WO2007035910A3 - Sub-threshold stimulation to precondition neurons for supra-threshold stimulation - Google Patents
Sub-threshold stimulation to precondition neurons for supra-threshold stimulation Download PDFInfo
- Publication number
- WO2007035910A3 WO2007035910A3 PCT/US2006/036962 US2006036962W WO2007035910A3 WO 2007035910 A3 WO2007035910 A3 WO 2007035910A3 US 2006036962 W US2006036962 W US 2006036962W WO 2007035910 A3 WO2007035910 A3 WO 2007035910A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cells
- phases
- pulse
- smaller
- threshold
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0543—Retinal electrodes
Abstract
In order to generate the smallest phosphenes possible, it is advantageous to selectively stimulate smaller cells. By hyperpolarizing the somas of the large cells selectively with sub-threshold anodic 'pre-pulse' stimuli (making them more difficult to stimulate) and then selectively depolarize the smaller cells one can selectively stimulate smaller cells. Alternatively, one can hyperpolarize the dendrites of the cells with larger dendritic fields by applying sub-threshold anodic currents on surrounding electrodes and then depolarizing the smaller cells in the center. Further, one can manipulate the phases of an individual biphasic wave to affect selective stimulation resulting in more focal responses. It is possible to increase resolution with the 'pre-pulse' described above. One can also effect resolution by modifying the pulse order of the cathodic and anodic phases. Further, one can isolate the effect of the phases by separating them in time (long inter-phase interval) or by making one of the phases long and low amplitude - always keeping equal total charge for the two phases. As an example, one can preferentially stimulate smaller ganglion cells by providing a longer sub-threshold anodic pulse balanced with a shorter supra-threshold cathodic pulse. Preferentially stimulating the smaller ganglion cells will allow stimulation of different brightness levels while maintaining high spatial resolution.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06825064A EP1937352B1 (en) | 2005-09-19 | 2006-09-19 | Sub-threshold stimulation to precondition neurons for supra-threshold stimulation |
AT06825064T ATE549060T1 (en) | 2005-09-19 | 2006-09-19 | SUB-THRESHOLD STIMULATION FOR PRECONDITIONING NEURONS FOR SUPRA-THRESHOLD STIMULATION |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71865905P | 2005-09-19 | 2005-09-19 | |
US60/718,659 | 2005-09-19 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007035910A2 WO2007035910A2 (en) | 2007-03-29 |
WO2007035910A3 true WO2007035910A3 (en) | 2007-06-07 |
Family
ID=37680609
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2006/036962 WO2007035910A2 (en) | 2005-09-19 | 2006-09-19 | Sub-threshold stimulation to precondition neurons for supra-threshold stimulation |
Country Status (4)
Country | Link |
---|---|
US (3) | US7734352B2 (en) |
EP (1) | EP1937352B1 (en) |
AT (1) | ATE549060T1 (en) |
WO (1) | WO2007035910A2 (en) |
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US8428740B2 (en) | 2010-08-06 | 2013-04-23 | Nano-Retina, Inc. | Retinal prosthesis techniques |
US8706243B2 (en) | 2009-02-09 | 2014-04-22 | Rainbow Medical Ltd. | Retinal prosthesis techniques |
US8718784B2 (en) | 2010-01-14 | 2014-05-06 | Nano-Retina, Inc. | Penetrating electrodes for retinal stimulation |
US8150526B2 (en) | 2009-02-09 | 2012-04-03 | Nano-Retina, Inc. | Retinal prosthesis |
US8442641B2 (en) | 2010-08-06 | 2013-05-14 | Nano-Retina, Inc. | Retinal prosthesis techniques |
US8545412B2 (en) * | 2009-05-29 | 2013-10-01 | Boston Scientific Scimed, Inc. | Systems and methods for making and using image-guided intravascular and endocardial therapy systems |
