WO2007028167A3 - Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof - Google Patents

Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof Download PDF

Info

Publication number
WO2007028167A3
WO2007028167A3 PCT/US2006/034620 US2006034620W WO2007028167A3 WO 2007028167 A3 WO2007028167 A3 WO 2007028167A3 US 2006034620 W US2006034620 W US 2006034620W WO 2007028167 A3 WO2007028167 A3 WO 2007028167A3
Authority
WO
WIPO (PCT)
Prior art keywords
devices
skin
delivery
drugs
mask
Prior art date
Application number
PCT/US2006/034620
Other languages
French (fr)
Other versions
WO2007028167A2 (en
Inventor
Gregory M Glenn
Kyle J Doerksen
Larry R Ellingsworth
Diane E Epperson
David Frerichs
Mervyn L Hamer
Aaron A Henningsgaard
Matthew D Inouye
Adrian B James
Jonathan I Kaplan
John W Lai
Robert I Lister
David A Lubensky
Peter S Macdonald
Sally H Madsen
Brian J Mason
Christine W Mcelhaney
Lionel Mohri
Anthony C Pigliacampo
Gina L Romero
Charles F Steeves Iii
Christina P Villar
Jianmei Yu
Original Assignee
Iomai Corp
Gregory M Glenn
Kyle J Doerksen
Larry R Ellingsworth
Diane E Epperson
David Frerichs
Mervyn L Hamer
Aaron A Henningsgaard
Matthew D Inouye
Adrian B James
Jonathan I Kaplan
John W Lai
Robert I Lister
David A Lubensky
Peter S Macdonald
Sally H Madsen
Brian J Mason
Christine W Mcelhaney
Lionel Mohri
Anthony C Pigliacampo
Gina L Romero
Charles F Steeves Iii
Christina P Villar
Jianmei Yu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iomai Corp, Gregory M Glenn, Kyle J Doerksen, Larry R Ellingsworth, Diane E Epperson, David Frerichs, Mervyn L Hamer, Aaron A Henningsgaard, Matthew D Inouye, Adrian B James, Jonathan I Kaplan, John W Lai, Robert I Lister, David A Lubensky, Peter S Macdonald, Sally H Madsen, Brian J Mason, Christine W Mcelhaney, Lionel Mohri, Anthony C Pigliacampo, Gina L Romero, Charles F Steeves Iii, Christina P Villar, Jianmei Yu filed Critical Iomai Corp
Priority to EP06814198.5A priority Critical patent/EP1928537B1/en
Priority to CA002620943A priority patent/CA2620943A1/en
Priority to CN2006800304903A priority patent/CN101242869B/en
Publication of WO2007028167A2 publication Critical patent/WO2007028167A2/en
Publication of WO2007028167A3 publication Critical patent/WO2007028167A3/en
Priority to IL189750A priority patent/IL189750A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00Devices for applying media, e.g. remedies, on the human body
    • A61M35/003Portable hand-held applicators having means for dispensing or spreading integral media
    • A61M35/006Portable hand-held applicators having means for dispensing or spreading integral media using sponges, foams, absorbent pads or swabs as spreading means
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017Electrical control of surgical instruments
    • A61B2017/00115Electrical control of surgical instruments with audible or visual output
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743Type of operation; Specification of treatment sites
    • A61B2017/00747Dermatology
    • A61B2017/00761Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/06Measuring instruments not otherwise provided for
    • A61B2090/064Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension
    • A61B2090/065Measuring instruments not otherwise provided for for measuring force, pressure or mechanical tension for measuring contact or contact pressure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023Drug applicators using microneedles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061Methods for using microneedles

Abstract

The invention provides devices for the disruption of one or more layers of skin and methods of their use to administer therapeutic agents, e.g., antigens or drugs. The devices are designed to disrupt a defined area of skin. The defined area can approximate the area that a patch or other suitable vehicle for therapeutic agent, e.g., drug or vaccine, delivery is designed to contact. Exemplary devices employ a mask to define the area to be disrupted. Other devices disrupt a defined area by rotating in place. For devices that employ a mask that is secured to the skin, the invention provides methods of disrupting the stratum corneum by first securing the mask to the skin and then disrupting the skin. For rotating devices, the disrupting member is simply placed against the skin and actuated to effect disruption.
PCT/US2006/034620 2005-09-02 2006-09-05 Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof WO2007028167A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP06814198.5A EP1928537B1 (en) 2005-09-02 2006-09-05 Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs
CA002620943A CA2620943A1 (en) 2005-09-02 2006-09-05 Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
CN2006800304903A CN101242869B (en) 2005-09-02 2006-09-05 Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
IL189750A IL189750A (en) 2005-09-02 2008-02-25 Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71407305P 2005-09-02 2005-09-02
US60/714,073 2005-09-02

