WO2007011504A1 - Breath freshening and oral cleansing product comprising a magnolia bark extract and surfactant - Google Patents
Breath freshening and oral cleansing product comprising a magnolia bark extract and surfactant Download PDFInfo
- Publication number
- WO2007011504A1 WO2007011504A1 PCT/US2006/025042 US2006025042W WO2007011504A1 WO 2007011504 A1 WO2007011504 A1 WO 2007011504A1 US 2006025042 W US2006025042 W US 2006025042W WO 2007011504 A1 WO2007011504 A1 WO 2007011504A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- surface active
- active agent
- composition
- agent comprises
- bark extract
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
- A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
- A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
- A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
- A23L27/70—Fixation, conservation, or encapsulation of flavouring agents
- A23L27/79—Fixation, conservation, or encapsulation of flavouring agents in the form of films
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3472—Compounds of undetermined constitution obtained from animals or plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
Definitions
- An active ingredient, or a combination of active ingredients, that can provide the benefits of either removing plaque, preventing or slowing down plaque formation, or that has an anti-inflammatory effect that would help maintain the healthy state of the gums would promote health gums and fresh breath. It is known to incorporate active agents into oral compositions for the purpose of providing oral benefits including breath freshening and bactericidal properties. Such systems have the advantage of providing rapid, efficient, and convenient delivery. BRIEF SUMMARY
- an oral composition for freshening the breath of consumers of the oral composition includes an oral cavity delivery agent and an effective amount of an antimicrobial agent comprising a synergistic ratio of Magnolia Bark Extract and surface active agents, wherein the synergistic ratio is at least about 1 part Magnolia Bark Extract to 1 part surface active agent.
- Suitable surface active agents include, but are not limited to, common surfactants, soaps, wetting agents, and emulsifiers. Some examples of surfactants include, but are not limited to, salts of potassium, ammonium, or sodium.
- the oral composition can also include additional breath freshening or oral health ingredients, which can be anti-microbial ingredients. Further, the additional breath freshening or oral health ingredients can comprise food acceptable salts of zinc or copper, cooling agents, pyrophosphates or polyphosphates, and the like.
- Chlorhexidine (40 ⁇ g/ml) was used as a positive control.
- sterile 96-well microtiter plates were used where each well was inoculated with S. mutans (5x10 6 CFU/ml), growth medium (brain-heart-infosion broth (BHI) with 0.5% sucrose), and incubated at 37°C under aerobic condition for biof ⁇ lm formation. After 48 hours, the non-attached supernatant was aspirated and serially diluted. Test compounds were added to the pre-formed biofilm and incubated at 37°C under aerobic condition. The controls included solvent without test compounds.
- the germ-kill active and/or surface active agent was dissolved in ethanol or sterile water to give an initial concentration 0.1% to 1%.
- the solution was diluted with a nutrient broth to give an initial concentration 0.05% to 0.5%, which was then serially diluted two-fold so that each subsequent dilution contained 50% of the compound concentration of the previous dilution while maintaining a constant level of nutrients for each dilution.
- These dilutions were inoculated with representative oral microorganisms, or incubated saliva, and incubated for 24 hours at 37°C. For each surface active agent, the lowest dilution that was not turbid was registered as the MIC.
- flavoring agents can also be used, if desired.
- the flavor can be used in amounts of about 0.1 to about 15 weight percent of the gum, and preferably, about 0.2% to about 5% by weight.
- Flavoring agents may include essential oils, synthetic flavors or mixtures thereof including, but not limited to, oils derived from plants and fruits such as citrus oils, fruit essences, peppermint oil, spearmint oil, other mint oils, clove oil, oil of wintergreen, anise and the like. Artificial flavoring agents and components may also be used. Natural and artificial flavoring agents may be combined in any sensorially acceptable fashion. Flavoring may include a cooling agent to enhance the flavor and perceived breath freshening of the product.