WO2011031498A2 (en) * | 2009-08-25 | 2011-03-17 | The Salk Institute For Biological Studies | Customization of irregular arrays |
WO2012100290A1 (en) * | 2011-01-24 | 2012-08-02 | Newsouth Innovations Pty Limited | Stimulation method for maintaining responsiveness of cells |
US8571669B2 (en) | 2011-02-24 | 2013-10-29 | Nano-Retina, Inc. | Retinal prosthesis with efficient processing circuits |
WO2012129175A1 (en) * | 2011-03-18 | 2012-09-27 | Salk Institute For Biological Studies | Method for identification of retinal cell types using intrinsic properties |
EP2750756B1 (en) | 2011-08-31 | 2016-08-10 | NewSouth Innovations Pty Limited | Neural prosthesis withstimulation electrodes |
US20160082250A1 (en) * | 2011-08-31 | 2016-03-24 | Newsouth Innovations Pty Limited | Multi-source stimulation |
US8909344B2 (en) | 2013-03-07 | 2014-12-09 | Jeffrey Edward Arle | Head worn brain stimulation device and method |
US9370417B2 (en) | 2013-03-14 | 2016-06-21 | Nano-Retina, Inc. | Foveated retinal prosthesis |
EP3005284A4 (en) | 2013-05-28 | 2016-11-16 | Pixium Vision Sa | Smart prosthesis for facilitating artificial vision using scene abstraction |
US9474902B2 (en) | 2013-12-31 | 2016-10-25 | Nano Retina Ltd. | Wearable apparatus for delivery of power to a retinal prosthesis |
US9331791B2 (en) | 2014-01-21 | 2016-05-03 | Nano Retina Ltd. | Transfer of power and data |
US9956404B2 (en) | 2014-11-19 | 2018-05-01 | Medtronic, Inc. | Electrical stimulation to inhibit bladder and/or bowel contraction |
US11318310B1 (en) | 2015-10-26 | 2022-05-03 | Nevro Corp. | Neuromodulation for altering autonomic functions, and associated systems and methods |
EP3389768B1 (en) | 2015-12-18 | 2023-03-01 | Medtronic, Inc. | High duty cycle electrical stimulation therapy |
WO2017219094A1 (en) * | 2016-06-23 | 2017-12-28 | Newsouth Innovations Pty Limited | A method and apparatus for facilitating artificial vision |
US10525268B2 (en) | 2016-08-23 | 2020-01-07 | Medtronic, Inc. | Delivery of independent interleaved programs to produce higher-frequency electrical stimulation therapy |
US10569088B2 (en) | 2016-09-16 | 2020-02-25 | Medtronic, Inc. | Dorsal spinal column characterization with evoked potentials |
EP3532151A1 (en) | 2016-10-28 | 2019-09-04 | Medtronic, Inc. | Controlling electrical stimulation therapy |
US11045650B2 (en) | 2016-12-06 | 2021-06-29 | Medtronic, Inc. | High frequency neurostimulation for pelvic symptom control |
US11116980B2 (en) | 2017-04-07 | 2021-09-14 | Medtronic, Inc. | Complex variation of electrical stimulation therapy parameters |
WO2019074949A1 (en) | 2017-10-10 | 2019-04-18 | Medtronic, Inc. | Management of electrical stimulation therapy |
WO2019246582A1 (en) | 2018-06-21 | 2019-12-26 | Medtronic, Inc. | Ecap based control of electrical stimulation therapy |
EP4085971B1 (en) | 2018-06-21 | 2023-12-13 | Medtronic, Inc. | Ecap based control of electrical stimulation therapy |
US11590352B2 (en) | 2019-01-29 | 2023-02-28 | Nevro Corp. | Ramped therapeutic signals for modulating inhibitory interneurons, and associated systems and methods |
US11547855B2 (en) | 2019-10-25 | 2023-01-10 | Medtronic, Inc. | ECAP sensing for high frequency neurostimulation |
US11931582B2 (en) | 2019-10-25 | 2024-03-19 | Medtronic, Inc. | Managing transient overstimulation based on ECAPs |
US11857793B2 (en) | 2020-06-10 | 2024-01-02 | Medtronic, Inc. | Managing storage of sensed information |
US11707626B2 (en) | 2020-09-02 | 2023-07-25 | Medtronic, Inc. | Analyzing ECAP signals |