Publications (2)

Publication Number Publication Date
WO2007028167A2 WO2007028167A2 (en) 2007-03-08
WO2007028167A3 true WO2007028167A3 (en) 2007-12-06

Family

ID=37809665

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/034620 WO2007028167A2 (en) 2005-09-02 2006-09-05 Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof

Country Status (6)

Country Link
US (1) US20070088248A1 (en)
EP (2) EP2258441A3 (en)
CN (2) CN101242869B (en)
CA (1) CA2620943A1 (en)
IL (1) IL189750A (en)
WO (1) WO2007028167A2 (en)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002250071B2 (en) * 2001-02-13 2008-02-14 Government Of The United States, As Represented By The Secretary Of The Army Vaccine for transcutaneous immunization
US7759506B2 (en) * 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
BR0307935A (en) * 2002-02-25 2005-03-29 Diffusion Pharmaceuticals Llc Bipolar Trans Carotenoid Salts And Their Uses
ES2780200T3 (en) 2005-02-24 2020-08-24 Diffusion Pharmaceuticals Llc Trans carotenoids, formulation and uses
US20080208145A1 (en) * 2007-02-26 2008-08-28 Mcculloch James S Disposable shower guard for renal access catheter
WO2009081262A1 (en) 2007-12-18 2009-07-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
MX2009010000A (en) 2007-03-19 2010-03-17 Insuline Medical Ltd Drug delivery device.
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
EP2589588A1 (en) * 2007-04-13 2013-05-08 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids as a pretreatment and in the treatment of peripheral vascular disease
US8150505B2 (en) * 2007-05-03 2012-04-03 Path Scientific, Llc Method and apparatus for the formation of multiple microconduits
US20090156982A1 (en) * 2007-09-06 2009-06-18 Arezou Petrie Transdermal treatment device and method
US20090093669A1 (en) * 2007-10-05 2009-04-09 Farone William A Magnetophoresis apparatus and method of use
CA2703946A1 (en) * 2007-10-31 2009-05-07 Diffusion Pharmaceuticals Llc A new class of therapeutics that enhance small molecule diffusion
FR2924349B1 (en) 2007-12-03 2010-01-01 Dbv Tech ALLERGEN DISENSIBILITY METHOD
FR2926466B1 (en) * 2008-01-23 2010-11-12 Dbv Tech METHOD FOR MANUFACTURING PATCHES BY ELECTROSPRAY
US20100016813A1 (en) * 2008-07-18 2010-01-21 Brown Medical Industries Product for treating heel fissures
JP5476062B2 (en) * 2008-07-25 2014-04-23 南部化成株式会社 Transdermal device
US8691502B2 (en) 2008-10-31 2014-04-08 Tremrx, Inc. T-cell vaccination with viral vectors via mechanical epidermal disruption
MX2011004817A (en) 2008-11-07 2011-07-28 Insuline Medical Ltd Device and method for drug delivery.
US8348856B1 (en) 2008-12-16 2013-01-08 Zanetta Malanowska-Stega Simultaneous multiple method out-patient uterus biopsy device and method
CN102405015B (en) 2009-03-02 2017-01-18 第七感生物系统有限公司 Devices and methods for the analysis of an extractable medium
WO2012018486A2 (en) 2010-07-26 2012-02-09 Seventh Sense Biosystems, Inc. Rapid delivery and/or receiving of fluids
US10130689B2 (en) * 2009-06-22 2018-11-20 Diffusion Pharmaceuticals Llc Diffusion enhancing compounds and their use alone or with thrombolytics
WO2011026966A2 (en) 2009-09-07 2011-03-10 Dbv Technologies Method of treating eosinophilic esophagitis
WO2011135531A2 (en) 2010-04-28 2011-11-03 Kimberly-Clark Worldwide, Inc. MEDICAL DEVICES FOR DELIVERY OF siRNA
MX345837B (en) 2010-04-28 2017-02-16 Kimberly-Clark Worldwide Incorporated Device for delivery of rheumatoid arthritis medication.
CA2796965C (en) 2010-04-28 2019-04-16 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
JP5868953B2 (en) 2010-04-28 2016-02-24 キンバリー クラーク ワールドワイド インコーポレイテッド Injection mold microneedle array and manufacturing method thereof
