WO2007035778A3 - Cell-support matrix and a method for preparation thereof - Google Patents

Cell-support matrix and a method for preparation thereof Download PDF

Info

Publication number
WO2007035778A3
WO2007035778A3 PCT/US2006/036555 US2006036555W WO2007035778A3 WO 2007035778 A3 WO2007035778 A3 WO 2007035778A3 US 2006036555 W US2006036555 W US 2006036555W WO 2007035778 A3 WO2007035778 A3 WO 2007035778A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
matrix
cell
support matrix
cartilage
Prior art date
Application number
PCT/US2006/036555
Other languages
French (fr)
Other versions
WO2007035778A2 (en
Inventor
R Lane Smith
Laurence J B Tarrant
Akihiko Kusanagi
Hans Peter Ingemar Claesson
Original Assignee
Histogenics Corp
R Lane Smith
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Histogenics Corp, R Lane Smith filed Critical Histogenics Corp
Priority to CA2623106A priority Critical patent/CA2623106C/en
Priority to EP20060814983 priority patent/EP1926459B1/en
Priority to JP2008531443A priority patent/JP2009508596A/en
Priority to AU2006292224A priority patent/AU2006292224B2/en
Publication of WO2007035778A2 publication Critical patent/WO2007035778A2/en
Publication of WO2007035778A3 publication Critical patent/WO2007035778A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3817—Cartilage-forming cells, e.g. pre-chondrocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • A61L27/3843—Connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/08—Muscles; Tendons; Ligaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30756—Cartilage endoprostheses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/38—Joints for elbows or knees
    • A61F2/3872—Meniscus for implantation between the natural bone surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00365—Proteins; Polypeptides; Degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2535/00—Supports or coatings for cell culture characterised by topography

Abstract

A cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof. The matrix suitable for preparation of cellular or acellular implants for growth and de novo formation of an articular hyaline-like cartilage. A gel-matrix composite system comprising collagen-based matrix having a narrowly defined porosity capable of inducing hyaline- like cartilage production from chondrocytes in vivo and in vitro.
PCT/US2006/036555 2005-09-19 2006-09-19 Cell-support matrix and a method for preparation thereof WO2007035778A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2623106A CA2623106C (en) 2005-09-19 2006-09-19 Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
EP20060814983 EP1926459B1 (en) 2005-09-19 2006-09-19 Cell-support matrix having narrowly defined uniformly vertically and non-randomly organized porosity and pore density and a method for preparation thereof
JP2008531443A JP2009508596A (en) 2005-09-19 2006-09-19 Cell support substrate and preparation method thereof
AU2006292224A AU2006292224B2 (en) 2005-09-19 2006-09-19 Cell-support matrix and a method for preparation thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71871405P 2005-09-19 2005-09-19
US60/718,714 2005-09-19

Publications (2)

Publication Number Publication Date
WO2007035778A2 WO2007035778A2 (en) 2007-03-29
WO2007035778A3 true WO2007035778A3 (en) 2007-12-06

Family

ID=37889483

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/036555 WO2007035778A2 (en) 2005-09-19 2006-09-19 Cell-support matrix and a method for preparation thereof

Country Status (6)

Country Link
US (5) US8921109B2 (en)
EP (1) EP1926459B1 (en)
JP (1) JP2009508596A (en)
AU (1) AU2006292224B2 (en)
CA (1) CA2623106C (en)
WO (1) WO2007035778A2 (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040151705A1 (en) * 2002-03-22 2004-08-05 Shuichi Mizuno Neo-cartilage constructs and a method for preparation thereof
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US20050222687A1 (en) * 2004-04-02 2005-10-06 Gordana Vunjak-Novakovic Cartilage implant assembly and method for implantation
US20050064042A1 (en) * 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US7488348B2 (en) * 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
WO2007035778A2 (en) 2005-09-19 2007-03-29 Histogenics Corporation Cell-support matrix and a method for preparation thereof
US9132208B2 (en) * 2008-08-07 2015-09-15 Lifenet Health Composition for a tissue repair implant and methods of making the same
US9005646B2 (en) 2005-10-12 2015-04-14 Lifenet Health Compositions for repair of defects in tissues, and methods of making the same
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
US8070827B2 (en) * 2007-07-03 2011-12-06 Histogenics Corporation Method for use of a double-structured tissue implant for treatment of tissue defects
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
US20090054984A1 (en) 2007-08-20 2009-02-26 Histogenics Corporation Method For Use Of A Double-Structured Tissue Implant For Treatment Of Tissue Defects
US9421304B2 (en) * 2007-07-03 2016-08-23 Histogenics Corporation Method for improvement of differentiation of mesenchymal stem cells using a double-structured tissue implant
KR20100130178A (en) * 2008-01-09 2010-12-10 이노베이티브 헬스 테크놀로지스, 엘엘씨 Implant pellets and methods for performing bone augmentation and preservation
WO2009105820A1 (en) * 2008-02-29 2009-09-03 The University Of Sydney Hydrogels derived from biological polymers
CA2717725A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US8114156B2 (en) * 2008-05-30 2012-02-14 Edwin Burton Hatch Flexibly compliant ceramic prosthetic meniscus for the replacement of damaged cartilage in orthopedic surgical repair or reconstruction of hip, knee, ankle, shoulder, elbow, wrist and other anatomical joints
DE102009018640A1 (en) * 2009-04-17 2010-10-21 Tetec Tissue Engineering Technologies Ag Implant and therapeutic composition for the treatment of damage and / or diseases in the field of the human and / or animal musculoskeletal system
US9603969B2 (en) * 2011-08-30 2017-03-28 Kyoto University Porous scaffold material, and method for producing same
CN102716515B (en) * 2012-07-02 2014-01-29 陕西博鸿生物科技有限公司 Biological material for repairing meniscus tear and preparation method for biological material
MX2015000463A (en) * 2012-07-11 2015-08-14 Osiris Therapeutics Inc Methods of manufacturing cartilage products.
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US10918767B2 (en) * 2015-05-12 2021-02-16 University Of Florida Research Foundation, Inc. Magnetically templated tissue engineering scaffolds and methods of making and using the magnetically templated tissue engineering scaffolds
US11090412B2 (en) 2018-12-21 2021-08-17 Zavation Medical Products Llc Bone repair composition and kit
JPWO2020209316A1 (en) * 2019-04-08 2020-10-15
JP6873436B2 (en) * 2019-05-17 2021-05-19 学校法人大阪医科薬科大学 Pharmaceutical composition for the treatment of joint diseases and its manufacturing method
CN110404110B (en) * 2019-08-21 2021-10-22 华南理工大学 Suture-resistant collagen-based cornea regeneration repair material and preparation method thereof
KR102293725B1 (en) * 2019-11-29 2021-08-26 한국과학기술연구원 Method for preparing bioink comprising collagen for 3d printing and method for 3d printing using bioink prepared the same
CN111249529B (en) * 2020-01-16 2021-12-21 广东省人民医院(广东省医学科学院) Bionic multilayer collagen scaffold for cartilage repair and preparation method thereof
US20230365934A1 (en) * 2020-09-23 2023-11-16 Jbm Incorporation Cell population production method
WO2023030435A1 (en) * 2021-09-01 2023-03-09 Shanghai Qisheng Biological Preparation Co., Ltd. Cartilage regeneration using injectable, in situ polymerizable collagen compositions containing chondrocytes or stem cells

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6454811B1 (en) * 1998-10-12 2002-09-24 Massachusetts Institute Of Technology Composites for tissue regeneration and methods of manufacture thereof
US20030040113A1 (en) * 2001-03-23 2003-02-27 Histogenics Corporation Composition and methods for the production of biological tissues and tissue constructs

