WO2007035864A3 - Electrophoresis standards, methods and kits - Google Patents

Electrophoresis standards, methods and kits Download PDF

Info

Publication number
WO2007035864A3
WO2007035864A3 PCT/US2006/036808 US2006036808W WO2007035864A3 WO 2007035864 A3 WO2007035864 A3 WO 2007035864A3 US 2006036808 W US2006036808 W US 2006036808W WO 2007035864 A3 WO2007035864 A3 WO 2007035864A3
Authority
WO
WIPO (PCT)
Prior art keywords
electrophoresis
methods
kits
electrophoresis standards
standards
Prior art date
Application number
PCT/US2006/036808
Other languages
French (fr)
Other versions
WO2007035864A2 (en
Inventor
Erik Gentalen
Daniel J Suich
Original Assignee
Cell Biosciences Inc
Erik Gentalen
Daniel J Suich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Biosciences Inc, Erik Gentalen, Daniel J Suich filed Critical Cell Biosciences Inc
Publication of WO2007035864A2 publication Critical patent/WO2007035864A2/en
Publication of WO2007035864A3 publication Critical patent/WO2007035864A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G01N27/44726—Arrangements for investigating the separated zones, e.g. localising zones by optical means using specific dyes, markers or binding molecules
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/13—Labelling of peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/24—Extraction; Separation; Purification by electrochemical means
    • C07K1/26—Electrophoresis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/24—Extraction; Separation; Purification by electrochemical means
    • C07K1/26—Electrophoresis
    • C07K1/28—Isoelectric focusing
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2550/00—Electrophoretic profiling, e.g. for proteome analysis

Abstract

Electrophoresis Compositions, methods and kits useful for, among other things, detecting, quantifying and/or characterizing analytes are provided. The compositions are useful as electrophoresis standards for determine the isoelectric point and molecular weight of an analyte. The electrophoresis standards generally comprise at least one label moiety and one or more reactive moieties that when activated attach the standard to a substrate.
PCT/US2006/036808 2005-09-20 2006-09-20 Electrophoresis standards, methods and kits WO2007035864A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71924605P 2005-09-20 2005-09-20
US60/719,246 2005-09-20

Publications (2)

Publication Number Publication Date
WO2007035864A2 WO2007035864A2 (en) 2007-03-29
WO2007035864A3 true WO2007035864A3 (en) 2007-11-22

Family

ID=37889533

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/036808 WO2007035864A2 (en) 2005-09-20 2006-09-20 Electrophoresis standards, methods and kits

Country Status (2)

Country Link
US (1) US8945361B2 (en)
WO (1) WO2007035864A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030012985A1 (en) 1998-08-03 2003-01-16 Mcalister Roy E. Pressure energy conversion systems
US7846676B2 (en) * 2004-07-19 2010-12-07 Cell Biosciences, Inc. Methods and devices for analyte detection
US7935479B2 (en) 2004-07-19 2011-05-03 Cell Biosciences, Inc. Methods and devices for analyte detection
US20080017512A1 (en) * 2006-07-24 2008-01-24 Bordunov Andrei V Coatings for capillaries capable of capturing analytes
US10107782B2 (en) 2008-01-25 2018-10-23 ProteinSimple Method to perform limited two dimensional separation of proteins and other biologicals
US20110011740A1 (en) * 2009-04-17 2011-01-20 Roach David J Capillary immunoassay systems and methods
EP2839276B1 (en) 2012-04-19 2018-06-27 ProteinSimple Dual wavelength isoelectric focusing for determining drug load in antibody drug conjugates
CN104471395B (en) * 2012-06-28 2017-05-03 生物辐射实验室股份有限公司 Multi-protein quantitation standard
US8838367B1 (en) 2013-03-12 2014-09-16 Mcalister Technologies, Llc Rotational sensor and controller
US9377105B2 (en) 2013-03-12 2016-06-28 Mcalister Technologies, Llc Insert kits for multi-stage compressors and associated systems, processes and methods
WO2014144581A1 (en) 2013-03-15 2014-09-18 Mcalister Technologies, Llc Internal combustion engine and associated systems and methods
US9255560B2 (en) 2013-03-15 2016-02-09 Mcalister Technologies, Llc Regenerative intensifier and associated systems and methods
US9766206B2 (en) 2013-09-27 2017-09-19 ProteinSimple Apparatus, systems, and methods for capillary electrophoresis
US20150093757A1 (en) 2013-09-27 2015-04-02 Protein Simple Methods. apparatus and systems for detection of total protein using capillary electrophoresis
US11782023B2 (en) 2018-12-19 2023-10-10 Regeneron Pharmaceuticals, Inc. Ce-western applications for antibody development
KR20220010543A (en) 2019-05-21 2022-01-25 리제너론 파아마슈티컬스, 인크. Methods for Identification and Quantification of Host Cell Proteins
US11420202B1 (en) 2021-08-31 2022-08-23 ProteinSimple Systems and methods for fractionation and collection of analytes in a sample
US20230075533A1 (en) 2021-09-03 2023-03-09 ProteinSimple Methods and systems for analysis of samples containing particles used for gene delivery

