WO2006115264A1

WO2006115264A1 - Film for ptp or blister pack, and packaging container for ptp or blister pack

Info

Publication number: WO2006115264A1
Application number: PCT/JP2006/308712
Authority: WO
Inventors: Tatsuya Ogawa; Shinichi Koizumi; Saori Takahashi; Junpei Nakagawa
Original assignee: Daiichi Sankyo Company, Limited; Kyodo Printing Co., Ltd.
Priority date: 2005-04-26
Filing date: 2006-04-26
Publication date: 2006-11-02
Also published as: CN101208244B; JP2006327690A; JP5429948B2; KR20080009297A; JP2006334819A; JP4659523B2; CN101208244A; KR100922490B1

Abstract

Disclosed is a film for a PTP or blister pack wherein the thermal shrinkage rate of a barrier layer serving as the outermost layer and that of a moisture-absorbing layer containing a desiccant are generally equal to each other. Specifically disclosed is a film for a PTP or blister pack, which film has a multilayer structure including an adsorbing layer and a barrier layer serving as the outermost layer. This film is characterized in that the adsorbing layer contains at least one adsorbent selected from the group consisting of physical adsorbents and chemical adsorbents.

Description

Specification

PTP or blister pack film and PTP or blister pack packaging

Technical field

[0001] The present invention relates to a film for PTP or prestar pack for pharmaceutical packaging and a packaging container thereof, and more particularly to a film for PTP or prestar knock having an adsorptivity for adsorbing moisture, odor, etc. and a packaging container for the same. .

Background art

[0002] Blister packaging called PTP is widely used for pharmaceutical packaging. In many cases, drugs with poor or insufficient moisture resistance, or drugs with strong odors, are put into the yard with priority on the medicinal properties of the drugs. At this time, an aluminum foil pillow bag is used as an outer bag of the PTP, and an adsorbent such as a desiccant or a deodorant is bundled. However, in the form where these adsorbents are bundled, the adsorbent bag is mistaken for a medicine bag and accidentally swallowed, or the adsorbent such as moisture and odor of the drug is guaranteed via the PTP packaging. Only the following effects could be maintained.

[0003] A PTP having a noria layer made of polypropylene, vinyl chloride, aluminum or the like, and an adsorbing layer formed by kneading an adsorbent laminated on the noria layer for the purpose of imparting dryness directly to pharmaceutical packaging Packaging has been developed. For example, Patent Document 1 discloses a film for PTP or a prestar pack in which a Noria layer having polypropylene and a low-density polyethylene kneaded with a desiccant are laminated in a PTP packaging for pharmaceutical packaging. Although such a film can directly impart drying properties to the sheet, due to the difference in heat resistance between the Noria single layer and the low-density polyethylene, there is a difference in the shrinkage ratio during PTP heat molding. Problems such as difficulty in molding have occurred.

[0004] In addition, a PTP container in which a desiccant is kneaded with an adhesive for bonding a film for PTP or blister pack and an aluminum foil is disclosed (for example, see Patent Document 2). In addition, there are problems such as being difficult to break from the aluminum foil side, and the area of the portion containing the desiccant is small and the moisture absorption capacity is insufficient. [0005] Furthermore, development has been made for the purpose of adsorbing the odor of drugs. For example, Patent Documents 3 and 4 disclose a packaging material having hydrophobic strength containing hydrophobic zeolite when a film in which a odor absorbing agent is kneaded with a packaging film is used. Patent Documents 5 to 8 disclose a container in which synthetic zeolite or activated carbon is kneaded into a material and contained. However, the problem is that the moisture in the air is first adsorbed while the odor cannot be adsorbed.

Patent Document 1: Japanese Translation of Special Publication 2003-535782

Patent Document 2: Japanese Utility Model Publication No. 5-94167

Patent Document 3: Japanese Patent No. 2538487

Patent Document 4: Japanese Patent No. 2994921

Patent Document 5: Japanese Patent Laid-Open No. 11-35077

Patent Document 6: Japanese Patent Laid-Open No. 10-16092

Patent Document 7: JP-A-7-22790

Patent Document 8: Registered Utility Model No. 3063963

Disclosure of the invention

Problems to be solved by the invention

[0006] The present invention has been made in view of the above problems, and provides a film for a PTP or blister pack in which the heat shrinkage rates of the outermost noria layer and the moisture absorbing layer containing a desiccant are substantially equal. The purpose is to do.

[0007] Another object of the present invention is to provide a film for PTP blisters and a packaging container thereof that can directly retain the function of a drug by giving the PTP film an adsorption function.

Means for solving the problem

[0008] The PTP or blister pack film according to the present invention is a PTP blister film in which an adsorption layer and a barrier layer are laminated on the outermost layer,

The adsorbing layer has at least one adsorbent selected from a group adsorbent consisting of a physical adsorbent and a chemical adsorbent.

[0009] The packaging container for PTP or prestar pack according to the present invention has an adsorption layer and a barrier on the outermost layer. A packaging container for PTP or prestar pack in which a film laminated with one layer is bonded to a base material,

The invention's effect

[0010] According to the present invention, it is possible to provide a film for a bag or a prestar pack, which is a packaging material for preventing accidental ingestion, and a packaging container for the bag by giving the film a function of adsorbing components such as moisture and odor. It became.

[0011] Furthermore, it has become possible to wrap and distribute the medicines without drying them immediately before packaging. As a result, it has become possible to provide a bag or prestar pack film and its packaging container that reduce the cost of the preparation.

Brief Description of Drawings

FIG. 1 is a schematic cross-sectional view of a bag or blister pack film according to the present invention.

FIG. 2 is another schematic cross-sectional view of a bag or blister pack film according to the present invention.