Family Cites Families (687)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3400199A (en) 1965-02-26 1968-09-03 Leslie L. Balassa Wound-healing cartilage powder
US3476855A (en) 1965-02-26 1969-11-04 Leslie L Balassa Sterilizing and enhancing activity of a finely divided cartilage powder
US3478146A (en) 1965-02-26 1969-11-11 Leslie L Balassa Wound-healing cartilage powder extracting process
US3551560A (en) 1967-10-02 1970-12-29 Heinrich F Thiele Process of reconstructing tendons,cartilage,nerve sheaths,and products
US3772432A (en) 1971-01-11 1973-11-13 Lescarden Ltd Cartilage compositions for dental use
SE391122B (en) 1971-01-25 1977-02-07 Cutter Lab PROTESTS IN THE FORM OF A SPINE BONIC DISC AND PROCEDURES FOR MANUFACTURE THEREOF
US3966908A (en) 1973-11-29 1976-06-29 Lescarden Ltd. Method of treating degenerative joint afflictions
US4172128A (en) 1975-03-26 1979-10-23 Erhard Thiele Process of degrading and regenerating bone and tooth material and products
US4280954A (en) 1975-07-15 1981-07-28 Massachusetts Institute Of Technology Crosslinked collagen-mucopolysaccharide composite materials
US4060081A (en) 1975-07-15 1977-11-29 Massachusetts Institute Of Technology Multilayer membrane useful as synthetic skin
US4201845A (en) 1976-04-12 1980-05-06 Monsanto Company Cell culture reactor
DE2636206C3 (en) 1976-08-12 1981-06-04 C.H. Boehringer Sohn, 6507 Ingelheim Carrier-fixed enzymes and their manufacture and use
US4296100A (en) 1980-06-30 1981-10-20 Franco Wayne P Method of treating the heart for myocardial infarction
US4378347A (en) 1980-06-30 1983-03-29 Franco Wayne P Composition for treating the heart for myocardial infarction
US4522753A (en) 1980-07-17 1985-06-11 Massachusetts Institute Of Technology Method for preserving porosity in porous materials
US4400833A (en) 1981-06-10 1983-08-30 Kurland Kenneth Z Means and method of implanting bioprosthetics
US4873191A (en) 1981-06-12 1989-10-10 Ohio University Genetic transformation of zygotes
EP0068149A3 (en) 1981-06-25 1983-07-20 Serapharm GmbH & Co. KG Dry preparation containing fibrinogene, its production and use
US4442655A (en) 1981-06-25 1984-04-17 Serapharm Michael Stroetmann Fibrinogen-containing dry preparation, manufacture and use thereof
AT369990B (en) 1981-07-28 1983-02-25 Immuno Ag METHOD FOR PRODUCING A TISSUE ADHESIVE
US4350629A (en) 1981-07-29 1982-09-21 Massachusetts Institute Of Technology Procedures for preparing composite materials from collagen and glycosaminoglycan
NZ201918A (en) 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
US4394370A (en) 1981-09-21 1983-07-19 Jefferies Steven R Bone graft material for osseous defects and method of making same
US4479271A (en) 1981-10-26 1984-10-30 Zimmer, Inc. Prosthetic device adapted to promote bone/tissue ingrowth
US4505266A (en) 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
US4458678A (en) 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4501269A (en) 1981-12-11 1985-02-26 Washington State University Research Foundation, Inc. Process for fusing bone joints
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4870009A (en) 1982-11-22 1989-09-26 The Salk Institute For Biological Studies Method of obtaining gene product through the generation of transgenic animals
IL68218A (en) 1983-03-23 1985-12-31 Univ Ramot Compositions for cartilage repair comprising embryonal chondrocytes
US4801299A (en) 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US4448718A (en) 1983-09-13 1984-05-15 Massachusetts Institute Of Technology Method for the preparation of collagen-glycosaminoglycan composite materials
US4932973A (en) 1983-09-30 1990-06-12 El Gendler Cartilage and bone induction by artificially perforated organic bone matrix
US5155214A (en) 1984-03-05 1992-10-13 The Salk Institute For Biological Studies Basic fibroblast growth factor
US4609551A (en) 1984-03-20 1986-09-02 Arnold Caplan Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites
US4600574A (en) 1984-03-21 1986-07-15 Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte Method of producing a tissue adhesive
US4736866B1 (en) 1984-06-22 1988-04-12 Transgenic non-human mammals
US4757017A (en) 1984-09-14 1988-07-12 Mcw Research Foundation, Inc. In vitro cell culture system
US4582865A (en) 1984-12-06 1986-04-15 Biomatrix, Inc. Cross-linked gels of hyaluronic acid and products containing such gels
US5629191A (en) 1985-01-03 1997-05-13 Integra Lifesciences Corporation Method of making a porous matrix particle
CH665348A5 (en) 1985-01-09 1988-05-13 Sulzer Ag IMPLANTS.
CH665770A5 (en) 1985-01-25 1988-06-15 Sulzer Ag PLASTIC BONE IMPLANT.
US4713448A (en) 1985-03-12 1987-12-15 Biomatrix, Inc. Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
CA1260391A (en) 1985-03-28 1989-09-26 Karl A. Piez Xenogeneic collagen/mineral preparations in bone repair
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5053049A (en) 1985-05-29 1991-10-01 Baxter International Flexible prostheses of predetermined shapes and process for making same
US4627853A (en) 1985-05-29 1986-12-09 American Hospital Supply Corporation Method of producing prostheses for replacement of articular cartilage and prostheses so produced
US4681763A (en) 1985-06-11 1987-07-21 University Of Medicine And Dentistry Of New Jersey Composition for stimulating bone growth
FR2585576B1 (en) 1985-07-30 1992-01-03 Bioetica Sa BONE MATRIX REPLACEMENT PROMOTING OSTEOGENESIS
IL76079A (en) 1985-08-13 1991-03-10 Univ Ramot Collagen implants
US5604293A (en) 1985-09-12 1997-02-18 Scios Inc. Recombinant human basic fibroblast growth factor
US5439818A (en) 1985-09-12 1995-08-08 Scios Nova Inc. DNA encoding human recombinant basic fibroblast growth factor
US4656137A (en) 1985-09-12 1987-04-07 Lescarden Inc Method of processing animal cartilage
US5859208A (en) 1988-07-06 1999-01-12 Fiddes; John C. Human basic fibroblast growth factor analog
US4994559A (en) 1985-12-17 1991-02-19 Synergen, Inc. Human basic fibroblast growth factor
US4776173A (en) 1985-12-20 1988-10-11 Angio-Medical Corporation Method for extracting a substance from animal derived material
US6005161A (en) 1986-01-28 1999-12-21 Thm Biomedical, Inc. Method and device for reconstruction of articular cartilage
US4981783A (en) 1986-04-16 1991-01-01 Montefiore Medical Center Method for detecting pathological conditions
US4912032A (en) 1986-04-17 1990-03-27 Genetec Systems Corporation Methods for selectively reacting ligands immobilized within a temperature-sensitive polymer gel
US5902741A (en) 1986-04-18 1999-05-11 Advanced Tissue Sciences, Inc. Three-dimensional cartilage cultures
US5032508A (en) 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US4963489A (en) 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5266480A (en) 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
GB8618374D0 (en) 1986-07-28 1986-09-03 Hsc Res Dev Corp Biological vascular prostheses
FI80605C (en) 1986-11-03 1990-07-10 Biocon Oy Bone surgical biocomposite material
US5736372A (en) 1986-11-20 1998-04-07 Massachusetts Institute Of Technology Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous structure
US5041138A (en) 1986-11-20 1991-08-20 Massachusetts Institute Of Technology Neomorphogenesis of cartilage in vivo from cell culture
CA1340581C (en) 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US4873192A (en) 1987-02-17 1989-10-10 The United States Of America As Represented By The Department Of Health And Human Services Process for site specific mutagenesis without phenotypic selection
GB8708009D0 (en) 1987-04-03 1987-05-07 Clayton Found Res Injectable soft tissue augmentation materials
US4846835A (en) 1987-06-15 1989-07-11 Grande Daniel A Technique for healing lesions in cartilage
US5681353A (en) 1987-07-20 1997-10-28 Regen Biologics, Inc. Meniscal augmentation device
US5007934A (en) 1987-07-20 1991-04-16 Regen Corporation Prosthetic meniscus
US4880429A (en) 1987-07-20 1989-11-14 Stone Kevin R Prosthetic meniscus
US5306311A (en) 1987-07-20 1994-04-26 Regen Corporation Prosthetic articular cartilage
US5260420A (en) 1987-07-30 1993-11-09 Centre Regional De Transfusion Sanguine De Lille Concentrate of thrombin coagulable proteins, the method of obtaining same and therapeutical use thereof
US4851354A (en) 1987-12-07 1989-07-25 Trustees Of The University Of Pennsylvania Apparatus for mechanically stimulating cells
US4950296A (en) 1988-04-07 1990-08-21 Mcintyre Jonathan L Bone grafting units
US5354557A (en) 1988-04-08 1994-10-11 Stryker Corporation Osteogenic devices
IL89964A0 (en) 1988-04-15 1989-12-15 Montefiore Med Center Method for determining malignant progression,cdna,polypeptides encoded thereby and pharmaceutical compositions containing the same
US4880610A (en) 1988-04-20 1989-11-14 Norian Corporation In situ calcium phosphate minerals--method and composition
CH674139A5 (en) 1988-04-21 1990-05-15 Sulzer Ag
US4904259A (en) 1988-04-29 1990-02-27 Samuel Itay Compositions and methods for repair of cartilage and bone
US5053050A (en) 1988-04-29 1991-10-01 Samuel Itay Compositions for repair of cartilage and bone
US5010892A (en) 1988-05-04 1991-04-30 Triangle Research And Development Corp. Body lumen measuring instrument
US4837379A (en) 1988-06-02 1989-06-06 Organogenesis Inc. Fibrin-collagen tissue equivalents and methods for preparation thereof
US5496722A (en) 1988-06-30 1996-03-05 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method for producing non-neoplastic, three dimensional, mammalian tissue and cell aggregates under microgravity culture conditions and the products produced therefrom
US4950483A (en) 1988-06-30 1990-08-21 Collagen Corporation Collagen wound healing matrices and process for their production
US4902508A (en) 1988-07-11 1990-02-20 Purdue Research Foundation Tissue graft composition
DE3823737A1 (en) 1988-07-13 1990-01-18 Lutz Biedermann CORRECTION AND HOLDING DEVICE, ESPECIALLY FOR THE SPINE
DE3826915A1 (en) 1988-08-09 1990-02-15 Henkel Kgaa NEW MATERIALS FOR BONE REPLACEMENT AND BONE OR PROSTHESIS COMPOSITION
US5352589A (en) 1988-09-16 1994-10-04 Farmitalia Carlo Erba S.R.L. Deletion mutant of basic fibroblast growth factor and production thereof
US5614587A (en) 1988-11-21 1997-03-25 Collagen Corporation Collagen-based bioadhesive compositions
US5565519A (en) 1988-11-21 1996-10-15 Collagen Corporation Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications
US5475052A (en) 1988-11-21 1995-12-12 Collagen Corporation Collagen-synthetic polymer matrices prepared using a multiple step reaction
US5306500A (en) 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
US4971954A (en) 1988-11-23 1990-11-20 University Of Medicine And Dentistry Of New Jersey Collagen-based matrices ribose cross-linked
FR2646438B1 (en) 1989-03-20 2007-11-02 Pasteur Institut A METHOD FOR SPECIFIC REPLACEMENT OF A COPY OF A GENE PRESENT IN THE RECEIVER GENOME BY INTEGRATION OF A GENE DIFFERENT FROM THAT OR INTEGRATION
US4963146A (en) 1989-04-20 1990-10-16 Colla-Tec Incorporated Multi-layered, semi-permeable conduit for nerve regeneration
US5191067A (en) 1989-04-27 1993-03-02 The Salk Institute For Biological Studies Fibroblast growth factor conjugates
US5576288A (en) 1989-04-27 1996-11-19 The Salk Institute For Biological Studies Fibroblast growth factor conjugates
US6551784B2 (en) 1989-06-07 2003-04-22 Affymetrix Inc Method of comparing nucleic acid sequences
EP0437576B1 (en) 1989-07-25 2002-07-03 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
US5356883A (en) 1989-08-01 1994-10-18 Research Foundation Of State University Of N.Y. Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use
US5290558A (en) 1989-09-21 1994-03-01 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
US5073373A (en) 1989-09-21 1991-12-17 Osteotech, Inc. Flowable demineralized bone powder composition and its use in bone repair
JPH03129862A (en) 1989-10-16 1991-06-03 Nec Corp Glass sealed type semiconductor device
US5256476A (en) 1989-11-02 1993-10-26 Kuraray Chemical Co., Ltd. Fan blade comprising adsorbent particles, fine plastic particles and reinforcing fibers
US5236456A (en) 1989-11-09 1993-08-17 Osteotech, Inc. Osteogenic composition and implant containing same
US5152791A (en) 1989-12-07 1992-10-06 Olympus Optical Co., Ltd. Prosthetic artificial bone having ceramic layers of different porosity
US5067964A (en) 1989-12-13 1991-11-26 Stryker Corporation Articular surface repair
JP3130313B2 (en) 1989-12-19 2001-01-31 武田薬品工業株式会社 Method for producing human bFGF mutein
US5118512A (en) 1990-01-23 1992-06-02 Osteotech, Inc. (A Delaware Corp.) Process for cryopreserving biological materials and materials prepared thereby
FR2657352B1 (en) 1990-01-25 1993-08-13 France Etat Armement NOVEL BIOLOGICAL CONJUNCTIVE TISSUE REPLACEMENT PRODUCT, WITH COMPOSITE STRUCTURE BASED ON COLLAGEN, AND PROCESS FOR ITS PREPARATION.
US5425769A (en) 1990-04-23 1995-06-20 Snyders, Jr.; Robert V. Composition of material for osseous repair
FR2664808A1 (en) 1990-07-23 1992-01-24 Gersberg Eduardo System of dental implants
US5067963A (en) 1990-08-21 1991-11-26 Washington University Method of making live autogenous skeletal replacement parts
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
ES2076467T3 (en) 1990-10-31 1995-11-01 El Gendler FLEXIBLE MEMBRANES PRODUCED WITH ORGANIC BONE MATTER FOR THE REPAIR AND RECONSTRUCTION OF PARTS OF THE SKELETON.
