WO2006101740A3 - Compounds having activity in correcting mutant-cftr processing and uses thereof - Google Patents
Compounds having activity in correcting mutant-cftr processing and uses thereofInfo
- Publication number
- WO2006101740A3 WO2006101740A3 PCT/US2006/008267 US2006008267W WO2006101740A3 WO 2006101740 A3 WO2006101740 A3 WO 2006101740A3 US 2006008267 W US2006008267 W US 2006008267W WO 2006101740 A3 WO2006101740 A3 WO 2006101740A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- containing compounds
- compounds
- activity
- mutant
- cftr
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D277/82—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/908,591 US8143295B2 (en) | 2005-03-18 | 2006-03-08 | Compounds having activity in correcting mutant-CFTR processing and uses thereof |
AU2006227833A AU2006227833A1 (en) | 2005-03-18 | 2006-03-08 | Compounds having activity in correcting mutant-CFTR processing and uses thereof |
BRPI0608453-2A BRPI0608453A2 (en) | 2005-03-18 | 2006-03-08 | compounds having activity in the correction of mutant cftr processing and uses of these |
CA002600869A CA2600869A1 (en) | 2005-03-18 | 2006-03-08 | Compounds having activity in correcting mutant-cftr processing and uses thereof |
MX2007011512A MX2007011512A (en) | 2005-03-18 | 2006-03-08 | Compounds having activity in correcting mutant-cftr processing and uses thereof. |
JP2008501913A JP2008538107A (en) | 2005-03-18 | 2006-03-08 | Compounds having activity in correcting mutant CFTR processing and uses thereof |
EP06737438A EP1863522A4 (en) | 2005-03-18 | 2006-03-08 | Compounds having activity in correcting mutant-cftr processing and uses thereof |
IL185999A IL185999A0 (en) | 2005-03-18 | 2007-09-17 | Compounds having activity in correcting mutant-cftr processing and uses thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66350105P | 2005-03-18 | 2005-03-18 | |
US60/663,501 | 2005-03-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006101740A2 WO2006101740A2 (en) | 2006-09-28 |
WO2006101740A3 true WO2006101740A3 (en) | 2009-06-04 |
Family
ID=37024308
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/008267 WO2006101740A2 (en) | 2005-03-18 | 2006-03-08 | Compounds having activity in correcting mutant-cftr processing and uses thereof |
Country Status (12)
Country | Link |
---|---|
US (1) | US8143295B2 (en) |
EP (1) | EP1863522A4 (en) |
JP (1) | JP2008538107A (en) |
KR (1) | KR20070114820A (en) |
CN (1) | CN101605543A (en) |
AU (1) | AU2006227833A1 (en) |
BR (1) | BRPI0608453A2 (en) |
CA (1) | CA2600869A1 (en) |
IL (1) | IL185999A0 (en) |
MX (1) | MX2007011512A (en) |
RU (1) | RU2007138584A (en) |
WO (1) | WO2006101740A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8952050B2 (en) | 2006-04-07 | 2015-02-10 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
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US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
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US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
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US8318935B2 (en) | 2007-05-07 | 2012-11-27 | Novartis Ag | Organic compounds 75074 |
US20110177999A1 (en) * | 2007-08-09 | 2011-07-21 | Vertex Pharmaceuticals Incorporated | Therapeutic Combinations Useful in Treating CFTR Related Diseases |
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ITMI20122065A1 (en) * | 2012-12-03 | 2014-06-04 | Univ Padova | USE OF CFTR CORRECTORS IN THE TREATMENT OF STRUCTURAL MUSCLE PATHOLOGIES |
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US10828288B2 (en) | 2015-01-27 | 2020-11-10 | Rutgers, The State University Of New Jersey | Hydrazone derivatives for the treatment of cancer |
ITUB20153714A1 (en) * | 2015-09-18 | 2017-03-18 | Luigina Romani | Thymosine alfa 1 for use in the treatment of cystic fibrosis. |
KR102648036B1 (en) * | 2015-02-09 | 2024-03-14 | 시클론 파마수티컬 인터내셔널 리미티드 | Thymosin alpha 1 for use in the treatment of cystic fibrosis |
WO2017060880A1 (en) * | 2015-10-09 | 2017-04-13 | AbbVie S.à.r.l. | Potentiator-corrector combinations useful in the treatment of cystic fibrosis |
WO2019138012A1 (en) | 2018-01-11 | 2019-07-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Combination treatment of sarcoglycanopathies |
WO2020049189A1 (en) | 2018-09-09 | 2020-03-12 | Qanatpharma Gmbh | Use of cftr modulators for treating cerebrovascular conditions |
