WO2007011622A3 - Microfluidic methods and apparatuses for sample preparation and analysis - Google Patents
Microfluidic methods and apparatuses for sample preparation and analysis Download PDFInfo
- Publication number
- WO2007011622A3 WO2007011622A3 PCT/US2006/027111 US2006027111W WO2007011622A3 WO 2007011622 A3 WO2007011622 A3 WO 2007011622A3 US 2006027111 W US2006027111 W US 2006027111W WO 2007011622 A3 WO2007011622 A3 WO 2007011622A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fluid
- targets
- apparatuses
- analysis
- carrier fluid
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0636—Focussing flows, e.g. to laminate flows
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0663—Stretching or orienting elongated molecules or particles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
- B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
Abstract
Microfludic channels are constructed for use in preparing and/or analyzing samples. In one embodiment, a microfluidic channel receives a carrier fluid having both non-targets and targets. The non-targets are moved from the carrier fluid by diffusion and into sheathing fluids also present in the channel before contents of the carrier fluid are analyzed. In another embodiment, a microchannel delivers multiple fluid samples from an upstream portion to a downstream portion of the channel where each of the fluid samples are separated from one another by a sheathing fluid that also travels toward the downstream portion. In another embodiment, a microchannel is constructed to create multiple elongational flows in series that can align polymers from a coiled state.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06787065A EP1904653A4 (en) | 2005-07-18 | 2006-07-13 | Microfluidic methods and apparatuses for sample preparation and analysis |
JP2008522826A JP2009501938A (en) | 2005-07-18 | 2006-07-13 | Microfluidic method and microfluidic device for sample preparation and analysis |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70049005P | 2005-07-18 | 2005-07-18 | |
US70048005P | 2005-07-18 | 2005-07-18 | |
US70068905P | 2005-07-18 | 2005-07-18 | |
US60/700,490 | 2005-07-18 | ||
US60/700,689 | 2005-07-18 | ||
US60/700,480 | 2005-07-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007011622A2 WO2007011622A2 (en) | 2007-01-25 |
WO2007011622A3 true WO2007011622A3 (en) | 2007-05-24 |
Family
ID=37669351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/027111 WO2007011622A2 (en) | 2005-07-18 | 2006-07-13 | Microfluidic methods and apparatuses for sample preparation and analysis |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1904653A4 (en) |
JP (1) | JP2009501938A (en) |
WO (1) | WO2007011622A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9360476B2 (en) | 2006-12-19 | 2016-06-07 | Fio Corporation | Microfluidic system and method to test for target molecules in a biological sample |
US9459200B2 (en) | 2008-08-29 | 2016-10-04 | Fio Corporation | Single-use handheld diagnostic test device, and an associated system and method for testing biological and environmental test samples |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2008276024A1 (en) * | 2007-07-16 | 2009-01-22 | California Institute Of Technology | Microfluidic devices, methods and systems for detecting target molecules |
JP5628037B2 (en) | 2007-10-12 | 2014-11-19 | フィオ コーポレイション | Flow focusing method and system for forming concentrated microbeads, and microbeads formed in the system |
BRPI0915514A2 (en) | 2008-06-25 | 2016-01-26 | Fio Corp | biohazard warning infrastructure system and method, biohazard warning device and a method for alerting a user |
CN104374932A (en) | 2009-01-13 | 2015-02-25 | Fio公司 | A handheld diagnostic test device used with an electronic device and a test cartridge in a rapid diagnostic test |
US8202486B2 (en) * | 2009-08-12 | 2012-06-19 | Caliper Life Sciences, Inc. | Pinching channels for fractionation of fragmented samples |
WO2012040098A2 (en) | 2010-09-21 | 2012-03-29 | The University Of North Carolina At Chapel Hill | Methods, systems and devices for forming nanochannels |
WO2013039778A2 (en) | 2011-09-12 | 2013-03-21 | The University Of North Carolina At Chapel Hill | Devices with a fluid transport nanochannel intersected by a fluid sensing nanochannel and related methods |
JP6339024B2 (en) | 2012-02-10 | 2018-06-06 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルThe University Of North Carolina At Chapel Hill | Apparatus having fluid nanofunnel, related method, manufacturing and analysis system |
EP2962117B1 (en) | 2013-02-28 | 2019-10-09 | The University of North Carolina At Chapel Hill | Nanofluidic devices with integrated components for the controlled capture, trapping, and transport of macromolecules and related methods of analysis |