US5226914A (en) 1990-11-16 1993-07-13 Caplan Arnold I Method for treating connective tissue disorders
JP3028375B2 (en) 1990-11-20 2000-04-04 三菱マテリアル株式会社 Apatite whisker and method for producing the same
DK0486862T3 (en) 1990-11-23 1996-06-24 American Cyanamid Co Chimeric fibrolast growth factor
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5270197A (en) 1990-12-20 1993-12-14 The Children's Medical Center Corporation Cells expressing a substantial number of surface high affinity HBGF receptors but relatively few low affinity HBGF binding sites and system for assaying binding to HBGF receptor
US5853746A (en) 1991-01-31 1998-12-29 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrier
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5206023A (en) 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5206028A (en) 1991-02-11 1993-04-27 Li Shu Tung Dense collagen membrane matrices for medical uses
JP3385040B2 (en) 1991-02-14 2003-03-10 武田薬品工業株式会社 Glial activator and method for producing the same
US5192312A (en) 1991-03-05 1993-03-09 Colorado State University Research Foundation Treated tissue for implantation and methods of treatment and use
CZ232593A3 (en) 1991-05-02 1994-07-13 Yeda Res & Dev Pharmaceutical preparation for preventing and/or therapy of pathological states
DE4215137A1 (en) 1991-06-04 1992-12-10 Man Ceramics Gmbh IMPLANT FOR SPINE PILLARS
US6440427B1 (en) 1991-06-17 2002-08-27 Biovitrum Ab Tissue treatment composition comprising fibrin or fibrinogen and biodegradable and biocompatible polymer
SE9101853D0 (en) 1991-06-17 1991-06-17 Jonas Wadstroem IMPROVED TISSUE ASHESIVE
DE4120325A1 (en) 1991-06-20 1992-12-24 Merck Patent Gmbh IMPLANT MATERIAL
DE4121043A1 (en) 1991-06-26 1993-01-07 Merck Patent Gmbh BONE REPLACEMENT MATERIAL WITH FGF
US5356629A (en) 1991-07-12 1994-10-18 United States Surgical Corporation Composition for effecting bone repair
US5092887A (en) 1991-08-12 1992-03-03 El Gendler Artificial ligament produced from demineralized bone for the replacement and augmentation of ligaments, tendons and other fibrous connective tissue
US6503277B2 (en) 1991-08-12 2003-01-07 Peter M. Bonutti Method of transplanting human body tissue
US5329846A (en) 1991-08-12 1994-07-19 Bonutti Peter M Tissue press and system
AU2515992A (en) 1991-08-20 1993-03-16 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US5270300A (en) 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone
US5281422A (en) 1991-09-24 1994-01-25 Purdue Research Foundation Graft for promoting autogenous tissue growth
US5284155A (en) 1991-12-06 1994-02-08 The General Hospital Corporation Cartilage degradation assay system
US5513662A (en) 1991-12-31 1996-05-07 Osteotech, Inc. Preparation of bone for transplantation
US5281265A (en) 1992-02-03 1994-01-25 Liu Sung Tsuen Resorbable surgical cements
US5314476A (en) 1992-02-04 1994-05-24 Osteotech, Inc. Demineralized bone particles and flowable osteogenic composition containing same
US6013853A (en) 1992-02-14 2000-01-11 The University Of Texas System Continuous release polymeric implant carrier
US5876452A (en) 1992-02-14 1999-03-02 Board Of Regents, University Of Texas System Biodegradable implant
JPH07503869A (en) 1992-02-14 1995-04-27 ボード・オヴ・リージェンツ，ザ・ユニヴァーシティ・オヴ・テキサス・システム Multiphasic bioerodible implant materials or carriers and methods of manufacture and use thereof
EP0626868A1 (en) 1992-02-19 1994-12-07 EBERLIN, Jean-Luc Collagen- and fibrin adhesive-based graft for osteocartilaginous reconstruction, and preparation method therefor
US5326357A (en) 1992-03-18 1994-07-05 Mount Sinai Hospital Corporation Reconstituted cartridge tissue
GB9206509D0 (en) 1992-03-25 1992-05-06 Jevco Ltd Heteromorphic sponges containing active agents
US5256140A (en) 1992-03-27 1993-10-26 Fallien Cosmeceuticals, Ltd. Composition for levelling skin
GB9206874D0 (en) 1992-03-30 1992-05-13 Connaught Lab Generation of improved inducible mammalian expression vectors
JP3170693B2 (en) * 1992-07-09 2001-05-28 株式会社高研 Collagen carrier for cell culture and method for producing the same
AU4693093A (en) 1992-07-27 1994-02-14 Haemacure Biotech Inc. Biocompatible surgical implant
US5800537A (en) 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
CA2141851A1 (en) 1992-08-07 1994-02-17 Eugene Bell Production of graft tissue from extracellular matrix
US5352463A (en) 1992-11-13 1994-10-04 Badylak Steven F Tissue graft for surgical reconstruction of a collagenous meniscus and method therefor
US5275826A (en) 1992-11-13 1994-01-04 Purdue Research Foundation Fluidized intestinal submucosa and its use as an injectable tissue graft
GB9225890D0 (en) 1992-12-11 1993-02-03 Eaton Corp Downshift inhibitor
EP0608546A3 (en) 1992-12-22 1995-09-27 Takeda Chemical Industries Ltd Glia activating factor (gaf), antibodies against it and their uses.
US5656492A (en) 1993-02-12 1997-08-12 Brigham And Women's Hospital, Inc. Cell induction device
FI92465C (en) 1993-04-14 1994-11-25 Risto Tapani Lehtinen A method for handling endo-osteal materials
US5606793A (en) 1993-05-24 1997-03-04 Texas Instruments Incorporated Multiple component assembly alignment tool
US5549904A (en) 1993-06-03 1996-08-27 Orthogene, Inc. Biological adhesive composition and method of promoting adhesion between tissue surfaces
US5589362A (en) 1993-06-14 1996-12-31 Basf Aktiengesellschaft Tetracycline regulated transcriptional modulators with altered DNA binding specificities
WO1994029442A2 (en) 1993-06-14 1994-12-22 Basf Aktiengesellschaft Tight control of gene expression in eucaryotic cells by tetracycline-responsive promoters
US5866755A (en) 1993-06-14 1999-02-02 Basf Aktiengellschaft Animals transgenic for a tetracycline-regulated transcriptional inhibitor
US6140087A (en) 1993-06-24 2000-10-31 Advec, Inc. Adenovirus vectors for gene therapy
US5380328A (en) 1993-08-09 1995-01-10 Timesh, Inc. Composite perforated implant structures
CA2149900C (en) 1993-09-24 2003-06-24 Yasuo Shikinami Implant material
US5491220A (en) 1993-09-24 1996-02-13 Yeda Research And Development Co., Ltd. Surface loop structural analogues of fibroblast growth factors
US5653730A (en) 1993-09-28 1997-08-05 Hemodynamics, Inc. Surface opening adhesive sealer
US5916557A (en) 1993-11-12 1999-06-29 The Trustees Of Columbia University In The City Of New York Methods of repairing connective tissues
US5616568A (en) 1993-11-30 1997-04-01 The Research Foundation Of State University Of New York Functionalized derivatives of hyaluronic acid
US5507813A (en) 1993-12-09 1996-04-16 Osteotech, Inc. Shaped materials derived from elongate bone particles
US5411885A (en) 1993-12-17 1995-05-02 New York Blood Center, Inc. Methods for tissue embedding and tissue culturing
CA2180980A1 (en) 1994-01-13 1995-07-20 Franciscus Abraham Antonius Tetteroo Method for the production of desiccation tolerant plant embryoids and methods for germination of desiccation tolerant embryoids
FR2715309B1 (en) 1994-01-24 1996-08-02 Imedex Adhesive composition, for surgical use, based on collagen modified by oxidative cutting and not crosslinked.
US5417602A (en) 1994-01-25 1995-05-23 Mcgraw; James E. Flying device having staggered parallel airfoils
US5837458A (en) 1994-02-17 1998-11-17 Maxygen, Inc. Methods and compositions for cellular and metabolic engineering
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US5763416A (en) 1994-02-18 1998-06-09 The Regent Of The University Of Michigan Gene transfer into bone cells and tissues
US5656598A (en) 1994-03-08 1997-08-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Use of fibroblast growth factors to stimulate bone growth
DK0881908T3 (en) 1994-03-08 2004-10-25 Osteosa Inc Use of fiber blast growth factors to stimulate bone growth
DK0871414T3 (en) 1994-03-14 2004-08-30 Cryolife Inc Methods for preparing tissue for implantation
WO1995025748A1 (en) 1994-03-18 1995-09-28 Baxter International Inc. Topical fibrinogen complex
CA2142209A1 (en) 1994-03-29 1995-09-30 George H. Chu Collagen implants having improved tensile properties
US5916265A (en) 1994-03-30 1999-06-29 Hu; Jie Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant
US5618925A (en) 1994-04-28 1997-04-08 Les Laboratories Aeterna Inc. Extracts of shark cartilage having an anti-angiogenic activity and an effect on tumor regression; process of making thereof
US6025334A (en) 1994-04-28 2000-02-15 Les Laboratoires Aeterna Inc. Extracts of shark cartilage having anti-collagenolytic, anti-inflammatory, anti-angiogenic and anti-tumoral activities; process of making, methods of using and compositions thereof
US5723331A (en) 1994-05-05 1998-03-03 Genzyme Corporation Methods and compositions for the repair of articular cartilage defects in mammals
DE69530553T2 (en) 1994-05-13 2004-03-25 KURARAY CO., LTD, Kurashiki MEDICAL POLYMER GEL
US7963997B2 (en) 2002-07-19 2011-06-21 Kensey Nash Corporation Device for regeneration of articular cartilage and other tissue
US5906827A (en) 1994-06-03 1999-05-25 Creative Biomolecules, Inc. Matrix for the manufacture of autogenous replacement body parts
US6174333B1 (en) 1994-06-06 2001-01-16 Osiris Therapeutics, Inc. Biomatrix for soft tissue regeneration using mesenchymal stem cells
IL110367A (en) 1994-07-19 2007-05-15 Colbar Lifescience Ltd Collagen-based matrix
US5834029A (en) 1994-07-20 1998-11-10 Cytotherapeutics, Inc. Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell adhesive peptide fragment
US5583114A (en) 1994-07-27 1996-12-10 Minnesota Mining And Manufacturing Company Adhesive sealant composition
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
US5769899A (en) 1994-08-12 1998-06-23 Matrix Biotechnologies, Inc. Cartilage repair unit
US5632745A (en) 1995-02-07 1997-05-27 R&D Biologicals, Inc. Surgical implantation of cartilage repair unit
US5707962A (en) 1994-09-28 1998-01-13 Gensci Regeneration Sciences Inc. Compositions with enhanced osteogenic potential, method for making the same and therapeutic uses thereof
TW369414B (en) 1994-09-30 1999-09-11 Yamanouchi Pharma Co Ltd Bone formation transplant
US6294202B1 (en) 1994-10-06 2001-09-25 Genzyme Corporation Compositions containing polyanionic polysaccharides and hydrophobic bioabsorbable polymers
US20010011131A1 (en) 1997-07-28 2001-08-02 Luyten Frank P. DNA molecules encoding cartilage-derived morphogenetic proteins
WO2003035851A1 (en) 2001-10-23 2003-05-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem In vitro micro-organs, and uses related thereto
US5709934A (en) 1994-11-22 1998-01-20 Tissue Engineering, Inc. Bipolymer foams having extracellular matrix particulates
US6599515B1 (en) 1995-01-16 2003-07-29 Baxter International Inc. Fibrin porous structure
ATE244584T1 (en) 1995-01-16 2003-07-15 Baxter Int SELF-SUPPORTING SURFACES MADE OF CROSS-LINKED FIBRIN FOR INHIBITING POSTOPERATIVE ADHESIONS
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5749874A (en) 1995-02-07 1998-05-12 Matrix Biotechnologies, Inc. Cartilage repair unit and method of assembling same
US6080194A (en) 1995-02-10 2000-06-27 The Hospital For Joint Disease Orthopaedic Institute Multi-stage collagen-based template or implant for use in the repair of cartilage lesions
US5695998A (en) 1995-02-10 1997-12-09 Purdue Research Foundation Submucosa as a growth substrate for islet cells
US5713374A (en) 1995-02-10 1998-02-03 The Hospital For Joint Diseases Orthopaedic Institute Fixation method for the attachment of wound repair materials to cartilage defects
GB9503492D0 (en) 1995-02-22 1995-04-12 Ed Geistlich S Hne A G F R Che Chemical product
US7141072B2 (en) 1998-10-05 2006-11-28 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering
GB9721585D0 (en) 1997-10-10 1997-12-10 Geistlich Soehne Ag Chemical product
US5782835A (en) 1995-03-07 1998-07-21 Innovasive Devices, Inc. Apparatus and methods for articular cartilage defect repair
US5554389A (en) 1995-04-07 1996-09-10 Purdue Research Foundation Urinary bladder submucosa derived tissue graft
US5733337A (en) 1995-04-07 1998-03-31 Organogenesis, Inc. Tissue repair fabric
EP0821573A4 (en) 1995-04-19 2000-08-09 St Jude Medical Matrix substrate for a viable body tissue-derived prosthesis and method for making the same
US5904716A (en) 1995-04-26 1999-05-18 Gendler; El Method for reconstituting cartilage tissue using demineralized bone and product thereof
US6060640A (en) 1995-05-19 2000-05-09 Baxter International Inc. Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
US5676976A (en) 1995-05-19 1997-10-14 Etex Corporation Synthesis of reactive amorphous calcium phosphates
US6027742A (en) 1995-05-19 2000-02-22 Etex Corporation Bioresorbable ceramic composites
US6039762A (en) 1995-06-07 2000-03-21 Sdgi Holdings, Inc. Reinforced bone graft substitutes
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
US6517872B1 (en) 1995-06-12 2003-02-11 Yeda Research And Development Co., Ltd. FGFR3 as a marker for mesenchymal skeletal progenitor cells
US6110746A (en) 1995-06-30 2000-08-29 Yeda Research And Development Co. Ltd. Peptides derived from human heat shock protein 60 for treatment of diabetes, compositions, methods and kits
GB9517780D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9517779D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
