WO2007030545A3 - Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates - Google Patents

Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates Download PDF

Info

Publication number
WO2007030545A3
WO2007030545A3 PCT/US2006/034722 US2006034722W WO2007030545A3 WO 2007030545 A3 WO2007030545 A3 WO 2007030545A3 US 2006034722 W US2006034722 W US 2006034722W WO 2007030545 A3 WO2007030545 A3 WO 2007030545A3
Authority
WO
WIPO (PCT)
Prior art keywords
release rates
pharmaceutical formulations
disk
exhibiting improved
active agents
Prior art date
Application number
PCT/US2006/034722
Other languages
French (fr)
Other versions
WO2007030545A2 (en
Inventor
Eliot M Slovin
Joseph T Persyn
Joseph A Mcdonough
Neal K Vail
Darren E Barlow
Albert M Zwiener
Original Assignee
Southwest Res Inst
Eliot M Slovin
Joseph T Persyn
Joseph A Mcdonough
Neal K Vail
Darren E Barlow
Albert M Zwiener
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/220,430 external-priority patent/US7758778B2/en
Priority claimed from US11/220,807 external-priority patent/US9693967B2/en
Priority claimed from US11/221,337 external-priority patent/US7261529B2/en
Application filed by Southwest Res Inst, Eliot M Slovin, Joseph T Persyn, Joseph A Mcdonough, Neal K Vail, Darren E Barlow, Albert M Zwiener filed Critical Southwest Res Inst
Priority to AU2006287499A priority Critical patent/AU2006287499A1/en
Priority to CA002621395A priority patent/CA2621395A1/en
Priority to JP2008530171A priority patent/JP2009507845A/en
Priority to BRPI0615563-4A priority patent/BRPI0615563A2/en
Priority to EP06803043A priority patent/EP1931387A4/en
Publication of WO2007030545A2 publication Critical patent/WO2007030545A2/en
Publication of WO2007030545A3 publication Critical patent/WO2007030545A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)

Abstract

This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus (100) includes a spinning disk (105) containing a reservoir (708) in the center thereof and a flat inclined surface. The apparatus optionally includes serrations (712) and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.
PCT/US2006/034722 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates WO2007030545A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2006287499A AU2006287499A1 (en) 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates
CA002621395A CA2621395A1 (en) 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates
JP2008530171A JP2009507845A (en) 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulation with improved release rate
BRPI0615563-4A BRPI0615563A2 (en) 2005-09-07 2006-09-06 biodegradable microparticle pharmaceutical formulations exhibiting improved release rates
EP06803043A EP1931387A4 (en) 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US22043105A 2005-09-07 2005-09-07
US22044505A 2005-09-07 2005-09-07
US11/220,430 US7758778B2 (en) 2005-09-07 2005-09-07 Methods for preparing biodegradable microparticle formulations containing pharmaceutically active agents
US11/220,430 2005-09-07
US11/220,807 US9693967B2 (en) 2005-09-07 2005-09-07 Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates
US11/220,807 2005-09-07
US11/221,337 2005-09-07
US11/220,445 2005-09-07
US11/220,431 2005-09-07
US11/221,337 US7261529B2 (en) 2005-09-07 2005-09-07 Apparatus for preparing biodegradable microparticle formulations containing pharmaceutically active agents

Publications (2)

Publication Number Publication Date
WO2007030545A2 WO2007030545A2 (en) 2007-03-15
WO2007030545A3 true WO2007030545A3 (en) 2007-11-08

Family

ID=37836422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/034722 WO2007030545A2 (en) 2005-09-07 2006-09-06 Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates

Country Status (7)

Country Link
EP (1) EP1931387A4 (en)
JP (1) JP2009507845A (en)
KR (1) KR20080059175A (en)
AU (1) AU2006287499A1 (en)
BR (1) BRPI0615563A2 (en)
CA (1) CA2621395A1 (en)
WO (1) WO2007030545A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2956345B1 (en) * 2010-02-17 2012-02-03 Ab7 Ind PROCESS FOR THE PREPARATION OF BIODEGRADABLE POLYMER GRANULES LOADED WITH ACTIVE LIPOPHILIC COMPOUNDS AND ACTIVE BIODEGRADABLE PRODUCTS OBTAINED
UA111162C2 (en) 2010-08-04 2016-04-11 Флекшен Терап'Ютікс, Інк. INJECTION COMPOSITION OF TRIAMCINOLONE ACETONIDE FOR TREATMENT OF PAIN
WO2012058138A1 (en) 2010-10-26 2012-05-03 Alcon Research, Ltd. Ophthalmoscopic surgical contact lens
WO2013019280A1 (en) * 2011-08-04 2013-02-07 Flexion Therapeutics Corticosteroids for the treatment of joint pain
JP2015532928A (en) * 2012-09-20 2015-11-16 アキナ， インク．Ａｋｉｎａ， Ｉｎｃ． Biodegradable microcapsules containing filler material

