WO2006125092A2 - Treatment device and method for treating skin lesions through application of heat - Google Patents
Treatment device and method for treating skin lesions through application of heat Download PDFInfo
- Publication number
- WO2006125092A2 WO2006125092A2 PCT/US2006/019260 US2006019260W WO2006125092A2 WO 2006125092 A2 WO2006125092 A2 WO 2006125092A2 US 2006019260 W US2006019260 W US 2006019260W WO 2006125092 A2 WO2006125092 A2 WO 2006125092A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treatment
- tip
- replaceable
- treatment device
- temperature
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00022—Sensing or detecting at the treatment site
- A61B2017/00084—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00017—Electrical control of surgical instruments
- A61B2017/00115—Electrical control of surgical instruments with audible or visual output
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/08—Accessories or related features not otherwise provided for
- A61B2090/0803—Counting the number of times an instrument is used
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/08—Accessories or related features not otherwise provided for
- A61B2090/0814—Preventing re-use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
- A61F2007/0071—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating using a resistor, e.g. near the spot to be heated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
- A61F2007/0077—Details of power supply
- A61F2007/0078—Details of power supply with a battery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0093—Heating or cooling appliances for medical or therapeutic treatment of the human body programmed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
- A61F2007/0095—Heating or cooling appliances for medical or therapeutic treatment of the human body with a temperature indicator
- A61F2007/0096—Heating or cooling appliances for medical or therapeutic treatment of the human body with a temperature indicator with a thermometer
Definitions
- bacterial skin lesions include bacterial folliculitis, (a localized infection of hair follicles) dermatitis, cellulitis, impetigo, ecthyma, furuncles and the like.
- hot compresses are generally non-uniform in the amount of heat delivered. Over-heating of the compresses by the user may easily result in burns.
- Other disadvantages include the fact that hot compresses generally only maintain heat for a very limited period of time, and when moved about or reused may result in spread of infectious agents to healthy tissue.
- a further type of skin lesion that has proved difficult to treat are viral skin lesions such as cold sores, also known as fever blisters.
- Cold sores are usually caused by strains of the Herpes Simplex virus and commonly result in lesions on and near the lips and inside the mouth of an infected individual.
- the sores are painful and unsightly, and like other facial lesions, frequently result in psychological stresses for the patients suffering from the condition.
- the eruption of the sores is often, but not always, preceded by a painful sensation that warns of an impending lesion.
- Certain anti- viral medications such as Acyclovir and Famvir, may also be used to prevent outbreaks and reduce healing time.
- these medications are generally expensive and only available with a prescription.
- they may result in adverse side effects such as renal toxicity and therefore physicians are sometimes reluctant to prescribe these medications for simple outbreak cases.
- the medications usually must be taken prophylactically or upon the first sign of an outbreak. Once the sore has erupted, the lesions generate infectious particles which may in turn infect other individuals.
- Alkali inhibition is commonly used for laboratory inhibition of Herpes viruses, but application of alkali is impractical in a clinical setting due to the harshness of the treatment to normal skin.
- a further type of skin lesions are fungal infections, also known as fungal dermatitis, including conditions known medically as Tinea corporis, Tinea pedis, Tinea unguium, Tinea capitis, Tinea cruris, and Tinea barbae.
- Particularly troublesome is the condition known as Tinea unguium which is a fungal infection occuring under toenails or fingernails, a condition also referred to medically as onychomycosis or ringworm of the nails.
- Onychomycosis may be caused by several types of fungi, including Trichophyton mentagrophytes, Candida albicans or Trichophyton rubrum. Such infections are extremely difficult to treat effectively due to the difficulty in delivering effective amounts of antifungal medications to the area beneath the nail.
- Onychomycosis can cause the nail to appear thickened and lusterless, and often causes nail discomfort. Also, the infected nail harbors a reservoir of pathogenic organisms which can spread to and re-infect other parts of the body, causing chronic diseases such as onychomycosis in other nails, athletes foot, foot dry skin and the like. Onychomycosis is prevalent throughout a large proportion of the population, with most of those afflicted from the ages of 40 years and older.
- a human's nail has a nail plate, which is a hard outer surface of dead cells, and a nail bed below the nail plate.
- the nail plate is non-porous, whereas the nail bed is porous.
- the nail plate and the nail bed are relatively insensitive to pain.
- the underlying flesh is sensitive to pain. In onychomycosis, the nail plate, nail bed, and, in severe cases, the flesh below the nail bed can be infected.
- Methods of treating onychomycosis include various methods of delivering medication to the nail bed, including various methods of introducing medication under or through the nail plate or of removing the nail plate partially or entirely to access the infected tissue.
- Other treatments include systemic anti-fungal medications. The difficulty with systemic medications is that they are not localized to the nail area and therefore it is difficult to achieve an effective dose without producing undesirable side effects in other parts of the body.
- Tinea corporis also known as tinea circinata or tinea glabrosa and referred to generally as ringworm of the body, is a fungal infection or dermatophytosis of the glabrous skin, i.e., areas of skin other than bearded area, scalp, groin, hands and feet, generally caused by fungal species such as those of Microsporum such as Microsporum cards, Trichophyton such as Trichophyton rubrum, T. Mentagrophytes, and Epidermophyton, particularly by the fungal species of Trichophyton and Epidermophyton.
- the condition generally includes the presence of one or more well- demarcated erythematous, scaly mascules with slightly raised borders and central healing, producing annular outlines.
- Various other types of lesions may also occur, such as those that are vesicular, eczematous, psoriasiform, verrucous, plaque-like, or deep.
- Tinea cruris also referred to generally as "jock itch" or ringworm of the groin, is a fungal infection or dermatophytosis of the groin, perineum and perineal regions, generally seen in males, and sometimes spreading to contiguous areas, generally caused by fungal species such as those of Microsporum, Trichophyton, and Epidermophyton, particularly by the fungal species of Trichophyton and Epidermophyton.
- the condition generally includes severely pruritic, sharply demarcated lesions with a raised erythematous margin and thin, dry scaling. Tinea cruris often accompanies tinea pedis (also known as "athlete's foot”).
- Tinea pedis results in interdigital lesions.
- Athlete's foot is an itching, malodorous, uncomfortable disorder resulting from large numbers of ordinary, nonvirulent bacteria proliferating in the fungus infected interspace.
- Certain insect bites and contact with certain plants can expose skin to irritants that result in an itchy or painful immune response. The symptoms generally manifest soon after the introduction of the irritant, but can persist or sporadically reoccur for extended periods of time when the irritant is not effectively removed or inactivated by the immune response.
- Various treatments have been proposed for the treatment of the symptoms caused by these irritants. Typically the treatment involves that application of compounds that inhibit the immune response that generates the itching and inflammation usually associated with these conditions. These compounds tend to mask the symptoms of the insect bite without addressing the root cause of the irritation. They also tend to require repeated applications in order to obtain continuous symptom relief and frequently do not speed healing time in any appreciable manner.