US5782915A (en) 1995-09-15 1998-07-21 Stone; Kevin R. Articular cartilage heterografts
ATE192779T1 (en) 1995-10-06 2000-05-15 Microcloning Cccd Ab COMPACT CELL CULTURE DISK
US5716413A (en) 1995-10-11 1998-02-10 Osteobiologics, Inc. Moldable, hand-shapable biodegradable implant material
US6902584B2 (en) 1995-10-16 2005-06-07 Depuy Spine, Inc. Bone grafting matrix
US5989289A (en) 1995-10-16 1999-11-23 Sdgi Holdings, Inc. Bone grafts
US5776193A (en) 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US5965125A (en) 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
US20020111695A1 (en) 1995-11-06 2002-08-15 Mount Sinai Hospital Corporation Reconstituted mineralized cartilage tissue
US5837534A (en) 1995-11-14 1998-11-17 The Board Of Regents Of The University Of Texas System Smooth muscle 22α promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells
US5630982A (en) 1995-12-12 1997-05-20 Sonoco Products Company Method and apparatus for extruding plastic tubing
IL116477A (en) 1995-12-21 2000-02-29 Hadasit Med Res Service Bone graft substitute and process for producing same
US5814084A (en) 1996-01-16 1998-09-29 University Of Florida Tissue Bank, Inc. Diaphysial cortical dowel
US5964724A (en) 1996-01-31 1999-10-12 Medtronic Electromedics, Inc. Apparatus and method for blood separation
WO1997029715A1 (en) 1996-02-20 1997-08-21 Fusion Medical Technologies, Inc. Compositions and methods for sealing tissue and preventing post-surgical adhesions
US5842477A (en) 1996-02-21 1998-12-01 Advanced Tissue Sciences, Inc. Method for repairing cartilage
US6352558B1 (en) 1996-02-22 2002-03-05 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Method for promoting regeneration of surface cartilage in a damage joint
AU2530797A (en) 1996-02-27 1997-09-16 Michigan State University Cloning and expression of the gene encoding thermoanaerobacter ethanolicus 39E secondary-alcohol dehydrogenase and enzyme biochemical c haracterization
US6221854B1 (en) 1996-03-05 2001-04-24 Orquest, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
US5700774A (en) 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
US5876444A (en) 1996-04-01 1999-03-02 Lai; Wen-Fu Reconstituted collagen template and the process to prepare the same
US5755791A (en) 1996-04-05 1998-05-26 Purdue Research Foundation Perforated submucosal tissue graft constructs
US5788625A (en) 1996-04-05 1998-08-04 Depuy Orthopaedics, Inc. Method of making reconstructive SIS structure for cartilaginous elements in situ
US6465438B1 (en) 1996-04-19 2002-10-15 Metin Colpan Nucleic acid vaccination for parvoviral infections
EP0906415B1 (en) 1996-04-19 2009-08-19 Osiris Therapeutics, Inc. Regeneration and augmentation of bone using mesenchymal stem cells
IL118376A0 (en) 1996-05-22 1996-09-12 Univ Ben Gurion Polysaccharide sponges for cell culture and transplantation
ATE250666T1 (en) 1996-06-04 2003-10-15 Sulzer Orthopedics Ltd METHOD FOR PRODUCING CARTILAGE TISSUE AND IMPLANTS
JPH1020974A (en) 1996-07-03 1998-01-23 Fujitsu Ltd Bus structure and input/output buffer
JP3638614B2 (en) 1996-07-25 2005-04-13 ジェンザイム・コーポレーション Chondrocyte medium composition and culture method
US6054142A (en) 1996-08-01 2000-04-25 Cyto Therapeutics, Inc. Biocompatible devices with foam scaffolds
US6280473B1 (en) 1996-08-19 2001-08-28 Macropore, Inc. Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration
US6666892B2 (en) 1996-08-23 2003-12-23 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
US5759190A (en) 1996-08-30 1998-06-02 Vts Holdings Limited Method and kit for autologous transplantation
US6569172B2 (en) 1996-08-30 2003-05-27 Verigen Transplantation Service International (Vtsi) Method, instruments, and kit for autologous transplantation
US5989269A (en) 1996-08-30 1999-11-23 Vts Holdings L.L.C. Method, instruments and kit for autologous transplantation
US6189537B1 (en) 1996-09-06 2001-02-20 Lifenet Process for producing osteoinductive bone, and osteoinductive bone produced thereby
US5964805A (en) 1997-02-12 1999-10-12 Stone; Kevin R. Method and paste for articular cartilage transplantation
US5881733A (en) 1996-09-13 1999-03-16 Depuy Orthopaedic Technology, Inc. Technique for osteocartilaginous transplantation in a mammalian joint
US6165487A (en) 1996-09-30 2000-12-26 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue
WO1998014222A1 (en) 1996-09-30 1998-04-09 Children's Medical Center Corporation Methods and compositions for programming an organic matrix for remodeling into a target tissue
AU725551B2 (en) 1996-10-16 2000-10-12 Zymogenetics Inc. Fibroblast growth factor homologs
CA2269342C (en) 1996-10-23 2006-09-12 Sdgi Holdings, Inc. Spinal spacer
US5974663A (en) 1996-10-25 1999-11-02 Honda Giken Kogya Kabushiki Kaisha Method of manufacturing connecting rod
JP4676580B2 (en) 1996-11-05 2011-04-27 パーデュー・リサーチ・ファウンデーション Myocardial graft composition
EP1230902A1 (en) 1996-11-15 2002-08-14 Advanced Bio Surfaces, Inc. Biomaterial system for in situ tissue repair
DE19647853A1 (en) 1996-11-19 1998-05-20 Bioph Biotech Entw Pharm Gmbh Compounds with improved cartilage and / or bone inducing activity
US5928945A (en) 1996-11-20 1999-07-27 Advanced Tissue Sciences, Inc. Application of shear flow stress to chondrocytes or chondrocyte stem cells to produce cartilage
US5728159A (en) 1997-01-02 1998-03-17 Musculoskeletal Transplant Foundation Serrated bone graft
US5976524A (en) 1997-01-06 1999-11-02 Washington University Chimeric kidney
US7468075B2 (en) 2001-05-25 2008-12-23 Conformis, Inc. Methods and compositions for articular repair
US5866165A (en) 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
AU6267798A (en) 1997-02-07 1998-08-26 Stryker Corporation Matrix-free osteogenic devices, implants and methods of use thereof
US6146385A (en) 1997-02-11 2000-11-14 Smith & Nephew, Inc. Repairing cartilage
GB9704749D0 (en) 1997-03-07 1997-04-23 Univ London Tissue Implant
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
US5866415A (en) 1997-03-25 1999-02-02 Villeneuve; Peter E. Materials for healing cartilage and bone defects
US5824055A (en) 1997-03-25 1998-10-20 Endotex Interventional Systems, Inc. Stent graft delivery system and methods of use
US6001352A (en) 1997-03-31 1999-12-14 Osteobiologics, Inc. Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor
CA2307954C (en) 1997-04-03 2010-07-13 California Institute Of Technology Enzyme-medicated modification of fibrin for tissue engineering
JP4394169B2 (en) 1997-04-04 2010-01-06 バーンズ − ジューウィッシュ・ホスピタル New cartilage and methods of use
US6489455B2 (en) 1997-05-21 2002-12-03 Clontech Laboratories, Inc. Methods of assaying differential expression
AU738334B2 (en) 1997-05-30 2001-09-13 Osteobiologics, Inc. Fiber-reinforced, porous, biodegradable implant device
US7524335B2 (en) 1997-05-30 2009-04-28 Smith & Nephew, Inc. Fiber-reinforced, porous, biodegradable implant device
US5972368A (en) 1997-06-11 1999-10-26 Sdgi Holdings, Inc. Bone graft composites and spacers
WO1999001143A1 (en) 1997-07-03 1999-01-14 Orquest, Inc. Cross-linked polysaccharide drug carrier
US5910315A (en) 1997-07-18 1999-06-08 Stevenson; Sharon Allograft tissue material for filling spinal fusion cages or related surgical spaces
US6090996A (en) 1997-08-04 2000-07-18 Collagen Matrix, Inc. Implant matrix
US6110209A (en) 1997-08-07 2000-08-29 Stone; Kevin R. Method and paste for articular cartilage transplantation
US6511958B1 (en) 1997-08-14 2003-01-28 Sulzer Biologics, Inc. Compositions for regeneration and repair of cartilage lesions
ATE220564T1 (en) 1997-08-14 2002-08-15 Sulzer Innotec Ag COMPOSITION AND DEVICE FOR REPAIRING CARTILAGE TISSUE IN VIVO CONSISTING OF NANOCAPSULES WITH OSTEOINDUCTIVE AND/OR CHONDROINDUCTIVE FACTORS
US7048762B1 (en) 1997-08-27 2006-05-23 Regeneration Technologies, Inc. Elongated cortical bone implant
US20010031254A1 (en) 1998-11-13 2001-10-18 Bianchi John R. Assembled implant
WO1999009914A1 (en) 1997-08-27 1999-03-04 University Of Florida Tissue Bank, Inc. Cortical bone cervical smith-robinson fusion implant
US20020138143A1 (en) 1997-08-27 2002-09-26 Grooms Jamie M. Cortical bone cervical Smith-Robinson fusion implant
US6309659B1 (en) 1997-09-02 2001-10-30 Gensci Orthobiologics, Inc. Reverse phase connective tissue repair composition
US6077987A (en) 1997-09-04 2000-06-20 North Shore-Long Island Jewish Research Institute Genetic engineering of cells to enhance healing and tissue regeneration
AT407117B (en) 1997-09-19 2000-12-27 Immuno Ag FIBRINE SPONGE
US5998170A (en) 1997-10-03 1999-12-07 Amgen Inc. Polynucleotides encoding hepatocyte-specific members of the FGF family
US6417247B1 (en) 1997-10-14 2002-07-09 Beth L. Armstrong Polymer/ceramic composites
US6673768B1 (en) 1997-10-16 2004-01-06 Board Of Regents, The University Of Texas System Transgenic animal models for cardiac hypertrophy and methods of use thereof (treating)
US6090998A (en) 1997-10-27 2000-07-18 University Of Florida Segmentally demineralized bone implant
US6652592B1 (en) 1997-10-27 2003-11-25 Regeneration Technologies, Inc. Segmentally demineralized bone implant
WO1999021497A1 (en) 1997-10-27 1999-05-06 Sulzer Orthopädie Ag Method and instruments for repairing endochondral and osteochondral defects
US20030099620A1 (en) 1997-10-30 2003-05-29 The General Hospital Corporation Bonding of cartilaginous matrices using isolated chondrocytes
DE69831589T2 (en) 1997-10-30 2006-06-22 The General Hospital Corp., Boston COMPOSITION OF CARTILES USING ISOLATED CHONDROCYTES
US6274663B1 (en) 1997-10-30 2001-08-14 Showa Denko K.K. Compound resin composition
US6472210B1 (en) * 1997-11-14 2002-10-29 Bonetec Corporation Polymer scaffold having microporous polymer struts defining interconnected macropores
DE19751031A1 (en) * 1997-11-19 1999-06-24 Ingo Dipl Ing Heschel Process for the production of porous structures
US6197586B1 (en) 1997-12-12 2001-03-06 The Regents Of The University Of California Chondrocyte-like cells useful for tissue engineering and methods
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
US5899939A (en) 1998-01-21 1999-05-04 Osteotech, Inc. Bone-derived implant for load-supporting applications
US6712851B1 (en) 1998-01-23 2004-03-30 Macropore Biosurgery, Inc. Resorbable, macro-porous non-collapsing and flexible membrane barrier for skeletal repair and regeneration
DE19803673A1 (en) 1998-01-30 1999-08-05 Norbert M Dr Meenen Biohybrid joint replacement
US7087082B2 (en) 1998-08-03 2006-08-08 Synthes (Usa) Bone implants with central chambers
US6123731A (en) 1998-02-06 2000-09-26 Osteotech, Inc. Osteoimplant and method for its manufacture
US6607879B1 (en) 1998-02-09 2003-08-19 Incyte Corporation Compositions for the detection of blood cell and immunological response gene expression
US6030635A (en) 1998-02-27 2000-02-29 Musculoskeletal Transplant Foundation Malleable paste for filling bone defects
US6437018B1 (en) 1998-02-27 2002-08-20 Musculoskeletal Transplant Foundation Malleable paste with high molecular weight buffered carrier for filling bone defects
US6911212B2 (en) 1998-02-27 2005-06-28 Musculoskeletal Transplant Foundation Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects
US6056777A (en) 1998-02-27 2000-05-02 Mcdowell; Charles L. Method and device for regenerating cartilage in articulating
US6458375B1 (en) 1998-02-27 2002-10-01 Musculoskeletal Transplant Foundation Malleable paste with allograft bone reinforcement for filling bone defects
US7019192B2 (en) 1998-02-27 2006-03-28 Musculoskeletal Transplant Foundation Composition for filling bone defects
US7045141B2 (en) 1998-02-27 2006-05-16 Musculoskeletal Transplant Foundation Allograft bone composition having a gelatin binder
US6143293A (en) 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
US6378527B1 (en) 1998-04-08 2002-04-30 Chondros, Inc. Cell-culture and polymer constructs
US20040044408A1 (en) 1998-04-08 2004-03-04 Hungerford David S. Cell-culture and polymer constructs
US6027744A (en) 1998-04-24 2000-02-22 University Of Massachusetts Medical Center Guided development and support of hydrogel-cell compositions
US6171610B1 (en) 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
JP4468577B2 (en) 1998-05-01 2010-05-26 ザイモジェネティクス，インコーポレイティド Completely recombinant tissue sealant composition
KR100267276B1 (en) 1998-06-16 2000-10-16 김영환 Base station maximum traffic capacity output method using markov call in digital mobile communcation system
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
US6734018B2 (en) 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
US20080077251A1 (en) 1999-06-07 2008-03-27 Chen Silvia S Cleaning and devitalization of cartilage
US6293970B1 (en) 1998-06-30 2001-09-25 Lifenet Plasticized bone and soft tissue grafts and methods of making and using same
DE69911609T2 (en) 1998-07-13 2004-07-01 University Of Southern California, Los Angeles PROCESS FOR ACCELERATING THE GROWTH AND HEALING OF BONES AND CARTILES
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
AU5341999A (en) 1998-08-06 2000-02-28 Sdgi Holdings, Inc. Composited intervertebral bone spacers
KR20040077968A (en) 1998-08-14 2004-09-07 페리겐 트란스플란타치온 서비스 인터나치오날 (파우테에스이) 아게 Methods, instruments and materials for chondrocyte cell transplantation
