WO2007025633A3 - Bone cement composition and method of making the same - Google Patents

Bone cement composition and method of making the same Download PDF

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Publication number
WO2007025633A3
WO2007025633A3 PCT/EP2006/007750 EP2006007750W WO2007025633A3 WO 2007025633 A3 WO2007025633 A3 WO 2007025633A3 EP 2006007750 W EP2006007750 W EP 2006007750W WO 2007025633 A3 WO2007025633 A3 WO 2007025633A3
Authority
WO
WIPO (PCT)
Prior art keywords
making
composition
same
bone cement
cement composition
Prior art date
Application number
PCT/EP2006/007750
Other languages
French (fr)
Other versions
WO2007025633A2 (en
Inventor
Joerg Meyer
Robert Wenz
Original Assignee
Sanatis Gmbh
Joerg Meyer
Robert Wenz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanatis Gmbh, Joerg Meyer, Robert Wenz filed Critical Sanatis Gmbh
Priority to DE602006014562T priority Critical patent/DE602006014562D1/en
Priority to CN200680031445.XA priority patent/CN101374556B/en
Priority to JP2008528373A priority patent/JP2009545332A/en
Priority to EP06776621A priority patent/EP1931399B1/en
Publication of WO2007025633A2 publication Critical patent/WO2007025633A2/en
Publication of WO2007025633A3 publication Critical patent/WO2007025633A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
    • A61L24/0084—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing fillers of phosphorus-containing inorganic compounds, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

Disclosed herein is a composition suitable for use in spinal surgery. The composition generally includes a reaction product or settable mixture of first and second components, the first component including a spray-dried inorganic filler, a radical donor, and a pre-polymerized vinyl polymer, and the second component including a radical scavenger, a diluent, a polymerization accelerator, and a reactive monomer. Furthermore, disclosed herein is a method of making the composition, which generally includes mixing the first and second components under conditions suitable to form a curable reaction product.
PCT/EP2006/007750 2005-08-29 2006-08-04 Bone cement composition and method of making the same WO2007025633A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE602006014562T DE602006014562D1 (en) 2005-08-29 2006-08-04 BONE CEMENT COMPOSITION AND MANUFACTURING METHOD
CN200680031445.XA CN101374556B (en) 2005-08-29 2006-08-04 Bone cement composition and method of making same
JP2008528373A JP2009545332A (en) 2005-08-29 2006-08-04 Bone cement composition and method of making the same
EP06776621A EP1931399B1 (en) 2005-08-29 2006-08-04 Bone cement composition and method of making the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/214,151 2005-08-29
US11/214,151 US7651701B2 (en) 2005-08-29 2005-08-29 Bone cement composition and method of making the same

Publications (2)

Publication Number Publication Date
WO2007025633A2 WO2007025633A2 (en) 2007-03-08
WO2007025633A3 true WO2007025633A3 (en) 2007-07-26

Family

ID=37804499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/007750 WO2007025633A2 (en) 2005-08-29 2006-08-04 Bone cement composition and method of making the same

Country Status (7)

Country Link
US (2) US7651701B2 (en)
EP (1) EP1931399B1 (en)
JP (1) JP2009545332A (en)
CN (1) CN101374556B (en)
DE (1) DE602006014562D1 (en)
ES (1) ES2346562T3 (en)
WO (1) WO2007025633A2 (en)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10032220A1 (en) 2000-07-03 2002-01-24 Sanatis Gmbh Magnesium ammonium phosphate cements, their manufacture and use
US7273523B2 (en) 2002-06-07 2007-09-25 Kyphon Inc. Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof
AU2004212942A1 (en) 2003-02-14 2004-09-02 Depuy Spine, Inc. In-situ formed intervertebral fusion device
MXPA06012420A (en) 2004-04-27 2007-03-28 Kyphon Inc Bone substitute compositions and method of use.