FIG. 3 is a schematic cross-sectional view of a bag or prestar pack packaging container according to the present invention. Explanation of symbols

[0013] 1 film for bag or blister pack

2 Adsorption layer

2a Main adsorption layer

2b Secondary adsorption layer

3 Noria

4 Base material

5 Contents

BEST MODE FOR CARRYING OUT THE INVENTION

[0014] The present inventors have found a film for PTP or blister pack having a physical adsorbent and Z or a chemical adsorbent in the adsorption layer, and a barrier layer laminated on the adsorption layer. As a result, the adsorption layer contains a high content of pigment so that the heat shrinkage rate is the same as that of the barrier layer. In recent years, it has become a value, and it has become possible to solve the problems during heat molding.

Hereinafter, embodiments of the present invention will be described in detail.

FIG. 1 shows a schematic cross-sectional view of a film for PTP or blister pack according to the present invention. The PTP or prestar pack film 1 according to the present invention comprises an adsorbing layer 2 containing an adsorbent as the innermost layer, and a barrier layer 3 that prevents the entry of moisture, oxygen, and the like, as the outermost layer, as an outermost layer. As another embodiment of the PTP or blister knock film according to the present invention, FIG. 2 shows another schematic cross-sectional view of the PTP or blister pack film according to the present invention. According to FIG. 2, the adsorption layer is composed of a main adsorption layer 2a mainly responsible for adsorption of moisture, odor, etc. (hereinafter also referred to as an adsorbed substance), and a sub-adsorption layer 2b for adsorbing the adsorbed substance. Have Thus, when the PTP or blister pack film according to the present invention has the adsorption layer 2 composed of the main adsorption layer 2a and the sub-adsorption layer 2b, the content of the adsorbent in the main adsorption layer is that of the sub-adsorption layer. It is preferable that there are more. Thereby, the efficiency of adsorption | suction is improved more. Further, instead of the sub-adsorption layer, a layer having a resin containing no adsorbent may be provided.

[0017] The resin material of the main adsorption layer is preferably a resin having a high melt flow rate, a low melting point (low softening point), and excellent low-temperature drawdown property. In the case of a high melt flow rate resin, even if the melt flow rate is lowered by adding an adsorbent, a certain degree of flow characteristics can be secured. In addition, if the melting point is low, the resin is softened at a low temperature, thereby enabling low-temperature extrusion and avoiding the risk of foaming. If the resin is excellent in low-temperature drawdown, it can be easily extruded by an extruder even if an adsorbent is added.

[0018] In particular, when the adsorbed substance has an odor, the resin component of the main adsorption layer has at least one melt flow rate of 10 or more and a low melting point (for the same reason as described above) Low softness point), it is preferable that the resin is excellent in low-temperature drawdown.

From this point of view, examples of the resin of the main adsorption layer include polymers such as LDPE (low density polyethylene), LLDPE (linear low density polyethylene), and PP (polypropylene). In addition, ionomers (for example, salts of ethylene acrylic acid copolymer), EAA (ethylene acrylic acid copolymer), EMAA (ethylene methacrylic acid copolymer), EVA (ethylene ethylene butyl copolymer), EEA (ethylene) Ethylene acrylate copolymer), EMA Examples thereof include various copolymers (copolymers) such as lenmethyl acrylate copolymer) and EMMA (ethylene methyl methacrylate copolymer). As the resin used for the main adsorption layer in order to achieve the same heat shrinkage rate as that of the barrier layer in a state of containing a high amount of pigment, the heat shrinkage of polypropylene, which is preferably used for the noria layer in the present invention, is used. Close to rate V ,: LDPE and LLDPE are preferred!

[0020] The resin material of the secondary adsorption layer has the same thermal shrinkage rate as that of the main adsorption layer of the polypropylene preferably used for the barrier layer in the present invention, and the secondary adsorption layer sandwiching the primary adsorption layer also has the same thermal shrinkage rate. Therefore, polypropylene LDPE and LLDPE are preferred!

[0021] The adsorption layer in the present invention may contain an adsorbent known in the art. Examples of these are, for example, adsorbents that physically adsorb adsorbents such as various molecular sieves (hereinafter referred to as “physical adsorbents”) and chemically adsorbents such as calcium oxide. An adsorbent that adsorbs (hereinafter referred to as “chemical adsorbent”) and the like.

In the present invention, as the adsorbent, a physical adsorbent and a chemical adsorbent may be used in combination due to the adsorption rate and adsorption characteristics of the object to be adsorbed. In general, physical adsorbents have a high adsorption rate. Further, the chemical adsorbent is less likely to be detached when the adsorbed material is adsorbed. Therefore, by using these physical adsorbents and chemical adsorbents in combination, it is possible to synergistically exhibit the adsorption rate and adsorption characteristics for the adsorbed object such as moisture and odor. For these reasons, among them, it may be configured to contain one or both of synthetic zeolite, which is an example of a physical adsorbent, and acid calcium, which is an example of a chemical adsorbent.

[0023] In addition, conventional power is also an issue, and the desorption of water with physical adsorbent power such as zeolite and silica gel can be effectively suppressed by using a physical adsorbent and a chemical adsorbent together. It becomes. In other words, when a layer having a physical adsorbent and a layer having a chemical adsorbent are provided adjacent to each other, the adsorbent such as moisture adsorbed by the physical adsorbent gradually moves to the adjacent chemical adsorbent. In addition, it can be held without being detached even in a high temperature environment.

[0024] Since synthetic zeolite, which is a physical adsorbent, has a high adsorption rate, it can quickly adsorb an object to be adsorbed. Molecular sieve, an example of synthetic zeolite, is a porous particulate material used to separate materials according to the difference in molecular size. It has a structure that has a function of sieving by adsorbing small molecules entering the pore cavity. In the present invention, when a molecular sieve is used, the adsorption port diameter is preferably 0.3 nm to Lnm. Usually, molecular sieves having pore sizes of 0.3 nm, 0.4 nm, 0.5 nm, and l nm are referred to as molecular sieve 3A, molecular sieve 4A, molecular sieve 5A, and molecular sieve 13X, respectively. In the present embodiment, molecular sieve 3A or molecular sieve 4A is used as a suitable adsorbent. Also, the average particle diameter of molecular sieves is, for example, about 10 μm.