- ItchZapperTM For insect bites, a device has recently been marketed that is known as an "ItchZapperTM". This device allegedly treats insect bites by applying one or more bursts of heat to the area of the bite thereby breaking down the irritants introduced by the insect bite and stopping the release of histamine.
- the device represented as heating to a temperature of 122°F, and insect proteins are said to break down at 118°F.
- the ItchZapperTM device heats to a peak temperature over a period of 2 to 4 seconds.
- the device cools as residual heat bled off the device for a few seconds after the heating cycle was completed.
- the upward and downward ramping of the temperature is pronounced and the device is not capable of holding a sustained temperature for any appreciable period of time. Additionally, the extremely brief treatment period is unlikely to have any appreciable effect on insect bite symptoms without repeated treatments.
- This invention relates to the use of a regulated heat source that can be applied to a skin lesion, such as pustular-form eruption or localized abscess, in order to accelerate the death of invading bacteria, fungi or viral particles, or to assist in the breakdown of a skin irritant and thereby speed the recovery process.
- a regulated heat source that can be applied to a skin lesion, such as pustular-form eruption or localized abscess, in order to accelerate the death of invading bacteria, fungi or viral particles, or to assist in the breakdown of a skin irritant and thereby speed the recovery process.
- FIGURE 1 shows a perspective view of an embodiment of treatment device according to the present invention
- FIGURE 2a shows a side view of an embodiment of a replaceable treatment tip according to the present invention
- FIGURE 2b shows a perspective view of the replaceable treatment tip of FIGURE 2a
- FIGURE 3 shows a simplified block diagram of the major electrical components treatment device of FIGURE 1;
- FIGURE 4 is a diagram illustrating the control functionality of the firmware used in the present invention.
- FIGURE 5 shows a state diagram illustrating the operation of a treatment device according to an embodiment of the present invention
- FIGURE 6 is a perspective view of an embodiment of a treatment device capable of treating multiple locations simultaneously according to the present invention.
- FIGURE 7 is a perspective view of an embodiment of a treatment device capable of wireless treatment of multiple locations simultaneously according to the present invention.
- FIGURE 8 is a perspective view of a treatment tip for use with the treatment device of FIGURE 5 or FIGURE 6;
- FIGURE 9 shows a graph of the Thermal Aspect Ratio in accordance with an embodiment of the present invention.
- FIGURE 10 shows temperature death curves for P. acnes.
- the present invention describes methods and devices for the treatment of skin diseases, lesions, irritants, and other localized skin conditions, collectively "lesions", involving the application of a controlled dose of thermal energy to the infected or irritated tissue and thereby speeding the recovery process.
- a lesion according to the present invention is any infected or irritated tissue caused by bacterial, fungal or viral infections, or other type of skin irritant, which can be treated through the application of a regulated amount of heat.
- the invention can also be used to cause the thermal breakdown of certain skin irritants.
- "treating" a skin lesion means to slow, halt or even reverse the development of skin lesions and to reduce the lesion's healing time.
- Skin lesions of the dermis, epidermis, follicle or other cutaneous structures can be treated by the methods and devices of the present invention, as well as skin lesions on mucosal surfaces such as the gums or other skin on the inside of the mouth. Additional skin structures in and around the finger or toe nails and cuticle are also potential sites prone to develop bacterial and fungal infections.
- the lesions can be the result of infection by a bacterial strain including but not limited to strains such as Propionibacterium acnes, Staphylococcus species or Streptococcus species, hi preferred embodiments, the present invention provides methods and devices for the treatment of skin lesions such as the kind commonly associated with acne vulgaris. These skin lesions include pustular eruptions and localized abscesses such as cysts, nodules, pustules, papules, comedones (blackheads) and the like. These lesions include those that are commonly referred to as pimples, whiteheads, zits, acne and the like.
- the lesions can further be result of infection by fungal species, including but not limited to fungal species capable of producing conditions such as toenail or fingernail infections, ringworm and the like.
- fungal species include Microsporuni species such as Microsporum canis, Trichophyton species such as Trichophyton rubrum, Trichophyton. Mentagrophytes,
- the skin lesions can be the result of viral infections, including infections caused by Herpes viruses such as Herpes simplex types I and II (cold sores and genital herpes), Varicella zoster (chicken pox) and the like.
- Herpes viruses such as Herpes simplex types I and II (cold sores and genital herpes), Varicella zoster (chicken pox) and the like.
- embodiments of the present invention provide methods and devices for the controlled application of heat for the treatment of skin lesions caused by an irritant.
- skin irritants that can be treated by the present invention include those introduced by bug bites, such as mosquito, chigger, ant, spider bites, scabies and the like.
- Other skin irritants introduced by other animal species, such as jellyfish, stingrays, snakes and the like, or by plants such as poison ivy, poison oak, poison sumac and the like, can also be treated using the methods and devices of the present invention.
- the application of regulated quantities of heat can result in the biochemical denaturation of the foreign irritant proteins, or can disrupt the host reaction to the particular irritant, or both.
- the disruption of the host reaction can occur by the heat producing an affect on the cellular response to the foreign material.
- the methods and devices of the present invention provide the application to a lesion of an amount of heat (thermal energy) wherein the heat is applied over one or more treatment periods in an amount sufficient to result in improved recovery times for the treated lesion.
- An effective therapeutic amount is therefore any application or applications of heat that are capable of measurably decreasing average recovery times for a given type of skin lesion, preferably by improving the average recovery time by 1, 2, 3, 4, 5 or more days, preventing nascent outbreaks of new lesions,
- Treatment device 10 operates to transfer heat energy to a skin lesion at a set temperature for a set period of time.
- the set temperature and set period of time can be varied to accommodate different skin lesions, but embodiments of treatment device 10 should be capable of heating a treatment surface to a temperature between 38°C and 67°C and sustaining one or more temperatures within that range for at least 5 seconds, but, in most cases, for between 60 seconds and 240 seconds.
- thermal damage generally occurs when human skin is heated to a temperature of approximately 66 0 C (150°F) or greater
- an interface according to an embodiment of the invention heated to this temperature or a higher temperature can nevertheless deliver an effective therapeutic amount of heat to a lesion without resulting in thermal damage, depending on the amount of thermal energy delivered over a particular surface area and how readily the thermal energy is dissipated by the heated tissue.
- Treatment device 10 of the illustrated embodiment includes body 14 and replaceable treatment tip 12.
- Replaceable treatment tip 12 is used to transfer the heat energy from treatment device 10 to the patient's skin.
- Replaceable treatment tip 12 will be described in greater detail with reference to Figures 2a and 2b, but generally includes heat transfer, or treatment surface 16 and tip housing 18.
- Replaceable treatment tip 12 connects to body 14 using tip engagement mechanism 20, which engages and holds treatment tip 12 in the proper orientation with respect to body 14.
- End 38 of treatment tip 12 is configured to selectively engage with body 14 to ensure the proper orientation of treatment tip 12.
- Tip engagement mechanism 20 includes electrical connectors 22 which provide electrical connection between the electrical components in treatment tip 12 and the electrical components in body 14.