US6187000B1 (en) 1998-08-20 2001-02-13 Endius Incorporated Cannula for receiving surgical instruments
US6530956B1 (en) 1998-09-10 2003-03-11 Kevin A. Mansmann Resorbable scaffolds to promote cartilage regeneration
WO2000017321A2 (en) 1998-09-18 2000-03-30 Massachusetts Institute Of Technology Use of growth factors and hormones for expansion of mammalian cells and tissue engineering
US6630457B1 (en) 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
US20030225355A1 (en) 1998-10-01 2003-12-04 Butler Charles E. Composite material for wound repair
US6440934B1 (en) 1998-10-13 2002-08-27 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
JP2002527402A (en) 1998-10-14 2002-08-27 オークエスト インコーポレイテッド A method for inducing or enhancing cartilage formation with an extracellular matrix containing GDF-5.
US6174311B1 (en) 1998-10-28 2001-01-16 Sdgi Holdings, Inc. Interbody fusion grafts and instrumentation
DE19851334C2 (en) 1998-11-06 2000-09-28 Aventis Behring Gmbh Flexible fibrin-based wound dressing and process for its manufacture
US6497726B1 (en) 2000-01-11 2002-12-24 Regeneration Technologies, Inc. Materials and methods for improved bone tendon bone transplantation
US6761887B1 (en) 1998-11-16 2004-07-13 Osiris Therapeutics, Inc. Alginate layer system for chondrogenic differentiation of human mesenchymal stem cells
US6025538A (en) 1998-11-20 2000-02-15 Musculoskeletal Transplant Foundation Compound bone structure fabricated from allograft tissue
DE19855890A1 (en) 1998-12-03 2000-06-08 Nerlich Michael Porous composite matrix, its production and use
US6306174B1 (en) 1998-12-18 2001-10-23 Benoist Girard Sas Femoral component
US20020165611A1 (en) 1998-12-22 2002-11-07 Robert-Jan Enzerink Graft material convenience package
US6200347B1 (en) 1999-01-05 2001-03-13 Lifenet Composite bone graft, method of making and using same
US6547823B2 (en) 1999-01-22 2003-04-15 Osteotech, Inc. Intervertebral implant
US6727224B1 (en) 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
MXPA01007777A (en) 1999-02-01 2003-10-06 Eidgenoess Tech Hochschule Biomaterials formed by nucleophilic addition reaction to conjugated unsaturated groups.
CA2362049A1 (en) 1999-02-04 2000-08-10 Sdgi Holdings, Inc. Highly-mineralized osteogenic sponge compositions, and uses thereof
WO2000047214A1 (en) 1999-02-09 2000-08-17 Sloan-Kettering Institute For Cancer Research Anti-resorptive bone cements and allogeneic, autografic, and xenografic bone grafts
US6267786B1 (en) 1999-02-11 2001-07-31 Crosscart, Inc. Proteoglycan-reduced soft tissue xenografts
WO2000047114A1 (en) 1999-02-12 2000-08-17 Collagenesis, Inc. Injectable collagen-based delivery system for bone morphogenic proteins
US6696073B2 (en) 1999-02-23 2004-02-24 Osteotech, Inc. Shaped load-bearing osteoimplant and methods of making same
US6294187B1 (en) 1999-02-23 2001-09-25 Osteotech, Inc. Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same
US6197061B1 (en) 1999-03-01 2001-03-06 Koichi Masuda In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage
US6159179A (en) 1999-03-12 2000-12-12 Simonson; Robert E. Cannula and sizing and insertion method
US6662805B2 (en) 1999-03-24 2003-12-16 The Johns Hopkins University Method for composite cell-based implants
US6451319B1 (en) 1999-04-09 2002-09-17 Schering-Plough Veterinary Corporation Recombinant and mutant adenoviruses
WO2000061256A1 (en) 1999-04-12 2000-10-19 Harvest Technologies Corporation Method and apparatus for producing platelet rich plasma and/or platelet concentrate
US6103255A (en) 1999-04-16 2000-08-15 Rutgers, The State University Porous polymer scaffolds for tissue engineering
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US7371400B2 (en) 2001-01-02 2008-05-13 The General Hospital Corporation Multilayer device for tissue engineering
US6315992B1 (en) 1999-06-30 2001-11-13 Tissuegene Co. Generating cartilage in a mammal using fibroblasts transfected with a vector encoding TGF-β-1
US7338524B2 (en) 1999-05-10 2008-03-04 Fell Barry M Surgically implantable knee prosthesis
US7297161B2 (en) 1999-05-10 2007-11-20 Fell Barry M Surgically implantable knee prosthesis
US6251143B1 (en) 1999-06-04 2001-06-26 Depuy Orthopaedics, Inc. Cartilage repair unit
WO2001087369A2 (en) 2000-05-12 2001-11-22 Osteotech, Inc. Osteoimplant and method for making same
US6288043B1 (en) 1999-06-18 2001-09-11 Orquest, Inc. Injectable hyaluronate-sulfated polysaccharide conjugates
US6306424B1 (en) 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
AU782297B2 (en) * 1999-06-30 2005-07-14 Ethicon Inc. Porous tissue scaffoldings for the repair or regeneration of tissue
US6333029B1 (en) 1999-06-30 2001-12-25 Ethicon, Inc. Porous tissue scaffoldings for the repair of regeneration of tissue
US6652872B2 (en) 1999-07-06 2003-11-25 Ramat At Tel Aviv University Ltd. Scaffold formed of tissue treated to eliminate cellular and cytosolic elements
US6632651B1 (en) 1999-07-06 2003-10-14 Ramot At Tel Aviv University Ltd. Tissue maintenance system that applies rhythmic pulses of pressure
US7056885B1 (en) 1999-07-27 2006-06-06 Curagen Corporation Fibroblast growth factor and nucleic acids encoding same
EP1441028A3 (en) 1999-07-28 2005-01-05 Interface Biotech A/S Cell cultivation method for the preparation of chondrocytes/chondroblasts
WO2001010463A1 (en) 1999-08-05 2001-02-15 Takeda Chemical Industries, Ltd. Pastes with the sustained release of osteogenesis promoter
US6429013B1 (en) 1999-08-19 2002-08-06 Artecel Science, Inc. Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
US7078232B2 (en) 1999-08-19 2006-07-18 Artecel, Inc. Adipose tissue-derived adult stem or stromal cells for the repair of articular cartilage fractures and uses thereof
US6322563B1 (en) 1999-09-17 2001-11-27 Genzyme Corporation Small tissue and membrane fixation apparatus and methods for use thereof
US6592794B1 (en) 1999-09-28 2003-07-15 Organogenesis Inc. Process of making bioengineered collagen fibrils
US6528052B1 (en) 2000-09-29 2003-03-04 The Board Of Trustees Of The Leland Stanford Junior University Method for in vivo ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling
US7687462B2 (en) 1999-10-05 2010-03-30 The Regents Of The University Of California Composition for promoting cartilage formation or repair comprising a nell gene product and method of treating cartilage-related conditions using such composition
WO2001038357A2 (en) 1999-11-22 2001-05-31 Millennium Pharmaceuticals, Inc. Jaffa, a novel fibroblast growth factor family member and uses therefor
DE19957388A1 (en) 1999-11-24 2001-06-13 Michael Sittinger Chondroinductive and implantable substrates for cartilage healing and protection
ATE539157T1 (en) 1999-12-02 2012-01-15 Zymogenetics Inc METHODS THAT TARGET CELLS EXPRESSING THE FIBROBLAS GROWTH FACTOR RECEPTORS-3 OR -2
CA2390794C (en) 1999-12-03 2010-04-27 University Of Leeds Fixation technology
EP1498089A1 (en) 1999-12-15 2005-01-19 Zimmer GmbH Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints
US6623963B1 (en) 1999-12-20 2003-09-23 Verigen Ag Cellular matrix
US6579538B1 (en) 1999-12-22 2003-06-17 Acell, Inc. Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof
ES2275361T3 (en) 1999-12-22 2007-06-01 Ortho-Mcneil Pharmaceutical, Inc. ANALOGS OF THE BASIC HUMAN FIBROBLASTIC GROWTH FACTOR.
US6576265B1 (en) 1999-12-22 2003-06-10 Acell, Inc. Tissue regenerative composition, method of making, and method of use thereof
US6376244B1 (en) 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
US6458144B1 (en) 1999-12-30 2002-10-01 Osteotech, Inc. Methods for manufacturing skeletal implants
US6379385B1 (en) 2000-01-06 2002-04-30 Tutogen Medical Gmbh Implant of bone matter
US6893462B2 (en) 2000-01-11 2005-05-17 Regeneration Technologies, Inc. Soft and calcified tissue implants
US20030095993A1 (en) 2000-01-28 2003-05-22 Hanne Bentz Gel-infused sponges for tissue repair and augmentation
BR0107890B1 (en) 2000-01-28 2010-09-08 process for decrypting and / or destroying liquid slag.
WO2001078798A1 (en) 2000-02-10 2001-10-25 Regeneration Technologies, Inc. Assembled implant
US6371958B1 (en) 2000-03-02 2002-04-16 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US7182781B1 (en) 2000-03-02 2007-02-27 Regeneration Technologies, Inc. Cervical tapered dowel
JP3865354B2 (en) 2000-03-02 2007-01-10 高木産業株式会社 Cell or tissue culture method
US6591581B2 (en) 2000-03-08 2003-07-15 Arthrex, Inc. Method for preparing and inserting round, size specific osteochondral cores in the knee
US6626945B2 (en) 2000-03-14 2003-09-30 Chondrosite, Llc Cartilage repair plug
AR027685A1 (en) 2000-03-22 2003-04-09 Synthes Ag METHOD AND METHOD FOR CARRYING OUT
EP1265630B1 (en) 2000-03-24 2006-06-07 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
US6629997B2 (en) 2000-03-27 2003-10-07 Kevin A. Mansmann Meniscus-type implant with hydrogel surface reinforced by three-dimensional mesh
US6932977B2 (en) 2000-04-14 2005-08-23 Depuy Spine, Inc. Method of inducing or enhancing chondrogenesis with extracellular matrix containing BMP-4
US6375935B1 (en) 2000-04-28 2002-04-23 Brent R. Constantz Calcium phosphate cements prepared from silicate solutions
US6520964B2 (en) 2000-05-01 2003-02-18 Std Manufacturing, Inc. System and method for joint resurface repair
US6993328B1 (en) 2000-05-08 2006-01-31 Nokia Corporation Method for over the air mobile station management
US7108721B2 (en) 2000-05-11 2006-09-19 Massachusetts Institute Of Technology Tissue regrafting
US6488033B1 (en) 2000-05-15 2002-12-03 Cryolife, Inc. Osteochondral transplant techniques
US6686184B1 (en) 2000-05-25 2004-02-03 President And Fellows Of Harvard College Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks
US6790454B1 (en) 2000-05-26 2004-09-14 Coletica Processes for the preparation of novel collagen-based supports for tissue engineering, and biomaterials obtained
CA2346362C (en) 2000-05-26 2010-06-15 Stemcell Technologies Inc. Novel antibody compositions for preparing enriched mesenchymal progenitor preparations
US6896684B2 (en) 2000-06-12 2005-05-24 Niti Medical Technologies Ltd. Surgical clip applicator device
US6991652B2 (en) 2000-06-13 2006-01-31 Burg Karen J L Tissue engineering composite
US6533821B1 (en) 2000-06-22 2003-03-18 Thomas Lally Bio-adhesive composition, method for adhering objects to bone
US20050158362A1 (en) 2000-06-23 2005-07-21 Wheatley Margaret A. Polymeric, fiber matrix delivery systems for bioactive compounds
BR0112109A (en) 2000-06-29 2007-05-29 Biosyntech Canada Inc composition and method for the correction and regeneration of cartilage and other tissues
TR200400527T4 (en) 2000-07-03 2004-07-21 Osteotech Inc. Bone-derived osteogenic implants
US7018416B2 (en) 2000-07-06 2006-03-28 Zimmer Spine, Inc. Bone implants and methods
DK177997B1 (en) 2000-07-19 2015-02-23 Ed Geistlich Söhne Ag Für Chemische Ind Bone material and collagen combination for healing of damaged joints
US9387094B2 (en) 2000-07-19 2016-07-12 Warsaw Orthopedic, Inc. Osteoimplant and method of making same
ATE277174T1 (en) 2000-07-20 2004-10-15 Univ Texas STIMULATION OF CARTILAGE GROWTH WITH AGONISTS OF THE NON-PROTEOLYTICALLY ACTIVATED THROMBIN RECEPTOR
US6440141B1 (en) 2000-07-24 2002-08-27 Oratec Interventions, Inc. Method and apparatus for treating osteochondral pathologies
AU2001275746B2 (en) 2000-07-29 2007-04-26 Smith & Nephew Plc Tissue implant for cartilage repair
US8366787B2 (en) 2000-08-04 2013-02-05 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
DE60116513T2 (en) 2000-08-10 2006-09-21 Crucell Holland B.V. ADENOVIRENVEKTOREN FOR THE TRANSDUCTION OF CHONDROCYTES
US6406476B1 (en) 2000-08-15 2002-06-18 Kirwan Surgical Products, Inc. Bipolar, fluid assisted coagulator/ablator probe for arthroscopy
US6962814B2 (en) 2000-08-16 2005-11-08 Duke University Decellularized tissue engineered constructs and tissues
WO2002016557A2 (en) 2000-08-21 2002-02-28 Rice University Tissue engineering scaffolds promoting matrix protein production
DE10042484A1 (en) 2000-08-29 2002-03-28 Merck Patent Gmbh Preparing human cartilage implants, useful for repairing damaged joints, comprises culturing autologous chondrocytes in alginate gel at reduced oxygen partial pressure
US6773723B1 (en) 2000-08-30 2004-08-10 Depuy Acromed, Inc. Collagen/polysaccharide bilayer matrix
US6620196B1 (en) 2000-08-30 2003-09-16 Sdgi Holdings, Inc. Intervertebral disc nucleus implants and methods
AU2001287023A1 (en) 2000-09-01 2002-03-13 Virginia Commonwealth University Intellectual Property Foundation Plasma-derived-fibrin-based matrices and tissue
DE10046119A1 (en) 2000-09-15 2002-03-28 Inst Textil & Faserforschung Medical bioresorbable implant, method of manufacture and use
IL138529A0 (en) 2000-09-18 2003-09-17 Yeda Res & Dev High level expression of heterologous proteins
US6432436B1 (en) 2000-10-03 2002-08-13 Musculoskeletal Transplant Foundation Partially demineralized cortical bone constructs
WO2002041877A1 (en) 2000-10-24 2002-05-30 Clear Solutions Biotech, Inc. Sodium hyaluronate microspheres
IL139380A0 (en) 2000-10-31 2001-11-25 Prochon Biotech Ltd Active variants of fibroblast growth factor
US6576285B1 (en) 2000-11-14 2003-06-10 Sunpure Ltd. Cholesterol lowering beverage
CA2365376C (en) 2000-12-21 2006-03-28 Ethicon, Inc. Use of reinforced foam implants with enhanced integrity for soft tissue repair and regeneration