[0025] When the adsorbed material has an odor, in the PTP or prestar pack film according to the present invention, the adsorption layer may contain hydrophobic zeolite, which is a kind of synthetic zeolite. Hydrophobic zeolite is a generic term for what is called high-silica zeolite by dealuminating and reducing aluminum atoms in the crystal skeleton of zeolite to increase the silica-alumina ratio. When hydrophobic zeolite is used, it loses affinity for polar substances such as water, and is a zeolite that more strongly adsorbs nonpolar substances such as odor components.

[0026] When using hydrophobic zeolite in the adsorption layer of the PTP or blister pack film according to the present invention, the content is 5 to 70% by weight based on the weight of the adsorbent. In particular, it is 10 to 70% by weight. If the content is less than 5% by weight, it is difficult for the molded product to obtain sufficient adsorption performance, and if it exceeds 70% by weight, molding becomes difficult.

On the other hand, when the adsorbent is moisture, in the PTP or prestar pack film according to the present invention, the adsorption layer may have a chemical adsorbent. An example of a chemical adsorbent is calcium oxide. Chemical adsorbents generally have a slower moisture adsorption rate than the above physical adsorbents, but gradually adsorb, and once adsorbed, the adsorbed components do not separate, so even if exposed to high temperature environments. There is no desorption of adsorbents such as moisture.

[0028] In the PTP or blister pack film according to the present invention, the adsorption layer may have a physical adsorbent and a chemical adsorbent. When molecular sieve is used as the physical adsorbent and acid calcium is used as the chemical adsorbent, the mixing ratio of molecular sieve and acid calcium is preferably molecular sieve: calcium oxide = 99: 1 to 1:99. 90: 1 0 to 40: 60 is more preferable! At this mixing ratio, molecular sieves (synthetic zeolites) Write) The is large, the molecular sieve while adsorbs moisture up to about 20 wt% of its own weight, and because the calcium oxide is large and up to about 30 weight ^_0/0 of its own weight, Morekyurashi over blanking is hygroscopic Even if the water moves to calcium carbonate, it can be retained without desorption in a high temperature environment.

[0029] In the adsorption layer of the film for PTP or blister pack according to the present invention, the content of the desiccant of synthetic zeolite and calcium oxide is preferably 5 to 70% by weight, particularly preferably 30. ~ 70% by weight. If the content is less than 5% by weight, it is difficult for the molded product to obtain sufficient drying performance, and if it exceeds 70% by weight, molding becomes difficult.

[0030] In the PTP or blister pack film according to the present invention, when the adsorption layer is composed of a main adsorption layer and a sub adsorption layer, a sub adsorption layer that assists in adsorbing adsorbed substances such as moisture and odor. The content of the adsorbent is preferably 5 to 50% by weight, which is less than that of the main adsorption layer mainly responsible for adsorption of the adsorbent.

[0031] It should be noted that the adsorption characteristics of the molecular sieve are related to the pore diameter, and in order to increase the moisture adsorption characteristics, the surface of the molecular sieve is substantially widened by making the molecular sieve powder finer. This can be dealt with by increasing the number of

[0032] The adsorption layer in the present invention preferably contains 30 to 70% by weight of a pigment component containing an adsorbent, more preferably 40 to 70% by weight, and even more preferably 45 to 65% by weight. . If the content is less than 30% by weight, the difference in thermal shrinkage between the adsorption layer and the barrier layer becomes large, and wrinkles are likely to occur during heat molding. Further, if it exceeds 70% by weight, molding becomes difficult.

[0033] As pigment components other than the above adsorbents, pigments that do not have functions such as moisture absorption performance and gas adsorption performance can be used, and various pigments can be used as long as pigments having these functions are contained. Effects can be obtained. Examples of such pigments include calcium carbonate, titanium oxide, zinc oxide, zirconium oxide, alumina, silica, my strength, talc, carbon, and activated carbon.

[0034] The adsorption layer is formed into a film or a sheet by extrusion or injection molding such as inflation method, T-die method, co-extrusion, etc. with a resin and an adsorbent, and in particular, an inflation method or A multilayer film by a T-die method is preferred. Multi-layer inflation method and Is a method of producing a multilayer film by extruding the molten resin in a plurality of extruders into a tube shape and sending the air into the tube to inflate it. The structure of the adsorption layer is preferably 2 or 3 layers or 3 or 3 layers.

The film thickness of the adsorption layer in the present invention is preferably 30 πι to 200 / ζ m. The thickness of the main adsorption layer is 10 111 to 190 111 particles, and the thickness of the adsorption layer is 5 111 to 190 111 particles.

[0036] The material used for the single layer of Noria is not particularly limited as long as it is excellent in moisture-proofing property to prevent entry of moisture, oxygen, and the like from the outside. For example, polypropylene, polyvinyl chloride, polyethylene terephthalate, polytetrafluoroethylene (PTFE), aluminum thin film, etc., in particular, polypropylene, polyvinyl chloride, polytetrafluoroethylene (PTFE) ), Aluminum thin film is preferred.

[0037] Examples of a method for bonding the adsorption layer and the barrier layer include a dry lamination method, a sand lamination method, and an extrusion lamination method. The dry laminating method is a method in which an adhesive is applied and dried, and then pressurized, and the adhesive is cured and bonded. The extrusion laminating method is a method of extruding and bonding adhesive layer resin melted by a plurality of extruders. Further, the sand lamination method is a method of extruding and adhering a molten hygroscopic resin between a substrate coated with an adhesive and a film to be bonded.

[0038] The film thickness of the PTP or blister pack film obtained by pasting is preferably 20 μm to 500 μm, more preferably 100 μm to 400 μm. If it is less than 20 μm, the noriality and strength are insufficient, and if it exceeds 500 m, it is too hard to be deformed when pressing the PTP contents such as drugs, making it difficult to take out the contents.