- Body 14 includes power button 24 and treatment button 26.
- Power button 14 is used to turn treatment device 10 on and off.
- Treatment button 26 is used to initiate and/or cancel treatments.
- Treatment button 26 can include light emitting diodes (LEDs) 28 that indicate whether treatment device 10 is ready to begin a treatment. While the illustrated embodiment is shown using LEDs as a display, any display technology such as LCDs or other display may be used without departing from the concepts described herein.
- LEDs 28 could include an amber light to indicate that the device is not ready to begin a treatment and a green light to indicate that treatment device 10 is ready to begin a treatment.
- LEDs 32 provide additional visual information to the user, such as the charge remaining in the battery, the number of remaining treatments available using the current replaceable treatment tip 12, the type of treatment tip 12 currently connected to body 14, and any other information which may be useful or interesting to the user.
- a speaker not shown, is also housed in body 14. The speaker can be used to provide audible information to the user such as the amount of time remaining in the treatment, an error condition, low battery charge, and any other audible information that might be useful or interesting to the user.
- Housing 30 of body 14 provides a protective cover to hold the internal components of treatment device 10.
- Housing 30 holds the internal electrical components and the power source, such as rechargeable batteries. While treatment device 10 is described as using rechargeable batteries as the preferred power source, any suitable power source may be used by embodiments of the invention, including receiving power from an ordinary wall socket using a power cord.
- Battery charge port 34 is used to plug in a charger to charge the internal batteries.
- a data port 36 can be included in body 14. Data port 36 allows treatment device 10 to communicate with another device, such as a computer or PDA, and allows the internal electrical components to receive new programs or new data to be used in treatment device 10.
- Replaceable treatment tip 12 is shown with tip housing 18 from Figure 1 removed.
- Replaceable treatment tip 12 of the illustrated embodiment includes thermal mass 40 which is used to transfer the heat energy of the applied treatment.
- Thermal mass 40 includes thermal transfer cup 46.
- Thermal transfer cup 46 has treatment surface 54 which is placed in contact with the region of skin that is being treated. Thermal transfer cup 46 is preferably formed from
- Thermal transfer cup 46 encloses a tip of circuit board 42.
- Circuit board 42 has electrical components used to perform the treatment mounted on its surface and provides the electrical contact between treatment tip 12 and body 14 of treatment device 10 shown in Figure 1.
- Resistors 48 are mounted onto the tip of circuit board 42 enclosed by thermal transfer cup 46 and are used to convert electrical energy from the batteries to heat energy used in the treatment. Resistors 48 are brought into thermal communication with thermal treatment cup 46 by means of a thermally conductive potting compound 56 that at least partially fills thermal transfer cup 46 and holds thermal transfer cup 46 onto circuit board 42. Potting compound 56 of the illustrated embodiment provides the majority of thermal mass for thermal mass 40. Thermal mass 40 is preferably be chosen to balance competing factors that come into play during each treatment.
- Thermal mass 40 is preferably be chosen large enough so that the treatment device can reach and hold as closely as possible to a constant treatment temperature during the entire treatment cycle. If the thermal mass is too small, the treatment device is unable to maintain a constant temperature when treatment surface 50 is brought into contact with the patient's skin which acts a heat sink, drawing heat out of thermal mass 40 as resistors 48 are unable to generate enough heat quickly enough to replace the heat transferred to the patient's skin. This also increases the chances of overshoot, where the temperature of the thermal mass, in trying to replace the heat transferred to the treatment site, overshoots the intended treatment temperature causing the thermal mass to reach a temperature higher than the intended temperature.
- thermal mass 40 is chosen too large, it becomes hard to control as the thermal mass becomes slow to respond to input changes. Additionally,
- Thermal mass 40 should be chosen to provide sufficient thermal mass to allow a well regulated treatment to occur at a set temperature.
- Control of the temperature of thermal mass 40 is done in response to signals from thermister 50, mounted on circuit board 42 in potting compound 56.
- Thermister 50 provides an electrical signal indicative of the temperature of thermal mass 40 to a microprocessor in body 14 of Figure 1.
- Thermister 50 is mounted as close as possible to treatment surface 54 such that the signal provided by thermister 50 most closely indicates the temperature of thermal mass 40 at the treatment site. Mounting thermister 50 further from treatment surface 54 might allow treatment surface 54 to exceed the treatment temperature despite readings from the thermister due to thermal gradients within thermal mass 40.
- redundant thermister 52 is provided in thermal mass 40 of embodiments to ensure that a failure of thermister 50 cannot result in thermal mass 40 reaching temperatures that could be dangerous to the patient.
- Redundant thermister 52 can be connected to the same microprocessor as thermister 50, but is preferably connected to a separate safety circuit outside of the control loop of thermister 50. This provides another level of safety to the treatment device as redundant thermister 52 would not be affected by a failure in the main control loop that includes thermister 50 and the microprocessor.
- Treatment tip 12 also includes memory element 44 mounted to circuit board 42.
- Memory element 44 can be any combination of processing and memory elements utilized to store and implement treatment tip specific functions. Memory element 44 is used to store tip specific information. One example of such tip specific information would be a limit to the number of uses for each replaceable treatment tip. Treatment tips can lose their ability to strictly maintain the treatment temperatures as the elements within the treatment tip are altered through repeated heating and cooling cycles. As a result, treatment tips are only intended for a limited number of
- Memory element 44 is able to track the number of treatments for a treatment tip and to disable a treatment tip after the predetermined number of treatment cycles.
- memory element 44 of the illustrated embodiment includes calibration information for its associated treatment tip. As the individual components used in each treatment tip have their own variances from their marked values, each tip is calibrated during manufacturing to provide calibration information stored in memory element 44 and used to adjust the heating algorithm of treatment device 10 to account for the particular values of the components in the treatment tip.
- the memory element can also store treatment variables such as treatment cycle duration, treatment temperature and treatment frequency based on the particular lesion the tip is designed to treat.
- treatment variables such as treatment cycle duration, treatment temperature and treatment frequency based on the particular lesion the tip is designed to treat.
- other treatment tip specific information can be stored in memory element 44 that aids the treatment device in its operation.
- Such information can, for example, be information that identifies the type of tip and the intended treatment protocols, as well as algorithm information used during a treatment cycle.
- Device 10 includes microprocessor 62.
- Microprocessor 62 is programmed to respond to and control the various inputs and outputs of treatment device 10 from Figure 1.
- Microprocessor 62 receives input from power button 24, and in response operates to power-up or power- down the treatment device accordingly.
- Microprocessor 62 also receives input from treatment button 70 and operates to start or stop treatment based on input from treatment button 70.
- LEDs 74 are turned on and off by microprocessor 62 to communicate visual information to information to the user, while speaker 90 is controlled by microprocessor 62 to communicate audible information to the user.