US20090088846A1 (en) 2007-04-17 2009-04-02 David Myung Hydrogel arthroplasty device
US8366773B2 (en) 2005-08-16 2013-02-05 Benvenue Medical, Inc. Apparatus and method for treating bone
US7670375B2 (en) 2005-08-16 2010-03-02 Benvenue Medical, Inc. Methods for limiting the movement of material introduced between layers of spinal tissue
US7651701B2 (en) * 2005-08-29 2010-01-26 Sanatis Gmbh Bone cement composition and method of making the same
DE102005058760A1 (en) * 2005-12-05 2007-06-06 Aesculap Ag & Co. Kg Method and device for preparing an implant from an implant material
US7754005B2 (en) * 2006-05-02 2010-07-13 Kyphon Sarl Bone cement compositions comprising an indicator agent and related methods thereof
US7507286B2 (en) * 2006-06-08 2009-03-24 Sanatis Gmbh Self-foaming cement for void filling and/or delivery systems
WO2008039382A2 (en) * 2006-09-21 2008-04-03 Kyphon Sarl Diammonium phosphate and other ammonium salts and their use in preventing clotting
WO2008073190A2 (en) * 2006-11-03 2008-06-19 Kyphon Sarl Materials and methods and systems for delivering localized medical treatments
US8105382B2 (en) 2006-12-07 2012-01-31 Interventional Spine, Inc. Intervertebral implant
CA2678006C (en) 2007-02-21 2014-10-14 Benvenue Medical, Inc. Devices for treating the spine
EP2124777A4 (en) 2007-02-21 2013-06-05 Benvenue Medical Inc Devices for treating the spine
WO2008109045A2 (en) * 2007-03-02 2008-09-12 Synthes Usa, Llc Bone cement with adapted mechanical properties
US8900307B2 (en) 2007-06-26 2014-12-02 DePuy Synthes Products, LLC Highly lordosed fusion cage
US20090062423A1 (en) * 2007-08-29 2009-03-05 Salumedica, Llc Orthopaedic cement mixtures with low weight percent polyvinyl alcohol (pva) solution
DE102007052116B4 (en) 2007-10-22 2013-02-21 Heraeus Medical Gmbh One-component bone cement pastes, their use and methods of curing them
DE102007050768A1 (en) * 2007-10-22 2009-04-23 Heraeus Medical Gmbh Polymethylmethacrylate bone cement
DE102007050762B3 (en) * 2007-10-22 2009-05-07 Heraeus Medical Gmbh Paste polymethyl methacrylate bone cement and its use
EP2471493A1 (en) 2008-01-17 2012-07-04 Synthes GmbH An expandable intervertebral implant and associated method of manufacturing the same
DE102008013620A1 (en) * 2008-02-12 2009-08-13 Charité - Universitätsmedizin Berlin Bone cement mixture for the preparation of an MRI-signaling bone cement
WO2009117737A2 (en) * 2008-03-21 2009-09-24 Biomimedica, Inc Methods, devices and compositions for adhering hydrated polymer implants to bone
BRPI0910325A8 (en) 2008-04-05 2019-01-29 Synthes Gmbh expandable intervertebral implant
US7968616B2 (en) * 2008-04-22 2011-06-28 Kyphon Sarl Bone cement composition and method
WO2009143236A1 (en) * 2008-05-20 2009-11-26 Albert Einstein Healthcare Network Compositions and methods for the treatment of skeletal metastatic lesions and fractures
US20120209396A1 (en) 2008-07-07 2012-08-16 David Myung Orthopedic implants having gradient polymer alloys
EP2297217B1 (en) * 2008-07-07 2021-10-20 Hyalex Orthopaedics, Inc. Hydrophilic interpenetrating polymer networks derived from hydrophobic polymers
US9492375B2 (en) 2008-07-23 2016-11-15 Warsaw Orthopedic, Inc. Foam carrier for bone grafting
AU2009279716A1 (en) 2008-08-05 2010-02-11 Biomimedica, Inc Polyurethane-grafted hydrogels
US8039433B2 (en) * 2008-08-19 2011-10-18 Warsaw Orthopedic, Inc. Osteogenic compositions containing a coloring agent
KR101089126B1 (en) * 2008-12-05 2011-12-02 (주) 코리아나메디칼 Polymer Line Bone Cement
US8658713B2 (en) 2009-02-25 2014-02-25 Kyoto University Bone cement composition and production method thereof, and kit for producing the same
WO2010098305A1 (en) 2009-02-25 2010-09-02 国立大学法人京都大学 Bone cement composition, bone cement composition kit, and method for forming bone cement cured body
US8535327B2 (en) 2009-03-17 2013-09-17 Benvenue Medical, Inc. Delivery apparatus for use with implantable medical devices
US9526620B2 (en) 2009-03-30 2016-12-27 DePuy Synthes Products, Inc. Zero profile spinal fusion cage
EP2322134B1 (en) * 2009-11-12 2012-09-12 BonAlive Biomaterials Oy Implantable paste and its use
US9393129B2 (en) 2009-12-10 2016-07-19 DePuy Synthes Products, Inc. Bellows-like expandable interbody fusion cage
AU2010330733A1 (en) * 2009-12-18 2012-08-02 Biomimedica, Inc. Method, device, and system for shaving and shaping of a joint
US8979860B2 (en) 2010-06-24 2015-03-17 DePuy Synthes Products. LLC Enhanced cage insertion device
US9282979B2 (en) 2010-06-24 2016-03-15 DePuy Synthes Products, Inc. Instruments and methods for non-parallel disc space preparation
EP2588034B1 (en) 2010-06-29 2018-01-03 Synthes GmbH Distractible intervertebral implant
CN103108660A (en) * 2010-07-26 2013-05-15 华沙整形外科股份有限公司 Calcium particle-embedded, snap-to-dough, high-viscosity bone cement
CN101934097A (en) * 2010-08-19 2011-01-05 马文 Injectable composite bone cement of hydroxyapatite-PMMA containing strontium, preparation method and application thereof
EP2609154B1 (en) 2010-08-27 2020-04-22 Hyalex Orthopaedics, Inc. Hydrophobic and hydrophilic interpenetrating polymer networks derived from hydrophobic polymers and methods of preparing the same
CN101961506A (en) * 2010-09-30 2011-02-02 深圳市第二人民医院 Composite nano biological bone glue with osteogenesis inducing activity and preparation method thereof
US9402732B2 (en) 2010-10-11 2016-08-02 DePuy Synthes Products, Inc. Expandable interspinous process spacer implant
US8858979B1 (en) 2011-01-28 2014-10-14 Clemson University Service induced byproducts for localized drug delivery in orthopaedic implants
US8814873B2 (en) 2011-06-24 2014-08-26 Benvenue Medical, Inc. Devices and methods for treating bone tissue
AU2012319183A1 (en) 2011-10-03 2014-05-22 Biomimedica, Inc. Polymeric adhesive for anchoring compliant materials to another surface
EP2782524B1 (en) 2011-11-21 2017-12-20 Biomimedica, Inc Systems for anchoring orthopaedic implants to bone
DE102012014702A1 (en) * 2012-07-25 2014-01-30 Heraeus Medical Gmbh Pasty bone cement
US9522070B2 (en) 2013-03-07 2016-12-20 Interventional Spine, Inc. Intervertebral implant
US10085783B2 (en) 2013-03-14 2018-10-02 Izi Medical Products, Llc Devices and methods for treating bone tissue
US20160310632A1 (en) * 2013-12-20 2016-10-27 Board Of Regents, The University Of Texas System Improved two-solution bone cement
DE102014105267A1 (en) * 2014-04-14 2015-10-15 Heraeus Medical Gmbh Polymethylmethacrylate bone cement
US11426290B2 (en) 2015-03-06 2022-08-30 DePuy Synthes Products, Inc. Expandable intervertebral implant, system, kit and method
CN104826160B (en) * 2015-05-26 2017-12-19 北京爱康宜诚医疗器材股份有限公司 The preparation method of bone cement pulvis
US11077228B2 (en) 2015-08-10 2021-08-03 Hyalex Orthopaedics, Inc. Interpenetrating polymer networks
US10029031B2 (en) * 2015-10-28 2018-07-24 Warsaw Orthopedic, Inc. Bone void filler having sustained therapeutic agent release
KR101815367B1 (en) 2016-02-15 2018-01-05 서울대학교산학협력단 Acrylic bone cement composite comprising calcium phosphate microsphere uniformly spreaded therein and a preparation method thereof
US11596522B2 (en) 2016-06-28 2023-03-07 Eit Emerging Implant Technologies Gmbh Expandable and angularly adjustable intervertebral cages with articulating joint
US11510788B2 (en) 2016-06-28 2022-11-29 Eit Emerging Implant Technologies Gmbh Expandable, angularly adjustable intervertebral cages
DE102016222158A1 (en) * 2016-11-11 2018-05-17 Heraeus Medical Gmbh A method for producing a polymethylmethacrylate bone cement, bone cement kit for use in such a method, and a bone cement producible by such a method
US10888433B2 (en) 2016-12-14 2021-01-12 DePuy Synthes Products, Inc. Intervertebral implant inserter and related methods
US10398563B2 (en) 2017-05-08 2019-09-03 Medos International Sarl Expandable cage
US11344424B2 (en) 2017-06-14 2022-05-31 Medos International Sarl Expandable intervertebral implant and related methods
US10940016B2 (en) 2017-07-05 2021-03-09 Medos International Sarl Expandable intervertebral fusion cage
CN107412852A (en) * 2017-07-26 2017-12-01 山东冠龙医疗用品有限公司 Bone cement compositions and its set group
US10869950B2 (en) 2018-07-17 2020-12-22 Hyalex Orthopaedics, Inc. Ionic polymer compositions
US11446156B2 (en) 2018-10-25 2022-09-20 Medos International Sarl Expandable intervertebral implant, inserter instrument, and related methods
US11426286B2 (en) 2020-03-06 2022-08-30 Eit Emerging Implant Technologies Gmbh Expandable intervertebral implant
US11850160B2 (en) 2021-03-26 2023-12-26 Medos International Sarl Expandable lordotic intervertebral fusion cage
US11752009B2 (en) 2021-04-06 2023-09-12 Medos International Sarl Expandable intervertebral fusion cage

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5847046A (en) * 1997-03-12 1998-12-08 United States Surgical Corporation Biodegradable bone cement
US6153664A (en) * 1997-04-18 2000-11-28 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys and internal fixation devices made therefrom
WO2001049327A2 (en) * 2000-01-03 2001-07-12 Hku/Hantak Ortho-Technology Limited Bioactive and osteoprorotic bone cement
WO2003103734A1 (en) * 2002-06-07 2003-12-18 Sanatis Gmbh Strontium-apatite-cement-preparations and the use thereof
US20040122359A1 (en) * 2002-09-17 2004-06-24 Kyphon Inc. Apparatus and methods for mixing two components
US20040226479A1 (en) * 1995-02-08 2004-11-18 M.E.D. Usa, Inc. Bone cement compositions comprising fused fibrous compounds

Family Cites Families (107)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3746680A (en) 1971-03-03 1973-07-17 Johnson & Johnson Plaster of paris composition
US4141864A (en) * 1974-03-15 1979-02-27 University Of Virginia Alumni Patents Foundation Osseous cement composition
AT352867B (en) 1976-05-12 1979-10-10 Battelle Institut E V BONE REPLACEMENT, BONE COMPOUND OR PROSTHESIS ANCHORING MATERIAL AND PROCESS FOR ITS PRODUCTION
DE2724814C3 (en) 1977-06-02 1980-03-27 Kulzer & Co Gmbh, 6380 Bad Homburg Preliminary product for the preparation of bone cement
US4404327A (en) 1979-10-31 1983-09-13 Crugnola Aldo M Orthopaedic cement from acrylate polymers
US4341691A (en) 1980-02-20 1982-07-27 Zimmer, Inc. Low viscosity bone cement
US4518430A (en) 1982-04-29 1985-05-21 American Dental Association Health Foundation Dental resptorative cement pastes
DE3245956A1 (en) * 1982-12-11 1984-06-14 Beiersdorf Ag, 2000 Hamburg SURGICAL MATERIAL
US4612053A (en) 1983-10-06 1986-09-16 American Dental Association Health Foundation Combinations of sparingly soluble calcium phosphates in slurries and pastes as mineralizers and cements
US4722948A (en) 1984-03-16 1988-02-02 Dynatech Corporation Bone replacement and repair putty material from unsaturated polyester resin and vinyl pyrrolidone
US4629464A (en) 1984-09-25 1986-12-16 Tdk Corporation Porous hydroxyapatite material for artificial bone substitute
JPS61271203A (en) 1985-05-27 1986-12-01 G C Dental Ind Corp Dental discoloring cement composition
GB8524152D0 (en) 1985-10-01 1985-11-06 Cole Polymers Ltd Bone cement
DE3536076A1 (en) * 1985-10-09 1987-04-09 Muehlbauer Ernst Kg POLYMERIZABLE CEMENT MIXTURES
JPS62182146A (en) 1985-10-11 1987-08-10 三井東圧化学株式会社 Hardenable material
GB2197329B (en) 1986-09-10 1990-01-10 Showa Denko Kk Hard tissue substitute composition
JPS63305188A (en) 1987-06-06 1988-12-13 Sony Corp Display material
JPS6433536A (en) 1987-07-29 1989-02-03 Sony Corp Electrochromic display device
JPH01230413A (en) 1988-03-11 1989-09-13 Kanto Chem Co Inc Production of spherical hydroxyapatite sintered form and chromatographic filler consisting thereof
US5205928A (en) 1988-03-11 1993-04-27 Kanto Kagaku Kabushiki Kaisha Process for the preparation of microspherical sintered bodies of hydroxyapatite and a chromatographic packing material comprising the microspherical sintered bodies of hydroxyapatite
US6002065A (en) 1988-04-20 1999-12-14 Norian Corporation Kits for preparing calcium phosphate minerals
US5962028A (en) 1988-04-20 1999-10-05 Norian Corporation Carbonated hydroxyapatite compositions and uses
IT1234978B (en) 1988-06-01 1992-06-09 Tecres Spa TWO-STAGE CEMENTITIOUS MIXTURE, PARTICULARLY SUITABLE FOR ORTHOPEDIC USES.
JPH01320251A (en) 1988-06-20 1989-12-26 Tokuyama Soda Co Ltd Pasty hardenable composition
DE68911811T2 (en) 1988-09-20 1994-06-09 Asahi Optical Co Ltd Porous ceramic sinter and process for its production.
JPH02116684A (en) 1988-10-21 1990-05-01 Permelec Electrode Ltd Production of porous body of calcium phosphate compound
JP2770409B2 (en) 1989-04-28 1998-07-02 ソニー株式会社 Display composition, coloring pigment and recording material
US5179065A (en) 1989-04-28 1993-01-12 Sony Corporation Recording material with a display composition including a coloring pigment
US5226877A (en) 1989-06-23 1993-07-13 Epstein Gordon H Method and apparatus for preparing fibrinogen adhesive from whole blood
EP0439250B1 (en) 1990-01-25 1994-11-02 Howmedica Inc. Bone cement
EP0542794B1 (en) 1990-07-27 1995-12-13 Exxon Chemical Patents Inc. Hydrocarbon treatment
EP0473048B1 (en) 1990-08-21 1996-11-27 Asahi Glass Company Ltd. Calcium phosphate type glass-ceramic
US5149368A (en) 1991-01-10 1992-09-22 Liu Sung Tsuen Resorbable bioactive calcium phosphate cement
US5462722A (en) 1991-04-17 1995-10-31 Liu; Sung-Tsuen Calcium phosphate calcium sulfate composite implant material
US5262166A (en) 1991-04-17 1993-11-16 Lty Medical Inc Resorbable bioactive phosphate containing cements
EP0511868B1 (en) 1991-05-01 1996-09-25 Chichibu Onoda Cement Corporation Medical or dental hardening compositions
EP0520690B1 (en) 1991-06-26 1995-11-02 Nitta Gelatin Inc. Calcium phosphate type hardening material for repairing living hard tissue
ES2040626B1 (en) 1991-11-22 1994-05-16 Boltong Maria G PROCEDURE FOR THE OBTAINING OF CALCIUM PHOSPHATE CEMENTS AND THEIR USE AS BIOMTERIALS.