FIG. 3 is a schematic cross-sectional view of a packaging container for PTP or prestar pack according to the present invention. The packaging container for PTP or prestar pack according to the present invention comprises a PTP or blister pack film 1 formed by laminating the above-described adsorption layer 2 and barrier layer 3, and a substrate 4 laminated on the adsorption layer 2 side of this film. And have. The packaging container for PTP or prestar pack according to the present invention comprises a film for PTP or prestar pack and a substrate so as to form a space for storing the contents 5 defined by the adsorption layer 2 and the substrate 4. 4 may be manufactured by molding with an appropriate molding method such as PTP molding. Content 5 is limited to tablets, capsules, granules, etc. It is not specified.

[0040] The base material used in the packaging container for PTP or the prestar pack according to the present invention can be suitably laminated with the above-mentioned film for PTP or blister pack while appropriately protecting the contents 5 from the external environment. If there is, there is no particular limitation. For example, aluminum foil etc. are mentioned. Among these, aluminum foil is preferable in consideration of the ability to remove the contents 5 from the PTP or prester pack packaging container.

[0041] Examples of the method for forming the above-described PTP or prester pack packaging container include known PTP forming methods such as a flat plate pressure forming method, a plug assist pressure forming method, a drum type vacuum forming method, and a plug forming method. . For example, in the packaging container for PTP or prestar pack according to the present invention, for example, first, the PTP or blister pack film described above is set in a roll shape, and the PTP or blister pack film is squeezed out at the downstream portion. In the state where heat is softened, a space for storing the contents 5 is defined in this soft part. After that, the PTP or prestar pack film and the contents 5 should be laminated using an adhesive method such as dry lamination.

Example

[0042] Hereinafter, the present invention will be described in more detail with specific examples, but the present invention is not limited to these examples.

[0043] (Preparation of masterbatch: Part :!)

As masterbatch 1 1 (MB1-1), 50 parts by weight of LDPE (trade name: Petrocene 204, manufactured by Tosohichi Co., Ltd.) is mixed with 50 parts by weight of molecular sieve 3A to produce pellet-shaped granular resin. Prepared.

[0044] As masterbatch 1-2 (MB1-2), 25 parts by weight of LDPE (trade name: Petrocene 204) was kneaded with 75 parts by weight of molecular sieve 3A to prepare a granular granular resin. did.

[0045] As master batch 1 3 (MB1-3), 50 parts by weight of LD PE (trade name: Petrocene 204) was kneaded with 50 parts by weight of calcium oxide to prepare a pellet-shaped granular resin.

[0046] As masterbatch 14 (MB1-4), 10 parts by weight of molecular sieve 3A Then, 90 parts by weight of polypropylene (trade name: Novatec PP BC06C, manufactured by Nippon Polypro Co., Ltd.) was kneaded to prepare a pellet-shaped granular resin.

[0047] As master batch 15 (MB1-5), 75 parts by weight of molecular sieve 3A was mixed with 25 parts by weight of polypropylene (trade name: Novatec PP BC06C) to prepare pellet-shaped granular resin. .

[0048] As masterbatch 1-6 (MB1-6), 50 parts by weight of LDPE (trade name: Petrocene 204) was kneaded with 50 parts by weight of titanium oxide to form a pellet of titanium oxide ZLDPE = 50Z50. A granular rosin was prepared.

[0049] As master batch 1-7 (MB1-7), prepared in the same manner as MB1-6, except that the mixing ratio of titanium oxide and LDPE in MB1-6 was changed to titanium oxide ZLDPE = 75Z25 A pellet-shaped granular rosin was prepared.

[0050] As master batch 1-8 (MB1-8), 50 parts by weight of polypropylene (trade name: Novatec PP BC06C) was mixed with 50 parts by weight of titanium oxide, and titanium oxide ZPP = 50

Z50 pellet-shaped granular resin was formed.

[0051] Masterbatch 1-9 (MB1-9) was prepared in the same manner as MB1-8, except that the mixing ratio of titanium oxide and polypropylene in MB1-8 was changed to titanium oxide ZPP = 75Z25. And pelletized granular rosin was prepared.

[0052] As master batch 1 10 (MB1-10), 60 parts by weight of molecular sieve 3A was kneaded with 40 parts by weight of LDPE (trade name: Petrocene 204, manufactured by Toso Co., Ltd.). Granular rosin was prepared.

[Example 1 1 1 1]

Two types of three-layer films were prepared by the multilayer inflation method using only MB1-1 as the main adsorption layer and only MB1-4 as the sub-adsorption layer. The film thickness of the two-type three-layer film is sub-hygroscopic layer Z main hygroscopic layer Z sub-hygroscopic layer = 5 m / 50 μνα / ΙΟ μm. The content of the pigment excluding the desiccant and the desiccant in the entire moisture-absorbing layer was 41% by weight and 0% by weight, respectively. Therefore, the total pigment including the desiccant was 41% by weight.

[0054] In order to improve the adhesion on the side of the 5 μm sub-adsorption layer of the obtained two-type three-layer film, a corona treatment for roughening the surface was performed. The heat shrinkage history is added to the 5 m sub-adsorption layer side The released polypropylene film having a film thickness of 250 μm (trade name: CPPE0025NA, manufactured by Mitsubishi Sewa Co., Ltd.) was bonded by a dry laminating method to obtain a PTP or prestar pack film. After that, PTP molding was performed with a blister pack molding machine (CKD Co., Ltd.) so that the contents could be put, and an aluminum foil with a film thickness of 30 μm was dry laminated on the 10 μm sub-adsorption layer side. Bonding was carried out by the method, and a PTP or pre-synthetic packaging container having the structure shown below was produced. The numbers for each layer indicate the film thickness m).

