | 2004-01-13 | 2005-07-28 | U.S. Genomics, Inc. | Detection and quantification of analytes in solution using polymers |
US7595160B2 (en) * | 2004-01-13 | 2009-09-29 | U.S. Genomics, Inc. | Analyte detection using barcoded polymers |
JP2007529758A (en) * | 2004-03-19 | 2007-10-25 | ユー.エス. ジェノミクス, インコーポレイテッド | Compositions and methods for single molecule detection |
US20080003689A1 (en) * | 2004-07-13 | 2008-01-03 | U.S. Genomics, Inc. | Systems and methods for sample modification using fluidic chambers |
US7351538B2 (en) * | 2004-08-23 | 2008-04-01 | U.S. Genomics | Systems and methods for detecting and analyzing polymers |
WO2006036182A2 (en) * | 2004-09-28 | 2006-04-06 | Singulex, Inc. | System and method for spectroscopic analysis of single particles |
US7572640B2 (en) * | 2004-09-28 | 2009-08-11 | Singulex, Inc. | Method for highly sensitive detection of single protein molecules labeled with fluorescent moieties |
US8685711B2 (en) * | 2004-09-28 | 2014-04-01 | Singulex, Inc. | Methods and compositions for highly sensitive detection of molecules |
US9040305B2 (en) * | 2004-09-28 | 2015-05-26 | Singulex, Inc. | Method of analysis for determining a specific protein in blood samples using fluorescence spectrometry |
WO2006098772A2 (en) * | 2004-10-13 | 2006-09-21 | U.S. Genomics, Inc. | Systems and methods for measurement optimization |
US20070128083A1 (en) * | 2005-07-18 | 2007-06-07 | U.S. Genomics, Inc. | Microfluidic methods and apparatuses for sample preparation and analysis |
WO2007056250A2 (en) * | 2005-11-04 | 2007-05-18 | U.S. Genomics, Inc. | Heterogeneous assay of analytes in solution using polymers |
EP2041478B1 (en) * | 2006-03-07 | 2014-08-06 | QD Vision, Inc. | An article including semiconductor nanocrystals |
US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
EP3495822B1 (en) | 2006-04-04 | 2023-12-20 | Novilux, LLC | Method for assessing acute myocardial infarction based on highly sensitive analysis of cardiac troponin |
WO2007117668A2 (en) | 2006-04-07 | 2007-10-18 | Qd Vision, Inc. | Methods and articles including nanomaterial |
US7750316B2 (en) * | 2006-05-10 | 2010-07-06 | Dublin City University | Polymer biochip for detecting fluorescence |
CN103203256B (en) | 2006-07-19 | 2015-09-23 | 博纳基因技术有限公司 | Nanometer mouth apparatus array: their preparation and the application in large analysis of molecules |
WO2008085991A2 (en) | 2007-01-08 | 2008-07-17 | U.S. Genomics, Inc. | Reaction chamber |
WO2008117651A1 (en) * | 2007-03-26 | 2008-10-02 | Konica Minolta Opto, Inc. | Microchip |
CN103305402A (en) | 2007-03-28 | 2013-09-18 | 博纳基因技术有限公司 | Method of macromolecular analysis using nanochannel arrays |
CN103495439B (en) | 2007-05-04 | 2015-09-16 | 欧普科诊断有限责任公司 | Fluid connector and microfluid system |
DE102007021544A1 (en) * | 2007-05-08 | 2008-11-13 | Siemens Ag | Measuring unit and method for optically examining a liquid for an analyte concentration |
US20100294665A1 (en) * | 2007-07-12 | 2010-11-25 | Richard Allen | Method and system for transferring and/or concentrating a sample |
EP2201136B1 (en) | 2007-10-01 | 2017-12-06 | Nabsys 2.0 LLC | Nanopore sequencing by hybridization of probes to form ternary complexes and variable range alignment |
US7914734B2 (en) | 2007-12-19 | 2011-03-29 | Singulex, Inc. | Scanning analyzer for single molecule detection and methods of use |
WO2009110222A1 (en) * | 2008-03-03 | 2009-09-11 | パナソニック株式会社 | Near-field light detection element and reproduction method for information recording medium |
KR101470997B1 (en) * | 2008-05-13 | 2014-12-09 | 가부시키가이샤 플래너즈 랜드 | Reflective collection-type light receiving unit and light receiving apparatus for spatial light communications |
JP5816083B2 (en) * | 2008-06-24 | 2015-11-17 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | Microarray evaluation system and method |
EP2163885A1 (en) * | 2008-06-24 | 2010-03-17 | Koninklijke Philips Electronics N.V. | Microarray characterization system and method |