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376249A (en) * 1992-11-25 1994-12-27 Perseptive Biosystems, Inc. Analysis utilizing isoelectric focusing
US5830539A (en) * 1995-11-17 1998-11-03 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for functionalizing and coating substrates and devices made according to the methods
US6054032A (en) * 1998-01-27 2000-04-25 3M Innovative Properties Company Capillary electrophoresis array
US6197173B1 (en) * 1995-11-08 2001-03-06 Francis H. Kirkpatrick Methods and reagents for gel electrophoresis
US20030175986A1 (en) * 2001-02-05 2003-09-18 Patricelli Matthew P. Activity based probe analysis

Family Cites Families (170)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622871A (en) 1987-04-27 1997-04-22 Unilever Patent Holdings B.V. Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents
US1015891A (en) 1911-05-02 1912-01-30 Kikunae Ikeda Proces of separating glutamic acid and other products of hydrolysis of albuminous substances from one another by electrolysis.
US2509399A (en) 1946-06-03 1950-05-30 Perfection Stove Co Means for controlling the supply of fuel to liquid fuel burners of heating systems for automotive engines or the like
US3669955A (en) 1968-12-26 1972-06-13 Cpc International Inc Quaternary pyridinium salt-starch ether derivatives
CH594444A5 (en) 1972-12-04 1978-01-13 Gerd Birrenbach
US4128470A (en) 1975-08-29 1978-12-05 Fuji Photo Film Co., Ltd. Supports for electrophoresis and process for the production of the same
US5002582A (en) 1982-09-29 1991-03-26 Bio-Metric Systems, Inc. Preparation of polymeric surfaces via covalently attaching polymers
US4843010A (en) 1983-11-10 1989-06-27 Genetic Systems Corporation Polymerization-induced separation immunoassays
US4716101A (en) 1984-12-18 1987-12-29 Calgene, Inc. Rapid enzyme assay by product selective blot
US5096807A (en) 1985-03-06 1992-03-17 Murex Corporation Imaging immunoassay detection system with background compensation and its use
US4666855A (en) 1985-07-31 1987-05-19 Massachusetts Institute Of Technology Rapid method for determining the isoelectric point for amphoteric molecules
US4680201A (en) 1985-10-30 1987-07-14 Stellan Hjerten Coating for electrophoresis tube
US5266273A (en) 1986-06-26 1993-11-30 Coombs David H Process and apparatus for forming a solution gradient and for conducting a blotting process
US4810781A (en) 1987-01-15 1989-03-07 The George Washington University Methods of preparing epitopes of tumor associated antigens
US4921790A (en) 1987-04-24 1990-05-01 Research Corporation Tumor specific assay for CA125 ovarian cancer antigen
US4788138A (en) 1987-04-30 1988-11-29 Beckman Instruments, Inc. Method to achieve a linear standard curve in a sandwich immunoassay
US4870003A (en) 1987-06-15 1989-09-26 Coulter Corporation Simultaneous enzyme immunoassay for detecting antigen and/or antibody in humans
EP0329184A3 (en) 1988-02-19 1990-05-23 Neorx Corporation Antimers and antimeric conjugation
US5260028A (en) 1988-02-22 1993-11-09 Astle Thomas W Method and apparatus for effecting solid phase extraction
US6300101B1 (en) 1988-10-24 2001-10-09 Board Of Regents, The University Of Texas System Methods and compositions including a 13kD B. burgdorferi protein
US5468359A (en) 1988-11-14 1995-11-21 Anthony R. Torres Method of determining presence of an analyte by isoelectric focusing
US5633129A (en) 1989-07-13 1997-05-27 Massachusetts Institute Of Technology Electrophoretic detection and separation of mutant DNA using replaceable polymer matrices
US5264101A (en) 1989-11-06 1993-11-23 Applied Biosystems, Inc. Capillary electrophoresis molecular weight separation of biomolecules using a polymer-containing solution