• PP ZZ2 3-layer film ZZ aluminum foil

250 65 30

[Example 1 1 2]

EXAMPLE 1 A packaging container for PTP or prestar pack was prepared in the same manner as Example 1-1-1 except that MB1-1 of the main moisture absorption layer was changed to MB1-2 in Example 1-1. . In this PTP or Prister Pack packaging container, the content of the pigment excluding the desiccant and the desiccant in the entire moisture absorption layer is 65% by weight and 0% by weight, respectively. Therefore, the total pigment including the desiccant is It was 65% by weight.

[Example 1 1 3]

In Example 1-1-1, except that MB1-1 and MB1-3 were mixed at a mixing ratio of 50:50 instead of MB1-1 of the main adsorption layer, PTP or A packaging container for prestar knock was prepared. The contents of the desiccant and the pigment excluding the desiccant in the entire moisture absorption layer were 41% by weight and 0% by weight, respectively, and the total pigment including the desiccant was 41% by weight.

[0057] (Example 1 1 4)

In Example 1 1 3! /, Except that the mixing ratio of MB1-1 and MB1-3 in the main moisture absorption layer was changed to 70:30, the same as Example 1-1-3 A packaging container for PTP or prestar pack was prepared. The contents of the desiccant and the pigment excluding the desiccant in the entire moisture-absorbing layer were 41% by weight and 0% by weight, respectively, and the total pigment including the desiccant was 41% by weight.

[0058] (Example 1 1 5)

Example 1 11 In Example 1, 1-1, except that a single-layer film having only the main adsorption layer was prepared instead of the two-type three-layer film, PTP or blister pack was prepared in the same manner as in Example 1-1-1. A packaging container was prepared. In addition, the content of the pigment excluding the desiccant and the desiccant in the entire moisture-absorbing layer is 50% by weight and 0% by weight, respectively, so the total pigment including the desiccant is 50% by weight.

[0059] (Example 1 1 6)

Example 1-1-1-5 is the same as Example 1-1-5 except that MB1-1 and MB1-6 were mixed in a 1: 1 ratio instead of MB1-1. Thus, a packaging container for PTP or blister pack was prepared. The contents of the desiccant and the pigment excluding the desiccant in the entire moisture-absorbing layer were 25% by weight and 25% by weight, respectively, and the total pigment including the desiccant was 50% by weight.

[0060] (Example 1 1 7)

Example 1-1-1 was the same as Example 1-1-1 except that a 10 μm layer made of LDPE (trade name: Petrocene 204) was used as a sub-adsorption layer. A packaging container for PTP or blister paste was prepared. Note that the desiccant and the pigment content excluding the desiccant in the entire moisture-absorbing layer were 45% by weight and 0% by weight, respectively, and the total pigment including the desiccant was 45% by weight.

[0061] (Example 1 2-1 to 1 2-4)

Example 1— 1— 1 to 1— 1 to 4! /, Except that the lamination between the two-layer three-layer film and the polypropylene film for PTP was changed to the sand lamination method. Examples 1 1 1 to 1 1-4 In the same manner as described above, PTP or prestar pack packaging containers were produced.

[0062] (Example 1 3— 1)

In Example 1-1-1-1, MB1-10 was used instead of MB1-1, and instead of MB1-4, polypropylene (trade name: Novatec PP BC03C (impact resistance) (manufactured by Nippon Polypro Co., Ltd.)) The film thickness of the two types of three-layer films is sub-absorbent layer Z main hygroscopic layer Z sub-hygroscopic layer = 10 m / 5 0 μm / 10 μm, and the 10 μm sub-adsorbent layer is corona-treated to form a film. Examples were used except that instead of the 250 μm thick polypropylene film for PTP, a polysalt resin bulge (trade name: Bifoil (manufactured by Mitsubishi Oil)) with a film thickness of 200 m was used. PTP or blister pack film was produced in the same manner as 1-1-1. Excluding desiccant and desiccant for the entire hygroscopic layer The pigment contents were 41% by weight and 0% by weight, respectively, so that the total pigment including the desiccant was 41% by weight.

[0063] (Example 1 3— 2)

In Example 1-3-1, the film thickness of the polychlorinated bulle is 150 m, and the bonding of the two types and three layers of the film to the polysalt bulb is replaced with the dry laminating method. A film for PTP or a prestar pack was produced in the same manner as in Example 1-3-1 except that the sand lamination method using 1 was used. The contents of the desiccant excluding the desiccant and the desiccant in the entire moisture-absorbing layer were 43% by weight and 0% by weight, respectively, and the total pigment including the desiccant was 43% by weight.

[0064] (Example 1 4 1)

Example 1-3-1 Example 1 except that instead of polypropylene, PET with a film thickness of 38 m and aluminum (PET) with a film thickness of 5 O / z m were used.

38 Proceed in the same way as ZA150 1-3-1 to produce a film for PTP or blister knock. The content of the desiccant and the pigment excluding the desiccant in the entire hygroscopic layer was 43% by weight and 0% by weight, respectively, and the total pigment including the desiccant was 43% by weight.

[0065] (Example 1 4 2)

In Example 1-3-2, except that polypropylene having a film thickness of 38 μm and aluminum (PP) having a film thickness were used instead of polypropylene, Example

It was carried out in the same manner as 50 ZA150 1-3-2, and a film for PTP or blister pack was produced. The contents of the desiccant and the pigment excluding the desiccant in the entire hygroscopic layer were 43% by weight and 0% by weight, respectively, and the total pigment including the desiccant was 43% by weight.

[0066] (Example 1 5— 1)

In Example 1-3-1, an aluminum thin film (trade name: BESPA (manufactured by Sumi Light Aluminum Foil)) having a thickness of 50 μm was used in place of the polychlorinated bur having a thickness of 200 m. Except for this, the same procedure as in Example 1-3-1 was carried out to produce a PTP or prestar pack film. Note that the contents of the desiccant and the pigment excluding the desiccant in the entire moisture absorption layer were 43% by weight and 0% by weight, respectively, and the total pigment including the desiccant was 43% by weight.