CA3062190C (en) | 2008-06-30 | 2023-03-28 | Bionano Genomics, Inc. | Methods and devices for single-molecule whole genome analysis |
US8256931B2 (en) * | 2008-07-24 | 2012-09-04 | Seward George H | Achromatic homogenizer and collimator for LEDs |
EP2151680A1 (en) * | 2008-08-05 | 2010-02-10 | F. Hoffmann-Roche AG | Assembly method for manufacturing an analysis system |
US8262879B2 (en) | 2008-09-03 | 2012-09-11 | Nabsys, Inc. | Devices and methods for determining the length of biopolymers and distances between probes bound thereto |
US9650668B2 (en) | 2008-09-03 | 2017-05-16 | Nabsys 2.0 Llc | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
EP2342362B1 (en) | 2008-09-03 | 2017-03-01 | Nabsys 2.0 LLC | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
US8361716B2 (en) | 2008-10-03 | 2013-01-29 | Pathogenetix, Inc. | Focusing chamber |
US9034277B2 (en) * | 2008-10-24 | 2015-05-19 | Honeywell International Inc. | Surface preparation for a microfluidic channel |
CN104372080B (en) | 2008-11-18 | 2018-03-30 | 博纳基因技术有限公司 | polynucleotide mapping and sequencing |
ES2695039T3 (en) | 2009-02-02 | 2018-12-28 | Opko Diagnostics, Llc | Structures to control the interaction of light with microfluidic devices |
US8455260B2 (en) | 2009-03-27 | 2013-06-04 | Massachusetts Institute Of Technology | Tagged-fragment map assembly |
US8246799B2 (en) | 2009-05-28 | 2012-08-21 | Nabsys, Inc. | Devices and methods for analyzing biomolecules and probes bound thereto |
US8450069B2 (en) | 2009-06-08 | 2013-05-28 | Singulex, Inc. | Highly sensitive biomarker panels |
JP2011038922A (en) * | 2009-08-12 | 2011-02-24 | Sony Corp | Light detection chip, and light detection device using the same |
AU2010322751B2 (en) | 2009-11-27 | 2014-05-29 | Ecole Polytechnique Federale De Lausanne (Epfl) | Nanofluidic biosensor and its use for rapid measurement of biomolecular interactions in solution and methods |
EP2566971B1 (en) | 2010-05-06 | 2019-03-27 | Singulex, Inc. | Methods for diagnosing, staging, predicting risk for developing and identifying treatment responders for rheumatoid arthritis |
US8715933B2 (en) | 2010-09-27 | 2014-05-06 | Nabsys, Inc. | Assay methods using nicking endonucleases |
US8859201B2 (en) | 2010-11-16 | 2014-10-14 | Nabsys, Inc. | Methods for sequencing a biomolecule by detecting relative positions of hybridized probes |
WO2012109574A2 (en) | 2011-02-11 | 2012-08-16 | Nabsys, Inc. | Assay methods using dna binding proteins |
JP5765081B2 (en) * | 2011-06-22 | 2015-08-19 | ソニー株式会社 | Image sensor, electronic device, manufacturing method, and inspection apparatus |
KR101890753B1 (en) * | 2011-11-30 | 2018-10-01 | 삼성전자 주식회사 | Gene analysis device |
CN102495213A (en) * | 2011-11-30 | 2012-06-13 | 中华人民共和国北京出入境检验检疫局 | Kit used for detecting phytopathogenic fungi and detection method thereof |
JP5575159B2 (en) * | 2012-01-26 | 2014-08-20 | シャープ株式会社 | Fluorescence information reading apparatus and fluorescence information reading method |
US9672329B2 (en) | 2012-03-05 | 2017-06-06 | Opko Diagnostics, Llc | Methods and apparatuses for predicting risk of prostate cancer and prostate gland volume |
AU2013204332B2 (en) | 2012-04-16 | 2015-07-16 | Commonwealth Scientific And Industrial Research Organisation | Methods and systems for detecting an analyte or classifying a sample |
US8685708B2 (en) | 2012-04-18 | 2014-04-01 | Pathogenetix, Inc. | Device for preparing a sample |
US8956815B2 (en) | 2012-04-18 | 2015-02-17 | Toxic Report Llc | Intercalation methods and devices |
US9028776B2 (en) | 2012-04-18 | 2015-05-12 | Toxic Report Llc | Device for stretching a polymer in a fluid sample |
US9914966B1 (en) | 2012-12-20 | 2018-03-13 | Nabsys 2.0 Llc | Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation |
EP2956550B1 (en) | 2013-01-18 | 2020-04-08 | Nabsys 2.0 LLC | Enhanced probe binding |
FI128503B (en) | 2013-02-27 | 2020-06-30 | Teknologian Tutkimuskeskus Vtt Oy | Sample plate and analyzing method |