US5252743A (en) 1989-11-13 1993-10-12 Affymax Technologies N.V. Spatially-addressable immobilization of anti-ligands on surfaces
US5935401A (en) 1996-09-18 1999-08-10 Aclara Biosciences Surface modified electrophoretic chambers
US5858188A (en) 1990-02-28 1999-01-12 Aclara Biosciences, Inc. Acrylic microchannels and their use in electrophoretic applications
US5143753A (en) 1990-10-26 1992-09-01 Indiana University Foundation Suppression of electroosmosis with hydrolytically stable coatings
US5074982A (en) 1990-10-26 1991-12-24 Indiana University Foundation Suppression of electroosmosis with hydrolytically stable coatings
US5110434A (en) 1990-12-20 1992-05-05 Bio-Rad Laboratories, Inc. Use of zwitterions to mobilize isoelectrically focused ampholyte zones
US5244813A (en) 1991-01-25 1993-09-14 Trustees Of Tufts College Fiber optic sensor, apparatus, and methods for detecting an organic analyte in a fluid or vapor sample
US5180475A (en) 1991-09-04 1993-01-19 Hewlett-Packard Company System and method for controlling electroosmotic flow
ATE191567T1 (en) 1991-10-31 2000-04-15 Matritech Inc DETERMINATION OF NUCLEAR MATRIX PROTEINS IN LIQUIDS
JPH05172815A (en) 1991-12-26 1993-07-13 Hitachi Ltd Immunity analyzing method and analyzing device therefor
US5784154A (en) 1992-01-13 1998-07-21 Anthony R. Torres Electrophoresis separation in a capillary passage
US5213669A (en) 1992-01-31 1993-05-25 Beckman Instruments, Inc. Capillary column containing a dynamically cross-linked composition and method of use
US5843680A (en) 1992-01-31 1998-12-01 Biometric Imaging, Inc. Differential separation assay methods and test kits
US5137609A (en) 1992-01-31 1992-08-11 Biometric Imaging Inc. Differential separation assay
SE500702C2 (en) 1992-04-07 1994-08-15 Staffan Birnbaum Methods and apparatus for optical analysis of samples separated into thin capillaries
US5228960A (en) 1992-07-17 1993-07-20 Beckman Instruments, Inc. Analysis of samples by capillary electrophoretic immunosubtraction
CA2094343A1 (en) 1992-07-17 1994-01-18 Gerald L. Klein Method and apparatus for displaying capillary electrophoresis data
AU671478B2 (en) 1992-08-19 1996-08-29 British Nuclear Fuels Plc Apparatus for dispensing substances which are biologically hazardous
US5759369A (en) 1992-09-24 1998-06-02 The Perkin-Elmer Corporation Viscous electrophoresis polymer medium and method
US5290418A (en) 1992-09-24 1994-03-01 Applied Biosystems, Inc. Viscous electrophoresis polymer medium and method
DK0591914T4 (en) 1992-10-06 2010-05-25 Siemens Healthcare Diagnostics Retrovirus from the HIV group and its use
US6087188A (en) 1992-11-13 2000-07-11 Alk A/S Two-site immunoassay for an antibody with chemiluminescent label and biotin bound ligand
WO1994013829A1 (en) 1992-12-04 1994-06-23 Biometric Imaging Inc. Isoelectric focusing differential separation assay
US5348633A (en) 1993-01-22 1994-09-20 Northeastern University Method for quantitating trace amounts of an analyte in a sample by affinity capillary electrophoresis
US5417922A (en) 1993-05-14 1995-05-23 Board Of Regents - University Of Nebraska Specimen carrier
US5295502A (en) * 1993-08-03 1994-03-22 Amtrol Inc. Non-refillable valve
US6355709B1 (en) 1993-12-17 2002-03-12 The Perkin-Elmer Corporation Polymers for separation of biomolecules by capillary electrophoresis
AU1254295A (en) 1993-12-17 1995-07-03 Perkin-Elmer Corporation, The Uncharged polymers for separation of biomolecules by capillary electrophoresis
US6358385B1 (en) 1993-12-17 2002-03-19 The Perkin-Elmer Corporation Polymers for separation of biomolecules by capillary electrophoresis
JPH09507571A (en) 1993-12-23 1997-07-29 トロピックス・インコーポレーテッド Chemiluminescent energy transfer assays
