WO2007021721A3 - Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas - Google Patents

Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas Download PDF

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Publication number
WO2007021721A3
WO2007021721A3 PCT/US2006/030993 US2006030993W WO2007021721A3 WO 2007021721 A3 WO2007021721 A3 WO 2007021721A3 US 2006030993 W US2006030993 W US 2006030993W WO 2007021721 A3 WO2007021721 A3 WO 2007021721A3
Authority
WO
WIPO (PCT)
Prior art keywords
lectin
pseudomonas
bacteria
lectins
methods
Prior art date
Application number
PCT/US2006/030993
Other languages
French (fr)
Other versions
WO2007021721A2 (en
Inventor
John L Magnani
John T Patton Jr
Arun K Sarkar
Original Assignee
Glycomimetics Inc
John L Magnani
John T Patton Jr
Arun K Sarkar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycomimetics Inc, John L Magnani, John T Patton Jr, Arun K Sarkar filed Critical Glycomimetics Inc
Priority to CA2618638A priority Critical patent/CA2618638C/en
Priority to AT06801019T priority patent/ATE528311T1/en
Priority to AU2006280101A priority patent/AU2006280101B2/en
Priority to EP06801019A priority patent/EP1928892B1/en
Priority to JP2008526154A priority patent/JP5175190B2/en
Priority to CN200680036323XA priority patent/CN101291946B/en
Priority to ES06801019T priority patent/ES2375979T3/en
Priority to DK06801019.8T priority patent/DK1928892T3/en
Publication of WO2007021721A2 publication Critical patent/WO2007021721A2/en
Publication of WO2007021721A3 publication Critical patent/WO2007021721A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/21—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Pseudomonadaceae (F)

Abstract

Compositions and methods are provided related to Pseudomonas bacteria. The compositions and methods may be used for diagnosis and therapy of medical conditions involving infection with Pseudomonas bacteria. Such infections include Pseudomonas aeruginosa in the lungs of patients with cystic fibrosis. A compound useful in the present methods may be used in combination with a therapeutic agent or may be linked to a therapeutic agent. Pseudomonas bacteria may be inhibited by blocking colonization, inhibiting virulence factors, arresting growth or killing the bacteria.
PCT/US2006/030993 2005-08-09 2006-08-08 Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas WO2007021721A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2618638A CA2618638C (en) 2005-08-09 2006-08-08 Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
AT06801019T ATE528311T1 (en) 2005-08-09 2006-08-08 GLYCOMIMETIC INHIBITORS OF PA-IL-LECTIN, PA-IIL-LECTIN OR BOTH LECTINS FROM PSEUDOMONAS
AU2006280101A AU2006280101B2 (en) 2005-08-09 2006-08-08 Glycomimetic inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas
EP06801019A EP1928892B1 (en) 2005-08-09 2006-08-08 Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
JP2008526154A JP5175190B2 (en) 2005-08-09 2006-08-08 Pseudomonas-derived PA-IL lectin, PA-IIL lectin or a glycomimetic inhibitor of both lectins
CN200680036323XA CN101291946B (en) 2005-08-09 2006-08-08 Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas
ES06801019T ES2375979T3 (en) 2005-08-09 2006-08-08 GLICOMIMETIC INHIBITORS OF PA-IL LECTIN, PA-IIL LECTIN OR BOTH LECTINES OF PSEUDOMONES.
DK06801019.8T DK1928892T3 (en) 2005-08-09 2006-08-08 Glycomimetic inhibitors of PA-IL lectin PA-IIL lectin or both pseudomonas lectins

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70654605P 2005-08-09 2005-08-09
US60/706,546 2005-08-09
US81019006P 2006-06-01 2006-06-01
US60/810,190 2006-06-01

Publications (2)

Publication Number Publication Date
WO2007021721A2 WO2007021721A2 (en) 2007-02-22
WO2007021721A3 true WO2007021721A3 (en) 2007-04-26

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/030993 WO2007021721A2 (en) 2005-08-09 2006-08-08 Glycomimetic inhibitors of the pa-il lectin, pa-iil lectin or both the lectins from pseudomonas

Country Status (10)

Country Link
US (3) US7517980B2 (en)
EP (1) EP1928892B1 (en)
JP (2) JP5175190B2 (en)
CN (1) CN101291946B (en)
AT (1) ATE528311T1 (en)
AU (1) AU2006280101B2 (en)
CA (1) CA2618638C (en)
DK (1) DK1928892T3 (en)
ES (1) ES2375979T3 (en)
WO (1) WO2007021721A2 (en)

Cited By (3)

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US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
US9109002B2 (en) 2011-12-22 2015-08-18 Glycomimetics, Inc. E-selectin antagonist compounds, compositions, and methods of use
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3

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WO2007143052A1 (en) * 2006-06-01 2007-12-13 Glycomimetics, Inc. Galactosides and thiodigalactosides as inhibitors of pa-il lectin from pseudomonas
EP2649085B1 (en) 2010-12-10 2014-08-20 Centre National de la Recherche Scientifique (CNRS) Glycomimetic compounds as anti-infectious against pathogens lectins
EP2650289B1 (en) * 2012-04-10 2016-07-27 Universität Konstanz Glycomimetics as pseudomonas Aeruginosa lectin inhibitors
AU2013355238B2 (en) 2012-12-07 2017-12-14 Glycomimetics, Inc. Compounds, compositions and methods using E-selectin antagonists for mobilization of hematopoietic cells
US9096880B2 (en) * 2013-05-15 2015-08-04 National Tsing Hua University Solubility enhancing peptide and use thereof
KR101492720B1 (en) * 2013-05-23 2015-02-12 경상대학교산학협력단 Antibiotic composition comprising 2-bromoalkanoic acids
CN103342725B (en) * 2013-07-26 2016-09-14 济南尚博生物科技有限公司 A kind of process for separation and purification of β end group thio glycoside compound
CN105017341B (en) * 2014-04-22 2018-05-15 华东师范大学 - half lactotetraose of sulphation rock algae and its preparation method and application
AU2015355136B2 (en) 2014-12-03 2020-06-25 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectins and CXCR4 chemokine receptors
US11045485B2 (en) 2016-01-22 2021-06-29 Glycomimetics, Inc. Glycomimetic inhibitors of PA-IL and PA-IIL lectins
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
BR112019006642A2 (en) 2016-10-07 2019-07-02 Glycomimetics Inc highly potent multimeric e-selectin antagonists
JP7272956B2 (en) 2017-03-15 2023-05-12 グリコミメティクス， インコーポレイテッド Galactopyranosyl-cyclohexyl derivatives as E-selectin antagonists
WO2019108750A1 (en) 2017-11-30 2019-06-06 Glycomimetics, Inc. Methods of mobilizing marrow infiltrating lymphocytes and uses thereof
WO2019133878A1 (en) 2017-12-29 2019-07-04 Glycomimetics, Inc. Heterobifunctional inhibitors of e-selectin and galectin-3
BR112020018184A2 (en) 2018-03-05 2021-02-02 Glycomimetics, Inc. compound uses
JP2022516075A (en) 2018-12-27 2022-02-24 グリコミメティクス， インコーポレイテッド Galectin-3 inhibitory C-glycosid

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CA2618638A1 (en) 2007-02-22
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