[0067] (Example 1 5-2) In Example 1-3-2, an aluminum thin film (trade name: BESPA (manufactured by Sumi Light Aluminum Foil Co., Ltd.)) having a thickness of 50 μm was used instead of polychlorinated bur having a thickness of 200 m. Except for this, the same procedure as in Example 1-3-2 was performed to produce a PTP or prestar pack film. Note that the contents of the desiccant and the pigment excluding the desiccant in the entire moisture absorption layer were 43% by weight and 0% by weight, respectively, and the total pigment including the desiccant was 43% by weight.

[0068] (Example 1 6— 1)

In Example 1-4-1, an aluminum thin film (trade name: BESPA (manufactured by Sumi Light Aluminum Foil)) having a film thickness of 50 μm was used in place of the polychlorinated bur having a film thickness of 200 m. Except for this, the same procedure as in Example 1-4-1 was carried out to produce a PTP or prestar pack film. Note that the contents of the desiccant and the pigment excluding the desiccant in the entire moisture absorption layer were 43% by weight and 0% by weight, respectively, and the total pigment including the desiccant was 43% by weight.

[0069] (Example 1 6-2)

In Example 1-4-2, an aluminum thin film (trade name: BESPA (manufactured by Sumi Light Aluminum Foil Co., Ltd.)) having a thickness of 50 μm was used in place of the polychlorinated bur having a thickness of 200 m. Except for this, the same procedure as in Example 1-4-2 was carried out to produce a PTP or prestar pack film. The contents of the desiccant and the pigment excluding the desiccant in the entire hygroscopic layer were 43% by weight and 0% by weight, respectively, and the total pigment including the desiccant was 41% by weight.

[0070] (Comparative Example 1 1 1)

Example 1 1 Example 1 except that only a polypropylene film for warts having a film thickness of 300 μm (trade name: CPPE0030NA, manufactured by Mitsubishi Sekiyu Co., Ltd.) was used in place of the PTP or blister pack film. — 1— In the same manner as in 1, a comparative PTP or blister pack packaging container was prepared.

• pp ZZ aluminum

300 foil 30

[Comparative Example 1 1 2]

Example 1 11 PTP or blister pack packaging in the same manner as Example 1-1-1 except that a single-layer film having only a sub-adsorption layer was prepared in place of the two-type three-layer film. A container was prepared. In addition, the content of the pigment excluding the desiccant and the desiccant in the entire moisture-absorbing layer is 10% by weight and 0% by weight, respectively, so the total pigment including the desiccant is 10% by weight. there were.

[0072] (Comparative Example 1 2— 1)

Example 1 1 1 In Example 1, except that MB1-1 was changed to only LDPE (trade name: Petrocene 202, manufactured by Toso Co., Ltd.), the same as in Example 1-1-1 A packaging container for prestar knock was prepared. In addition, the content of the desiccant and the pigment excluding the desiccant in the entire moisture absorption layer was 2% by weight and 0% by weight, respectively, so that the total pigment including the desiccant was 2% by weight.

[0073] (Comparative Example 1 2— 2)

Comparative PTP or Prestar Pack in the same manner as in Example 1-1-1 except that MB1- ^ MB1-2 and MB1-4 were changed to MB1-5 in Example 1-1-1 A packaging container was prepared. Note that the desiccant and the pigment content excluding the desiccant in the entire moisture-absorbing layer were 75% by weight and 0% by weight, respectively, and the total pigment including the desiccant was 75% by weight.

[0074] (Comparative Example 1 2-3)

Comparative PTP or Prestar pack in the same manner as in Example 1-1-1 except that MB1- ^ MB1-6 and MB1-4 were changed to MB1-8 in Example 1-1-1 A packaging container was prepared. Note that the desiccant and the pigment content excluding the desiccant in the entire hygroscopic layer were 0% by weight and 41% by weight, respectively, and the total pigment including the desiccant was 41% by weight.

[0075] (Comparative Example 1 2— 4)

Example 1-1-1 Same as Example 1-1-1 except that MB1-1 was changed to MB1-6 and MB1-4 was changed to polypropylene (product name: Novatec PP FA3EB). Thus, a packaging container for comparative PTP or prestar pack was prepared. The content of the desiccant and the pigment excluding the desiccant in the entire hygroscopic layer was 0% by weight and 38% by weight, respectively, and the total pigment including the desiccant was 38% by weight.

[0076] (Comparative Example 1 2-5)

Comparative PTP or Prestar Pack in the same manner as Example 1-1-1 except that MB1- ^ MB1-7 and MB1-4 were changed to MB1-9 in Example 1-1-1 A packaging container was prepared. In addition, the content of the pigment excluding the desiccant and the desiccant in the entire moisture absorption layer is

0% by weight and 75% by weight, respectively, so the total pigment including desiccant was 75% by weight o

[0077] (Comparative Example 1 2-6)

In Example 1-1-1-1, instead of MB1-1, MB1-6 and LDPE (trade name: Petrocene 204) were mixed at a mixing ratio of 30:70. A comparative PTP or blister tank / pack packaging container was prepared in the same manner as in Example 1-1-1 except that 4 was changed to MB1-5. The content of the desiccant and the pigment excluding the desiccant in the entire moisture-absorbing layer was 17% by weight and 12% by weight, respectively, and the total pigment including the desiccant was 29% by weight.

[0078] (Comparative Example 1 2-7)

Comparative PTP or Prestar pack in the same manner as Example 1-1-1 except that MB1- ^ MB1-9 and MB1-4 were changed to MB1-5 in Example 1-1-1 A packaging container was prepared. The content of the desiccant and the pigment excluding the desiccant in the entire moisture-absorbing layer is 17% by weight and 58% by weight, respectively, so the total pigment including the desiccant is 75% by weight.