AU2013202635B2 (en) * | 2013-03-14 | 2015-10-29 | Inguran, Llc | Apparatus and methods for high throughput sperm sorting |
GB201418897D0 (en) * | 2014-10-23 | 2014-12-10 | Univ Hull | Methods and apparatus for the analysis of compounds |
GB201418893D0 (en) | 2014-10-23 | 2014-12-10 | Univ Hull | Monolithic body |
GB201418899D0 (en) | 2014-10-23 | 2014-12-10 | Univ Hull | System for radiopharmaceutical production |
EP3091347A1 (en) * | 2015-05-04 | 2016-11-09 | The European Union, represented by the European Commission | Screening of nanoparticle properties |
CN107567582B (en) * | 2015-07-24 | 2020-10-13 | 惠普发展公司,有限责任合伙企业 | Light guide for fluid testing unit |
AU2018315053B2 (en) | 2017-08-08 | 2022-04-28 | PPB Technology Pty Ltd | Carbohydrate sensors |
JP2020003215A (en) * | 2018-06-25 | 2020-01-09 | 新光電気工業株式会社 | Flow cell |
US10908065B2 (en) * | 2018-09-17 | 2021-02-02 | Inguran, Llc | Light collection from objects within a fluid column |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869001A (en) * | 1993-09-17 | 1999-02-09 | Boehringer Mannheim Gmbh | Apparatus for the quantitative analysis of sample liquid |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3123249B2 (en) | 1991-09-10 | 2001-01-09 | 株式会社日立製作所 | DNA molecule length measuring method and measuring device |
WO1994016104A1 (en) | 1993-01-08 | 1994-07-21 | Ctrc Research Foundation | Color imaging system for use in molecular biology |
US5675155A (en) | 1995-04-26 | 1997-10-07 | Beckman Instruments, Inc. | Multicapillary fluorescent detection system |
US5867266A (en) * | 1996-04-17 | 1999-02-02 | Cornell Research Foundation, Inc. | Multiple optical channels for chemical analysis |
WO1998010097A2 (en) | 1996-09-03 | 1998-03-12 | Pioneer Hi-Bred International, Inc. | Method and apparatus for single molecule two color fluorescent detection and molecular weight and concentration determination |
US6403311B1 (en) | 1997-02-12 | 2002-06-11 | Us Genomics | Methods of analyzing polymers using ordered label strategies |
DE69825601T2 (en) | 1997-02-12 | 2005-04-28 | Chan, Eugene Y, Brookline | METHOD FOR THE ANALYSIS OF POLYMERS |
US6100541A (en) | 1998-02-24 | 2000-08-08 | Caliper Technologies Corporation | Microfluidic devices and systems incorporating integrated optical elements |
US6210896B1 (en) | 1998-08-13 | 2001-04-03 | Us Genomics | Molecular motors |
EP1105535A1 (en) | 1998-08-13 | 2001-06-13 | U.S. Genomics | Optically characterizing polymers |
US6263286B1 (en) | 1998-08-13 | 2001-07-17 | U.S. Genomics, Inc. | Methods of analyzing polymers using a spatial network of fluorophores and fluorescence resonance energy transfer |
US6790671B1 (en) | 1998-08-13 | 2004-09-14 | Princeton University | Optically characterizing polymers |
US6014270A (en) | 1998-11-23 | 2000-01-11 | Lucent Technologies Inc | Cylindrical lenses for alignment of optical sources and destinations |
US6927065B2 (en) | 1999-08-13 | 2005-08-09 | U.S. Genomics, Inc. | Methods and apparatus for characterization of single polymers |
US6762059B2 (en) | 1999-08-13 | 2004-07-13 | U.S. Genomics, Inc. | Methods and apparatuses for characterization of single polymers |
US6696022B1 (en) | 1999-08-13 | 2004-02-24 | U.S. Genomics, Inc. | Methods and apparatuses for stretching polymers |
US20020187508A1 (en) | 2001-06-08 | 2002-12-12 | Wong Gordon G. | Methods and products for analyzing nucleic acids using nick translation |
WO2002101353A2 (en) | 2001-06-08 | 2002-12-19 | U.S. Genomics, Inc. | Methods and products for analyzing nucleic acids based on methylation status |
JP2005504275A (en) | 2001-09-18 | 2005-02-10 | ユー.エス. ジェノミクス, インコーポレイテッド | Differential tagging of polymers for high-resolution linear analysis |
US8423294B2 (en) | 2001-09-18 | 2013-04-16 | Pathogenetix, Inc. | High resolution linear analysis of polymers |
WO2003091455A1 (en) | 2002-04-23 | 2003-11-06 | U.S.Genomics, Inc. | Compositions and methods related to two-arm nucleic acid probes |
EP1540017A4 (en) | 2002-05-09 | 2006-05-24 | Us Genomics Inc | Methods for analyzing a nucleic acid |