DE69409626T2 (en) 1994-01-28 1998-11-05 Hewlett Packard Gmbh Plastic capillary for capillary electrophoresis and process for its manufacture
US5976896A (en) 1994-06-06 1999-11-02 Idexx Laboratories, Inc. Immunoassays in capillary tubes
DE69633962T2 (en) 1995-01-27 2005-12-01 Northeastern University, Boston A method of forming a covalently bonded hydrophilic layer based on polyvinyl alcohol for capillary electrophoresis
US5614073A (en) 1995-03-13 1997-03-25 Board Of Trustees Of The University Of Arkansas Method and apparatus for detection of underivatized amines and amino acids utilizing end column addition of Ru(bpy)32+
EP0744614B1 (en) * 1995-03-31 1999-12-22 Laboratory of Molecular Biophotonics Use of Isoelectric point markers for isoelectric focusing with fluorescence detection
US5630924A (en) 1995-04-20 1997-05-20 Perseptive Biosystems, Inc. Compositions, methods and apparatus for ultrafast electroseparation analysis
GB9509905D0 (en) 1995-05-11 1995-07-12 Watson Arthur H Fast sample device for capillary isoelectric focusing
WO1996039619A1 (en) 1995-06-06 1996-12-12 Kla Instruments Corporation Optical inspection of a specimen using multi-channel responses from the specimen
US5785926A (en) 1995-09-19 1998-07-28 University Of Washington Precision small volume fluid processing apparatus
US5835211A (en) 1996-03-28 1998-11-10 Particle Sizing Systems, Inc. Single-particle optical sensor with improved sensitivity and dynamic size range
US5824478A (en) 1996-04-30 1998-10-20 Vysis, Inc. Diagnostic methods and probes
CA2744096C (en) 1996-07-31 2013-07-30 Laboratory Corporation Of America Holdings Biomarkers and targets for diagnosis, prognosis and management of prostate disease
US5853744A (en) * 1996-08-20 1998-12-29 Regents Of The University Of Minnesota Solid-phase method for attaching a biomolecule to a substrate surface with a photoreactive crosslinking agent
WO1998011258A1 (en) 1996-09-16 1998-03-19 University Of Utah Research Foundation Method and apparatus for analysis of chromatographic migration patterns
US5798035A (en) 1996-10-03 1998-08-25 Pharmacopeia, Inc. High throughput solid phase chemical synthesis utilizing thin cylindrical reaction vessels useable for biological assay
US5804384A (en) 1996-12-06 1998-09-08 Vysis, Inc. Devices and methods for detecting multiple analytes in samples
AU5301598A (en) 1997-02-10 1998-08-13 Gist-Brocades B.V. Detection of analytes using electrochemistry
US5976336A (en) 1997-04-25 1999-11-02 Caliper Technologies Corp. Microfluidic devices incorporating improved channel geometries
US6165800A (en) 1997-05-30 2000-12-26 Bayer Corporation Chemiluminescent energy transfer conjugates and their uses as labels in binding assays
US5932080A (en) 1997-05-30 1999-08-03 Bio-Rad Laboratories, Inc. Mobility-based and normalized capillary electrophoresis
GB2326229A (en) 1997-06-13 1998-12-16 Robert Jeffrey Geddes Carr Detecting and analysing submicron particles
US6589789B1 (en) 1997-07-21 2003-07-08 Quest Diagnostics Incorporated Automated centrifuge loading device
US6139797A (en) 1997-08-20 2000-10-31 Suzuki Motor Corporation Immunoassay apparatus
US6207370B1 (en) * 1997-09-02 2001-03-27 Sequenom, Inc. Diagnostics based on mass spectrometric detection of translated target polypeptides
US6126870A (en) 1997-09-12 2000-10-03 Lumigen, Inc. Chemiluminescent labeling compounds
US6430512B1 (en) 1997-12-30 2002-08-06 Caliper Technologies Corp. Software for the display of chromatographic separation data
DE19802141C1 (en) 1998-01-22 1999-04-22 Retsch Kurt Gmbh & Co Kg Arrangement for determining the particle size distribution of a particle mixture
US6080868A (en) 1998-01-23 2000-06-27 The Perkin-Elmer Corporation Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