- additional active ingredients or medicaments may be added for various purposes.
- the medicament or active is water soluble in the chewing gum, it preferably will include a base/emulsifier system which leads to the desired concentration of the medicament in the saliva (more hydrophilic balance).
- the chewing gum preferably includes a base/emulsifier system which leads to the desired concentration of the medicament in the saliva (more lipophilic balance).
- an effective amount of Magnolia Bark Extract can range between about 1% by weight to about 10% by weight of the composition.
- the absolute amount of sodium lauryl sulfate in the edible film formulation can range from about 4 mg to about 10 mg.
- the present invention provides edible film formulations for oral mucoadhesion and methods of using and making same.
- the edible films of the present invention include at least three types of film forming agents other than pullulan.
- the edible film formulations are prepared by forming a base solution that includes at least three types of film forming agents, such as maltodextrins, hydrocolloids and fillers and processing the base solution to form an edible film.
- the base solution is prepared by adding an initial mixture of dry ingredients to water that is stirred.
- additional ingredients such as flavor/emulsifier blends, sweeteners, softeners, color, the like or combinations thereof, can be added.
- the solution is stirred continuously and heated at a temperature ranging from about 40 0 C to about 60°C.
- the solution then can be dried in any suitable manner, thereby forming the edible film.
- any suitable type, number and arrangement of process procedures or steps Le., mixing, heating, drying, cooling, addition of ingredients), process parameters (i.e., temperature, pressure, pH, process times) or the like can be utilized.
- the continuous process of making the deposited glass types with a sugar base are as follows. Corn syrup is spread over a cylinder heated by high pressure steam. Rapid heat exchange causes the water in the syrup to evaporate. The cooked syrup is discharged, colors and flavors are added. The syrup is cooled and deposited onto a stainless steel conveyor. The syrup can be conveyed directly to hoppers which then discharge directly into molds.
- the candy is conveyed to batch rollers, which shapes and sizes the batch.
- the candy enters a former, which shapes the individual pieces into discs, balls, barrels, etc.
- the present invention can be made into any shape, circles, squares, triangles etc., also into animal shapes or any other novelty molding available.
- the candy is then cooled, wrapped and packaged.
- water and sugar are the basic components being mixed with other ingredients, and cooked at high temperatures (143-155°C, i.e. approximately 290-310 0 F), causing the. water to turn to steam.
- the product is transferred to a cooling wheel, where it is collected in about 68 kg (approximately 150 pound) batches, placed in a pulling machine to aerate the product, and the flavor is added.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2614988A CA2614988C (en) | 2005-07-14 | 2006-06-27 | Breath freshening and oral cleansing product comprising a magnolia bark extract and surfactant |
AU2006270385A AU2006270385B2 (en) | 2005-07-14 | 2006-06-27 | Breath freshening and oral cleansing product comprising a Magnolia Bark Extract and surfactant |
MX2008000563A MX2008000563A (en) | 2005-07-14 | 2006-06-27 | Breath freshening and oral cleansing product comprising a magnolia bark extract and surfactant. |
CN2006800256492A CN101222909B (en) | 2005-07-14 | 2006-06-27 | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
EP06774132A EP1901704A1 (en) | 2005-07-14 | 2006-06-27 | Breath freshening and oral cleansing product comprising a magnolia bark extract and surfactant |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11/181,579 US7632525B2 (en) | 2002-06-25 | 2005-07-14 | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
US11/181,579 | 2005-07-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2007011504A1 true WO2007011504A1 (en) | 2007-01-25 |
Family