JP2005527220A (en) | 2002-05-28 | 2005-09-15 | ユー.エス. ジェノミクス, インコーポレイテッド | Method and apparatus using single polymer analysis |
US7282330B2 (en) * | 2002-05-28 | 2007-10-16 | U.S. Genomics, Inc. | Methods and apparati using single polymer analysis |
WO2004007692A2 (en) | 2002-07-17 | 2004-01-22 | U.S.Genomics, Inc. | Methods and compositions for analyzing polymers using chimeric tags |
WO2004066185A1 (en) | 2003-01-23 | 2004-08-05 | U.S. Genomics, Inc. | Methods for analyzing polymer populations |
EP1620203A2 (en) | 2003-04-10 | 2006-02-01 | U.S. Genomics, Inc. | Manipulation of polymers in a microchannel |
JP2007501003A (en) | 2003-08-01 | 2007-01-25 | ユー.エス. ジェノミクス, インコーポレイテッド | Methods and compositions related to the use of sequence-specific endonucleases for analyzing nucleic acids under non-cleaving conditions |
WO2005017205A2 (en) | 2003-08-04 | 2005-02-24 | U. S. Genomics, Inc. | Nucleic acid mapping using linear analysis |
US20050042665A1 (en) | 2003-08-21 | 2005-02-24 | U.S. Genomics, Inc. | Quantum dots and methods of use thereof |
WO2005047471A2 (en) | 2003-11-07 | 2005-05-26 | U.S. Genomics, Inc. | Improved fret efficiency methods |
WO2005047470A2 (en) | 2003-11-07 | 2005-05-26 | U.S. Genomics, Inc. | Intercalator fret donors or acceptors |
WO2005050171A2 (en) | 2003-11-17 | 2005-06-02 | U.S. Genomics, Inc. | Methods and compositions relating to single reactive center reagents |
WO2005067692A2 (en) | 2004-01-13 | 2005-07-28 | U.S. Genomics, Inc. | Detection and quantification of analytes in solution using polymers |
US7595160B2 (en) * | 2004-01-13 | 2009-09-29 | U.S. Genomics, Inc. | Analyte detection using barcoded polymers |
US20050196790A1 (en) | 2004-02-05 | 2005-09-08 | U.S. Genomics, Inc. | Methods for detection and quantitation of minimum length polymers |
JP2007529758A (en) | 2004-03-19 | 2007-10-25 | ユー.エス. ジェノミクス, インコーポレイテッド | Compositions and methods for single molecule detection |
US20080003689A1 (en) * | 2004-07-13 | 2008-01-03 | U.S. Genomics, Inc. | Systems and methods for sample modification using fluidic chambers |
US7351538B2 (en) | 2004-08-23 | 2008-04-01 | U.S. Genomics | Systems and methods for detecting and analyzing polymers |
WO2006098772A2 (en) | 2004-10-13 | 2006-09-21 | U.S. Genomics, Inc. | Systems and methods for measurement optimization |
US7888011B2 (en) * | 2004-10-18 | 2011-02-15 | U.S. Genomics, Inc. | Methods for isolation of nucleic acids from prokaryotic spores |
US20060160231A1 (en) | 2004-11-24 | 2006-07-20 | U.S. Genomics, Inc. | Linear analysis of polymers |
US20060134679A1 (en) | 2004-12-17 | 2006-06-22 | U.S. Genomics, Inc. | Methods and compositions for acquiring information from unstretched polymer conformations |
US20060292617A1 (en) * | 2005-06-23 | 2006-12-28 | U.S. Genomics, Inc. | Methods and compositions for analysis of microRNA |
US20060292616A1 (en) * | 2005-06-23 | 2006-12-28 | U.S. Genomics, Inc. | Single molecule miRNA-based disease diagnostic methods |
US20070128083A1 (en) * | 2005-07-18 | 2007-06-07 | U.S. Genomics, Inc. | Microfluidic methods and apparatuses for sample preparation and analysis |
US20070042406A1 (en) * | 2005-07-18 | 2007-02-22 | U.S. Genomics, Inc. | Diffusion mediated clean-up of a target carrier fluid |
-
2005
- 2005-10-13 WO PCT/US2005/037092 patent/WO2006098772A2/en active Application Filing
- 2005-10-13 US US11/250,179 patent/US7262859B2/en not_active Expired - Fee Related
-
2007
- 2007-07-03 US US11/772,961 patent/US20080085552A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5869001A (en) * | 1993-09-17 | 1999-02-09 | Boehringer Mannheim Gmbh | Apparatus for the quantitative analysis of sample liquid |
Also Published As
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WO2006098772A2 (en) | 2006-09-21 |
US7262859B2 (en) | 2007-08-28 |
US20080085552A1 (en) | 2008-04-10 |
US20060160209A1 (en) | 2006-07-20 |
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