WO1999038840A1 (en) 1998-01-30 1999-08-05 Molecular Dynamics, Inc. Compounds for molecular separations
US6111238A (en) 1998-03-04 2000-08-29 R. J. Reynolds Tobacco Company Automated focused microwave sample digestion system
GB9811655D0 (en) 1998-05-29 1998-07-29 Univ Cambridge Tech Methods and materials for producing holographic sensors
US6254634B1 (en) 1998-06-10 2001-07-03 Surmodics, Inc. Coating compositions
CA2306752C (en) 1998-08-14 2008-11-18 Dainichiseika Color & Chemicals Mfg. Co., Ltd. Chemiluminescent reagent and chemiluminescent analysis using the same
US6107038A (en) 1998-08-14 2000-08-22 Agilent Technologies Inc. Method of binding a plurality of chemicals on a substrate by electrophoretic self-assembly
US6162341A (en) 1998-09-11 2000-12-19 The Perkin-Elmer Corporation Multi-channel capillary electrophoresis device including sheath-flow cuvette and replacable capillary array
US6391937B1 (en) 1998-11-25 2002-05-21 Motorola, Inc. Polyacrylamide hydrogels and hydrogel arrays made from polyacrylamide reactive prepolymers
EP1006355A3 (en) 1998-11-30 2000-11-08 The Institute of Physical and Chemical Research Capillary electrophoretic apparatus
JP3871456B2 (en) 1998-12-10 2007-01-24 シスメックス株式会社 Particle image analyzer
WO2000042423A1 (en) 1999-01-12 2000-07-20 Spectrumedix Corporation Copolymers for capillary gel electrophoresis
US7450229B2 (en) 1999-01-25 2008-11-11 Amnis Corporation Methods for analyzing inter-cellular phenomena
WO2000046594A1 (en) 1999-02-02 2000-08-10 Caliper Technologies Corp. Methods, devices and systems for characterizing proteins
DE60044491D1 (en) 1999-02-12 2010-07-15 Univ Louisville Res Found DIHYDROOUABIN-SIMILAR FACTOR, DIAGNOSTIC AND THERAPEUTIC COMPOUNDS AND METHODS
US6326083B1 (en) 1999-03-08 2001-12-04 Calipher Technologies Corp. Surface coating for microfluidic devices that incorporate a biopolymer resistant moiety
US6375817B1 (en) 1999-04-16 2002-04-23 Perseptive Biosystems, Inc. Apparatus and methods for sample analysis
US6764817B1 (en) 1999-04-20 2004-07-20 Target Discovery, Inc. Methods for conducting metabolic analyses
US6818112B2 (en) 1999-04-20 2004-11-16 Target Discovery, Inc. Protein separation via multidimensional electrophoresis
US6919044B1 (en) 1999-06-17 2005-07-19 Beckman Coulter, Inc. Sample loading and handling interface to multiple chemistry analyzers
US6372813B1 (en) 1999-06-25 2002-04-16 Motorola Methods and compositions for attachment of biomolecules to solid supports, hydrogels, and hydrogel arrays
US6423536B1 (en) 1999-08-02 2002-07-23 Molecular Dynamics, Inc. Low volume chemical and biochemical reaction system
CA2387500C (en) 1999-10-20 2007-07-31 Gentra Systems, Inc. Mixing and pouring apparatus with rotatable arm and related vessel
US7329388B2 (en) 1999-11-08 2008-02-12 Princeton Biochemicals, Inc. Electrophoresis apparatus having staggered passage configuration
JP2001249079A (en) 1999-12-28 2001-09-14 Fujirebio Inc Chemiluminescence measuring method using luminous quantity regulating agent and method of enzyme immunoassay
WO2001055721A2 (en) 2000-01-28 2001-08-02 Applied Hydrogel Technology Corporation Detection of biomolecules in gels following electrophoresis
CA2343700C (en) 2000-04-13 2011-01-11 Janusz Pawliszyn Measurement of fluorescence using capillary isoelectric focusing
US6787016B2 (en) 2000-05-01 2004-09-07 Aclara Biosciences, Inc. Dynamic coating with linear polymer mixture for electrophoresis
FR2810905B1 (en) 2000-06-30 2003-05-16 Inst Curie ADDITIVE FOR MINIMIZING ADSORPTION AND / OR ELECTROOSMOSIS PHENOMENES
WO2002014851A2 (en) * 2000-08-10 2002-02-21 Lynx Therapeutics, Inc. Electrophoresis apparatus and method
JP3882484B2 (en) 2000-08-25 2007-02-14 株式会社日立製作所 Electrophoresis method, electrophoresis apparatus and capillary array