US5605713A (en) 1991-11-22 1997-02-25 Boltong; Maria G. Process for the preparation of calcium phosphate cements and its application as bio-materials
US5281265A (en) 1992-02-03 1994-01-25 Liu Sung Tsuen Resorbable surgical cements
US5204382A (en) 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
ATE269371T1 (en) 1992-02-28 2004-07-15 Cohesion Tech Inc INJECTABLE CERAMIC COMPOUNDS AND METHOD FOR THEIR PRODUCTION AND USE
US5522893A (en) 1993-03-12 1996-06-04 American Dental Association Health Foundation Calcium phosphate hydroxyapatite precursor and methods for making and using the same
US6248110B1 (en) 1994-01-26 2001-06-19 Kyphon, Inc. Systems and methods for treating fractured or diseased bone using expandable bodies
US6241734B1 (en) 1998-08-14 2001-06-05 Kyphon, Inc. Systems and methods for placing materials into bone
US5462356A (en) 1994-06-01 1995-10-31 Murray; William M. Bone and dental cement method and preform
US6075067A (en) 1994-08-15 2000-06-13 Corpipharm Gmbh & Co Cement for medical use, method for producing the cement, and use of the cement
DE4433201A1 (en) 1994-09-17 1996-03-21 Merck Patent Gmbh Process for the production of active ingredient-containing bone cements
DE4435680A1 (en) * 1994-10-06 1996-04-11 Merck Patent Gmbh Porous bone substitute materials
US5569442A (en) 1994-11-04 1996-10-29 Norian Corporation Reactive tricalcium phosphate compositions and uses
US5795922A (en) 1995-06-06 1998-08-18 Clemson University Bone cement composistion containing microencapsulated radiopacifier and method of making same
US5814683A (en) 1995-12-06 1998-09-29 Hewlett-Packard Company Polymeric additives for the elimination of ink jet aerosol generation
DE29607832U1 (en) 1996-04-30 1996-10-24 Huebner Eike Gerhard Indicator for the hardening of bone cement
US5702677A (en) * 1996-07-10 1997-12-30 Osteotech, Inc. Spherical hydroxyapatite particles and process for the production thereof
US6953594B2 (en) 1996-10-10 2005-10-11 Etex Corporation Method of preparing a poorly crystalline calcium phosphate and methods of its use
US5914356A (en) 1996-12-06 1999-06-22 Orthovita, Inc. Bioactive load bearing bone bonding compositions
AU5289598A (en) * 1997-03-03 1998-09-03 Rohm And Haas Company Polymer emulsions and polymer powders therefrom
JP3679570B2 (en) 1997-03-14 2005-08-03 ペンタックス株式会社 Bone prosthetic material and manufacturing method thereof
US6309420B1 (en) 1997-10-14 2001-10-30 Parallax Medical, Inc. Enhanced visibility materials for implantation in hard tissue
FR2772746B1 (en) 1997-12-23 2000-01-28 Commissariat Energie Atomique PROCESS FOR THE MANUFACTURE OF AN APATITIC CERAMIC, PARTICULARLY FOR BIOLOGICAL USE
FR2776282B1 (en) 1998-03-20 2000-05-19 Toulouse Inst Nat Polytech PROCESS FOR THE PREPARATION OF A HYDROXYAPATITE-BASED BIOMATERIAL, BIOMATERIAL OBTAINED AND SURGICAL OR DENTAL APPLICATION
CA2327730A1 (en) 1998-04-10 1999-10-21 Wm Marsh Rice University Synthesis of poly(propylene fumarate) by acylation of propylene glycol in the presence of a proton scavenger
JP3360810B2 (en) 1998-04-14 2003-01-07 ペンタックス株式会社 Method for producing bone replacement material
