WO2006102099A3 - ANTIBODIES SPECIFIC FOR HUMAN AND BOVINE PrP - Google Patents

ANTIBODIES SPECIFIC FOR HUMAN AND BOVINE PrP Download PDF

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Publication number
WO2006102099A3
WO2006102099A3 PCT/US2006/009752 US2006009752W WO2006102099A3 WO 2006102099 A3 WO2006102099 A3 WO 2006102099A3 US 2006009752 W US2006009752 W US 2006009752W WO 2006102099 A3 WO2006102099 A3 WO 2006102099A3
Authority
WO
WIPO (PCT)
Prior art keywords
human
antibodies
prpsc
antibodies specific
bovine
Prior art date
Application number
PCT/US2006/009752
Other languages
French (fr)
Other versions
WO2006102099A2 (en
Inventor
Stanley B Prusiner
Ana Veronica Serban
Jiri G Safar
Larry Stanker
Original Assignee
Univ California
Stanley B Prusiner
Ana Veronica Serban
Jiri G Safar
Larry Stanker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California, Stanley B Prusiner, Ana Veronica Serban, Jiri G Safar, Larry Stanker filed Critical Univ California
Publication of WO2006102099A2 publication Critical patent/WO2006102099A2/en
Publication of WO2006102099A3 publication Critical patent/WO2006102099A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2872—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against prion molecules, e.g. CD230
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Abstract

The present invention provides antibodies that specifically bind with a high degree of binding affinity to a native bovine PrPC and/or a denatured bovine PrPSc, but not to a native bovine PrPSc. The antibodies are useful as capture reagents for solid substrate format immunoassays. Such antibodies can be used in an assay to determine if a sample is infected with infectious prions, i.e. PrPSc.
PCT/US2006/009752 2005-03-18 2006-03-15 ANTIBODIES SPECIFIC FOR HUMAN AND BOVINE PrP WO2006102099A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US66354805P 2005-03-18 2005-03-18
US60/663,548 2005-03-18
US70970705P 2005-08-18 2005-08-18
US60/709,707 2005-08-18

Publications (2)

Publication Number Publication Date
WO2006102099A2 WO2006102099A2 (en) 2006-09-28
WO2006102099A3 true WO2006102099A3 (en) 2007-04-05

Family

ID=37024428

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/009752 WO2006102099A2 (en) 2005-03-18 2006-03-15 ANTIBODIES SPECIFIC FOR HUMAN AND BOVINE PrP

Country Status (1)

Country Link
WO (1) WO2006102099A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ572892A (en) * 2002-12-03 2010-03-26 Univ North Carolina State Prion protein ligands with the sequence YVHEA

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US6261790B1 (en) * 1999-07-15 2001-07-17 The United States Of America As Represented By The Secretary Of Agriculture Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies
US6537548B1 (en) * 2000-07-27 2003-03-25 The Regents Of The University Of California Antibodies specific for ungulate PrP
US20030092094A1 (en) * 2001-10-19 2003-05-15 Martin Vey Antibodies for specifically detecting pathogenic prions of human origin, and detection methods carried out using these antibodies
US6765088B1 (en) * 1997-02-21 2004-07-20 Universität Zürich Immunological detection of prions

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891641A (en) * 1997-02-21 1999-04-06 The Regents Of The University Of California Assay for disease related conformation of a protein
US6765088B1 (en) * 1997-02-21 2004-07-20 Universität Zürich Immunological detection of prions
US6261790B1 (en) * 1999-07-15 2001-07-17 The United States Of America As Represented By The Secretary Of Agriculture Monoclonal antibodies and antibody cocktail for detection of prion protein as an indication of transmissible spongiform encephalopathies
US6537548B1 (en) * 2000-07-27 2003-03-25 The Regents Of The University Of California Antibodies specific for ungulate PrP
US20030092094A1 (en) * 2001-10-19 2003-05-15 Martin Vey Antibodies for specifically detecting pathogenic prions of human origin, and detection methods carried out using these antibodies

Also Published As

Publication number Publication date
WO2006102099A2 (en) 2006-09-28

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