US20020123134A1 (en) 2000-12-26 2002-09-05 Mingxian Huang Active and biocompatible platforms prepared by polymerization of surface coating films
EP1236738A1 (en) 2001-02-23 2002-09-04 Jungbauer, Alois, Professor Dr. Internal standard for electrophoretic and chromatographic separation process
US6878256B2 (en) 2001-04-02 2005-04-12 Hitachi, Ltd. Capillary array device
US20050176070A1 (en) 2001-04-05 2005-08-11 Auton Kevin A. Protein analysis
US6916626B1 (en) 2001-04-25 2005-07-12 Rockeby Biomed Ltd. Detection of Candida
WO2002089972A1 (en) 2001-05-03 2002-11-14 Commissariat A L'energie Atomique Microfluidic device for analyzing nucleic acids and/or proteins, methods of preparation and uses thereof
US7374724B2 (en) 2001-05-29 2008-05-20 Tecan Trading Ag Device for processing samples, use of the device, and method for producing the device
CA2448728C (en) 2001-05-29 2009-08-18 Japan Science And Technology Agency Electrophoresis methods
DE10152690A1 (en) 2001-10-19 2003-05-08 Genescan Europ Ag Flow reaction chamber for sensor chips
US20050101841A9 (en) * 2001-12-04 2005-05-12 Kimberly-Clark Worldwide, Inc. Healthcare networks with biosensors
WO2003061453A2 (en) 2001-12-04 2003-07-31 Lifepoint, Inc. Device and method for the identification of analytes in bodily fluids
US6864480B2 (en) 2001-12-19 2005-03-08 Sau Lan Tang Staats Interface members and holders for microfluidic array devices
EP1487568A4 (en) 2002-03-12 2005-10-05 Syngenta Participations Ag Microcapillary hybridization chamber
US20040110208A1 (en) 2002-03-26 2004-06-10 Selena Chan Methods and device for DNA sequencing using surface enhanced Raman scattering (SERS)
GB2388189B (en) 2002-04-29 2006-01-11 Robert Jeffrey Geddes Carr Optical detection and analysis of particles
AU2003242354A1 (en) 2002-05-23 2003-12-12 Fuji Electric Holdings Co., Ltd. Living cell counting method and device
US7122640B2 (en) 2002-06-10 2006-10-17 Phynexus, Inc. Open channel solid phase extraction systems and methods
US6794671B2 (en) 2002-07-17 2004-09-21 Particle Sizing Systems, Inc. Sensors and methods for high-sensitivity optical particle counting and sizing
ATE480573T1 (en) 2002-07-29 2010-09-15 Life Technologies Corp GRAFT COPOLYMERS, THEIR PRODUCTION AND USE IN CAPILLARY ELECTROPHORESIS
US20040181443A1 (en) 2003-03-10 2004-09-16 Horton Carl A. Method and apparatus for the management of infrastructure assets, work orders,service requests, and work flows, utilizing an integrated call center, database, GIS system, and wireless handheld device
US7270784B2 (en) 2003-04-30 2007-09-18 Aurora Discovery, Incorporated Automated laboratory for high-throughput biological assays and RNA interference
IL156856A (en) 2003-07-09 2011-11-30 Joseph Shamir Method for particle size and concentration measurement
US7300523B2 (en) 2003-07-18 2007-11-27 Dade Behring Inc. Method for selectively washing used reaction cuvettes in an automatic analyzer
FR2859113B1 (en) 2003-08-29 2006-02-17 Centre Nat Rech Scient METHOD FOR TWO-DIMENSIONAL SEPARATION BY CAPILLARY ELECTROPHORESIS CARRIED OUT IN A SINGLE CAPILLARY
US7064826B2 (en) 2003-09-03 2006-06-20 Brightwell Technologies Digital optical measurement of particle populations using reduced magnification
US7410560B2 (en) 2003-09-11 2008-08-12 Bio-Rad Laboratories, Inc. Device for storage and delivery of standards for gel electrophoresis
DE10343900A1 (en) 2003-09-19 2005-04-21 Basf Ag Use of N-vinyllactam-containing copolymers for the production of functionalized membranes
US7309593B2 (en) 2003-10-01 2007-12-18 Surmodics, Inc. Attachment of molecules to surfaces
CA2487233C (en) 2003-11-10 2014-05-13 Frederick David King Method and apparatus for particle measurement employing optical imaging
