WO2007021721A3 - Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas - Google Patents
Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas Download PDFInfo
- Publication number
- WO2007021721A3 WO2007021721A3 PCT/US2006/030993 US2006030993W WO2007021721A3 WO 2007021721 A3 WO2007021721 A3 WO 2007021721A3 US 2006030993 W US2006030993 W US 2006030993W WO 2007021721 A3 WO2007021721 A3 WO 2007021721A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- lectin
- pseudomonas
- bacteria
- lectins
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/21—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Pseudomonadaceae (F)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Veterinary Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2618638A CA2618638C (en) | 2005-08-09 | 2006-08-08 | Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas |
AT06801019T ATE528311T1 (en) | 2005-08-09 | 2006-08-08 | GLYCOMIMETIC INHIBITORS OF PA-IL-LECTIN, PA-IIL-LECTIN OR BOTH LECTINS FROM PSEUDOMONAS |
AU2006280101A AU2006280101B2 (en) | 2005-08-09 | 2006-08-08 | Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas |
EP06801019A EP1928892B1 (en) | 2005-08-09 | 2006-08-08 | Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas |
JP2008526154A JP5175190B2 (en) | 2005-08-09 | 2006-08-08 | Pseudomonas-derived PA-IL lectin, PA-IIL lectin or a glycomimetic inhibitor of both lectins |
CN200680036323XA CN101291946B (en) | 2005-08-09 | 2006-08-08 | Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas |
ES06801019T ES2375979T3 (en) | 2005-08-09 | 2006-08-08 | GLICOMIMETIC INHIBITORS OF PA-IL LECTIN, PA-IIL LECTIN OR BOTH LECTINES OF PSEUDOMONES. |
DK06801019.8T DK1928892T3 (en) | 2005-08-09 | 2006-08-08 | Glycomimetic inhibitors of PA-IL lectin PA-IIL lectin or both pseudomonas lectins |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70654605P | 2005-08-09 | 2005-08-09 | |
US60/706,546 | 2005-08-09 | ||
US81019006P | 2006-06-01 | 2006-06-01 | |
US60/810,190 | 2006-06-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007021721A2 WO2007021721A2 (en) | 2007-02-22 |
WO2007021721A3 true WO2007021721A3 (en) | 2007-04-26 |
Family
ID=37600887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/030993 WO2007021721A2 (en) | 2005-08-09 | 2006-08-08 | Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas |
Country Status (10)
Country | Link |
---|---|
US (3) | US7517980B2 (en) |
EP (1) | EP1928892B1 (en) |
JP (2) | JP5175190B2 (en) |
CN (1) | CN101291946B (en) |
AT (1) | ATE528311T1 (en) |
AU (1) | AU2006280101B2 (en) |
CA (1) | CA2618638C (en) |
DK (1) | DK1928892T3 (en) |
ES (1) | ES2375979T3 (en) |
WO (1) | WO2007021721A2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
US9109002B2 (en) | 2011-12-22 | 2015-08-18 | Glycomimetics, Inc. | E-selectin antagonist compounds, compositions, and methods of use |
US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007143052A1 (en) * | 2006-06-01 | 2007-12-13 | Glycomimetics, Inc. | Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas |
EP2649085B1 (en) | 2010-12-10 | 2014-08-20 | Centre National de la Recherche Scientifique (CNRS) | Glycomimetic compounds as anti-infectious against pathogens lectins |
EP2650289B1 (en) * | 2012-04-10 | 2016-07-27 | Universität Konstanz | Glycomimetics as pseudomonas Aeruginosa lectin inhibitors |
AU2013355238B2 (en) | 2012-12-07 | 2017-12-14 | Glycomimetics, Inc. | Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells |
US9096880B2 (en) * | 2013-05-15 | 2015-08-04 | National Tsing Hua University | Solubility enhancing peptide and use thereof |
KR101492720B1 (en) * | 2013-05-23 | 2015-02-12 | 경상대학교산학협력단 | Antibiotic composition comprising 2-bromoalkanoic acids |
CN103342725B (en) * | 2013-07-26 | 2016-09-14 | 济南尚博生物科技有限公司 | A kind of process for separation and purification of β end group thio glycoside compound |
CN105017341B (en) * | 2014-04-22 | 2018-05-15 | 华东师范大学 | - half lactotetraose of sulphation rock algae and its preparation method and application |
AU2015355136B2 (en) | 2014-12-03 | 2020-06-25 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors |
US11045485B2 (en) | 2016-01-22 | 2021-06-29 | Glycomimetics, Inc. | Glycomimetic inhibitors of PA-IL and PA-IIL lectins |
US11291678B2 (en) | 2016-03-02 | 2022-04-05 | Glycomimetics, Inc | Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin |
EP3497131B1 (en) | 2016-08-08 | 2022-03-09 | GlycoMimetics, Inc. | Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4. |
BR112019006642A2 (en) | 2016-10-07 | 2019-07-02 | Glycomimetics Inc | highly potent multimeric e-selectin antagonists |
JP7272956B2 (en) | 2017-03-15 | 2023-05-12 | グリコミメティクス, インコーポレイテッド | Galactopyranosyl-cyclohexyl derivatives as E-selectin antagonists |
WO2019108750A1 (en) | 2017-11-30 | 2019-06-06 | Glycomimetics, Inc. | Methods of mobilizing marrow infiltrating lymphocytes and uses thereof |
WO2019133878A1 (en) | 2017-12-29 | 2019-07-04 | Glycomimetics, Inc. | Heterobifunctional inhibitors of e-selectin and galectin-3 |
BR112020018184A2 (en) | 2018-03-05 | 2021-02-02 | Glycomimetics, Inc. | compound uses |
JP2022516075A (en) | 2018-12-27 | 2022-02-24 | グリコミメティクス, インコーポレイテッド | Galectin-3 inhibitory C-glycosid |
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Cited By (3)
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US8921328B2 (en) | 2010-09-14 | 2014-12-30 | Glycomimetics, Inc. | E-selectin antagonists |
US9109002B2 (en) | 2011-12-22 | 2015-08-18 | Glycomimetics, Inc. | E-selectin antagonist compounds, compositions, and methods of use |
US11845771B2 (en) | 2018-12-27 | 2023-12-19 | Glycomimetics, Inc. | Heterobifunctional inhibitors of E-selectin and galectin-3 |
Also Published As
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CN101291946A (en) | 2008-10-22 |
JP2009504660A (en) | 2009-02-05 |
EP1928892A2 (en) | 2008-06-11 |
AU2006280101A1 (en) | 2007-02-22 |
ES2375979T3 (en) | 2012-03-07 |
CA2618638C (en) | 2014-03-11 |
ATE528311T1 (en) | 2011-10-15 |
US20120329755A1 (en) | 2012-12-27 |
CN101291946B (en) | 2011-06-29 |
DK1928892T3 (en) | 2012-01-30 |
US7517980B2 (en) | 2009-04-14 |
AU2006280101B2 (en) | 2012-06-28 |
US8258290B2 (en) | 2012-09-04 |
JP5175190B2 (en) | 2013-04-03 |
WO2007021721A2 (en) | 2007-02-22 |
CA2618638A1 (en) | 2007-02-22 |
JP2013049718A (en) | 2013-03-14 |
EP1928892B1 (en) | 2011-10-12 |
US20100041626A1 (en) | 2010-02-18 |
US20070037775A1 (en) | 2007-02-15 |
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