WO2007024601A3 - Methods for intraoperative organotypic nerve mapping - Google Patents

Methods for intraoperative organotypic nerve mapping Download PDF

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Publication number
WO2007024601A3
WO2007024601A3 PCT/US2006/032028 US2006032028W WO2007024601A3 WO 2007024601 A3 WO2007024601 A3 WO 2007024601A3 US 2006032028 W US2006032028 W US 2006032028W WO 2007024601 A3 WO2007024601 A3 WO 2007024601A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
organotypic
intraoperative
nerve mapping
nerve
Prior art date
Application number
PCT/US2006/032028
Other languages
French (fr)
Other versions
WO2007024601A2 (en
Inventor
William D Steers
Lisa B Boyette
Original Assignee
Univ Virginia
William D Steers
Lisa B Boyette
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Virginia, William D Steers, Lisa B Boyette filed Critical Univ Virginia
Priority to US11/997,978 priority Critical patent/US20080194970A1/en
Publication of WO2007024601A2 publication Critical patent/WO2007024601A2/en
Publication of WO2007024601A3 publication Critical patent/WO2007024601A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/43—Detecting, measuring or recording for evaluating the reproductive systems
    • A61B5/4375—Detecting, measuring or recording for evaluating the reproductive systems for evaluating the male reproductive system
    • A61B5/4393—Sexual arousal or erectile dysfunction evaluation, e.g. tumescence evaluation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/48—Other medical applications
    • A61B5/4887—Locating particular structures in or on the body
    • A61B5/4893—Nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0056—Peptides, proteins, polyamino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Toxicology (AREA)
  • Reproductive Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to compositions, methods and apparatuses for locating a nerve during a surgical procedure.
PCT/US2006/032028 2005-08-19 2006-08-16 Methods for intraoperative organotypic nerve mapping WO2007024601A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/997,978 US20080194970A1 (en) 2005-08-19 2006-08-16 Methods for Intraoperative Organotypic Nerve Mapping

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70987205P 2005-08-19 2005-08-19
US60/709,872 2005-08-19

Publications (2)

Publication Number Publication Date
WO2007024601A2 WO2007024601A2 (en) 2007-03-01
WO2007024601A3 true WO2007024601A3 (en) 2007-05-10

Family

ID=37772167

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/032028 WO2007024601A2 (en) 2005-08-19 2006-08-16 Methods for intraoperative organotypic nerve mapping

Country Status (2)

Country Link
US (1) US20080194970A1 (en)
WO (1) WO2007024601A2 (en)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8406860B2 (en) 2008-01-25 2013-03-26 Novadaq Technologies Inc. Method for evaluating blush in myocardial tissue
US9155503B2 (en) 2010-10-27 2015-10-13 Cadwell Labs Apparatus, system, and method for mapping the location of a nerve
US20130166001A1 (en) * 2011-06-23 2013-06-27 University Of North Carolina At Charlotte Continuous-wave optical stimulation of nerve tissue
CA2914778A1 (en) 2012-06-21 2013-12-27 Novadaq Technologies Inc. Quantification and analysis of angiography and perfusion
US9040019B2 (en) 2012-11-30 2015-05-26 General Electric Company Methods of detecting myelin basic protein
US10098585B2 (en) 2013-03-15 2018-10-16 Cadwell Laboratories, Inc. Neuromonitoring systems and methods
US10433793B1 (en) 2015-03-27 2019-10-08 Cadwell Laboratories, Inc. Methods and systems for simultaneous review of brain activity and physical manifestations of users
US10744212B2 (en) 2016-03-14 2020-08-18 General Electric Company Topical application of nerve labeling dyes for image-guided surgery
US11241297B2 (en) 2016-12-12 2022-02-08 Cadwell Laboratories, Inc. System and method for high density electrode management
US9935395B1 (en) 2017-01-23 2018-04-03 Cadwell Laboratories, Inc. Mass connection plate for electrical connectors
US10674924B2 (en) * 2018-02-22 2020-06-09 Seoul National University Hospital Mapping cavernous nerves during surgery
US11517239B2 (en) 2018-04-05 2022-12-06 Cadwell Laboratories, Inc. Systems and methods for processing and displaying electromyographic signals
US11596337B2 (en) 2018-04-24 2023-03-07 Cadwell Laboratories, Inc Methods and systems for operating an intraoperative neurophysiological monitoring system in conjunction with electrocautery procedures
US11253182B2 (en) 2018-05-04 2022-02-22 Cadwell Laboratories, Inc. Apparatus and method for polyphasic multi-output constant-current and constant-voltage neurophysiological stimulation
US11443649B2 (en) 2018-06-29 2022-09-13 Cadwell Laboratories, Inc. Neurophysiological monitoring training simulator
US11185684B2 (en) 2018-09-18 2021-11-30 Cadwell Laboratories, Inc. Minimally invasive two-dimensional grid electrode
US11517245B2 (en) 2018-10-30 2022-12-06 Cadwell Laboratories, Inc. Method and system for data synchronization
US11471087B2 (en) 2018-11-09 2022-10-18 Cadwell Laboratories, Inc. Integrity verification system for testing high channel count neuromonitoring recording equipment
US11317841B2 (en) 2018-11-14 2022-05-03 Cadwell Laboratories, Inc. Method and system for electrode verification
US11529107B2 (en) 2018-11-27 2022-12-20 Cadwell Laboratories, Inc. Methods for automatic generation of EEG montages
US11128076B2 (en) 2019-01-21 2021-09-21 Cadwell Laboratories, Inc. Connector receptacle

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030232016A1 (en) * 2002-04-17 2003-12-18 Russell Heinrich Nerve identification and sparing method
US20050060761A1 (en) * 1997-08-14 2005-03-17 Rafael Vazquez-Martinez Methods for direct visualization of active synapses

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050060761A1 (en) * 1997-08-14 2005-03-17 Rafael Vazquez-Martinez Methods for direct visualization of active synapses
US20030232016A1 (en) * 2002-04-17 2003-12-18 Russell Heinrich Nerve identification and sparing method

Also Published As

Publication number Publication date
WO2007024601A2 (en) 2007-03-01
US20080194970A1 (en) 2008-08-14

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