US11896828B2 (en) | 2020-10-30 | 2024-02-13 | Medtronic, Inc. | Implantable lead location using ECAP |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0271766A (en) * | 1988-09-06 | 1990-03-12 | Hiroshi Yamamoto | Electrical stimulator |
US6505078B1 (en) * | 1996-04-04 | 2003-01-07 | Medtronic, Inc. | Technique for adjusting the locus of excitation of electrically excitable tissue |
US20040044379A1 (en) * | 1998-04-30 | 2004-03-04 | Medtronic, Inc. | Selective dorsal column stimulation in SCS, using conditioning pulses |
US6882881B1 (en) * | 1999-10-19 | 2005-04-19 | The Johns Hopkins University | Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders |
US20060167528A1 (en) * | 2005-01-26 | 2006-07-27 | Arup Roy | Neural stimulation for increased persistence |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5109844A (en) * | 1990-10-11 | 1992-05-05 | Duke University | Retinal microstimulation |
DE19707046A1 (en) * | 1997-02-21 | 1998-08-27 | Rolf Prof Dr Ing Eckmiller | Learnable "Active Vision" implant encoder |
US6458157B1 (en) * | 1997-08-04 | 2002-10-01 | Suaning Gregg Joergen | Retinal stimulator |
US5935155A (en) * | 1998-03-13 | 1999-08-10 | John Hopkins University, School Of Medicine | Visual prosthesis and method of using same |
US6560490B2 (en) * | 2000-09-26 | 2003-05-06 | Case Western Reserve University | Waveforms for selective stimulation of central nervous system neurons |
JP4204066B2 (en) * | 2002-12-05 | 2009-01-07 | 保雄 田野 | Artificial vision system |
US6990377B2 (en) * | 2003-04-24 | 2006-01-24 | Northstar Neuroscience, Inc. | Systems and methods for facilitating and/or effectuating development, rehabilitation, restoration, and/or recovery of visual function through neural stimulation |
US7684866B2 (en) * | 2003-08-01 | 2010-03-23 | Advanced Neuromodulation Systems, Inc. | Apparatus and methods for applying neural stimulation to a patient |
-
2006
- 2006-09-19 AT AT06825064T patent/ATE549060T1/en active
- 2006-09-19 US US11/523,897 patent/US7734352B2/en active Active
- 2006-09-19 WO PCT/US2006/036962 patent/WO2007035910A2/en active Application Filing
- 2006-09-19 EP EP06825064A patent/EP1937352B1/en not_active Revoked
-
2007
- 2007-10-25 US US11/924,313 patent/US7765009B2/en active Active
-
2010
- 2010-06-15 US US12/815,988 patent/US8620441B2/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0271766A (en) * | 1988-09-06 | 1990-03-12 | Hiroshi Yamamoto | Electrical stimulator |
US6505078B1 (en) * | 1996-04-04 | 2003-01-07 | Medtronic, Inc. | Technique for adjusting the locus of excitation of electrically excitable tissue |
US20040044379A1 (en) * | 1998-04-30 | 2004-03-04 | Medtronic, Inc. | Selective dorsal column stimulation in SCS, using conditioning pulses |
US6882881B1 (en) * | 1999-10-19 | 2005-04-19 | The Johns Hopkins University | Techniques using heat flow management, stimulation, and signal analysis to treat medical disorders |
US20060167528A1 (en) * | 2005-01-26 | 2006-07-27 | Arup Roy | Neural stimulation for increased persistence |
Non-Patent Citations (1)
Title |
---|
WARREN M GRILL ET AL: "Stimulus Waveforms for Selective Neural Stimulation", IEEE ENGINEERING IN MEDICINE AND BIOLOGY MAGAZINE, IEEE SERVICE CENTER, PISACATAWAY, NJ, US, vol. 14, no. 4, July 1995 (1995-07-01), pages 375 - 385, XP011084621, ISSN: 0739-5175 * |
Also Published As
Publication number | Publication date |
---|---|
US7765009B2 (en) | 2010-07-27 |
US8620441B2 (en) | 2013-12-31 |
EP1937352A2 (en) | 2008-07-02 |
US7734352B2 (en) | 2010-06-08 |
US20070078496A1 (en) | 2007-04-05 |
EP1937352B1 (en) | 2012-03-14 |
US20100256706A1 (en) | 2010-10-07 |
ATE549060T1 (en) | 2012-03-15 |
US20080046031A1 (en) | 2008-02-21 |
WO2007035910A2 (en) | 2007-03-29 |
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