EP2971181B1 (en) | 2013-03-13 | 2019-02-20 | The University of North Carolina At Chapel Hill | Nanofluidic devices for the rapid mapping of whole genomes and related systems and methods of analysis |
EP3295148A4 (en) | 2015-05-11 | 2018-11-07 | The University of North Carolina at Chapel Hill | Fluidic devices with nanoscale manifolds for molecular transport, related systems and methods of analysis |
WO2019006190A1 (en) | 2017-06-28 | 2019-01-03 | Bio-Rad Laboratories, Inc. | System and method for droplet detection |
WO2019089979A1 (en) | 2017-11-01 | 2019-05-09 | Bio-Rad Laboratories, Inc. | Microfluidic system and method for arranging objects |
US10898895B2 (en) | 2018-09-13 | 2021-01-26 | Talis Biomedical Corporation | Vented converging capillary biological sample port and reservoir |
US20220146399A1 (en) * | 2019-02-27 | 2022-05-12 | Kyocera Corporation | Particle separating and measuring device and particle separating and measuring apparatus |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4793705A (en) * | 1987-10-07 | 1988-12-27 | The United States Of America As Represented By The United States Department Of Energy | Single molecule tracking |
US5274240A (en) * | 1990-01-12 | 1993-12-28 | The Regents Of The University Of California | Capillary array confocal fluorescence scanner and method |
US5356776A (en) * | 1991-09-10 | 1994-10-18 | Hitachi, Ltd. | DNA measuring method |
US5674743A (en) * | 1993-02-01 | 1997-10-07 | Seq, Ltd. | Methods and apparatus for DNA sequencing |
US6355420B1 (en) * | 1997-02-12 | 2002-03-12 | Us Genomics | Methods and products for analyzing polymers |
US6790671B1 (en) * | 1998-08-13 | 2004-09-14 | Princeton University | Optically characterizing polymers |
US6818395B1 (en) * | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US7118910B2 (en) * | 2001-11-30 | 2006-10-10 | Fluidigm Corporation | Microfluidic device and methods of using same |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU770678B2 (en) * | 1999-05-17 | 2004-02-26 | Caliper Life Sciences, Inc. | Focusing of microparticles in microfluidic systems |
US6770182B1 (en) * | 2000-11-14 | 2004-08-03 | Sandia National Laboratories | Method for producing a thin sample band in a microchannel device |
JP2005514187A (en) * | 2001-06-20 | 2005-05-19 | サイトノーム インコーポレーテッド | Microfluidic system including virtual wall fluidic interconnect ports for interconnecting fluids with microfluidic systems |
US7318902B2 (en) * | 2002-02-04 | 2008-01-15 | Colorado School Of Mines | Laminar flow-based separations of colloidal and cellular particles |
EP1380337B1 (en) * | 2002-07-12 | 2012-11-14 | Tosoh Corporation | Fine channel device and a chemically operating method for fluid using the device |
EP1620203A2 (en) * | 2003-04-10 | 2006-02-01 | U.S. Genomics, Inc. | Manipulation of polymers in a microchannel |
-
2006
- 2006-07-13 JP JP2008522826A patent/JP2009501938A/en not_active Withdrawn
- 2006-07-13 WO PCT/US2006/027111 patent/WO2007011622A2/en active Application Filing
- 2006-07-13 EP EP06787065A patent/EP1904653A4/en not_active Withdrawn
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4793705A (en) * | 1987-10-07 | 1988-12-27 | The United States Of America As Represented By The United States Department Of Energy | Single molecule tracking |
US5274240A (en) * | 1990-01-12 | 1993-12-28 | The Regents Of The University Of California | Capillary array confocal fluorescence scanner and method |
US5356776A (en) * | 1991-09-10 | 1994-10-18 | Hitachi, Ltd. | DNA measuring method |
US5674743A (en) * | 1993-02-01 | 1997-10-07 | Seq, Ltd. | Methods and apparatus for DNA sequencing |
US6355420B1 (en) * | 1997-02-12 | 2002-03-12 | Us Genomics | Methods and products for analyzing polymers |
US6790671B1 (en) * | 1998-08-13 | 2004-09-14 | Princeton University | Optically characterizing polymers |
US6818395B1 (en) * | 1999-06-28 | 2004-11-16 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US6911345B2 (en) * | 1999-06-28 | 2005-06-28 | California Institute Of Technology | Methods and apparatus for analyzing polynucleotide sequences |
US7118910B2 (en) * | 2001-11-30 | 2006-10-10 | Fluidigm Corporation | Microfluidic device and methods of using same |
Non-Patent Citations (1)
Title |
---|
See also references of EP1904653A4 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9360476B2 (en) | 2006-12-19 | 2016-06-07 | Fio Corporation | Microfluidic system and method to test for target molecules in a biological sample |
US9459200B2 (en) | 2008-08-29 | 2016-10-04 | Fio Corporation | Single-use handheld diagnostic test device, and an associated system and method for testing biological and environmental test samples |
Also Published As
Publication number | Publication date |
---|---|
EP1904653A4 (en) | 2010-04-14 |
WO2007011622A2 (en) | 2007-01-25 |
EP1904653A2 (en) | 2008-04-02 |
JP2009501938A (en) | 2009-01-22 |
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