KR102399037B1 (en) * | 2020-01-06 | 2022-05-17 | 성균관대학교산학협력단 | Novel Production Method for Aminated Azine |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4501750A (en) * | 1981-01-13 | 1985-02-26 | Mitsui Toatsu Kaguku Kabushiki Kaisha | Thiazole compounds, a process for preparing same and a pharmaceutical composition containing the thiazole compounds |
EP0519449A1 (en) * | 1991-06-21 | 1992-12-23 | Boehringer Mannheim Italia S.P.A. | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract |
US6770663B2 (en) * | 2000-12-29 | 2004-08-03 | Alteon, Inc. | Method for treating fibrotic diseases or other indications utilizing thiazole, oxazole and imidazole compounds |
WO2004110352A2 (en) * | 2003-05-16 | 2004-12-23 | The Regents Of The University Of California | Compounds having activity in increasing ion transport by mutant-cftr and uses thereof |
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---|---|---|---|---|
JPS649935A (en) * | 1987-06-30 | 1989-01-13 | Kyowa Hakko Kogyo Kk | Remedy for hepatopathy |
US6262096B1 (en) * | 1997-11-12 | 2001-07-17 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
HN2002000156A (en) * | 2001-07-06 | 2003-11-27 | Inc Agouron Pharmaceuticals | BENZAMIDE THIAZOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS TO INHIBIT THE PROLIFERATION OF CELLS AND METHODS FOR THEIR USE. |
SE0201837D0 (en) * | 2002-06-14 | 2002-06-14 | Astrazeneca Ab | Chemical compounds |
US7329682B2 (en) * | 2003-04-03 | 2008-02-12 | Ewha University-Industry Collaboration Foundation | Method for inhibiting 5-lipoxygenase using a benzoxazole derivative |
WO2004098510A2 (en) * | 2003-04-30 | 2004-11-18 | Beth Israel Deaconess Medical Center | Cystic fibrosis therapy |
-
2006
- 2006-03-08 EP EP06737438A patent/EP1863522A4/en not_active Withdrawn
- 2006-03-08 BR BRPI0608453-2A patent/BRPI0608453A2/en not_active Application Discontinuation
- 2006-03-08 CN CNA2006800150356A patent/CN101605543A/en active Pending
- 2006-03-08 MX MX2007011512A patent/MX2007011512A/en not_active Application Discontinuation
- 2006-03-08 CA CA002600869A patent/CA2600869A1/en not_active Abandoned
- 2006-03-08 US US11/908,591 patent/US8143295B2/en active Active
- 2006-03-08 RU RU2007138584/04A patent/RU2007138584A/en not_active Application Discontinuation
- 2006-03-08 KR KR1020077024001A patent/KR20070114820A/en not_active Application Discontinuation
- 2006-03-08 JP JP2008501913A patent/JP2008538107A/en not_active Withdrawn
- 2006-03-08 WO PCT/US2006/008267 patent/WO2006101740A2/en active Application Filing
- 2006-03-08 AU AU2006227833A patent/AU2006227833A1/en not_active Abandoned
-
2007
- 2007-09-17 IL IL185999A patent/IL185999A0/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4501750A (en) * | 1981-01-13 | 1985-02-26 | Mitsui Toatsu Kaguku Kabushiki Kaisha | Thiazole compounds, a process for preparing same and a pharmaceutical composition containing the thiazole compounds |
EP0519449A1 (en) * | 1991-06-21 | 1992-12-23 | Boehringer Mannheim Italia S.P.A. | 2-Amino-4-aryl thiazoles with antiasthmatic and antiinflammatory activities on the respiratory tract |
US6770663B2 (en) * | 2000-12-29 | 2004-08-03 | Alteon, Inc. | Method for treating fibrotic diseases or other indications utilizing thiazole, oxazole and imidazole compounds |
WO2004110352A2 (en) * | 2003-05-16 | 2004-12-23 | The Regents Of The University Of California | Compounds having activity in increasing ion transport by mutant-cftr and uses thereof |
Non-Patent Citations (1)
Title |
---|
BOYAKA. E. C. ET AL.: "Rescuing Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)-Processing Mutants by Transcomplementation", PNAS, vol. 101, no. 21, May 2004 (2004-05-01), pages 8221 - 8226, XP003024143 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8952050B2 (en) | 2006-04-07 | 2015-02-10 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
Also Published As
Publication number | Publication date |
---|---|
BRPI0608453A2 (en) | 2009-12-29 |
KR20070114820A (en) | 2007-12-04 |
JP2008538107A (en) | 2008-10-09 |
RU2007138584A (en) | 2009-04-27 |
AU2006227833A1 (en) | 2006-09-28 |
IL185999A0 (en) | 2008-08-07 |
US8143295B2 (en) | 2012-03-27 |
CA2600869A1 (en) | 2006-09-28 |
WO2006101740A2 (en) | 2006-09-28 |
MX2007011512A (en) | 2007-12-07 |
US20080318984A1 (en) | 2008-12-25 |
CN101605543A (en) | 2009-12-16 |
EP1863522A4 (en) | 2010-11-10 |
EP1863522A2 (en) | 2007-12-12 |
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