- Microprocessor 62 is also connected to treatment tip 12. Microprocessor corrrmunicates with memory element 44 and exchanges information on tip cycles, calibration, treatment variations and other tip specific information. Microprocessor also receives the signal from thermister 50 through interface 88. Using
- microprocessor 62 is operable to control the temperature of the thermal mass of treatment tip 12.
- Microprocessor 62 of the illustrated embodiment is connected to the gate of field effect transistor ("FET") 86, and by varying the voltage at the gate of FET 86 is able to control the amount of current flowing through resistors 48.
- the heat produced by resistors 48 is proportional to the amount of current passing through them.
- Thermal interlock 80 provides a safety mechanism to ensure that the failure of thermister 50 does not cause a dangerous operating temperature in the treatment tip.
- Microprocessor 62 is programmed with a control algorithm referred to as a proportional, integral, derivative or PID.
- a PID is a control algorithm which uses three modes of operation: the proportional action is used to dampen the system response, the integral corrects for droop, and the derivative prevents overshoot and undershoot.
- the PID algorithm implemented in Microprocessor 62 operates to bring the thermal mass to the desired operating temperature as quickly as possible with minimal overshoot, and also operates to respond to changes in the temperature of the thermal mass during the treatment cycle that are caused by the heat sink effect of the treatment area.
- resistors 48 are connected to battery 64 through thermal interlock 80, which can be a fuse having a maximum current rating chosen to prevent runaway overheating of resistors 48.
- Battery 64 which can be comprised of one or more individual cells, is charged by battery charger 66 when battery charger 66 is connected to external power supply 68.
- External power supply 68 can be any type of power supply, but is normally an AC to DC converter connected between battery charger 66 and an ordinary wall outlet.
- the output voltage of battery 66 is directly related to the amount of charge left in battery 66, therefore, by monitoring the voltage across battery 66 microprocessor 62 can determine the amount of charge remaining in battery 66 and convey this information to the user using LEDs 74 or speaker 90.
- Other methods of determining battery voltages or charge for different battery technologies can also be used and are well within the scope of the present invention.
- microprocessor 62 is operable to respond to and control the various aspects of treatment device 10 from Figure 1.
- Firmware 92 is able to accept inputs from power button 70, treatment button 26, tip thermister 50 and battery 64.
- Firmware 92 is also able to exchange information with memory element 44, such as the maximum number of treatments for the tip, the number of tip treatments actually performed by the tip, and calibration data.
- the microprocessor 62 and memory element 44 may exchange any other information that may increase the efficacy of treatment device 10.
- firmware 92 controls FET 86 to regulate the temperature of the thermal mass in the treatment tip according to the PID algorithm programmed into firmware 92.
- Firmware 92 also controls speaker 90 to provide audible feedback to the user and LEDs 94, 96, and 98 which are subsets of LEDs 74 from Figure 3, and provide indications of tip life (LEDs 94), battery charge (LED 96), and treatment status (LEDs 98).
- the state diagram begins a Suspended state 110 which is the power off state. During the power off mode the microprocessor is still receiving some power to allow it to monitor the power button. The Suspended state 110 is left when the power on button is pressed, and the state proceeds to the Processing Tip Memory state 112. In the Processing Tip Memory state 112 the microprocessor 62 and memory element 44 from Figure 3 exchange tip specific treatment information. If the tip usage count is not low or zero, the state passes to Heating state 116.
- the state progresses to the Warning state which provides visual and or audible signals to the user to indicate that the tip count is low or zero. If the tip count is zero or the tip is removed, the state passes from the Warning state 114 to the Suspended state 110. If the tip count is low, but not zero the state passes from the Warning state 114 to the Heating state 116.
- the tip is heated using resistors 48 from Figure 3.
- a predictive model is used to set a timer based on the amount of time that should be required for the tip to come to temperature. This timer acts as in indicator
- thermal mass 21 that the thermal mass is responding to the heating correctly. If the tip does not reach the predetermined operating temperature by the expiration of the timer, it is an indication of a potentially faulty component and the treatment device shuts down by transitioning to Suspended state 110. Other predictions of thermal mass behavior can also be used to detect potentially faulty components.
- the treatment device powers down by transitioning to the Suspended state if the power button is pressed, the tip is removed or the battery voltage falls below a threshold, and indication of the fault is provided to the user through visual and/or audible signals. If the tip successfully reaches the operating temperature within the designated time the state transitions to Ready state 118. A timer is started upon entering the Ready state 118. If the timer expires or the power button is pressed while in the Ready state 118, the state transitions to the Suspended state 110.
- Treatment state 120 If the treatment button is pressed while in Ready state 118 the state transitions to Treatment state 120.
- the safety timer is slightly longer than the treatment timer so that if there is a failure in the treatment timer the safety timer will expire and transition the state to the Power Reset state 124 before transitioning to the Suspended state 110.
- the state also transitions from Treatment state 120 to Suspended state 110 if the power button is pressed during a treatment cycle.
- the treatment device can also be programmed to provide visual and/or audible indications of the progress of the treatment timer.
- speaker 90 of Figure 3 can be used to provide intermittent tones during the treatment to let the user know that the treatment is continuing.
- the time between the tones could be spaced to provide an indication of the remaining time in the treatment cycle, such as by shortening the time between the tones as the cycle gets closer to the end.
- Many other methods of providing visual or audible feedback could be contemplated and are well within the scope of the present invention.
- the Wait state 122 can be used to force a temporal treatment limit. While the inter-treatment delay forces a relatively brief delay between treatment cycles, the temporal treatment limit acts to limit the number of treatments that can be performed in specified period. For example, if the treatment cycle is two and a half minutes and the inter-treatment delay is 10 seconds, a temporal treatment limit of 30 minutes could be used to limit the device to approximately 10 to 11 consecutive treatments before a forced interval is imposed.
- Multi-location treatment device 130 includes treatment base station 132 and multiple treatment dots 134.
- Base station 132 includes all the essential functionality of the body 14 of treatment device 10 from Figure 1, while treatment dots 134 each contain the essential functionality of replaceable treatment tip 12 from Figure 1.
- the change between treatment device 10 of Figure 1 and multi-location treatment device 10 is primarily a change in form factor to accommodate multiple treatment locations simultaneously.
- Base station 132 communicates with treatment dots 134 either by wires 136 connecting the base station 132 to the treatment dots 134, as is shown in Figure 6, or by means of a wireless connection as is shown in Figure 7 using wireless transmitters 142.
- the base station 132 also includes LEDs used to convey visual information to the user of device 130.
- Base station 132 and treatment dots operate in the same manner as described above for the single tip treatment system.
- Treatment dots 134 can be formed with an adhesive coating on the treatment surface to allow treatment dots 134 to adhere to the treatment area.
- Treatment dot 134 includes housing 146, which holds the electrical components mounted on circuit board 160. As with tip 12 from Figure 2, the circuit board and electrical components are covered with a thermally conductive potting compound to create a
- treatment dot 134 includes port 156 which can either be the connection point for wire 136 from Figure 6, or can hold a wireless transceiver for use with the wireless treatment device shown in Figure 7.