US7192604B2 (en) 2000-12-22 2007-03-20 Ethicon, Inc. Implantable biodegradable devices for musculoskeletal repair or regeneration
US6838440B2 (en) 2001-01-24 2005-01-04 Collagen Nutraceuticals, Inc. Kolla2-desiccated avian sternal cartilage powder
KR20040008125A (en) 2001-01-30 2004-01-28 오르쏘젠 인크. Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
US7931692B2 (en) 2001-02-14 2011-04-26 Osteotech, Inc. Implant derived from bone
AU2002244116A1 (en) 2001-02-16 2002-09-04 Sulzer Spine-Tech Inc. Bone implants and methods
US20030050709A1 (en) 2001-02-23 2003-03-13 Ulrich Noth Trabecular bone-derived human mesenchymal stem cells
US6575986B2 (en) 2001-02-26 2003-06-10 Ethicon, Inc. Scaffold fixation device for use in articular cartilage repair
US6743232B2 (en) 2001-02-26 2004-06-01 David W. Overaker Tissue scaffold anchor for cartilage repair
US6855169B2 (en) 2001-02-28 2005-02-15 Synthes (Usa) Demineralized bone-derived implants
IL141813A (en) 2001-03-05 2010-04-15 Hadasit Med Res Service Mixture comprising bone marrow cells together with demineralized and/or mineralized bone matrix and uses thereof in the preparation of compositions for the treatment of hematopoietic dusirders
US6995013B2 (en) 2002-07-08 2006-02-07 Biomed Solutions, Llc Cell-scaffold composition containing five layers
US7252982B2 (en) 2001-03-15 2007-08-07 Massachusetts Institute Of Technology Tissue engineering enhanced by the transfer of a growth factor gene
US20040151705A1 (en) 2002-03-22 2004-08-05 Shuichi Mizuno Neo-cartilage constructs and a method for preparation thereof
JP2005503120A (en) 2001-03-27 2005-02-03 マサチューセッツ　インスティテュート　オブ　テクノロジー Methods and products for FGF dimerization
WO2002083080A2 (en) 2001-04-17 2002-10-24 Genetix Pharmaceuticals, Inc. Method of treating arthritis using lentiviral vectors in gene therapy
US6444222B1 (en) 2001-05-08 2002-09-03 Verigen Transplantation Services International Ag Reinforced matrices
WO2002095019A1 (en) 2001-05-21 2002-11-28 Omrix Biopharmaceuticals S.A. Removal of plasmin(ogen) from protein solutions
ATE504264T1 (en) 2001-05-25 2011-04-15 Conformis Inc METHODS AND COMPOSITIONS FOR REPAIRING THE SURFACE OF JOINTS
US20020183858A1 (en) 2001-06-05 2002-12-05 Contiliano Joseph H. Attachment of absorbable tissue scaffolds to scaffold fixation devices
US7524513B2 (en) 2001-06-15 2009-04-28 Mao Hai-Quan Biofunctional fibers
US6626950B2 (en) 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
DE10135275A1 (en) 2001-07-13 2003-01-30 Jotec Gmbh Implant and process for its manufacture
AU2002354913B2 (en) 2001-07-16 2008-07-17 Depuy Products, Inc. Unitary surgical device and method
US7201917B2 (en) 2001-07-16 2007-04-10 Depuy Products, Inc. Porous delivery scaffold and method
AU2002322567B2 (en) 2001-07-16 2007-09-06 Depuy Products, Inc. Devices form naturally occurring biologically derived
EP1416874A4 (en) 2001-07-16 2007-04-18 Depuy Products Inc Hybrid biologic/synthetic porous extracellular matrix scaffolds
AU2002354911B2 (en) 2001-07-16 2007-08-30 Depuy Products, Inc. Meniscus regeneration device and method
US7819918B2 (en) 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
US8025896B2 (en) 2001-07-16 2011-09-27 Depuy Products, Inc. Porous extracellular matrix scaffold and method
EP1416880B1 (en) 2001-07-16 2011-03-02 DePuy Products, Inc. Cartilage repair apparatus
WO2003007787A2 (en) 2001-07-16 2003-01-30 Depuy Products, Inc. Cartilage repair and regeneration device and method
IL144446A0 (en) 2001-07-19 2002-05-23 Prochon Biotech Ltd Plasma protein matrices and methods for their preparation
WO2003012053A2 (en) 2001-08-01 2003-02-13 New York University Identification of receptor and heparin binding sites in fgf4 by structure-based mutagenesis
TW520383B (en) 2001-08-03 2003-02-11 Ind Tech Res Inst Method of making porous biodegradable polymers
AU2002300450B2 (en) 2001-08-10 2007-04-05 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Collagen Carrier of Therapeutic Genetic Material, and Method
US8178123B2 (en) 2001-08-29 2012-05-15 Femina Pharma Incorporated Method for augmentation of intraepithelial and systemic exposure of therapeutic agents having substrate activity for cytochrome P450 enzymes and membrane efflux systems following vaginal and oral cavity administration
US7132110B2 (en) 2001-08-30 2006-11-07 Isotis Orthobiologics, Inc. Tissue repair compositions and methods for their manufacture and use
US20030096016A1 (en) 2001-09-07 2003-05-22 Yeda Research And Development Co. Ltd. Methods of kidney transplantation utilizing developing nephric tissue
AU2002335747B2 (en) 2001-09-15 2009-01-29 Rush University Medical Center Stratified cartilage tissue and methods to engineer same
AU2002347575A1 (en) 2001-11-05 2003-05-19 Medgenics, Inc. Dosing and administration of therapeutic micro-organs in living subjects and devices and methods for same
KR100789567B1 (en) 2001-11-06 2007-12-28 동화약품공업주식회사 A 3-amido-1,2-benzoisoxazole derivatives, process for preparation, and use thereof
US6855167B2 (en) 2001-12-05 2005-02-15 Osteotech, Inc. Spinal intervertebral implant, interconnections for such implant and processes for making
US7252987B2 (en) 2001-12-06 2007-08-07 Islet Technology, Inc. System for analysis and selection of encapsulated cellular materials
US7169610B2 (en) 2002-01-25 2007-01-30 Genzyme Corporation Serum-free media for chondrocytes and methods of use thereof
US20020106625A1 (en) 2002-02-07 2002-08-08 Hung Clark T. Bioreactor for generating functional cartilaginous tissue
US6852331B2 (en) 2002-02-11 2005-02-08 Taipei Biotechnology Ltd., Inc. Fabrication of a cartilage implant
US6890354B2 (en) 2002-03-08 2005-05-10 Musculoskeletal Transplant Foundation Bone-tendon-bone assembly with allograft bone block and method for inserting same
US20030175410A1 (en) 2002-03-18 2003-09-18 Campbell Phil G. Method and apparatus for preparing biomimetic scaffold
US7537780B2 (en) 2002-03-22 2009-05-26 Histogenics Corporation Method for preparing and implanting a cartilage construct to treat cartilage lesions
US7468192B2 (en) 2002-03-22 2008-12-23 Histogenics Corporation Method for repair of cartilage lesions
ATE484576T1 (en) 2002-03-25 2010-10-15 Univ Washington CHIMERIC PANCREAS
GB0208418D0 (en) 2002-04-11 2002-05-22 Univ Aston Polymeric fibre
NL1020426C2 (en) 2002-04-18 2003-10-21 Tno Modification of the properties of a fibrin matrix with respect to cell growth and ingrowth.
IL149562A0 (en) 2002-05-09 2002-11-10 Prochon Ltd Fgf variants and methods for use thereof
US7931687B2 (en) 2002-05-13 2011-04-26 Articular Engineering, Llc Tissue engineered osteochondral implant
US20050159820A1 (en) 2002-05-13 2005-07-21 Hideki Yoshikawa Member for regenerating joint cartilage and process for producing the same, method of regenerating joint cartilage and artificial cartilage for transplantation
US7338492B2 (en) 2002-05-15 2008-03-04 Linvatec Corporation Cross-pin graft fixation, instruments, and methods
US6989034B2 (en) 2002-05-31 2006-01-24 Ethicon, Inc. Attachment of absorbable tissue scaffolds to fixation devices
US7299805B2 (en) 2002-06-07 2007-11-27 Marctec, Llc Scaffold and method for implanting cells
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
US7291179B2 (en) 2002-06-24 2007-11-06 Wright Medical Technology, Inc. Bone graft substitute composition
US7622562B2 (en) 2002-06-26 2009-11-24 Zimmer Orthobiologics, Inc. Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue
US20040166169A1 (en) 2002-07-15 2004-08-26 Prasanna Malaviya Porous extracellular matrix scaffold and method
AU2003251992A1 (en) 2002-07-17 2004-02-02 Rutgers, The State University Therapeutic devices for patterned cell growth
GB0218916D0 (en) 2002-08-14 2002-09-25 Plc Kidney foundation
US20050255458A1 (en) 2002-08-14 2005-11-17 Hanan Polansky Drug discovery assays based on the biology of chronic disease
US7264634B2 (en) 2002-09-20 2007-09-04 Arthrex, Inc. Method and instrumentation for osteochondral repair using preformed implants
US20040062753A1 (en) 2002-09-27 2004-04-01 Alireza Rezania Composite scaffolds seeded with mammalian cells
US20040078090A1 (en) 2002-10-18 2004-04-22 Francois Binette Biocompatible scaffolds with tissue fragments
US7323011B2 (en) 2002-10-18 2008-01-29 Musculoskeletal Transplant Foundation Cortical and cancellous allograft cervical fusion block
US7824701B2 (en) 2002-10-18 2010-11-02 Ethicon, Inc. Biocompatible scaffold for ligament or tendon repair
US6761739B2 (en) 2002-11-25 2004-07-13 Musculoskeletal Transplant Foundation Cortical and cancellous allograft spacer
AT500418B1 (en) 2002-12-05 2009-12-15 Winkler Heinz Dr CULTIVATED CELLULAR CELLS CONTAINING THE IMPLANT AND METHOD FOR THE PRODUCTION THEREOF
EP1433489A1 (en) 2002-12-23 2004-06-30 Degradable Solutions AG Biodegradable porous bone implant with a barrier membrane sealed thereto
WO2004060404A1 (en) 2002-12-27 2004-07-22 Chugai Seiyaku Kabushiki Kaisha Drug carrier
AU2004208038B2 (en) 2003-01-30 2007-09-06 Prochon Biotech Ltd. Freeze-dried fibrin matrices and methods for preparation thereof
US7985414B2 (en) 2003-02-04 2011-07-26 Warsaw Orthopedic, Inc. Polyurethanes for osteoimplants
EP1444995A1 (en) 2003-02-06 2004-08-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) FGF-2 derived proteins for the preparation of biomaterials or medical devices such as stents
EP1601320A4 (en) 2003-02-21 2012-02-22 Osteobiologics Inc Bone and cartilage implant delivery device
US20070043376A1 (en) 2003-02-21 2007-02-22 Osteobiologics, Inc. Bone and cartilage implant delivery device
WO2004075940A1 (en) 2003-02-26 2004-09-10 Zimmer Orthobiologics, Inc. Preparation for repairing cartilage tissue, especially articular cartilage defects
US7642092B2 (en) 2003-03-03 2010-01-05 Technion Research & Development Foundation Ltd. Cultured cartilage/bone cells/tissue, method of generating same and uses thereof
DE10312144B4 (en) 2003-03-13 2006-12-14 Technische Universität Dresden Carrier material for tissue and cell culture and the production of implant materials
US7125423B2 (en) 2003-03-31 2006-10-24 Depuy Products, Inc. Intercalary prosthesis, kit and method
US20040197375A1 (en) 2003-04-02 2004-10-07 Alireza Rezania Composite scaffolds seeded with mammalian cells
SE0301087D0 (en) 2003-04-14 2003-04-14 Cartela Ab New monoclonal antibody
US20050064042A1 (en) 2003-04-29 2005-03-24 Musculoskeletal Transplant Foundation Cartilage implant plug with fibrin glue and method for implantation
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US20050222687A1 (en) 2004-04-02 2005-10-06 Gordana Vunjak-Novakovic Cartilage implant assembly and method for implantation
JP4444918B2 (en) 2003-05-15 2010-03-31 学校法人早稲田大学 Decellularization method and biological tissue processing apparatus
US7488348B2 (en) 2003-05-16 2009-02-10 Musculoskeletal Transplant Foundation Cartilage allograft plug
US20090291112A1 (en) 2003-05-16 2009-11-26 Truncale Katherine G Allograft osteochondral plug combined with cartilage particle mixture
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7537617B2 (en) 2003-06-05 2009-05-26 Warsaw Orthopedic, Inc. Bone strip implants and method of making same
CA2527578A1 (en) 2003-06-06 2004-12-16 Humanautocell Gmbh Matrix, cell implantation and method for their production and use
US20070067032A1 (en) 2003-06-27 2007-03-22 Felt Jeffrey C Meniscus preserving implant method and apparatus
US7819880B2 (en) 2003-06-30 2010-10-26 Depuy Products, Inc. Implant delivery instrument
EP1649008A2 (en) 2003-07-16 2006-04-26 Boston Scientific Limited Aligned scaffolds for improved myocardial regeneration
US7326571B2 (en) 2003-07-17 2008-02-05 Boston Scientific Scimed, Inc. Decellularized bone marrow extracellular matrix
JP4339855B2 (en) 2003-07-31 2009-10-07 日本メディカルマテリアル株式会社 How to make an artificial joint
US10583220B2 (en) 2003-08-11 2020-03-10 DePuy Synthes Products, Inc. Method and apparatus for resurfacing an articular surface
ATE449608T1 (en) 2003-08-12 2009-12-15 Tigenix Nv USE OF CXCL6 CHEMOKINE IN PREVENTING OR REPAIRING CARTILAGE DEFECTS
WO2005018429A2 (en) 2003-08-20 2005-03-03 Histogenics Corporation Acellular matrix implanted into an articular cartilage or osteochondral lesion protected with a biodegradable polymer modified to have extended polymerization time and methods for preparation and use thereof
US7217294B2 (en) 2003-08-20 2007-05-15 Histogenics Corp. Acellular matrix implants for treatment of articular cartilage, bone or osteochondral defects and injuries and method for use thereof
US7226482B2 (en) 2003-09-02 2007-06-05 Synthes (U.S.A.) Multipiece allograft implant
AU2004270239C1 (en) 2003-09-04 2011-07-07 Cook Biotech Incorporated Extracellular matrix composite materials, and manufacture and use thereof
CA2539751C (en) 2003-09-05 2016-04-26 Norian Corporation Bone cement compositions having fiber-reinforcement and/or increased flowability
WO2005023906A1 (en) 2003-09-08 2005-03-17 Chugai Seiyaku Kabushiki Kaisha Hyaluronic acid modification product and drug carrier therefrom
WO2005032473A2 (en) 2003-10-02 2005-04-14 Depuy Spine, Inc. Chemical treatment for removing cellular and nuclear material from naturally occurring extracellular matrix-based biomaterials
