WO2007025244B1 - Treatment systems for delivery of sensitizer solutions - Google Patents

Treatment systems for delivery of sensitizer solutions

Info

Publication number
WO2007025244B1
WO2007025244B1 PCT/US2006/033458 US2006033458W WO2007025244B1 WO 2007025244 B1 WO2007025244 B1 WO 2007025244B1 US 2006033458 W US2006033458 W US 2006033458W WO 2007025244 B1 WO2007025244 B1 WO 2007025244B1
Authority
WO
WIPO (PCT)
Prior art keywords
oxygen
treatment solution
treatment
transducer
fluid delivery
Prior art date
Application number
PCT/US2006/033458
Other languages
French (fr)
Other versions
WO2007025244A3 (en
WO2007025244A2 (en
Inventor
Philip R Houle
Original Assignee
Philip R Houle
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philip R Houle filed Critical Philip R Houle
Priority to EP06802445A priority Critical patent/EP1933941A2/en
Priority to CA002632183A priority patent/CA2632183A1/en
Publication of WO2007025244A2 publication Critical patent/WO2007025244A2/en
Publication of WO2007025244A3 publication Critical patent/WO2007025244A3/en
Publication of WO2007025244B1 publication Critical patent/WO2007025244B1/en
Priority to US12/036,984 priority patent/US20080255498A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
    • A61C17/02—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication
    • A61C17/0205—Container filling apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
    • A61C17/02—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication
    • A61C17/0208—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication combined with means providing suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
    • A61C17/02—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication
    • A61C17/0211—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication specially adapted for rinsing the teeth of at least one jaw simultaneously
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
    • A61C17/02—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication
    • A61C17/024—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication with constant liquid flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C17/00—Devices for cleaning, polishing, rinsing or drying teeth, teeth cavities or prostheses; Saliva removers; Dental appliances for receiving spittle
    • A61C17/02—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication
    • A61C17/028—Rinsing or air-blowing devices, e.g. using fluid jets or comprising liquid medication with intermittent liquid flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0076—PDT with expanded (metallo)porphyrins, i.e. having more than 20 ring atoms, e.g. texaphyrins, sapphyrins, hexaphyrins, pentaphyrins, porphocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/084—Visible light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/085—Infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/08—Radiation
    • A61L2/10—Ultra-violet radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A61L2/186—Peroxide solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/12—Apparatus for isolating biocidal substances from the environment
    • A61L2202/122—Chambers for sterilisation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/17—Combination with washing or cleaning means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A61N5/0603—Apparatus for use inside the body for treatment of body cavities
    • A61N2005/0604—Lungs and/or airways
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0601—Apparatus for use inside the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/0613—Apparatus adapted for a specific treatment
    • A61N5/062—Photodynamic therapy, i.e. excitation of an agent

Abstract

A kit cleaning system and method is disclosed. One embodiment of the present invention has a photosensitizer solution supplied by a pressurized nozzle to the target site. Specific application of the solution is to an oral or skin surface target site. The photosensitizer solution is illuminated with sensitizing light creating reactive chemical species. Pressure and a solvent having an elevated concentration of oxygen or oxygen species improve the efficiency of the killing of pathogens. Methods of using the system within an oral cavity are also disclosed.

Claims

AMENDED CLAIMS received by the International Bureau on 28 Dec 2006 (28.12.2006)
1. A system for cleaning of a site in need of cleaning or in need of treatment, which system, comprises: a fluid delivery system comprising a container; at least one oxygen-boosting element; a treatment solution in the container, optionally a transducer; and optionally a photosensitizing compoυnd. wherein the fluid delivery system is configured to deliver the sensitizer solution at about ambient temperature and pressure or under pressure.
2. The system of Claim 1, wherein the oxygeu-boosting device comprises a mixer,
3. The system of Claim 1 wherein the oxygen-boosting device comprises a pump.
4. The system of Claim 1, wherein the oxygen-boosting device comprises a container of pressurized oxygen.
5. The system of Claim 1 , wherein the container comprises a pressurized container.
6. The system of Claim 5, wherein the pressurized container comprises a propellant
7. The system of Claim 6, wherein, the propellant comprises an inert gas. 8. The system of Claim 6, wherein the propellant comprises oxygen.
9. The system of Claim 6, wherein the propellant comprises air.
10. The system of Claim 6, wherein the propellant comprises ozone.
11. The system of Claim 1 , wherein the treatment solution comprises at least one oxygen-enhanced compound.
12. The system of Claim 1 , wherein, the oxygen-enhanced compound comprises a peroxy compound.
13. The system, of Claim 12, wherein the peroxy compound comprises hydrogen peroxide.
14. The system of Claim 1 , wherein the container comprises a bladder.
15. The system of Claim 14, wherein the bladder comprises a first chamber and a second chamber.
16. The system of Claim 1 , wherein the treatment solution comprises an oxygen solubility-increasing material,
17. The system of Claim 16, wherein the oxygen solubility-increasing material comprises a perfluorocarbon.
18. The system of Claim 17, wherein the oxygen solubility-increasing material comprises perfluorodecalin.
19. The system of Claim 1, wherein the treatment solution comprises a first component and a second component, and wherein the container is configured to hold the first component separately from the second component.
20. The system of Claim 19, wherein the fluid delivery system is configured to combine the first component and the second component,
21. The system of Claim 19, wherein, the container is configured to combine the first component and the second component,
22. The system of Claim 19, wherein the first and second components of the treatment solution are separated until an exit from the fluid delivery system.
23. The system of Claim 1 , wherein the transducer is integral with the fluid delivery system.
24. The system of Claim 1, wherein the transducer is removably attached to the fluid delivery system.
25. The system of Claim 1, wherein the transducer is separate and distinct from the fluid delivery system.
26. The system of Claim 1, wherein the container comprises an open reservoir.
27. The system of Claim 26, wherein the reservoir comprises a first compartment and a second compartment, wherein the compartments arc configured to hold contents.
28. The system of Claim 27, wherein the reservoir is configured to be closeable.
29. The system of Claim 27, wherein the reservoir is configured to combine contents of the first compartment with contents of the second compartment.
30. The system of Claim 1 , wherein the fluid delivery system comprises a pump,
31. The system of Claim 1 , wherein the treatment solution, comprises at least one reactive component and water.
32. The system of Claim 31, wherein the fluid delivery system is configured to combine the first component and the water.
33. The system of Claim 1 , wherein the container comprises a frangible seal.
34. The system of Claim 1 , wherein the container comprises a valve.
35. The system of Claim 33, wherein the fluid delivery system is configured to open the frangible seal.
36. The system of Claim 1, wherein the fluid delivery system comprises a mixing chamber.
37. The system of Claim 1, wherein the fluid delivery system comprises a venturi.
38. The system of Claim 37, wherein the venturi is configured to mix a fluid component with air.
39. The system of Claim 1, wherein the fluid delivery system comprises a pressurized fluid source.
40. The system of Claim 39, wherein the pressurized fluid source comprises a water faucet.
41. The system of Claim 1 , wherein the fluid delivery system comprises a conduit in fluid communication with the container.
42. The system of Claim 41, wherein the conduit comprises a flexible conduit.
43. The system of Claim 41, wherein, the conduit comprises a rigid conduit.
44. The system of Claim 41, wherein the conduit comprises a first channel and a second channel.
45. The system of Claim 1, wherein the fluid delivery system is configured to pressurize the treatment solution for delivery to a target.
46. The system of Claim 1, wherein the fluid delivery system is configured to pulse flow of the treatment solution at a frequency for delivery to a target.
47. The system of Claim 46, wherein the fluid delivery system is configured to adjust the frequency.
48. The system of Claim 1 , wherein the transducer is configured to emit sonic energy.
49. The system of Claim 1 , wherein the transducer is configured to emit RF energy.
50. The system of Claim 49, wherein the RF energy comprises IR energy.
51. The system of Claim 49, wherein the RF energy comprises UV energy.
52. The system of Claim 49, wherein the RF energy comprises visible light energy.
53. The system of Claim 1, wherein the transducer is integral with the fluid delivery system.
54. The system of Claim 53, wherein, a power source is integral with the fluid delivery system.
55. The system of Claim 1, wherein the transducer is releasably attachable to the fluid delivery system.
56. The system of Claim 55, wherein a power source is releasably attachable to the fluid delivery system.
57. The system of Claim 1, wherein the transducer is permanently attached to the fluid delivery system.
58. The system of Claim 1, wherein the transducer is rotatably actuated.
59. The system of Claim 1 , wherein the fluid delivery system fuuther comprises an applicator. 128
60. The system of Claim 59, wherein the applicator comprises a mouthpiece,
61. The syBtem of Claim 1, wherein the transducer is configured to emit an RF energy at a frequency, and wherein the transducer is configured to adjust the frequency.
62. The system of Claim 1, wherein the transducer is configured to emit an RF energy at an energy level, and wherein the transducer is configured to adjust the energy level.
63. The system of Claim 1, wherein the treatment solution comprises at least one oxygen-containing species,
64. The system of Claim I, wherein cleaning comprises the damage or destruction of micro-organisms.
65. A device for delivering energy to an oral cavity comprising; optionally a flexible sheet, and a transducer attached to or integral with a mouthpiece,
66. The device of Claim 65, wherein the transducer is inside the mouthpiece.
67. The device of Claim 65» wherein the mouthpiece is substantially transparent.
68. The device of Claim 65, wherein the transducer comprises an LED,
69. The device of Claim 65 , further comprising a power source integral with or releasably attachable to the transducer.
70. A treatment solution comprising: an energy-absorbing sensitizer andl an increased oxygen concentration,
71. The treatment solution of Claim 70, further comprising water.
72. The treatment solution of Claim 7Q,,further comprising a flavor agent
73. The treatment solution of Claim 70, further comprising a transport-iiπproving compound.
74. The treatment solution of Claim 73, wherein the transport-improving compound comprises EDTA. 129
75. The treatment solution of Claim 73 , wherein the transport- impio vLog compound comprises BPL
16. The treatment solution of Claim 70, wherein the RF absorber comprises a coloring agent.
77. The treatment solution of Claim 70, wherein the treatment solution comprises a peroxy compound.
78. The treatment solution of CMm 77, wherein the peroxy compound comprises a peroxide.
79. The treatment solution of Claim 78, wherein the peroxide comprises hydrogen peroxide.
80. The treatment solution of Claim 78, wherein the peroxide comprises carbamide peroxide.
81. The treatment solution of Claim 77, wherein the peroxy compound comprises a perborate,
82. The treatment solution o f Claim 77, wherein the peroxy compound comprises a percarbonatβ.
S3. A treatment -solution comprising: an energy-absorbing sensitizer, and a perfluσiocafbon,
84. The treatment solution of Claim.83, wherein the perflu-orocarbon comprises perfhiorodecalin.
85. A method for cleaning a treatment site, comprising: delivering a pressurized treatment solution comprising a, sensitizer to the treatment site; and emitting sensitizing energy at the treatment solution.
86. The method of Claim SS1 wherein emitting comprises strobing the sensitizer energy. 130
87. The method of Claim S5, wherein delivering the pressurised treatment solution comprises altering the oxygen concentration in -fche treatment solution.
88. The method of Claim 87, wherein altering the oxygen concentration comprises increasing the oxygen concentration.
89. The method of Claim 87, wherein altering the oxygen concentration, comprises mixing air with the treatment solution,
90. The method of Claim 87, wherein altering the oxygen concentration comprises mixing an oxygen-enhancing compound with the treatment solution.
91. The method of Claim 9O1, wherein the oxygen-enhancing compound? further comprises a peroxy compound.
92. The method of Claim S 5, wherein the treatment solution further comprises a fluorocaxboπ.
93. A method of increasing the performance of a treatment solution, wherein the treatment solution comprises oxygen, the method comprising: enhancing oxygen, effectiveness in the treatment solution, applying the treatment solution to a target site.
94. The method of Claim 93, wherein the enhancing oxygen effectiveness comprises increasing an effective lifetime of the reactive chemical species.
95. The method of Claim 94, wherein the enhancing comprises using a perQuorocaxbon.
96. The method of Claim 93, wherein enhancing oxygen effectiveness comprises increasing an oxygen quantity in the treatment solution.
97. The method of Claim 96, wherein increasing the oxygen quantity in the sensitizer solution comprises dissolving oxygen in th© treatment solution.
9S. The method of Claim 97, wherein di$solving comprises reversibly dissolving. 131
99. The method of Claim 96, wherein increasing the oxygen quantity in the treatment solution comprises mixing the treatment solution with oxygen before applying the treatment solution.
100. The method of Claim 98, wherein, mixing comprises forcing the treatment solution through a venturi.
101, The method of Claim 98, wherein mixing comprises introducing oxygen to the treatment solution in a mixing chamber,
' 102. The method of Claim.98, wherein mixing comprises pumping an oxygen- comprising gas into a mixing chamber with, the treatment solution through a mixer,
103. The method of Claim 93, wherein enhancing oxygen effectiveness comprises increasing an oxygen-releasing ability of the treatment solution.
104. The method of Claim 103, wherein increasing tiie oxygen-releasing ability of the treatment solution comprises using a formulation of the treatment solution comprising a peroxy compound.
105. The method of claim 104 having a treatment solution, wherein the peroxy compound comprises a peroxide.
106. The method of claim 105 having a treatment solution, wherein the peroxide comprises hydrogen peroxide.
107. The method of claim 105 having a treatment solution, wherein the peroxide comprises carbamide peroxide.
1OS. The method of claim 104 having a sensitizer solution^ wherein the peroxy compound comprises a perborate.
109, The method of claim 104 Jhaving a sensitizer solution, wherein the peroxy compound comprises a percarboriate.
UO. The method of Claim 103, wherein increasing the oxygen-releasing ability of the treatment solution comprises using a formulation of the sensitizer solution comprising a perfluotocarbσn. 132
111. The? method of Claim 93, wherein enhancing oxygen effectiveness comprises increasing a transport effectiveness σf the oxygen.
112. A composition for treatment of a site having microorganisms and/or unwanted color, which composition comprises; at least one oxygen-boosting component; and. a treatment compound, wherein all components of said reactive composition axe optionally under pressure and include increased reactive chemical species* increased reactive oxygen species or combinations thereof, wherein a fluid delivery system is optionally configured to deliver the reactive composition to a treatment site under pressure,
113. A system for treatment of a site having microorganisms and/or unwanted color, which system comprises: a container which farther includes the reactive composition of claim 112 and optionally a transducer for providing radioirequenoy energy to the treatment site, wherein, the reactive composition is within said container, wherein, all contents of said container are optionally underpressure and wherein the fluid delivery system is optionally configured to deli vex the reactive composition as a solution to the treatment site under pressure.
114. The system for treatment of a site having rmeroorganisms and/or unwanted color of claim 112 wherein; the system further includes a transducer.
115. A kit for treatment of a site having microorganisms^ pathogens or unwanted color xαader professional care or at home, which kit comprises: the system of Claim 113 or Claim 114 where The reactive composition is in said container, -wherein all contents of said container are optionally under pressors* wherein tbe fluid delivery system 133
is optionally configured to deliver the reactive composition to the treatment site under pressure; and instructions for the use of said kit.
116. A method for the treatment of a site having unwanted microorganisms or unwanted color under professional care or at home, which method comprises:
A. obtaining the kit of Claim 115 and folio-wing the instructions therein by
B. contacting the site in need of treatment with an effective amount of the reactive composition delivered from the container for a time to obtain effective treatment;
C. optionally contacting concurrently or subsequently the delivered composition at the site for a time to obtain effective treatment with an effective amount of radioirequency" energy using the transducer to create increased levels of reactive chemical species, reactive oxygen species or combinations thereof; and subsequently
D. optionally removing the reactive composition.
117. A method far improved cleaning, which method comprises: contacting the surface in need of cleaning with a composition itself comprising magnetically susceptible constituents, which magnetic constituents move in the presence of a magnetic field.
1 IS. The method of claim 117 wherein the composition is a pharmaceutically acceptable composition.
119. The method of claim 118 wherein the pharmac eαtically acceptable composition is a toothpastes.
120, A system for cleaning of a site in need of cleaning or treatment of a site in need of treatment, which, system comprises: a fluid delivery system comprising a container, at least one reactive chemical species, at least one reactive oxygen species or combinations thereof, 134
at least one oxygen-boosting component having meanB to add or to increase the concentration of at least one reactive chemical species, at least one reactive oxygen species or combinations thereof, wherein said fluid delivery system is configured to deliver the increased concentration of at least one reactive chemical species, at least one reactive oxygen, speoies ox combinations thereof to said site, wherein said oxygen-boosting component is selected from the group comprising, a sensitizer and a transducer, increased oxygen, concentration at ambient pressure, increased oxygen concentration at pressures above ambient pressure, a fluorocarbαti., or comboiations Uiereo£
121.The system of claim 120 wherein said at least one reactive chemical species, at least one reactive oxygen speoies or combinations thereof comprise an aqueous medium.
122.Thβ system of claim 120 wherein the system performs; a) at about ambient temperature and pressure conditions, b) at pressures above ambient pressure at any temperature;, c) at or above ambient temperature at any pressure and d) at ternperatureg below ambient temperature at any pressure.
123.Thβ system of claim 120 wherβiri the oxygen-boosting component having means to increase the concentrations of reactive chemical species in a solution is selected from a) a combination of a transducer and an added sensitizer in tne presence of abotrt 20% ambient oxygen concentration and at a pressure above ambient pressure, b) a combination of a transducer and an added sensitizer in the presence of oxygen at concentrations above 20% ambient concentration and at a pressure of about ambient pressure c)) a combination of a transducer and an added sensitizer in the presence of concentrations of oxygen above 20 % ambient concentration and at pressures above ambient pressure, d) a compound having increased solubility of oxygen and/or reactive chemical species in the presence of oxygen at about 20% ambient concentration at pressures above ambient pressure and a reactive chemical species in addition to molecular oxygen, s) a, compound having increased solubility of oxygen and/or reactive
125 135
chemical species in the- presence of oxygen above 20% ambient concentration at a pressure of about ambient pressure and a reactive chemical species in addition to molecular oxygen, £) a compound having increased solubility of oxygen and/or reactive chemical species in the presence of oxygen, at concentrations of oxygen above 20% ambient concentration and at a pressure above ambient pressure and a reactive chemical species in addition to molecular oxygen, g) any of (a) through (f) in combination with a transducer.
124. The system of claim 120 wherein the system optionally further includes a propellaiii
125. The system of claim 120 wherein the oxygen-boosting component is a perfluorocarbon.
126.The system of claim 120 wherein said oxygen-boosting component is a fluorocarbon having between 1 and 20 carbon atoms.
127.The system of claim 124 wherein no additional compound is present having increased solubility of oxygen and reactive oxygen species.
128. The system of Claim 120 wherein the increase in reactive chemical species, reactive oxygen species and combinations thereof is about 20% or greater.
129.The method of claim 116 wherein subpart B the time is between about 0.5 and 60 minutes.
13O.The method, of claim 116 wherein subpart C the time is between about 0.5 and 60 rπinutes.
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