US7217937B2 (en) 2003-11-21 2007-05-15 Brightwell Technologies Automatic identification of suspended particles
US20050115837A1 (en) 2003-12-01 2005-06-02 Dean Burgi Analyte identification in transformed electropherograms
US20070275193A1 (en) 2004-02-13 2007-11-29 Desimone Joseph M Functional Materials and Novel Methods for the Fabrication of Microfluidic Devices
WO2005091970A2 (en) 2004-03-06 2005-10-06 Michael Trainer Methods and apparatus for determining the size and shape of particles
US7382258B2 (en) 2004-03-19 2008-06-03 Applera Corporation Sample carrier device incorporating radio frequency identification, and method
JP4861308B2 (en) 2004-04-07 2012-01-25 ジェネンテック， インコーポレイテッド Mass spectrometry of antibody conjugates
EP1738212B1 (en) 2004-04-16 2010-08-25 Auburn University Microscope illumination device and adapter thereof
US20050249882A1 (en) 2004-05-04 2005-11-10 Shaorong Liu Coatings for molecule transport and separations
WO2006014680A1 (en) 2004-07-19 2006-02-09 Cell Biosciences, Inc. Methods and devices for analyte detection
US20060292558A1 (en) 2004-07-19 2006-12-28 Cell Biosciences Inc. Methods and apparatus for protein assay diagnostics
US20060292649A1 (en) 2004-07-19 2006-12-28 Cell Biosciences Inc. Methods and apparatus for reference lab diagnostics
US7846676B2 (en) 2004-07-19 2010-12-07 Cell Biosciences, Inc. Methods and devices for analyte detection
US7935479B2 (en) 2004-07-19 2011-05-03 Cell Biosciences, Inc. Methods and devices for analyte detection
US7807750B2 (en) 2004-08-06 2010-10-05 Surmodics, Inc. Thermally-reactive polymers
BRPI0519976A2 (en) 2005-02-10 2009-04-07 Commissariat Energie Atomique method for photochemically binding biomolecules to a substrate
JP2008536128A (en) 2005-04-09 2008-09-04 セル バイオサイエンシズ，インコーポレイテッド Automated microvolume assay system
CA2543521C (en) 2005-04-13 2014-05-27 Frederick David King Particle imaging system with a varying flow rate
CA2657317C (en) 2006-07-10 2012-10-02 Convergent Bioscience Ltd. Method and apparatus for precise selection and extraction of a focused component in isoelectric focusing performed in micro-channels
US20080017512A1 (en) 2006-07-24 2008-01-24 Bordunov Andrei V Coatings for capillaries capable of capturing analytes
US8080144B2 (en) 2006-10-04 2011-12-20 The United States of America as represented by the Secretary of Commerce, the National Institute of Standards and Technology Gradient elution electrophoresis
US7605919B2 (en) 2006-10-30 2009-10-20 Brightwell Technologies Inc. Method and apparatus for analyzing particles in a fluid
US20090023156A1 (en) 2007-07-20 2009-01-22 Voss Karl O Methods and reagents for quantifying analytes
US8000905B1 (en) 2007-09-14 2011-08-16 Kla-Tencor Technologies Corp. Computer-implemented methods, carrier media, and systems for determining sizes of defects detected on a wafer
US10107782B2 (en) 2008-01-25 2018-10-23 ProteinSimple Method to perform limited two dimensional separation of proteins and other biologicals
SG163442A1 (en) 2009-01-13 2010-08-30 Semiconductor Technologies & Instruments System and method for inspecting a wafer
US20110011740A1 (en) 2009-04-17 2011-01-20 Roach David J Capillary immunoassay systems and methods
WO2011005469A2 (en) 2009-06-24 2011-01-13 Carl Zeiss Nts, Llc Charged particle detectors
WO2012020038A1 (en) 2010-08-13 2012-02-16 Roche Glycart Ag Anti-tenascin-c a2 antibodies and methods of use
US8681215B2 (en) 2011-04-29 2014-03-25 ProteinSimple Method and particle analyzer for determining a broad particle size distribution
EP2839276B1 (en) 2012-04-19 2018-06-27 ProteinSimple Dual wavelength isoelectric focusing for determining drug load in antibody drug conjugates