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675140A (en) * 1984-05-18 1987-06-23 Washington University Technology Associates Method for coating particles or liquid droplets
US20050064010A1 (en) * 2003-09-18 2005-03-24 Cooper Eugene R. Transscleral delivery
US20050181023A1 (en) * 2004-02-17 2005-08-18 Young Janel E. Drug-enhanced adhesion prevention

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4256677A (en) * 1976-04-12 1981-03-17 Magnavox Government And Industrial Electronics Co. Apparatus and method for making small spheres
US5643594A (en) * 1992-05-29 1997-07-01 The Regents Of The University Of California Spin encapsulation apparatus and method of use
SE505146C2 (en) * 1995-10-19 1997-06-30 Biogram Ab Particles for delayed release
US5665428A (en) * 1995-10-25 1997-09-09 Macromed, Inc. Preparation of peptide containing biodegradable microspheres by melt process
MX272648B (en) * 2002-11-04 2009-12-10 Ocean Nutrition Canada Ltd Microcapsules having multiple shells and method for the preparation thereof.
EP1594511A2 (en) * 2003-02-20 2005-11-16 Alcon, Inc. Formulations of glucocorticoids to treat pathologic ocular angiogenesis
JP4487141B2 (en) * 2003-08-20 2010-06-23 参天製薬株式会社 Drug delivery system for microtenon subcapsular administration
EP1663471A1 (en) * 2003-08-22 2006-06-07 Danisco A/S Microcapsules

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675140A (en) * 1984-05-18 1987-06-23 Washington University Technology Associates Method for coating particles or liquid droplets
US20050064010A1 (en) * 2003-09-18 2005-03-24 Cooper Eugene R. Transscleral delivery
US20050181023A1 (en) * 2004-02-17 2005-08-18 Young Janel E. Drug-enhanced adhesion prevention

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1931387A4 *

Also Published As

Publication number Publication date
BRPI0615563A2 (en) 2011-05-24
JP2009507845A (en) 2009-02-26
AU2006287499A1 (en) 2007-03-15
WO2007030545A2 (en) 2007-03-15
EP1931387A2 (en) 2008-06-18
KR20080059175A (en) 2008-06-26
CA2621395A1 (en) 2007-03-15
EP1931387A4 (en) 2012-07-11

Similar Documents

Publication Publication Date Title
WO2002043702A3 (en) Pharmaceutical compositions for inhalation
WO2007033372A3 (en) Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
WO2006035417A3 (en) Dihydropyrimidine microcapsule - formulations
EP2298279A3 (en) Pharmaceutical compositions for inhalation
WO2007030545A3 (en) Biodegradable microparticle pharmaceutical formulations exhibiting improved release rates
WO2005070462A3 (en) Compositions comprising (s)-amlodipine and an angiotensin receptor blocker and methods of their use
WO2006002365A3 (en) Microparticles with high loadings of a bioactive agent
WO2006124047A3 (en) Pharmaceutical formulations containing microparticles or nanoparticles of a delivery agent
TNSN03138A1 (en) PHARMACEUTICAL COMPOSITIONS OF ADSORBATES OF AN AMORPHOUS MEDICINAL PRODUCT
MX2008000099A (en) Modified release pharmaceutical compositions on the basis of two polymers and processes thereof.
WO2003084518A3 (en) Oral suspension of active principle microcapsules
WO2004012699A3 (en) Modified release composition comprising coated micro matrix particles containing the high soluble active ingredient and a release controlling agent
WO2006023207A3 (en) Coacervate of anionic and cationic polymer forming microparticles for the sustained release of therapeutic agents
TNSN08365A1 (en) Sustained release pharmaceutical composition on the basis of release system comprising an acid-soluble polymer and a ph-dependent polymer
AU2003229084A1 (en) Methods and formulations for the delivery of pharmacologically active agents
WO2006089674A3 (en) Tablets with improved drug substance dispersibility
WO2003037337A8 (en) Depot formulations of iloperidone and a star polymer
HUP0301416A2 (en) Improved thyroid hormone formulations
IS8430A (en) Medicines containing (2R) -2-propyl octanoic acid as the active ingredient
WO2005027843A3 (en) Chronotherapeutic dosage forms
WO2005049074A3 (en) Methods for modulating the th2 immuneresponse to an antigen by adding or removing activated carbonyl groups from the antigen
WO2003082262A3 (en) Compositions of venlafaxine base
WO2001034125A3 (en) Therapeutic use and formulation of (-)-tramadol
SK500402007A3 (en) Escitalopram free base in solid form, pharmaceutical composition containing the same, process for its manufacture, orodispersible tablet and method for its manufacture
WO2006127321A3 (en) Formulations of suberoylanilide hydroxamic acid and methods for producing same

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200680041440.5

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2621395

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2006287499

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: MX/a/2008/003116

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2008530171

Country of ref document: JP

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006803043

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1020087008002

Country of ref document: KR

ENP Entry into the national phase

Ref document number: 2006287499

Country of ref document: AU

Date of ref document: 20060906

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: PI0615563

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20080307