- power source 150 might also be utilized to supply the power necessary for resistors 148 to generate the desired heat.
- Treatment dot 134 shown in Figure 8 also illustrates an alternative treatment surface.
- Treatment surface 54 from Figure 2 was described as formed from aluminum or other rigid thermally conductive material.
- a rigid surface such as aluminum works very well when used against a deformable surface such as skin.
- a non-deformable surface such as a fingernail or toenail
- the rigid treatment surface is unable to contact all of the surface to be treated.
- heat is not transferred to the entire treatment area.
- a deformable treatment surface and thermal mass can be used such that the treatment surface and thermal mass conform to the treatment area.
- tip 162 One embodiment of such a deformable treatment tip is illustrated by tip 162.
- Tip 162 is formed by a deformable material 158 such as silicon or similar material formed by a thermally conductive material 164 which is also deformable, such as a silicon or similar gel. Resistors 148 are able to transfer heat to the thermal material 164 and deformable surface 158.
- the treatment device can be sterilized by heating the device to a high enough temperature and for a sufficient period of time to result in loss of viability of any microorganisms that are present on the treatment surface.
- the treatment surface itself can be sterilized by conventional methods of sterilization such as application of an antiseptic to the surface to be sterilized.
- the shape of the treatment surface can be any shape and composed of any material that is appropriate for the treatment of a particular type of lesion.
- the interface can be substantially planar, convex or concave.
- a treatment surface intended for the treatment of pustular eruptions or localized abscesses on the face might preferably be substanially planar or convex so as to come in contact with one or more lesions and possibly their immediate surroundings.
- a treatment surface for the treatment of fungal infections of the toenail might preferably be shaped as a ring, arc, cap, or other appropriate shape so as to be placed in close proximity to the infected tissue.
- Other shapes for the treatment surface will be readily apparent, depending on the types of lesions intended to be treated with a treatment device in accordance with the present invention.
- the aspect ratio between a thermal transfer area and thermal contact area plays a significant role in determining the internal skin temperature resulting from a
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002607612A CA2607612A1 (en) | 2005-05-18 | 2006-05-17 | Treatment device and method for treating skin lesions through application of heat |
EP06760108A EP1885252A4 (en) | 2005-05-18 | 2006-05-17 | Treatment device and method for treating skin lesions through application of heat |
MX2007014439A MX2007014439A (en) | 2005-05-18 | 2006-05-17 | Treatment device and method for treating skin lesions through application of heat. |
JP2008512509A JP2008540050A (en) | 2005-05-18 | 2006-05-17 | Treatment apparatus and method for treating skin lesions by applying heat |
BRPI0611269-2A BRPI0611269A2 (en) | 2005-05-18 | 2006-05-17 | treatment device and method for treating skin lesions by applying heat |
AU2006247109A AU2006247109A1 (en) | 2005-05-18 | 2006-05-17 | Treatment device and method for treating skin lesions through application of heat |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68222905P | 2005-05-18 | 2005-05-18 | |
US60/682,229 | 2005-05-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006125092A2 true WO2006125092A2 (en) | 2006-11-23 |
WO2006125092A3 WO2006125092A3 (en) | 2007-09-27 |
Family
ID=37432146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/019260 WO2006125092A2 (en) | 2005-05-18 | 2006-05-17 | Treatment device and method for treating skin lesions through application of heat |
Country Status (13)
Country | Link |
---|---|
US (1) | US20070049998A1 (en) |
EP (2) | EP2389885A1 (en) |
JP (1) | JP2008540050A (en) |
KR (1) | KR20080039340A (en) |
CN (1) | CN101175450A (en) |
AU (1) | AU2006247109A1 (en) |
BR (1) | BRPI0611269A2 (en) |
CA (1) | CA2607612A1 (en) |
MX (1) | MX2007014439A (en) |
RU (1) | RU2007146978A (en) |
TW (1) | TW200716055A (en) |
WO (1) | WO2006125092A2 (en) |
ZA (1) | ZA200709045B (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2187848A1 (en) * | 2007-08-15 | 2010-05-26 | Zeno Corporation | Treatment of nail-bed fungus by application of heat |
WO2011064528A1 (en) * | 2009-11-25 | 2011-06-03 | Louise Mohn | Inline control system for therapeutic pad |
WO2011064527A1 (en) * | 2009-11-25 | 2011-06-03 | Louise Mohn | Electrostimulation pad with integrated temperature sensor |
WO2011064526A1 (en) * | 2009-11-25 | 2011-06-03 | Louise Mohn | Thermostimulation system including multilayer pads with integrated temperature regulation |
WO2011095887A1 (en) * | 2010-02-04 | 2011-08-11 | Americo Fernandes | Chemical warming device and method for the treatment of viruses such as herpes |
EP2897687A4 (en) * | 2012-09-20 | 2016-05-25 | Ct P C | Stretch mark removal device |
WO2018011262A1 (en) * | 2016-07-12 | 2018-01-18 | Dermapharm Ag | Device for hyperthermia treatment of pruritus |
EP3620142A1 (en) * | 2018-09-05 | 2020-03-11 | Dermapharm AG | Device for treating herpes illnesses |
EP3620141A1 (en) * | 2018-09-05 | 2020-03-11 | Dermapharm AG | Device for the treatment of itching and herpes diseases comprising a contact sensor |
WO2020049071A1 (en) | 2018-09-05 | 2020-03-12 | Dermapharm Ag | Device for treating herpetic diseases |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7648483B2 (en) * | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
US7793666B2 (en) * | 2005-07-28 | 2010-09-14 | Innovation Biomedical Devices, Inc. | Apparatus and method for treatment of infected nail |
US20070259316A1 (en) * | 2006-05-08 | 2007-11-08 | Tyrell, Inc. | Treatment device and method for treating or preventing periodontal disease through application of heat |
US20080008978A1 (en) * | 2006-05-08 | 2008-01-10 | Tyrell, Inc. | Treatment device and method for treating or preventing periodontal disease through application of heat |