DE19816858A1 (en) 1998-04-16 1999-10-21 Merck Patent Gmbh Tricalcium phosphate-containing bio-cement pastes with cohesion promoters
US6224635B1 (en) 1998-11-06 2001-05-01 Hospital For Joint Diseases Implantation of surgical implants with calcium sulfate
DE19853832A1 (en) 1998-11-21 2000-05-25 Merck Patent Gmbh Calcium phosphate cements containing polyalkenoic acids
US6436143B1 (en) 1999-02-22 2002-08-20 Anthony C. Ross Method and apparatus for treating intervertebral disks
CA2287112C (en) 1999-09-02 2008-02-19 Kieran Murphy Method and apparatus for strengthening vertebral bodies
GB9922562D0 (en) * 1999-09-24 1999-11-24 Biocomposites Ltd Implant material
DE60003459T2 (en) 1999-12-09 2004-05-06 Biosyntech Canada Inc., Laval MINERAL-POLYMER HYBRID COMPOSITION
AU2001231264A1 (en) * 2000-01-31 2001-08-07 Advanced Research And Technology Institute, Inc. Composite biomaterial including anisometric calcium phosphate reinforcement particles and related methods
SE520688C2 (en) * 2000-04-11 2003-08-12 Bone Support Ab An injectable bone mineral replacement material
DE10032220A1 (en) 2000-07-03 2002-01-24 Sanatis Gmbh Magnesium ammonium phosphate cements, their manufacture and use
SE517168C2 (en) 2000-07-17 2002-04-23 Bone Support Ab A composition for an injectable bone mineral replacement material
US6808561B2 (en) 2000-10-16 2004-10-26 University Of South Carolina Biocompatible cement containing reactive calcium phosphate nanoparticles and methods for making and using such cement
EP1333912A2 (en) 2000-10-25 2003-08-13 Kyphon Inc. Systems and methods for mixing and transferring flowable materials
US6547866B1 (en) 2000-10-30 2003-04-15 Howmedica Osteonics Corp. Porous calcium phosphate cement
US6562755B1 (en) 2000-10-31 2003-05-13 Ncr Corporation Thermal paper with security features
US6497901B1 (en) 2000-11-02 2002-12-24 Royer Biomedical, Inc. Resorbable matrices for delivery of bioactive compounds
DE10106372A1 (en) 2001-02-12 2002-08-29 Ivoclar Vivadent Ag Thermochromic dental material
US7008433B2 (en) 2001-02-15 2006-03-07 Depuy Acromed, Inc. Vertebroplasty injection device
US20070191964A1 (en) 2001-04-04 2007-08-16 Arthrocare Corporation Enhanced visibility materials for implantation in hard tissue
US20040265385A1 (en) 2001-04-12 2004-12-30 Therics, Inc. Porous biostructure partially occupied by interpenetrant and method for making same
EP1388024A1 (en) 2001-04-25 2004-02-11 Koninklijke Philips Electronics N.V. Electrophoretic color display device
US20030055512A1 (en) 2001-05-21 2003-03-20 Genin Francois Y. Calcium based neutral and bioresorbable bone graft
ITVI20010126A1 (en) 2001-05-30 2002-11-30 Tecres Spa RADIOPACO BONE CEMENT FOR ORTHOPEDIC USE AND METHOD OF REALIZATION
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
US6890399B2 (en) 2002-01-18 2005-05-10 Henkel Corporation (Meth)acrylate compositions having a self-indicator of cure and methods of detecting cure
EP1499267A4 (en) 2002-02-05 2008-10-29 Depuy Mitek Inc Bioresorbable osteoconductive compositions for bone regeneration