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376249A (en) * 1992-11-25 1994-12-27 Perseptive Biosystems, Inc. Analysis utilizing isoelectric focusing
US6197173B1 (en) * 1995-11-08 2001-03-06 Francis H. Kirkpatrick Methods and reagents for gel electrophoresis
US5830539A (en) * 1995-11-17 1998-11-03 The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of The University Of Oregon Methods for functionalizing and coating substrates and devices made according to the methods
US6054032A (en) * 1998-01-27 2000-04-25 3M Innovative Properties Company Capillary electrophoresis array
US20030175986A1 (en) * 2001-02-05 2003-09-18 Patricelli Matthew P. Activity based probe analysis

Also Published As

Publication number Publication date
WO2007035864A2 (en) 2007-03-29
US8945361B2 (en) 2015-02-03
US20070062813A1 (en) 2007-03-22

Similar Documents

Publication Publication Date Title
WO2007035864A3 (en) Electrophoresis standards, methods and kits
WO2006078289A3 (en) Bio-barcode based detection of target analytes
WO2008105896A3 (en) Analyte determination utilizing mass tagging reagents comprising a non-encoded detectable label
WO2009073201A3 (en) Alternate labeling strategies for single molecule sequencing
WO2008014280A3 (en) Flourescent dyes for use in glucose sensing
WO2009048530A3 (en) Highly multiplexed particle-based assays
WO2006117161A3 (en) New labelling strategies for the sensitive detection of analytes
WO2008048230A3 (en) Methods of identifying biological targets and instrumentation to identify biological targets
WO2008020823A3 (en) Cooperative reporter systems, components, and methods for analyte detection
WO2009058902A3 (en) Methods and devices for analyte detection
WO2004072238A3 (en) Terminal-phosphate-labeled nucleotides with new linkers
WO2006057918A3 (en) Detection of nucleic acid variation by cleavage-amplification method
WO2005071096A3 (en) Derivatives of cephalosporin and clavulanic acid for detecting beta-lacamase in a sample
WO2007098184A3 (en) Methods and compositions for analyte detection
WO2007086904A3 (en) Compositions for use in identification of adenoviruses
WO2007098279A3 (en) Analyte detection using barcoded polymers
WO2006089091A3 (en) Methods for detecting minimum residual disease
WO2005087951A3 (en) Reagents, methods and kits for use in deactivating nucleic acids
WO2007040559A3 (en) Electrochemiluminescent assay
WO2008106648A3 (en) Immunoassays exhibiting a reduction in prozone phenomena
WO2009007846A3 (en) Methods for modifying, isolating, detecting, visualizing, and quantifying citrullinated and/or homocitrullinated peptides, polypeptides and proteins
WO2006119326A3 (en) Oligonucleotide probe/primer compositions and methods for polynucleotide detection
WO2005042771A3 (en) Colorimetric substrates, colorimetric sensors, and methods of use
WO2008124091A3 (en) Compositions and methods of detection
WO2008034622A3 (en) A method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06803977

Country of ref document: EP

Kind code of ref document: A2