US20080027399A1 (en) * | 2006-07-28 | 2008-01-31 | Becton, Dickinson And Company | Antimicrobial vascular access device |
US8921746B2 (en) * | 2008-05-23 | 2014-12-30 | Access Business Group International Llc | Inductively-heated applicator system |
US20100021530A1 (en) * | 2008-07-25 | 2010-01-28 | Innovation Biomedical Devices, Inc. | Enhanced trans-keratin drug delivery |
US8788060B2 (en) * | 2009-07-16 | 2014-07-22 | Solta Medical, Inc. | Tissue treatment systems with high powered functional electrical stimulation and methods for reducing pain during tissue treatments |
KR101159779B1 (en) * | 2009-08-17 | 2012-06-26 | (주)메딕콘 | A portable skin treatment devices using light and heat |
US8882378B2 (en) * | 2010-02-15 | 2014-11-11 | Access Business Group International Llc | Heating and dispenser system |
US10384076B2 (en) * | 2010-08-17 | 2019-08-20 | Koninklijke Philips N.V. | Flexible light therapy device, a plaster and a bandage |
KR101024468B1 (en) * | 2010-08-20 | 2011-03-23 | 정일우 | Operating system for exposing tumor mass |
US9592374B2 (en) | 2010-09-01 | 2017-03-14 | Becton, Dickinson And Company | Catheter adapter having UV-C antimicrobial radiation source and access window within catheter lumen for intravenous therapy |
EP2446865A1 (en) | 2010-10-28 | 2012-05-02 | Louise Mohn | Thermostimulation apparatus |
LT3209319T (en) | 2014-10-21 | 2021-10-25 | Hexima Limited | A method of treatment of fungal infections |
EP3209236B1 (en) | 2015-03-31 | 2020-06-10 | St. Jude Medical, Cardiology Division, Inc. | Device for delivering pulsed rf energy during catheter ablation |
ITUA20164304A1 (en) * | 2016-05-24 | 2016-08-24 | Umberto Trotta | DEVICE AND METHOD AFTER - INSECT BIT |
US20170354533A1 (en) * | 2016-06-08 | 2017-12-14 | Larada Sciences, Inc. | Heated air ectoparasite treatment devices and related methods |
EP3308752B1 (en) * | 2016-10-11 | 2020-04-08 | Dermapharm AG | Device for hyperthermal treatment of itching |
US11344707B2 (en) * | 2016-11-28 | 2022-05-31 | Therma Bright Inc. | Devices for applying a topical treatment |
KR200483954Y1 (en) * | 2017-02-09 | 2017-07-12 | 고재정 | Apparatus for preventing and relieving pruritus of body parts bitten by harmful insects |
EP3578146A1 (en) * | 2018-06-07 | 2019-12-11 | Dermapharm AG | Mobile device with interface for treating itchy skin |
EP3685810A1 (en) | 2019-01-23 | 2020-07-29 | Dermapharm AG | Mobile device with interface for the treatment of irritation of the skin |
CN112244993B (en) * | 2020-10-31 | 2022-03-15 | 杭州诺生医疗科技有限公司 | Radio frequency ablation instrument |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040243181A1 (en) | 2003-05-31 | 2004-12-02 | Tyrell, Inc. | Methods and devices for the treatment of skin lesions |
Family Cites Families (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1771076A (en) * | 1929-07-08 | 1930-07-22 | Ultra Violet Generator Corp | Orificial therapeutic device |
US1817823A (en) * | 1930-02-07 | 1931-08-04 | Ito Kinitsu | Medical moxa heater |
US2533955A (en) * | 1948-10-22 | 1950-12-12 | Norman H Pitts | Portable therapeutic device |
US3938526A (en) * | 1974-05-20 | 1976-02-17 | Anderson Weston A | Electrical acupuncture needle heater |
US3978312A (en) * | 1974-10-17 | 1976-08-31 | Concept, Inc. | Variable temperature electric cautery assembly |
US4106478A (en) * | 1975-06-09 | 1978-08-15 | Sunao Higashijima | Packaged heat generator |
US4074110A (en) * | 1975-12-02 | 1978-02-14 | Slaughter Philip E | Hand held electric heating device |
US4359052A (en) * | 1976-01-26 | 1982-11-16 | Concept Inc. | Removable tip cautery |
JPS536088U (en) * | 1976-07-01 | 1978-01-19 | ||
US4381009A (en) * | 1980-01-28 | 1983-04-26 | Bon F Del | Hand-held device for the local heat-treatment of the skin |
US4449528A (en) * | 1980-03-20 | 1984-05-22 | University Of Washington | Fast pulse thermal cautery probe and method |
US4511829A (en) * | 1980-07-17 | 1985-04-16 | Exploration Logging, Inc. | Direct current control in inductive loads |
US4582057A (en) * | 1981-07-20 | 1986-04-15 | Regents Of The University Of Washington | Fast pulse thermal cautery probe |
US4531524A (en) * | 1982-12-27 | 1985-07-30 | Rdm International, Inc. | Circuit apparatus and method for electrothermal treatment of cancer eye |
US4961422A (en) * | 1983-01-21 | 1990-10-09 | Marchosky J Alexander | Method and apparatus for volumetric interstitial conductive hyperthermia |
US4878493A (en) * | 1983-10-28 | 1989-11-07 | Ninetronix Venture I | Hand-held diathermy apparatus |
DE3532603A1 (en) * | 1984-09-13 | 1986-03-20 | Olympus Optical Co., Ltd., Tokio/Tokyo | CAUTERIZATION BLOODSTYLE DEVICE |
US4657531A (en) * | 1985-02-10 | 1987-04-14 | Choi Jei C | Therapeutic heating apparatus |
US4658823A (en) * | 1986-04-15 | 1987-04-21 | Beddoe Alexander F | Incandescent lamp structure for applying therapeutic heat |
US4691703A (en) * | 1986-04-25 | 1987-09-08 | Board Of Regents, University Of Washington | Thermal cautery system |
US4763657A (en) * | 1987-04-06 | 1988-08-16 | Chen Chen Wei | Thermally-treated electronic acupuncturer |
US5074305A (en) * | 1987-07-14 | 1991-12-24 | Venomex, Incorporated | Method for treatment of toxins received from snake bites and the like |
EP0312413B1 (en) * | 1987-10-07 | 1993-05-05 | Georges Ratkoff | Portable device for the local heating of the skin for therapeutic purposes |
US4907589A (en) * | 1988-04-29 | 1990-03-13 | Cosman Eric R | Automatic over-temperature control apparatus for a therapeutic heating device |
US4873609A (en) * | 1988-06-20 | 1989-10-10 | Mackey Clifford R | Portable electronic unit for treatment of bites by poisonous snakes or other animals or allergic contracts |
US5097828A (en) * | 1990-09-25 | 1992-03-24 | Richard Deutsch | Thermoelectric therapy device |
US5235990A (en) * | 1991-06-28 | 1993-08-17 | Dempsey Robert N | Apparatus for neutralizing irritants introduced into a body via a bite or sting |
US5445146A (en) * | 1995-03-31 | 1995-08-29 | Bellinger; Gary J. | Biological tissue stimulation by low level optical energy |
US5531775A (en) * | 1991-07-19 | 1996-07-02 | Kabushiki Kaisya Advance | Skin attachment type electric thermal treatment device |
US5169384A (en) * | 1991-08-16 | 1992-12-08 | Bosniak Stephen L | Apparatus for facilitating post-traumatic, post-surgical, and/or post-inflammatory healing of tissue |
CA2106410C (en) * | 1991-11-08 | 2004-07-06 | Stuart D. Edwards | Ablation electrode with insulated temperature sensing elements |
DK168420B1 (en) * | 1992-03-27 | 1994-03-28 | Coloplast As | A heat dressing |
US5290281A (en) * | 1992-06-15 | 1994-03-01 | Medicon Eg | Surgical system |
US5327886A (en) * | 1992-08-18 | 1994-07-12 | Chiu Cheng Pang | Electronic massage device with cold/hot compress function |
US5421816A (en) * | 1992-10-14 | 1995-06-06 | Endodermic Medical Technologies Company | Ultrasonic transdermal drug delivery system |
US5496356A (en) * | 1993-03-29 | 1996-03-05 | Hudz; Paul H. | Piezo de-toxifier |
US5406053A (en) * | 1993-07-29 | 1995-04-11 | Masreliez; C. Johan | Heating probe having a heated tip forming a thermocouple |
US5445608A (en) * | 1993-08-16 | 1995-08-29 | James C. Chen | Method and apparatus for providing light-activated therapy |
US7537605B2 (en) * | 1993-10-04 | 2009-05-26 | Huan-Chen Li | Medical device for treating skin itch and rash |
US6245093B1 (en) * | 1993-10-04 | 2001-06-12 | Huan-Chen Li | Method and apparatus for treatment of skin itch and disease |
US20030088298A1 (en) * | 1993-10-04 | 2003-05-08 | Huan-Chen Li | Method and apparatus for treatment of skin itch and disease |
US6635075B2 (en) * | 1993-10-04 | 2003-10-21 | Huan-Chen Li | Method and apparatus for treatment of skin itch and disease |
US5524809A (en) * | 1994-08-22 | 1996-06-11 | The United States Of America As Represented By The United States Department Of Energy | Soldering instrument safety improvements |
US5817145A (en) * | 1994-11-21 | 1998-10-06 | Augustine Medical, Inc. | Wound treatment device |
US6245347B1 (en) * | 1995-07-28 | 2001-06-12 | Zars, Inc. | Methods and apparatus for improved administration of pharmaceutically active compounds |
US7115123B2 (en) * | 1996-01-05 | 2006-10-03 | Thermage, Inc. | Handpiece with electrode and non-volatile memory |
IT1281688B1 (en) * | 1996-01-19 | 1998-02-26 | Tecnica S R L | PORTABLE TOOL TO TREAT INSECT BITS |
EP0715809A3 (en) * | 1996-02-08 | 1996-08-21 | Klaus Nielsen Radgivende Ingen | Method of improving indoor air quality by thermally inactivating fungi on building surfaces |
US5792211A (en) * | 1996-05-01 | 1998-08-11 | Teague; Thomas Wade | Method for localized neutralization of poison |
US5804795A (en) * | 1996-05-28 | 1998-09-08 | Fortune; William S. | Soldering tip heat accumulator |
US6091995A (en) * | 1996-11-08 | 2000-07-18 | Surx, Inc. | Devices, methods, and systems for shrinking tissues |
US6134475A (en) * | 1997-01-22 | 2000-10-17 | Will; Frank J. | Therapeutic device |
US7083613B2 (en) * | 1997-03-05 | 2006-08-01 | The Trustees Of Columbia University In The City Of New York | Ringed forceps |
US6626901B1 (en) * | 1997-03-05 | 2003-09-30 | The Trustees Of Columbia University In The City Of New York | Electrothermal instrument for sealing and joining or cutting tissue |
US5830211A (en) * | 1997-03-10 | 1998-11-03 | Santana; Jose A. | Probe to treat viral lesions |
AT407480B (en) * | 1997-05-06 | 2001-03-26 | Macher David | HEATING DEVICE FOR HEATING A SKIN SURFACE OR PARTIAL AREAS OF A HUMAN BODY |
US5817139A (en) * | 1997-05-22 | 1998-10-06 | Polytronics, Ltd. | Skin-contact type antiallergic skin-therapeutic apparatus using voltage pulse train |
CA2298526A1 (en) * | 1997-07-28 | 1999-02-04 | Dermatolazer Technologies Ltd | Phototherapy based method for treating pathogens and composition for effecting same |
US20020169442A1 (en) * | 1997-08-12 | 2002-11-14 | Joseph Neev | Device and a method for treating skin conditions |
US6176857B1 (en) * | 1997-10-22 | 2001-01-23 | Oratec Interventions, Inc. | Method and apparatus for applying thermal energy to tissue asymmetrically |
US6080189A (en) * | 1998-04-06 | 2000-06-27 | Augustine Medical, Inc. | Wound treatment apparatus including a heater and an IR-Transparent or IR-Transmissive bandage |
US6095992A (en) * | 1998-04-06 | 2000-08-01 | Augustine Medical, Inc. | Wound treatment apparatus for normothermic treatment of wounds |
SE9903407L (en) * | 1998-09-26 | 2000-03-27 | Kijang Medical Co | Method for the preparation of pharmaceutical artemisia extracts and apparatus for electric moxa burning using the extract |
US6726673B1 (en) * | 1999-05-24 | 2004-04-27 | Zars, Inc. | Methods and apparatus for improved administration of testosterone pharmaceuticals |
US6708060B1 (en) * | 1998-11-09 | 2004-03-16 | Transpharma Ltd. | Handheld apparatus and method for transdermal drug delivery and analyte extraction |
US6183500B1 (en) | 1998-12-03 | 2001-02-06 | Sli Lichtsysteme Gmbh | Process and apparatus for the cosmetic treatment of acne vulgaris |
US6235027B1 (en) * | 1999-01-21 | 2001-05-22 | Garrett D. Herzon | Thermal cautery surgical forceps |
JP4102031B2 (en) * | 1999-03-09 | 2008-06-18 | サーメイジ インコーポレイテッド | Apparatus and method for treating tissue |
US6162217A (en) * | 1999-04-21 | 2000-12-19 | Oratec Interventions, Inc. | Method and apparatus for controlling a temperature-controlled probe |
US6743222B2 (en) * | 1999-12-10 | 2004-06-01 | Candela Corporation | Method of treating disorders associated with sebaceous follicles |
US20030036749A1 (en) * | 1999-12-10 | 2003-02-20 | Durkin Anthony J. | Method of treating disorders associated with sebaceous follicles |
US6840955B2 (en) * | 2000-01-27 | 2005-01-11 | Robert J. Ein | Therapeutic apparatus |
US6629974B2 (en) * | 2000-02-22 | 2003-10-07 | Gyrus Medical Limited | Tissue treatment method |
US6471716B1 (en) * | 2000-07-11 | 2002-10-29 | Joseph P. Pecukonis | Low level light therapy method and apparatus with improved wavelength, temperature and voltage control |
US20020165529A1 (en) * | 2001-04-05 | 2002-11-07 | Danek Christopher James | Method and apparatus for non-invasive energy delivery |
AU2001267804B2 (en) * | 2001-06-27 | 2007-05-31 | Radiancy Inc. | Acne treatment |
US7041102B2 (en) * | 2001-10-22 | 2006-05-09 | Surgrx, Inc. | Electrosurgical working end with replaceable cartridges |
US6960201B2 (en) * | 2002-02-11 | 2005-11-01 | Quanticum, Llc | Method for the prevention and treatment of skin and nail infections |
US7108694B2 (en) * | 2002-11-08 | 2006-09-19 | Olympus Corporation | Heat-emitting treatment device |
