WO2006113352A3 - Implantable biosensor comprising transgenic mammalian cells - Google Patents

Implantable biosensor comprising transgenic mammalian cells Download PDF

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Publication number
WO2006113352A3
WO2006113352A3 PCT/US2006/013866 US2006013866W WO2006113352A3 WO 2006113352 A3 WO2006113352 A3 WO 2006113352A3 US 2006013866 W US2006013866 W US 2006013866W WO 2006113352 A3 WO2006113352 A3 WO 2006113352A3
Authority
WO
WIPO (PCT)
Prior art keywords
cells
excitable
tissue
activity
mammalian cells
Prior art date
Application number
PCT/US2006/013866
Other languages
French (fr)
Other versions
WO2006113352A2 (en
Inventor
Haris J Sih
Original Assignee
Cardiac Pacemakers Inc
Haris J Sih
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cardiac Pacemakers Inc, Haris J Sih filed Critical Cardiac Pacemakers Inc
Priority to EP06750040A priority Critical patent/EP1879495A2/en
Publication of WO2006113352A2 publication Critical patent/WO2006113352A2/en
Publication of WO2006113352A3 publication Critical patent/WO2006113352A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/413—Monitoring transplanted tissue or organ, e.g. for possible rejection reactions after a transplant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
    • A61B5/0031—Implanted circuitry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/45—For evaluating or diagnosing the musculoskeletal system or teeth
    • A61B5/4519—Muscles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement

Abstract

The present invention provides implantable biosensors having tissue or cells which are electrically excitable- or are capable of differentiating into electrically excitable cells, and which can be used to monitor the presence or level of a molecule in a physiological fluid, and methods which employ the biosensors. In one embodiment, the tissue or cells are coupled via an electrical interface to an electronic measuring device or an electronic amplifying device. In one embodiment, transgenic electrically excitable mammalian tissue or cells are augmented with an expression cassette comprising an open reading frame for a protein capable of associating with the cell membrane and binding an analyte found in physiological fluids. The binding modulates the activity or amount of one or more intracellular second messengers that modulate the activity of one or more ion channels of the excitable cells. Suitable excitable cells are muscular or neural cells.
PCT/US2006/013866 2005-04-14 2006-04-13 Implantable biosensor comprising transgenic mammalian cells WO2006113352A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06750040A EP1879495A2 (en) 2005-04-14 2006-04-13 Implantable biosensor comprising transgenic mammalian cells

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US67114005P 2005-04-14 2005-04-14
US60/671,140 2005-04-14
US11/269,384 US20060234369A1 (en) 2005-04-14 2005-11-08 Implantable biosensor
US11/269,384 2005-11-08

Publications (2)

Publication Number Publication Date
WO2006113352A2 WO2006113352A2 (en) 2006-10-26
WO2006113352A3 true WO2006113352A3 (en) 2006-12-21

Family

ID=36945727

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/013866 WO2006113352A2 (en) 2005-04-14 2006-04-13 Implantable biosensor comprising transgenic mammalian cells

Country Status (3)

Country Link
US (1) US20060234369A1 (en)
EP (1) EP1879495A2 (en)
WO (1) WO2006113352A2 (en)

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Publication number Publication date
EP1879495A2 (en) 2008-01-23
WO2006113352A2 (en) 2006-10-26
US20060234369A1 (en) 2006-10-19

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