US9687640B2 (en) 2010-05-04 2017-06-27 Corium International, Inc. Applicators for microneedles
CN105287473A (en) 2010-06-02 2016-02-03 扩散药品有限公司 Oral formulations of bipolar trans carotenoids and uses thereof
US20120039809A1 (en) 2010-08-13 2012-02-16 Seventh Sense Biosystems, Inc. Systems and techniques for monitoring subjects
CN103874461B (en) 2011-04-29 2017-05-10 第七感生物系统有限公司 Devices for collection and/or manipulation of blood spots or other bodily fluids
AU2012249692A1 (en) 2011-04-29 2013-11-14 Seventh Sense Biosystems, Inc. Delivering and/or receiving fluids
US20130158468A1 (en) 2011-12-19 2013-06-20 Seventh Sense Biosystems, Inc. Delivering and/or receiving material with respect to a subject surface
KR20140079429A (en) 2011-10-27 2014-06-26 킴벌리-클라크 월드와이드, 인크. Implantable devices for delivery of bioactive agents
EP2771059B1 (en) 2011-10-27 2019-07-17 Sorrento Therapeutics, Inc. Transdermal delivery of high viscosity bioactive agents
US20170246439A9 (en) * 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
WO2013136185A2 (en) 2012-03-13 2013-09-19 Becton Dickinson France Method of manufacture for a miniaturized drug delivery device
JP5903016B2 (en) 2012-06-27 2016-04-13 コスメディ製薬株式会社 Protective release sheet for microneedle patch
WO2014044690A1 (en) 2012-09-18 2014-03-27 Valneva Austria Gmbh Improved vaccines
GB2517707B (en) * 2013-08-28 2020-09-02 Pci Biotech As A device for light-induced rupture of endocytic vesicles to effect the delivery of an antigen
CA2925333C (en) * 2013-09-30 2021-09-07 Georgia Tech Research Corporation Microneedle patches, systems, and methods
CN106414704B (en) * 2014-03-14 2020-11-03 生命技术公司 Integrated system for nucleic acid amplification and detection
CN113908424A (en) 2014-04-24 2022-01-11 佐治亚科技研究公司 Microneedle and method for producing same
WO2016088886A1 (en) * 2014-12-05 2016-06-09 久光製薬株式会社 Microneedle device system
TW201707737A (en) 2015-06-03 2017-03-01 賽諾菲阿凡提斯德意志有限公司 Drug delivery device
TW201711713A (en) 2015-06-03 2017-04-01 賽諾菲阿凡提斯德意志有限公司 Drug delivery device
TW201709940A (en) * 2015-06-03 2017-03-16 賽諾菲阿凡提斯德意志有限公司 Audible indicator
TW201709941A (en) 2015-06-03 2017-03-16 賽諾菲阿凡提斯德意志有限公司 Audible indicator
GB2547062B (en) 2015-09-09 2020-03-04 Drawbridge Health Inc Systems, methods, and devices for sample collection, stabilization and preservation
WO2017079764A1 (en) * 2015-11-06 2017-05-11 Bkr Ip Holdco Llc Method for the attenuation enhancement of absorbent materials used in both passive and active transdermal drug delivery systems
WO2017165667A1 (en) 2016-03-24 2017-09-28 Diffusion Pharmaceuticals Llc Use of bipolar trans carotenoids with chemotherapy and radiotherapy for treatment of cancer
US20190321234A1 (en) * 2016-11-09 2019-10-24 Emv Enhance (Hk) Limited Devices and methods for enhancing immunogenicity to intradermal vaccination
CN110248609A (en) 2016-12-09 2019-09-17 扎内塔·马拉诺夫斯卡-斯蒂加 Brush biopsy device, tool set and method
WO2018132515A1 (en) 2017-01-10 2018-07-19 Drawbridge Health, Inc. Devices, systems, and methods for sample collection
EP3668595A4 (en) * 2017-08-14 2021-07-21 Veralase, LLC Miniature wearable laser treatment device
EP3703783A1 (en) 2017-11-03 2020-09-09 Sanofi Drug delivery device
US11400232B2 (en) 2017-11-03 2022-08-02 Sanofi Drug delivery device
GB2579575B (en) * 2018-12-03 2021-10-06 Dermal Diagnostics Ltd Skin preparation patches
US11216742B2 (en) 2019-03-04 2022-01-04 Iocurrents, Inc. Data compression and communication using machine learning
US11622943B2 (en) * 2019-05-10 2023-04-11 Chamkurkishtiah Panduranga Rao System and method for allergen-specific epicutaneous immunotherapy

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599545A (en) * 1990-05-07 1997-02-04 University College London Mycobacterium as adjuvant for antigens
WO2002074244A2 (en) * 2001-03-19 2002-09-26 Iomai Corporation Transcutaneous immunostimulation
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US6797276B1 (en) * 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response

Family Cites Families (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4117841A (en) * 1977-02-07 1978-10-03 Anthony Perrotta Medicated bandage pocket
DE3176404D1 (en) 1980-04-22 1987-10-08 Pasteur Institut Vaccine against viral hepatitis b, method and transformed eucaryotic cells for the preparation of this vaccine
US4816249A (en) 1981-11-17 1989-03-28 The Board Of Trustees Of The Leland Stanford Junior University Monoclonal anti-idiotype antibodies
US5068177A (en) 1983-12-28 1991-11-26 Scripps Clinic And Research Foundation Anti-idiotype antibodies induced by synthetic polypeptides
US5262177A (en) 1986-02-07 1993-11-16 Oncogen Recombinant viruses encoding the human melanoma-associated antigen
US5141742A (en) 1986-02-07 1992-08-25 Oncogen Vaccines against melanoma
US5229490A (en) 1987-05-06 1993-07-20 The Rockefeller University Multiple antigen peptide system
AU614092B2 (en) * 1987-09-11 1991-08-22 Paul Max Grinwald Improved method and apparatus for enhanced drug permeation of skin
US5997856A (en) 1988-10-05 1999-12-07 Chiron Corporation Method and compositions for solubilization and stabilization of polypeptides, especially proteins
US5102663A (en) 1988-10-18 1992-04-07 Sloan-Kettering Instutute For Cancer Research Vaccine for stimulating or enhancing production of antibodies against 9-O-acetyl GD3
DE3844247A1 (en) * 1988-12-29 1990-07-12 Minnesota Mining & Mfg DEVICE, IN PARTICULAR PLASTER FOR TRANSDERMAL ADMINISTRATION OF A MEDICINAL PRODUCT
US5227159A (en) 1989-01-31 1993-07-13 Miller Richard A Anti-idiotype antibodies reactive with shared idiotopes expressed by B cell lymphomas and autoantibodies
US5612035A (en) 1989-03-21 1997-03-18 The Immune Response Corporation Vaccination against diseases resulting from pathogenic responses by specific T cell populations
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5614192A (en) 1989-07-19 1997-03-25 Connective Therapeutics, Inc. T cell receptor peptides as therapeutics for immune-related disease
US6090790A (en) 1989-12-14 2000-07-18 Eriksson; Elof Gene delivery by microneedle injection
KR940000755B1 (en) 1990-02-16 1994-01-29 유나이티드 바이오메디칼 인코오포레이티드 Synthetic peptides specific for the detection of antibodies to hcv
US5462743A (en) * 1992-10-30 1995-10-31 Medipro Sciences Limited Substance transfer system for topical application
DK0668777T3 (en) 1992-11-05 2007-02-19 Sloan Kettering Inst Cancer Prostate-specific membrane antigen
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
TW404844B (en) 1993-04-08 2000-09-11 Oxford Biosciences Ltd Needleless syringe
US5390111A (en) 1993-11-12 1995-02-14 General Electric Company Method and system for processing cone beam data for reconstructing free of boundary-induced artifacts a three dimensional computerized tomography image
US5885211A (en) * 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
CN1094768C (en) * 1993-12-29 2002-11-27 久光制药株式会社 Patch agent for percutaneous pharmaceutical supply
US5552300A (en) 1994-01-13 1996-09-03 T Cell Sciences, Inc. T cell antigen receptor V region proteins and methods of preparation thereof
KR100382706B1 (en) 1994-09-14 2003-10-10 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 Matrix for transdermal drug delivery
AU5740496A (en) * 1995-05-22 1996-12-11 General Hospital Corporation, The Micromechanical device and method for enhancing delivery of compounds through the skin
US5980898A (en) * 1996-11-14 1999-11-09 The United States Of America As Represented By The U.S. Army Medical Research & Material Command Adjuvant for transcutaneous immunization
JP2001512329A (en) 1996-12-31 2001-08-21 アルテア テクノロジーズ,インコーポレイテッド Tissue microperforation for bioactive drug delivery
US6610235B1 (en) * 1997-06-30 2003-08-26 The Regents Of The University Of California Method of fabricating epidermal abrasion device
US5928207A (en) * 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US5836998A (en) * 1997-10-08 1998-11-17 Mueller; Linda Adhesive stencil for body art
BR9908278A (en) 1998-02-25 2002-01-02 Iomai Corp Use of agents to improve penetration and break through skin barriers, improve the immune transcutaneous response induced by the adp ribosylation ethoxine
US6289801B1 (en) * 1998-05-14 2001-09-18 Patrick M. Raymond Face painting stencils
US6352506B1 (en) * 1998-07-14 2002-03-05 Altea Technologies Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport
CA2376368C (en) * 1999-06-08 2009-08-11 Altea Technologies, Inc. Apparatus for microporation of biological membranes using thin film tissue interface devices, and method therefor
US7354423B2 (en) * 1999-08-09 2008-04-08 J&J Consumer Co., Inc. Skin abrasion system and method
US6623457B1 (en) * 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) * 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
MXPA02005765A (en) * 1999-12-10 2003-01-28 Alza Corp Skin treatment apparatus for sustained transdermal drug delivery.
US20020016601A1 (en) * 2000-01-03 2002-02-07 Shadduck John H. Instruments and techniques for inducing neocollagenesis in skin treatments
US6595947B1 (en) * 2000-05-22 2003-07-22 Becton, Dickinson And Company Topical delivery of vaccines
US6283978B1 (en) * 2000-06-09 2001-09-04 Peter J. Cheski Method and apparatus for microdermabrasion
US6440096B1 (en) * 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6471712B2 (en) * 2000-10-05 2002-10-29 Steven A. Burres Dermabrasion and skin care apparatus
HUP0303576A2 (en) * 2000-10-13 2004-01-28 Alza Corp Microprotrusion member retainer for impact applicator
CA2427381A1 (en) * 2000-10-26 2002-11-28 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
EP1695727B1 (en) * 2000-11-09 2008-07-23 Insulet Corporation Transcutaneous delivery means
AU2002312380A1 (en) * 2001-06-08 2002-12-23 Becton, Dickinson And Company Device for manipulating a needle or abrader array
JP2005511248A (en) * 2001-10-29 2005-04-28 ベクトン・ディキンソン・アンド・カンパニー Methods and devices for delivering substances
US20030113827A1 (en) * 2001-12-17 2003-06-19 Burkoth Terry L. Non-or minimally invasive monitoring methods
WO2003074102A2 (en) * 2002-03-04 2003-09-12 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
US20040137004A1 (en) * 2002-03-19 2004-07-15 Glenn Gregory M Patch for transcutaneous immunization
US6780171B2 (en) * 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
KR101323980B1 (en) * 2002-07-19 2013-10-30 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Microneedle device, method of using microneedle device and method of delivering microneedle device
WO2004020015A2 (en) * 2002-08-29 2004-03-11 Becton Dickinson And Company Microprotrusion arrays and methods for using same to deliver substances into tissue
US20040236269A1 (en) * 2002-09-25 2004-11-25 Marchitto Kevin S. Microsurgical tissue treatment system
US20040059282A1 (en) * 2002-09-25 2004-03-25 Flock Stephen T. Microsurgical tissue treatment system
US20040107975A1 (en) * 2002-12-06 2004-06-10 Beth Bender Eye makeup stencil
ATE474611T1 (en) * 2003-05-08 2010-08-15 Novo Nordisk As AN INJECTION DEVICE THAT CAN BE APPLIED TO THE SKIN WITH A SEPARABLE ACTUATING PART FOR INSERTING THE NEEDLE
CN1897898A (en) * 2003-10-24 2007-01-17 阿尔扎公司 Pretreatment method and system for enhancing transdermal drug delivery
CA2546443A1 (en) * 2003-11-18 2005-06-02 Nanopass Technologies Ltd. Enhanced penetration system and method for sliding microneedles
US20050143754A1 (en) * 2003-12-31 2005-06-30 Zelickson Brian D. Skin abrasion system and method
US7316665B2 (en) * 2004-08-25 2008-01-08 Becton, Dickinson And Company Method and device for the delivery of a substance including a covering
KR20130026511A (en) * 2004-11-18 2013-03-13 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Low-profile microneedle array applicator
US20080195035A1 (en) * 2005-06-24 2008-08-14 Frederickson Franklyn L Collapsible Patch and Method of Application