ID=37016752
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/025042 WO2007011504A1 (en) | 2005-07-14 | 2006-06-27 | Breath freshening and oral cleansing product comprising a magnolia bark extract and surfactant |
Country Status (8)
Country | Link |
---|---|
US (2) | US7632525B2 (en) |
EP (1) | EP1901704A1 (en) |
CN (1) | CN101222909B (en) |
AU (1) | AU2006270385B2 (en) |
CA (1) | CA2614988C (en) |
MX (1) | MX2008000563A (en) |
RU (1) | RU2388457C2 (en) |
WO (1) | WO2007011504A1 (en) |
Cited By (8)
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WO2007064519A1 (en) * | 2005-12-02 | 2007-06-07 | Gic Innovations Company | Vehicles for oral care with magnolia bark extract |
WO2007064505A1 (en) * | 2005-12-02 | 2007-06-07 | Gic Innovations Company | Confectionary compositions with magnolia bark extract |
WO2007067340A1 (en) * | 2005-12-02 | 2007-06-14 | Gic Innovations Company | Chewable compositions with fast release magnolia bark extract |
WO2008074896A1 (en) * | 2006-12-21 | 2008-06-26 | Prendergast Patrick T | Compositions and methods for treatment of chronic neurological disorders |
US7595065B2 (en) | 2002-06-25 | 2009-09-29 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing products with synergistic combinations of magnolia bark extract and essential oils |
US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
US8012514B2 (en) | 2002-06-25 | 2011-09-06 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with Magnolia Bark Extract |
US9101555B1 (en) | 2007-04-19 | 2015-08-11 | Mary Kay Inc. | Magnolia extract containing compositions |
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US20090226549A1 (en) * | 2008-03-06 | 2009-09-10 | Kenneth John Hughes | Herbal extracts and flavor systems for oral products and methods of making the same |
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JP2013532684A (en) | 2010-07-29 | 2013-08-19 | コルゲート・パーモリブ・カンパニー | Phosphate-free oral care composition based on magnolia-derived antibacterial agent |
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US9277977B2 (en) | 2011-01-24 | 2016-03-08 | Leonard G. Lorch | Dental floss |
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US10413516B2 (en) | 2013-05-09 | 2019-09-17 | Cure Pharmaceutical Corporation | Thin film with high load of active ingredient |
US20140335153A1 (en) * | 2013-05-09 | 2014-11-13 | Cure Pharmaceutical Corporation | Thin film with high load of active ingredient |
US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
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HUE054161T2 (en) | 2015-08-17 | 2021-08-30 | St Ip Holding Ag | Honokiol and magnolol formulations with increased stability and improved uptake, and methods of use thereof |
CA2998139C (en) | 2015-09-11 | 2021-07-27 | Wm. Wrigley Jr. Company | Synergistic antibacterial effects of magnolia bark extract and l-arginine, n-lauroyl ethyl ester on plaque biofilm |
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JPS5785319A (en) * | 1980-11-16 | 1982-05-28 | Tsurui Yakuhin Kogyo Kk | Agent for dental caries |
JPH01151512A (en) * | 1988-07-21 | 1989-06-14 | Tsurui Yakuhin Kogyo Kk | Preventive agent for dental caries |
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US7632525B2 (en) | 2002-06-25 | 2009-12-15 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
US8163304B2 (en) | 2002-06-25 | 2012-04-24 | Wm. Wrigley Jr. Company | Breath freshening and oral cleansing product with magnolia bark extract in combination with surface active agents |
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Also Published As
Publication number | Publication date |
---|---|
US8163304B2 (en) | 2012-04-24 |
EP1901704A1 (en) | 2008-03-26 |
US20060013779A1 (en) | 2006-01-19 |
CA2614988C (en) | 2013-08-06 |
RU2008100107A (en) | 2009-08-20 |
CN101222909B (en) | 2011-05-11 |
US20100040564A1 (en) | 2010-02-18 |
AU2006270385A1 (en) | 2007-01-25 |
CA2614988A1 (en) | 2007-01-25 |
US7632525B2 (en) | 2009-12-15 |
RU2388457C2 (en) | 2010-05-10 |
AU2006270385B2 (en) | 2010-02-18 |
CN101222909A (en) | 2008-07-16 |
MX2008000563A (en) | 2008-03-10 |
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