US20050011876A1 (en) * | 2002-11-26 | 2005-01-20 | Takashi Uetani | Soldering iron with replaceable tip cap |
WO2004083797A2 (en) * | 2003-03-14 | 2004-09-30 | Thermosurgery Technologies, Inc. | Hyperthermia treatment system |
US20070179482A1 (en) * | 2004-05-07 | 2007-08-02 | Anderson Robert S | Apparatuses and methods to treat biological external tissue |
US8277495B2 (en) * | 2005-01-13 | 2012-10-02 | Candela Corporation | Method and apparatus for treating a diseased nail |
US7793666B2 (en) * | 2005-07-28 | 2010-09-14 | Innovation Biomedical Devices, Inc. | Apparatus and method for treatment of infected nail |
US20070104664A1 (en) * | 2005-10-26 | 2007-05-10 | California Institute Of Technology | Treatment of toenail fungus |
US20110202048A1 (en) * | 2010-02-12 | 2011-08-18 | Solta Medical, Inc. | Methods for pain reduction with functional thermal stimulation and tissue treatment systems |
-
2006
- 2006-05-17 AU AU2006247109A patent/AU2006247109A1/en not_active Abandoned
- 2006-05-17 JP JP2008512509A patent/JP2008540050A/en active Pending
- 2006-05-17 MX MX2007014439A patent/MX2007014439A/en not_active Application Discontinuation
- 2006-05-17 BR BRPI0611269-2A patent/BRPI0611269A2/en not_active Application Discontinuation
- 2006-05-17 CA CA002607612A patent/CA2607612A1/en not_active Abandoned
- 2006-05-17 EP EP11174303A patent/EP2389885A1/en not_active Withdrawn
- 2006-05-17 KR KR1020077029125A patent/KR20080039340A/en not_active Application Discontinuation
- 2006-05-17 US US11/435,568 patent/US20070049998A1/en not_active Abandoned
- 2006-05-17 WO PCT/US2006/019260 patent/WO2006125092A2/en active Application Filing
- 2006-05-17 RU RU2007146978/14A patent/RU2007146978A/en not_active Application Discontinuation
- 2006-05-17 EP EP06760108A patent/EP1885252A4/en not_active Withdrawn
- 2006-05-17 CN CNA2006800167836A patent/CN101175450A/en active Pending
- 2006-05-18 TW TW095117684A patent/TW200716055A/en unknown
-
2007
- 2007-10-19 ZA ZA200709045A patent/ZA200709045B/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040243181A1 (en) | 2003-05-31 | 2004-12-02 | Tyrell, Inc. | Methods and devices for the treatment of skin lesions |
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2187848A1 (en) * | 2007-08-15 | 2010-05-26 | Zeno Corporation | Treatment of nail-bed fungus by application of heat |
EP2187848A4 (en) * | 2007-08-15 | 2011-04-20 | Zeno Corp | Treatment of nail-bed fungus by application of heat |
WO2011064528A1 (en) * | 2009-11-25 | 2011-06-03 | Louise Mohn | Inline control system for therapeutic pad |
WO2011064527A1 (en) * | 2009-11-25 | 2011-06-03 | Louise Mohn | Electrostimulation pad with integrated temperature sensor |
WO2011064526A1 (en) * | 2009-11-25 | 2011-06-03 | Louise Mohn | Thermostimulation system including multilayer pads with integrated temperature regulation |
WO2011095887A1 (en) * | 2010-02-04 | 2011-08-11 | Americo Fernandes | Chemical warming device and method for the treatment of viruses such as herpes |
EP2897687A4 (en) * | 2012-09-20 | 2016-05-25 | Ct P C | Stretch mark removal device |
WO2018011262A1 (en) * | 2016-07-12 | 2018-01-18 | Dermapharm Ag | Device for hyperthermia treatment of pruritus |
KR20190053175A (en) * | 2016-07-12 | 2019-05-17 | 데어마팜 에이쥐 | Devices for treatment of hyperthermia of itching |
KR102456457B1 (en) | 2016-07-12 | 2022-10-21 | 데어마팜 에이쥐 | Device for the treatment of itch and high fever |
EP3620142A1 (en) * | 2018-09-05 | 2020-03-11 | Dermapharm AG | Device for treating herpes illnesses |
EP3620141A1 (en) * | 2018-09-05 | 2020-03-11 | Dermapharm AG | Device for the treatment of itching and herpes diseases comprising a contact sensor |
WO2020049071A1 (en) | 2018-09-05 | 2020-03-12 | Dermapharm Ag | Device for treating herpetic diseases |
WO2020049070A1 (en) | 2018-09-05 | 2020-03-12 | Dermapharm Ag | Device for treating pruritus and herpetic diseases with a contact sensor |
US20210322205A1 (en) * | 2018-09-05 | 2021-10-21 | Dermapharm Ag | Device for the treatment of itching and herpes diseases with a contact sensor |
Also Published As
Publication number | Publication date |
---|---|
AU2006247109A1 (en) | 2006-11-23 |
KR20080039340A (en) | 2008-05-07 |
CN101175450A (en) | 2008-05-07 |
ZA200709045B (en) | 2008-11-26 |
WO2006125092A3 (en) | 2007-09-27 |
JP2008540050A (en) | 2008-11-20 |
MX2007014439A (en) | 2008-02-11 |
BRPI0611269A2 (en) | 2010-08-24 |
RU2007146978A (en) | 2009-06-27 |
CA2607612A1 (en) | 2006-11-23 |
EP1885252A4 (en) | 2009-10-21 |
TW200716055A (en) | 2007-05-01 |
EP2389885A1 (en) | 2011-11-30 |
EP1885252A2 (en) | 2008-02-13 |
US20070049998A1 (en) | 2007-03-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20070049998A1 (en) | Treatment device and method for treating skin lesions through application of heat | |
US8182475B2 (en) | Methods and devices for the treatment of skin lesions | |
US10238814B2 (en) | Applicator for cryoanesthesia and analgesia | |
EP2187848A1 (en) | Treatment of nail-bed fungus by application of heat | |
Young et al. | Prevention of perioperative hypothermia in plastic surgery | |
WO2007133840A2 (en) | Treatment device and method for treating or preventing periodontal disease through application of heat | |
EP2162087A1 (en) | Treatment device and method for treating or preventing periodontal disease through application of heat | |
ZA200509668B (en) | Methods and devices for the treatment of skin lesions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200680016783.6 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
WWE | Wipo information: entry into national phase |
Ref document number: 8290/DELNP/2007 Country of ref document: IN |
|
ENP | Entry into the national phase |
Ref document number: 2607612 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2006247109 Country of ref document: AU |
|
ENP | Entry into the national phase |
Ref document number: 2008512509 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: MX/a/2007/014439 Country of ref document: MX |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 1020077029125 Country of ref document: KR Ref document number: 2006760108 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007146978 Country of ref document: RU |
|
ENP | Entry into the national phase |
Ref document number: PI0611269 Country of ref document: BR Kind code of ref document: A2 |