FR2838334B1 (en) 2002-04-16 2006-05-26 Polymerexpert Sa NON-TOXIC RADICAL POLYMERIZATION ACTIVATOR FOR BONE OR DENTAL CEMENT
US7273523B2 (en) 2002-06-07 2007-09-25 Kyphon Inc. Strontium-apatite-cement-preparations, cements formed therefrom, and uses thereof
US7138442B2 (en) 2002-08-30 2006-11-21 Biomet, Inc. Reduced exothermic bone replacement cement
US7135027B2 (en) 2002-10-04 2006-11-14 Baxter International, Inc. Devices and methods for mixing and extruding medically useful compositions
DE20218668U1 (en) 2002-12-03 2003-03-06 Sanatis Gmbh Recipes for cement preparations as a bone substitute
DE10340800A1 (en) 2002-12-20 2004-07-01 Merck Patent Gmbh Production of acrylic bone cement, e.g. for anchoring prostheses in bone, involves using X-ray contrast medium which has been functionalised with (meth)acrylate after coating with melamine-formaldehyde resin
WO2006011152A2 (en) 2004-06-17 2006-02-02 Disc-O-Tech Medical Technologies, Ltd. Methods for treating bone and other tissue
US20070032567A1 (en) 2003-06-17 2007-02-08 Disc-O-Tech Medical Bone Cement And Methods Of Use Thereof
DE112004001799D2 (en) 2003-07-18 2006-07-06 Biomet Deutschland Gmbh Surfactant-containing bone cement
US6994726B2 (en) 2004-05-25 2006-02-07 Calcitec, Inc. Dual function prosthetic bone implant and method for preparing the same
US20050105384A1 (en) 2003-11-18 2005-05-19 Scimed Life Systems, Inc. Apparatus for mixing and dispensing a multi-component bone cement
DE10355992A1 (en) 2003-11-27 2005-06-30 Curasan Ag Bioresorbable composite material
US7351280B2 (en) 2004-02-10 2008-04-01 New York University Macroporous, resorbable and injectible calcium phosphate-based cements (MCPC) for bone repair, augmentation, regeneration, and osteoporosis treatment
FR2870129A1 (en) 2004-05-14 2005-11-18 Ceravic Sas Soc Par Actions Si POLYMERIC CEMENT FOR PERCUTANEOUS VERTEBROPLASTY
EP1885650A4 (en) * 2005-04-29 2011-01-05 Ada Foundation Nanostructured bioactive materials prepared by dual nozzle spray drying techniques
US20070021526A1 (en) 2005-07-22 2007-01-25 Howmedica Osteonics Corp. Setting time indicator for acrylic bone cement
US7651701B2 (en) 2005-08-29 2010-01-26 Sanatis Gmbh Bone cement composition and method of making the same
US8147860B2 (en) 2005-12-06 2012-04-03 Etex Corporation Porous calcium phosphate bone material

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040226479A1 (en) * 1995-02-08 2004-11-18 M.E.D. Usa, Inc. Bone cement compositions comprising fused fibrous compounds
US5847046A (en) * 1997-03-12 1998-12-08 United States Surgical Corporation Biodegradable bone cement
US6153664A (en) * 1997-04-18 2000-11-28 Cambridge Scientific, Inc. Bioerodible polymeric semi-interpenetrating network alloys and internal fixation devices made therefrom
WO2001049327A2 (en) * 2000-01-03 2001-07-12 Hku/Hantak Ortho-Technology Limited Bioactive and osteoprorotic bone cement
WO2003103734A1 (en) * 2002-06-07 2003-12-18 Sanatis Gmbh Strontium-apatite-cement-preparations and the use thereof
US20040122359A1 (en) * 2002-09-17 2004-06-24 Kyphon Inc. Apparatus and methods for mixing two components

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