US20050074476A1 (en) 2003-10-03 2005-04-07 El Gendler Cartilidge and bone induction by artificially perforated organic bone matrix augmented by undifferentiated cells suspended in bone gel
US7309232B2 (en) 2003-10-10 2007-12-18 Dentigenix Inc. Methods for treating dental conditions using tissue scaffolds
GB0325141D0 (en) 2003-10-28 2003-12-03 Xiros Plc Repair of damaged tissue on a bone site
CA2536041A1 (en) 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
WO2005048897A1 (en) 2003-11-18 2005-06-02 Quantum Orthopedics Osteoconductive integrated spinal cage and method of making same
US7560432B2 (en) 2003-11-26 2009-07-14 Histogenics Corporation In situ method for treatment and repair of meniscal injuries
US7316822B2 (en) 2003-11-26 2008-01-08 Ethicon, Inc. Conformable tissue repair implant capable of injection delivery
US7157428B2 (en) 2003-11-26 2007-01-02 Histogenics, Corp. Method for treatment and repair of meniscal injuries
US7901461B2 (en) 2003-12-05 2011-03-08 Ethicon, Inc. Viable tissue repair implants and methods of use
US7666230B2 (en) 2003-12-08 2010-02-23 Depuy Products, Inc. Implant device for cartilage regeneration in load bearing articulation regions
ATE515245T1 (en) 2003-12-11 2011-07-15 Isto Technologies Inc PARTICLE CARTILAGE SYSTEM
US7625581B2 (en) 2003-12-19 2009-12-01 Ethicon, Inc. Tissue scaffolds for use in muscoloskeletal repairs
US11395865B2 (en) 2004-02-09 2022-07-26 DePuy Synthes Products, Inc. Scaffolds with viable tissue
US20050196460A1 (en) 2004-03-08 2005-09-08 Malinin Theodore I. Particulate cartilage compositions, processes for their preparation and methods for regenerating cartilage
WO2005086849A2 (en) 2004-03-09 2005-09-22 Osteobiologics, Inc. Implant scaffold combined with autologous or allogenic tissue
US20070185585A1 (en) 2004-03-09 2007-08-09 Brat Bracy Implant Scaffold Combined With Autologous Tissue, Allogenic Tissue, Cultured Tissue, or combinations Thereof
EP1735022B1 (en) 2004-04-15 2009-07-08 Nexilis AG Osteogenic composite matrix, method for the production thereof and implant and scaffold for tissue engineering provided with a coating formed by said osteogenic composite matrix
US7531518B2 (en) 2004-05-14 2009-05-12 Unigene Laboratories Inc. Method for fostering bone formation and preservation
US7648965B2 (en) 2004-05-14 2010-01-19 Unigene Laboratories Inc. Method for fostering bone formation and preservation
ES2245879B1 (en) 2004-05-21 2006-12-16 Universidad De Malaga COMPOSITION FOR OSEA OR CARTILAGINOUS REPAIR.
US7846466B2 (en) 2004-06-10 2010-12-07 Northwestern University Biodegradable scaffolds and uses thereof
US20050288796A1 (en) 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
ITRM20040318A1 (en) 2004-06-28 2004-09-28 Univ Palermo HYALURONIC AND ALPHA HYDROGEL, BETA-POLYASPARTYL HYDRAZIDE AND THEIR BIOMEDICAL AND PHARMACEUTICAL APPLICATIONS.
US7335508B2 (en) 2004-07-22 2008-02-26 Prochon Biotech Ltd. Porous plasma protein matrices and methods for preparation thereof
US8043315B2 (en) 2004-09-23 2011-10-25 Arthrex, Inc. Osteochondral repair using plug fashioned from partial distal allograft femur or condyle
US8039258B2 (en) 2004-09-28 2011-10-18 Ethicon, Inc. Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
JPWO2006038287A1 (en) 2004-10-06 2008-05-15 株式会社シンクプラス Synchronization system and synchronization program
US20090149893A1 (en) 2007-12-05 2009-06-11 Semler Eric J Cancellous Bone Implant for Cartilage Repair
US20080220044A1 (en) 2007-03-06 2008-09-11 Semler Eric J Cancellous construct with support ring for repair of osteochondral defects
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
WO2006050213A2 (en) 2004-10-29 2006-05-11 Michalow Alexander E Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway
US8329202B2 (en) 2004-11-12 2012-12-11 Depuy Products, Inc. System and method for attaching soft tissue to an implant
WO2007044026A2 (en) 2004-11-23 2007-04-19 The Johns Hopkins University Compositions comprising modified collagen and uses therefore
WO2006060416A2 (en) 2004-11-30 2006-06-08 Osteobiologics, Inc. Implants and delivery system for treating defects in articulating surfaces
SE0403020D0 (en) 2004-12-13 2004-12-13 Rickard Braanemark Implant
WO2006083946A2 (en) 2005-02-01 2006-08-10 Osteobiologics, Inc. Method and device for selective addition of a bioactive agent to a multi-phase implant
US20060204445A1 (en) 2005-03-11 2006-09-14 Anthony Atala Cell scaffold matrices with image contrast agents
US7531503B2 (en) 2005-03-11 2009-05-12 Wake Forest University Health Sciences Cell scaffold matrices with incorporated therapeutic agents
US7621963B2 (en) 2005-04-13 2009-11-24 Ebi, Llc Composite bone graft material
US7291169B2 (en) 2005-04-15 2007-11-06 Zimmer Technology, Inc. Cartilage implant
EP1868539A2 (en) 2005-04-15 2007-12-26 Musculoskeletal Transplant Foundation Vertebral disc repair
US8506646B2 (en) 2005-04-29 2013-08-13 Warsaw Orthopedic, Inc. Multi-purpose medical implant devices
US20060247790A1 (en) 2005-04-30 2006-11-02 Mckay William F Shaped osteochondral grafts and methods of using same
WO2006121612A1 (en) 2005-05-05 2006-11-16 Isto Technologies, Inc. Treatment of joint disease, methods and apparatuses therefor
US20060286144A1 (en) 2005-06-17 2006-12-21 Chunlin Yang Reinforced collagen scaffold
US7815926B2 (en) 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
WO2007011610A2 (en) 2005-07-18 2007-01-25 Acologix, Inc. Protein formulation for promoting hard tissue formation
US20070026030A1 (en) 2005-07-27 2007-02-01 Berkeley Advanced Biomaterials, Inc. Method of preparing rheological materials for bone and cartilage repair
US7595062B2 (en) 2005-07-28 2009-09-29 Depuy Products, Inc. Joint resurfacing orthopaedic implant and associated method
EP1923457B1 (en) 2005-08-18 2017-06-28 KOKEN CO., Ltd. Cell culture support embeddable in vivo
AU2006282754A1 (en) 2005-08-26 2007-03-01 Zimmer, Inc. Implants and methods for repair, replacement and treatment of joint disease
US7372024B2 (en) 2005-09-13 2008-05-13 Agilent Technologies, Inc. Two dimensional ion traps with improved ion isolation and method of use
WO2007035778A2 (en) 2005-09-19 2007-03-29 Histogenics Corporation Cell-support matrix and a method for preparation thereof
US9132208B2 (en) 2008-08-07 2015-09-15 Lifenet Health Composition for a tissue repair implant and methods of making the same
US20080166329A1 (en) 2005-10-24 2008-07-10 Hsing-Wen Sung Medical device and methods for living cell injection
US8029575B2 (en) 2005-10-25 2011-10-04 Globus Medical, Inc. Porous and nonporous materials for tissue grafting and repair
US7371260B2 (en) 2005-10-26 2008-05-13 Biomet Sports Medicine, Inc. Method and instrumentation for the preparation and transplantation of osteochondral allografts
US8403985B2 (en) 2005-11-02 2013-03-26 Zimmer, Inc. Joint spacer implant
TWI274591B (en) 2005-11-07 2007-03-01 Univ Tsinghua Composite scaffold for remedying articular cartilage tissue and preparation thereof
DE102005054940A1 (en) 2005-11-17 2007-05-24 Gelita Ag Composite material, in particular for medical use, and method for its production
EP1951158A4 (en) 2005-11-21 2010-03-31 Vertegen Inc Devices and methods for treating facet joints, uncovertebral joints, costovertebral joints and other joints
US20070129630A1 (en) 2005-12-07 2007-06-07 Shimko Daniel A Imaging method, device and system
US8444968B2 (en) 2005-12-07 2013-05-21 Isto Technologies, Inc. Cartilage repair methods
TWI316860B (en) 2005-12-29 2009-11-11 Ind Tech Res Inst Multi-layered matrix, method of tissue repair using the same and multi-layered implant prepared thereof
AU2007204815A1 (en) 2006-01-12 2007-07-19 Histogenics Corporation Method for repair and reconstruction of ruptured ligaments or tendons and for treatment of ligament and tendon injuries
US7833269B2 (en) 2006-01-25 2010-11-16 Warsaw Orthopedic, Inc Osteochondral implant procedure
US20070178159A1 (en) 2006-01-30 2007-08-02 Alza Corporation In-Situ Forming Porous Scaffold
US20070179607A1 (en) 2006-01-31 2007-08-02 Zimmer Technology, Inc. Cartilage resurfacing implant
US8235939B2 (en) 2006-02-06 2012-08-07 Kci Licensing, Inc. System and method for purging a reduced pressure apparatus during the administration of reduced pressure treatment
DE102006006904A1 (en) 2006-02-09 2007-08-23 Universität Rostock New haemostatic agents and adhesives for medical applications
US7785634B2 (en) 2006-02-27 2010-08-31 Globus Medical, Inc. Bone graft materials derived from mineralized gelatin
US20070276506A1 (en) 2006-05-25 2007-11-29 Biomet Manufacturing Corp. Demineralized osteochondral plug
US7507286B2 (en) 2006-06-08 2009-03-24 Sanatis Gmbh Self-foaming cement for void filling and/or delivery systems
US20070299517A1 (en) 2006-06-21 2007-12-27 Howmedica Osteonics Corp. Articular cartilage implant
EP2076220A2 (en) 2006-07-25 2009-07-08 Musculoskeletal Transplant Foundation Packed demineralized cancellous tissue forms for disc nucleus augmentation, restoration, or replacement and methods of implantation
CN101332314B (en) 2008-07-22 2012-11-14 广东冠昊生物科技股份有限公司 Biotype articular cartilage repair piece
WO2008021127A2 (en) 2006-08-08 2008-02-21 Howmedica Osteonics Corp. Expandable cartilage implant
US8449622B2 (en) 2006-09-11 2013-05-28 Warsaw Orthopedic, Inc. Multi-phase osteochondral implantable device
US8962556B2 (en) 2006-09-28 2015-02-24 Prochon Biotech Ltd. FGF-2 variants having N-terminal deletions and increased receptor selectivity and uses thereof
US8105380B2 (en) 2006-10-23 2012-01-31 Stemedica Cell Technologies, Inc. Cellular scaffold
EP2462895B1 (en) * 2006-11-03 2016-11-02 BioMimetic Therapeutics, LLC Compositions and methods for arthrodetic procedures
GB0623065D0 (en) 2006-11-18 2006-12-27 Smith & Nephew Annular ring
US20080125863A1 (en) 2006-11-28 2008-05-29 Mckay William F Implant designs and methods of improving cartilage repair
EP1929945A3 (en) 2006-12-07 2009-01-14 Arthrex, Inc. Measuring device
US20080138414A1 (en) 2006-12-08 2008-06-12 Smith & Nephew, Inc. Methods of Regenerating Cartilage
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US20080154372A1 (en) 2006-12-21 2008-06-26 Peckham Steven M Osteochondral implant using a growth factor concentration gradient for repair of bone and cartilage tissue
EP2106263B1 (en) 2007-01-04 2016-12-21 Hepacore Ltd. Water soluble reactive derivatives of carboxy polysaccharides and fibrinogen conjugates thereof
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
KR20090127153A (en) 2007-04-06 2009-12-09 겐자임 코포레이션 Methods of evaluating cells and cell cultures
US8574825B2 (en) 2007-06-01 2013-11-05 Bacterin International, Inc. Process for demineralization of bone matrix with preservation of natural growth factors
JP5497980B2 (en) 2007-06-29 2014-05-21 株式会社日立ハイテクノロジーズ Charged particle beam application apparatus and sample inspection method
US8070827B2 (en) * 2007-07-03 2011-12-06 Histogenics Corporation Method for use of a double-structured tissue implant for treatment of tissue defects
US8685107B2 (en) 2007-07-03 2014-04-01 Histogenics Corporation Double-structured tissue implant and a method for preparation and use thereof
US8685099B2 (en) 2007-08-14 2014-04-01 Warsaw Orthopedic, Inc. Multiple component osteoimplant
US8062655B2 (en) 2007-08-31 2011-11-22 Phillips Plastics Corporation Composite scaffold structure
US20090069904A1 (en) 2007-09-12 2009-03-12 Applied Medical Research Biomaterial including micropores
US8641774B2 (en) 2007-09-14 2014-02-04 The Curators Of The University Of Missouri Synthetic osteochondral composite and method of fabrication thereof
ES2446544T3 (en) 2007-10-19 2014-03-10 Warsaw Orthopedic, Inc. Demineralized bone matrix compositions and methods
WO2009059236A2 (en) 2007-10-31 2009-05-07 Kim Stanley I Rotating biopsy device and biopsy robot
US8961571B2 (en) 2007-11-19 2015-02-24 David Lee Method and apparatus for spinal facet joint fusion using irregularly shaped cortical bone implants
US20090139045A1 (en) 2007-12-03 2009-06-04 William Michael Cannon Head for a cleaning device and cleaning device usable therewith
CA2717725A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
KR101098553B1 (en) 2008-04-30 2011-12-26 주식회사 엘지생명과학 Novel Process for Preparation of Iopromide
JP2009291304A (en) 2008-06-03 2009-12-17 Gc Corp Bone graft substitute
US20090312842A1 (en) 2008-06-16 2009-12-17 Predrag Bursac Assembled Cartilage Repair Graft
EP2339990A4 (en) 2008-07-06 2013-01-23 Univ Missouri Osteochondral implants, arthroplasty methods, devices, and systems
US8185485B2 (en) 2008-08-27 2012-05-22 Lifeline Biotechnologies, Inc. Device for analyzing thermal data based on breast surface temperature for the detection for use in determining cancerous conditions
US20100274362A1 (en) 2009-01-15 2010-10-28 Avner Yayon Cartilage particle tissue mixtures optionally combined with a cancellous construct
US8308814B2 (en) 2009-03-27 2012-11-13 Depuy Mitek, Inc. Methods and devices for preparing and implanting tissue scaffolds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6454811B1 (en) * 1998-10-12 2002-09-24 Massachusetts Institute Of Technology Composites for tissue regeneration and methods of manufacture thereof
US20030040113A1 (en) * 2001-03-23 2003-02-27 Histogenics Corporation Composition and methods for the production of biological tissues and tissue constructs