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5599545A (en) * 1990-05-07 1997-02-04 University College London Mycobacterium as adjuvant for antigens
US6797276B1 (en) * 1996-11-14 2004-09-28 The United States Of America As Represented By The Secretary Of The Army Use of penetration enhancers and barrier disruption agents to enhance the transcutaneous immune response
WO2002074244A2 (en) * 2001-03-19 2002-09-26 Iomai Corporation Transcutaneous immunostimulation
US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RICHARD W. ET AL.: "Parenteral Adjuvant Activities of Escherichia coli Heat-Labile Toxin and its B Subunit for Immunization of Mice against Gastric Helicobacter pylori Infection", INFECT. IMMUN., vol. 68, no. 5, May 2000 (2000-05-01), pages 2775 - 2782, XP008126642 *

Also Published As

Publication number Publication date
CN101242869A (en) 2008-08-13
IL189750A (en) 2010-12-30
CN101912288A (en) 2010-12-15
CN101242869B (en) 2010-05-26
EP1928537A4 (en) 2009-12-02
EP2258441A3 (en) 2011-09-21
US20070088248A1 (en) 2007-04-19
EP1928537A2 (en) 2008-06-11
IL189750A0 (en) 2008-08-07
EP2258441A2 (en) 2010-12-08
CA2620943A1 (en) 2007-03-08
EP1928537B1 (en) 2015-01-21
WO2007028167A2 (en) 2007-03-08

Similar Documents

Publication Publication Date Title
WO2007028167A3 (en) Devices for transcutaneous delivery of vaccines and transdermal delivery of drugs and uses thereof
Paudel et al. Challenges and opportunities in dermal/transdermal delivery
JP2012041355A5 (en)
WO2008157103A3 (en) Modified release solid or semi-solid dosage forms
WO2005099751A3 (en) Apparatus and method for transdermal delivery of influenza vaccine
WO2008064192A3 (en) Modified release analgesic suspensions
AR046697A1 (en) METHOD AND SYSTEM OF TRANSDERMAL ADMINISTRATION OF AGENT ASSISTED BY FREQUENCY
WO2010068281A3 (en) Contact lens drug delivery device
MX2009010000A (en) Drug delivery device.
WO2004087011A3 (en) Therapeutic agent delivery device with controlled therapeutic agent release rates
WO2011076621A3 (en) Transdermal therapeutic system for administering rivastigmine or derivatives thereof
WO2005102334A3 (en) Apparatus and method for transdermal delivery of fentany-based agents
DK2613784T3 (en) DEVICE FOR TRANSDERMAL ADMINISTRATION OF MEDICINE
MX2016008138A (en) System for the transdermal delivery of active ingredient.
WO2011029948A3 (en) Transdermal therapeutic system for administering fentanyl or an analogue thereof
WO2008025790A3 (en) Use of opioid formulations in needle-less drug delivery devices
MX2013012206A (en) Method of producing substances with supersaturated gas, transdermal delivery thereof, and uses thereof.
WO2009121514A3 (en) Self-destructing transdermal therapeutic system having improved functionality and efficacy
MX2021002833A (en) Transdermal drug delivery system.
WO2012111996A3 (en) Transdermal delivery system containing galantamine or salts thereof
Edwards et al. Exploiting unique features of microneedles to modulate immunity
WO2012145554A3 (en) Method of producing substances with supersaturated gas,transdermal delivery device thereof, and uses thereof
WO2006089056A3 (en) Apparatus and method for transdermal delivery of erythropoetin-based agents
Pierce et al. Sumatriptan iontophoretic transdermal system: history, study results, and use in clinical practice
CA2569285A1 (en) Methods of device-assisted drug delivery

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200680030490.3

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 189750

Country of ref document: IL

ENP Entry into the national phase

Ref document number: 2620943

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006814198

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1607/CHENP/2008

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 207441

Country of ref document: IL