[0079] (Comparative Example 1 3)

In Comparative Example 1-1-1, except that a polysalt gel film having a thickness of 200 μm was used instead of the 300 / zm PTP polypropylene film, Comparative Example 1-1-1 Similarly, a comparative PTP or prestar pack packaging container was prepared.

[0080] (Comparative Example 1 4)

In Comparative Example 1/3, instead of the polychlorinated bulle film having a thickness of 200 μm, an aluminum blister film (a laminate of an aluminum film and a polypropylene film, the film thickness of the aluminum film) A comparative PTP or prestar pack packaging container was prepared in the same manner as in Comparative Example 13 except that the film thickness was 50 μm and the polypropylene film had a thickness of 80 μm.

[0081] (Comparative Example 1 5)

In Comparative Example 1 3! /, Instead of a polychlorinated bulle film having a thickness of 200 μm, Aluminum blister film (a laminate of polyethylene film, aluminum film and polypropylene film, with a polyethylene film thickness of 38 μm and an aluminum film thickness of 50 μm)

A comparative PTP or prestar pack packaging container was prepared in the same manner as in Comparative Example 3 except that a polypropylene film having a film thickness of 80 / zm was used.

[0082] The moldability of the PTP blister packaging container obtained by the above production method and the heat sealability with the aluminum lid were evaluated as follows. The results are shown in Tables 1 to 3.

[0083] The evaluation method of formability is:

◯: Good without any wrinkles during PTP molding.

Δ: Wrinkles and the like are partially observed during PTP molding.

X: Wrinkles and other defects occur during the molding process.

[0084] The evaluation method of heat sealability is

A: No peeling at the bonded part with the aluminum lid.

◯: No peeling at the bonded part with the aluminum lid, but easy to peel off.

Δ: Peeled off at a part of the bonded portion with the aluminum lid.

X: The bonded portion with the aluminum lid peeled off.

[0085] Also, insert the probe of the thermo-hygrometer into the empty ΡΤΡ molded product that does not contain the contents.

Evaluation was made based on the reached humidity after 24 hours from 50% in the cage. In addition, the environment inside the pillow package was evaluated using a data logger type thermo-hygrometer. The results are shown in Table 1. The hygroscopic evaluation method is

○: Achieving humidity less than 10%

Δ: Achieving humidity 10% or more and less than 40%.

X: Ultimate humidity 40% or more or no change.

[0086] [Table 1]

¾ [[008

§3 [

[0089] From the results shown in Tables 1 to 3, it is possible to provide a film for PTP blisters and a packaging container thereof that can maintain a dry state without including a desiccant in an aluminum pillow bag. It has become possible.

[0090] (Preparation of masterbatch-2)

As masterbatch 2-1 (MB2-1), 50 parts by weight of hydrophobic zeolite (trade name: AB

SCENTS3000) was mixed with 50 parts by weight of LDPE (trade name: Petrocene 204, manufactured by Tosohichi Co., Ltd.) to prepare a pellet-shaped granular resin.

[0091] As masterbatch 2-2 (MB2-2), 75 parts by weight of molecular sieve 3A were mixed with 25 parts by weight of LDPE (trade name: Petrocene 204) to prepare pelletized granular fat. did.

[0092] As master batch 2-3 (MB2-3), 50 parts by weight of LDPE (trade name: Petrocene 204) is mixed with 50 parts by weight of molecular sieve 13X to prepare pellet-shaped granular resin. did.

[0093] As masterbatch 2-4 (MB2-4), 90 parts by weight of L DPE (trade name: Petrocene 204) was kneaded with 10 parts by weight of hydrophobic zeolite to prepare a pellet-shaped granular resin. did.

[0094] (Example 2—1 1 1)

Two types of three-layer films were prepared by multilayer inflation method using only MB2-1 as the main adsorption layer and MB2-4 as the sub-adsorption layer. The film thickness of the 2 types, 3 layers film is sub-adsorption layer Z main adsorption layer Z sub-adsorption layer = 10 m / 50 μm / 10 μm.

[0095] Corona treatment was performed to improve the adhesion of one of the two types of three-layer films on the 10 μm side of polypropylene. A 250 μm-thick polypropylene film (product name: CPPE0025NA, manufactured by Mitsubishi Sekiyu Co., Ltd.) with a heat-shrinkage history released by additional baking is bonded to this 10 m sub-adsorption layer by dry lamination. To obtain Pino or Pinostar pack Finolem.

[0096] (Example 2— 1 2)

In Example 2-11, in place of MB2-1 used for the main adsorption layer, 80 parts by weight of MB2-1 and LLDPE (trade name: Evolue SP2020) were changed to 20 parts by weight. Example 2-1-1 A film for PTP or prestar pack was produced in the same manner as described above.

[Example] (Example 2— 1 3 to 2— 1 6)

A film for PTP or prestar pack was prepared in the same manner as in Example 2-1-2, except that the mixing ratio of MB2-1 and LLDPE in the main adsorption layer was changed as shown in Table 4.

[0098] (Comparative Example 2— 1 1)

In Example 2-1-1, a film for PTP or prestar pack was prepared in the same manner except that MB2-1 of the main adsorption layer was changed to MB2-2.

[0099] (Comparative Example 2— 1 2 to 2 — 1 6)

A film for PTP or prestar pack was prepared in the same manner as in Comparative Example 2-1-1 except that the mixing ratio of MB2-2 and LLDPE in the main adsorption layer was changed as shown in Table 5.

[0100] (Example 2— 2— 1)

In Example 2-11, in place of MB2-1 used in the main adsorption layer, Example 2-1-1 was changed to 90 parts by weight of MB2-1 and 10 parts by weight of MB2-3. In the same manner as in 1, a film for PTP or blister pack was prepared.

[0101] (Example 2—2-2—2-2—6)

In Example 2-2-1, except that the mixing ratio of MB2-1 and MB2-3 in the main adsorption layer was changed as shown in Table 6, the film for PTP or prestar pack was prepared in the same manner. Produced.

[0102] The PTP or blister pack film obtained by the above production method was subjected to PTP molding with a blister knock molding machine (manufactured by CKD) to obtain a packaging container for PTP or prestar pack. The formability of each PTP or Prister Pack packaging container was evaluated as follows. The results are shown in Tables 4-6.

[0103] The evaluation method of formability is:

○: Wrinkle etc. is good at PTP molding

△: Some wrinkles are observed during PTP molding

X: Wrinkles are generated during the molding process [0104] In addition, triethylamine or toluene is dropped into two vials, and a film for PTP or blister pack is put on one side and sealed. Place the vial in a constant temperature bath at 40 ° C for 24 hours. After that, it smelled when it was opened (sensory test), and the odor absorption was evaluated as ○: odor decreased, X: no change. The results are shown in Tables 4-6.

[0105] [Table 4]

[0106] [Table 5]

[0107] [Table 6]

Of the main adsorption layer

Odor absorption

Mixing ratio (part) Formability

MB2-1 MB2 -3 Triethylamine Toluene Example 2 _ 2 _ 1 90 10 O ○ ○ Example 2 _ 2 _ 2 80 20 O ○ ○ Example 2— 2— 3 50 50 0 ○ ○ Example 2 2— 4 30 70 ○ o ○

Example 2-2-5 20 80 0 〇〇

Example 2 2 6 10 90 ○ ○ ○ From the results in Table 4 to Table 6, provide a film for PTP or blister pack and a packaging container for PTP or blister pack that can maintain the odor absorption effect even if the adsorbent is not included in the aluminum pillow bag. Became possible.

Claims

The scope of the claims

[I] A PTP blister film in which an adsorption layer and a single outer layer are laminated, wherein the adsorption layer is a group force consisting of a physical adsorbent and a chemical adsorbent, and at least one adsorbent selected A film for PTP or prestar pack characterized by having an agent.

[2] The PTP or prestar pack film according to [1], wherein the adsorbent is contained in an amount of 5 wt% to 70 wt% with respect to the weight of the adsorbing layer.

[3] The PTP or prestar pack film according to claim 1 or 2, wherein the adsorption layer contains a pigment component in an amount of 30% by weight to 70% by weight with respect to the weight of the adsorption layer. Nolem.

[4] The film for PTP or blister pack according to any one of claims 1 to 3, wherein the physical adsorbent is synthetic zeolite.

[5] The film for PTP or blister pack according to any one of claims 1 to 4, wherein the physical adsorbent is hydrophobic zeolite.

[6] The film for PTP or blister pack according to any one of claims 1 to 5, wherein the chemical adsorbent is calcium carbonate.

[7] The film for PTP or blister pack according to any one of claims 1 to 6, wherein the adsorption layer comprises a main adsorption layer and a sub-adsorption layer.

[8] The film for PTP or blister pack according to claim 7, wherein the content of the adsorbent in the main adsorption layer is larger than the content of the adsorbent in the sub-adsorption layer.

[9] The barrier layer according to any one of claims 1 to 8, wherein the barrier layer contains at least one compound selected from the group force of polypropylene, polyvinyl chloride, polytetrafluoroethylene, and aluminum. Film for PTP or blister pack according to any one of the above.

[10] The film for PTP or blister pack according to any one of claims 1 to 9, wherein the film thickness of the film for PTP or blister pack is 20 μm or more and 500 μm or less. the film.

[II] The PTP or prestar pack film comprises a barrier layer and an adsorption layer, The film for PTP or blister pack according to any one of claims 1 to 10, wherein the film is laminated by a lie lamination method.

[12] The PTP according to any one of claims 1 to 10, wherein the PTP or prestar pack film is formed by laminating the barrier layer and the adsorption layer by an extrusion laminating method. Or a film for blister packs.

[13] The film for PTP or prestar pack according to any one of claims 1 to 10, wherein the barrier layer and the adsorption layer are laminated by a lamination method. Film for PTP or blister pack.

[14] A packaging container for PTP or blister pack, in which a film in which an adsorption layer and a noria layer is laminated on the outermost layer are bonded to a base material,

The PTP or prestar pack packaging container, wherein the adsorption layer has at least one adsorbent selected from a group adsorbent consisting of a physical adsorbent and a chemical adsorbent.

15. The PTP or prestar pack packaging container according to claim 14, wherein the adsorbent is contained in an amount of 5% by weight to 70% by weight with respect to the weight of the adsorption layer.

[16] The packaging for PTP or prestar pack according to claim 14 or 15, wherein the adsorption layer contains a pigment component in an amount of 30% by weight or more and 70% by weight or less based on the weight of the adsorption layer. container.

[17] The packaging container for PTP or prestar pack according to any one of claims 14 to 16, wherein the physical adsorbent is synthetic zeolite.

[18] The packaging container for PTP or prestar pack according to any one of [14] to [17], wherein the physical adsorbent is hydrophobic zeolite.

[19] The PTP or prestar pack packaging container according to any one of claims 14 to 18, wherein the chemical adsorbent is calcium carbonate.

[20] The PTP or prestar pack packaging container according to any one of claims 14 to 19, wherein the adsorption layer comprises a main adsorption layer and a sub-adsorption layer.

[21] The PTP or blister pack according to any one of claims 14 to 20, wherein the content of the adsorbent in the main adsorption layer is greater than the content of the adsorbent in the sub-adsorption layer. Packaging container.

[22] The barrier layer according to any one of claims 14 to 21, wherein the barrier layer contains at least one compound selected from the group force of polypropylene, polyvinyl chloride, polytetrafluoroethylene, and aluminum. PTP or blister pack wrap according to any one of the above paragraphs:

[23] The PTP or prestar pack packaging container according to any one of claims 14 to 22, wherein the base material is an aluminum foil.