Also Published As

Publication number Publication date
EP1926459B1 (en) 2015-01-07
AU2006292224B2 (en) 2013-08-01
JP2009508596A (en) 2009-03-05
CA2623106C (en) 2013-12-24
US8921109B2 (en) 2014-12-30
US20150104872A1 (en) 2015-04-16
CA2623106A1 (en) 2007-03-29
US20170298320A1 (en) 2017-10-19
US10900017B2 (en) 2021-01-26
US20210246418A1 (en) 2021-08-12
US20070065943A1 (en) 2007-03-22
WO2007035778A2 (en) 2007-03-29
EP1926459A2 (en) 2008-06-04
US9701940B2 (en) 2017-07-11
EP1926459A4 (en) 2012-05-23
US20200224155A1 (en) 2020-07-16
AU2006292224A1 (en) 2007-03-29

Similar Documents

Publication Publication Date Title
WO2007035778A3 (en) Cell-support matrix and a method for preparation thereof
Pan et al. Effect of porosities of bilayered porous scaffolds on spontaneous osteochondral repair in cartilage tissue engineering
Kumar et al. Biological functionality of extracellular matrix‐ornamented three‐dimensional printed hydroxyapatite scaffolds
WO2003094987A1 (en) Member for regenerating joint cartilage and process for producing the same, method of regenerating joint cartilage and aritficial cartilage for transplantation
Hokugo et al. Preparation of hybrid scaffold from fibrin and biodegradable polymer fiber
WO2003092471A3 (en) Cell-seeded extracellular matrix grafts
MX2012004917A (en) Dynamic bioactive bone graft material having an engineered porosity.
WO2007035968A3 (en) Hybrid intervertebral spinal fusion implant
MX2012004919A (en) Bone graft material.
TW200724175A (en) Multi-layered matrix, method of tissue repair using the same and multi-layered implant prepared thereof
WO2007051120A3 (en) Porous and nonporous materials for tissue grafting and repair
WO2004078069A3 (en) Process for manufacturing biomedical articles by infiltrating biocompatible metal alloys in porous matrices
WO2007097949A3 (en) Method and apparatus for forming porous metal implants
EP1962729A4 (en) An intervertebral prosthesis for supporting adjacent vertebral bodies enabling the creation of soft fusion and method
RU2001132074A (en) ELEMENT FOR MAKING GROWTH AND GROWTH OF BONE TISSUE AND / OR CONNECTIVE TISSUE AND METHOD FOR PRODUCING SUCH ELEMENT
WO2008003320A3 (en) Three-dimensional cell scaffolds
WO2007048935A3 (en) Method for obtaining a biocompatible composite implant
WO2006027622A3 (en) Transglutaminase crosslinked collagen biomaterial for medical implant materials
WO2010102123A3 (en) A matrix that prolongs growth factor release
WO2002009790A8 (en) Collagen membrane arranged at macromolecular level
Knight et al. Fabrication of a multi-layer three-dimensional scaffold with controlled porous micro-architecture for application in small intestine tissue engineering
DK1715900T3 (en) Composite Structures Containing Hyaluronic Acid Derivatives as New Bone Substitutes and Transplants
Deng et al. Cartilage regeneration using a novel gelatin–chondroitin–hyaluronan hybrid scaffold containing bFGF-impregnated microspheres
ATE457752T1 (en) IMPLANT CONTAINING CULTURED CARTILAGE CELLS AND METHOD FOR PRODUCTION
EP2512377B1 (en) A biomaterial

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
DPE2 Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2006814983

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2006292224

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2006292224

Country of ref document: AU

Date of ref document: 20060919

Kind code of ref document: A

ENP Entry into the national phase

Ref document number: 2008531443

Country of ref document: JP

Kind code of ref document: A

Ref document number: 2623106

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE