WO2007038540A1 - Prosthetic cardiac and venous valves - Google Patents
Prosthetic cardiac and venous valves Download PDFInfo
- Publication number
- WO2007038540A1 WO2007038540A1 PCT/US2006/037543 US2006037543W WO2007038540A1 WO 2007038540 A1 WO2007038540 A1 WO 2007038540A1 US 2006037543 W US2006037543 W US 2006037543W WO 2007038540 A1 WO2007038540 A1 WO 2007038540A1
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- Prior art keywords
- valve
- stent
- leaflets
- tube
- extending
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
- A61F2/2418—Scaffolds therefor, e.g. support stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2475—Venous valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/2436—Deployment by retracting a sheath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0008—Fixation appliances for connecting prostheses to the body
- A61F2220/0016—Fixation appliances for connecting prostheses to the body with sharp anchoring protrusions, e.g. barbs, pins, spikes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/005—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements using adhesives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
- A61F2220/0066—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements stapled
Definitions
- the present invention relates to prosthetic heart and venous valves used in the treatment of cardiac and venous valve disease. More particularly, it relates to minimally invasive and percutaneous replacement of cardiac and venous valves. Background
- U.S. Patent No. 5,411,552 discloses a percutaneously deliverable valve for aortic valve replacement. Like the Tower et al. valve, this valve system employs a stent external to the valve to exert pressure against the vessel at the implant site to provide a seal. This pressure of the stent against the vessel also helps to keep the valve from becoming displaced once it has been implanted. With these and other percutaneously delivered valves, the stent or other expandable member is typically designed to surround at least the valve orifice. This basic configuration allows blood to flow through the center of the valve when the valve is open, with the multiple valve leaflets sealing against themselves to close the valve.
- the native aortic valve annulus in which the replacement is to be implanted may be calcified and have an irregular perimeter
- this basic configuration can be problematic, particularly in the context of replacement aortic valves.
- a valve annulus with an irregular perimeter can make it difficult for an expanded stent to accurately follow the contours of the native annulus, which can result in peripheral fluid leakage.
- This problem is typically not present in traditional surgically implanted valves, since their relatively rigid stents are typically sealed to the valve annulus with a sealing ring that is attached to the annulus by means of numerous sutures.
- valves include, for example, surgically implantable valves disclosed in U.S. Patent Nos. 4,339,831 (Johnson) and 5,449,384 (Johnson), both of which are incorporated herein in their entireties. These valves have a configuration that is essentially the opposite of the natural configuration, such that the valve leaflets open inwardly and close by expanding outwardly to contact the native aortic valve annulus. These valves further include a framework comprising a plurality of struts that are sutured to the patient's annulus or an artificial annulus reconstruction ring and a flexible membrane attached to the framework to allow the membrane segments or leaflets to freely open inward to allow forward blood flow through the valve.
- the present invention is particularly directed to improvements in minimally invasive and percutaneously delivered valves for use in pulmonary and aortic positions.
- the invention may also be useful in other types of valves, including other heart valves and peripheral venous valves.
- a valve of the invention has leaflets that are configured to operate in an essentially an opposite manner from a typical artificial valve. Using this reverse or opposite configuration in a minimally invasively or percutaneously delivered valve with a collapsible stent can provide certain benefits.
- the outwardly sealing valve leaflets may adapt themselves or conform more readily to irregular configurations of the orifice in which the valve is mounted, thereby overcoming or reducing the sealing problems sometimes associated with expandable stents that are external to the valve leaflets.
- the present invention also includes embodiments of a variety of outwardly sealing multi-leaflet valves, which are believed to be especially useful in conjunction with a number of different embodiments of collapsible stents.
- the valve leaflets are produced by inverting a section of a naturally valved vessel, such as a porcine aorta or a bovine jugular vein.
- the valve leaflets are produced by sealing one end of a flexible tube and employing the unsealed end to define the leaflets.
- the valve is produced by stitching together leaflets of flexible material such as pericardial tissue to provide a generally cup shaped structure.
- the valve leaflets are mounted to an expandable stent which is to be anchored to the orifice in which the valve is implanted. This valve implantation is positioned to be downstream of or adjacent to the free edges of the leaflets.
- the expandable stent may be configured with a flexible frame that is manufactured of a material consistent with being collapsed to allow delivery through a tubular percutaneous catheter or minimally invasive tubular surgical port type device.
- the stent may include a self-expanding or balloon expandable circumferential stent that is located downstream of the free edges of the valve leaflets.
- the stent may include outwardly extending barbs that are preferably, but not necessarily, located downstream of the free edges of the leaflets.
- a prosthetic heart or venous valve comprising a central tissue structure comprising multiple tissue lobes extending from a common central area, wherein each of the lobes includes a longitudinal slot.
- the valve further comprises a plurality of leaflets extending from the central tissue structure and positioned between two adjacent lobes, wherein each of the leaflets comprises a free end spaced from the central tissue structure, and also comprises a compressible and expandable stent frame comprising a plurality of extending arms, wherein each of the extending arms of the stent frame is positioned at least partially within one of the longitudinal slots of the central tissue structure.
- the central tissue structure can comprise a native valve segment that has been inverted to provide the plurality of leaflets, wherein the multiple tissue lobes can be formed by folded portions of an aortic wall of the native valve segment.
- a prosthetic valve which comprises a flexible tube having an inflow end and a outflow end, wherein the inflow end of the tube is folded against and attached to itself and the outflow end of the tube is unattached to itself, and a stent having multiple longitudinally extending members located at least partially within the tube and extending to the open outflow end of the tube, wherein portions of the tube that are adjacent the outflow end of the tube and between the longitudinally extending members of the stent are moveable toward and away from a central area of the valve to provide a plurality of valve leaflets.
- Figure 1 is a top view of a natural aortic valve
- Figure 2 is a top view of the natural aortic valve of Figure 1 with the valve structure turned "inside-out” on itself such that the leaflets are positioned on the outside of the valve in a tri-lobed configuration;
- Figure 3 is a side view of the natural aortic valve turned "inside-out” as in Figure 2, with the aortic wall sutured to itself at an inflow end of the valve;
- Figure 4 is a side view of the natural aortic valve turned “inside-out” as in Figure 2, with the aortic wall sutured to itself at an inflow end of the valve, wherein the aortic wall is trimmed to more closely match the configuration of typical valve leaflets;
- Figure 5 is a side view of one embodiment of a stent for use in conjunction with valves of the type illustrated in Figures 3 and 4;
- Figure 6 is a side view of the stent of Figure 5 mounted inside a valve of the type illustrated in Figure 4 to provide one embodiment of a completed replacement valve of the invention;
- Figure 7 is a side view of the replacement valve of Figure 6, as positioned within an aortic annulus, which is illustrated in cross-section;
- Figure 8 is a side view of a delivery catheter or device positioned within an aortic annulus, with the replacement valve of Figure 6 partially advanced from one end of the catheter or device;
- Figure 9 is a side view of the delivery catheter or device illustrated in Figure 8, with the replacement valve of Figure 6 being further advanced from one end of the catheter into the aortic annulus;
- Figure 10 is a side view of the replacement valve of Figure 6 in a desired position within an aortic annulus, which is also the position it will generally be in after it has been completely advanced from the end of the delivery device of Figures 8 and 9;
- Figure 11 is a side view of a delivery catheter within an aortic annulus that includes a balloon catheter that is radially expandable to anchor a replacement valve into the tissue of a patient;
- Figure 12 is a side view of an alternative embodiment of a replacement valve of the type illustrated in Figure 6 as positioned within an aortic annulus, which includes an alternative embodiment for anchoring the valve;
- Figure 13 is a side view of another alternative embodiment of a replacement valve of the type illustrated in Figure 6 as positioned within an aortic annulus, which includes another alternative embodiment for anchoring the valve;
- Figure 14 is a top view of a replacement valve generally of the type illustrated in Figure 6, which further includes optional tissue or fabric portions to prevent leakage adjacent the valve commissures;
- Figure 15 is a side view of an alternative structure to provide valve leaflets that are mounted to a stent to provide an alternative embodiment of a completed replacement valve of the invention
- Figure 16 is a side view of the alternative valve leaflet structure of Figure 15, which uses an alternative stent configuration
- Figure 17 is a side view of a flexible tube of natural or synthetic material as can be used for replacement valves of the invention.
- Figure 18 is a perspective view of a replacement valve fabricated from the tube of Figure 17 and mounted to a stent, which includes having its inflow end sutured to produce a tri-Iobed structure;
- Figure 19 is a top view of the replacement valve of Figure 18, as located within the aortic annulus;
- Figure 20 is atop view of an alternative structure of the replacement valve of Figure 18;
- Figure 21 is at top view of another alternative structure of the replacement valve of Figure 18;
- Figure 22 is an enlarged top view of a portion of the replacement valve of Figure 21;
- Figure 23 is a perspective view of a replacement valve fabricated from the tube of the type illustrated in Figure 17 and mounted to a stent, which includes having its inflow end sutured to create a bi-lobed structure;
- Figure 24 is an enlarged top view of a portion of the replacement valve of Figure 23;
- Figure 25 is a perspective view of an alternative embodiment of the replacement valve of Figure 23, which is folded onto itself to provide for passage through a catheter;
- Figure 26 is a perspective view of an alternative stent configuration for use with the leaflets configured in accordance with the present invention.
- Figure 27 is a top view of another embodiment of a replacement valve having a bi-lobed structure.
- Figure 28 is a top view of another embodiment of a replacement valve having a bi-lobed structure.
- a natural aortic valve 3 which generally comprises three leaflets 2 extending from an aortic wall 4.
- the leaflets 2 meet at their free edges 6 to seal the valve orifice when the valve 3 is in its closed position.
- the free edges 6 can move away from each other and toward the aortic wall 4, however, when the valve 3 is in its open configuration, thereby creating an open passage for blood flow.
- Such a natural aortic valve 3 may be a valved segment of a porcine valve, for example, which can be particularly advantageous in certain aspects of the invention due to the relatively thin aortic walls of these valves.
- Figure 2 illustrates an top view of an aortic valve 16, which is basically the valve
- the aortic wall 4 is further configured so that it defines a tri-lobed configuration, with the leaflets 2 on the outside of the valve 16 rather than the inside of the valve, as will be described in further detail below.
- the free edges 6 of leaflets 2 are located at the external periphery of the valve 16 such that the free edges 6 no longer will be in contact with each other when the valve 16 is in its closed configuration, but instead will be in contact with the vessel in which it is implanted (e.g., aorta).
- the leaflets 2 are facing in a generally opposite direction from the direction they are facing in a valve in its natural state.
- the aortic wall 4 further defines three internal longitudinally extending slots 8 in the area where the wall 4 is folded onto or toward itself. That is, each of the lobes of the tri-lobed configuration includes a slot 8 extending through it. Because the valve 16 opens inwardly, rather than outwardly, relative to the structure in which it is positioned (e.g., an aorta), the leaflets 2 will seal against the aorta or other structure in which the valve is positioned when the valve 16 is in a closed state and will move toward the inner, tri-lobed structure when the valve 16 is in an open state. Thus, paravalvular leakage can be minimized or eliminated as compared to valves in which the radial strength of a stent is an issue.
- the leaflets 2 In order to allow the free edges 6 of leaflets 2 of Figure 2 to better conform to the tissue annulus in which the valve 16 is positioned, it is desirable for the leaflets 2 to have a certain level of elasticity. This can be accomplished by fixing the valve material with glutaraldehyde, for example, using conventional high, low or zero pressure fixation techniques, although other fixing techniques and materials can be used. In some embodiments, the aortic wall 4 may be trimmed to reduce the thickness of the wall, which will provide different properties for the valve (e.g., strength, flexibility, and the like).
- such a valve structure can be produced, for example, starting with a valved segment of bovine jugular vein that is trimmed to make its walls thinner and thus more adaptable to at least some of the valve configurations of the invention.
- Figure 3 illustrates a side view of the valve 16 of Figure 2, with adjacent portions of an inflow end 12 of the folded aortic wall 4 attached to each other by sutures 10 to seal the end of the valve 16 and maintain the tri-lobed structure.
- adhesive or other surgical fasteners can be used to secure the inflow end 12 of the structure in such a configuration.
- a vacuum can be pulled on the valve 16 prior to using the sutures or other material to seal the end of the valve 16.
- Figure 4 illustrates an alternative embodiment of the aortic valve of Figure 3, with the inflow end 12 of the aortic wall 4 being trimmed into a curved shape to more closely match the configuration of the bases of the valve leaflets 2 and to eliminate excess valve material extending beyond the leaflets 2.
- the stent 18 includes three longitudinally extending curved a ⁇ ns 20 that extend from a common point 22, which will be positioned adjacent to the inflow end of a replacement valve.
- the arms 20 are shown as being generally the same length as each other in this figure, which will be adaptable to the implantation location of most replacement valves. It is possible, however, that at least one of the arms 20 is a different length than the other arms 20, such as in cases where particular anatomical needs of a patient need to be accommodated, when certain anchoring techniques are used, or when other considerations of the patient, the valve, or the delivery systems need to be considered, for example.
- the three arms 20 can be angularly displaced approximately 120 degrees from one another so that they are evenly spaced around the perimeter of the stent 18; however, it may instead be desirable to position the arms 20 at different angular spacings from each other.
- one or more of the arms 20 further include outwardly extending barbs or connectors 24 at an outflow end 14 of the stent 18.
- These connectors 24 are designed to engage with the wall of the aorta or other tissue structure in which the stent 18 may be positioned.
- Connectors 24 can include a wide variety of configurations and features, such as the arrow-shaped tips shown, or other configurations that provide for engagement with tissue through a piercing or other similar motion, and further do not allow the connector to disengage from the tissue with normal movement of the stent within the tissue.
- Each of the arms 20 of this embodiment are shown as including two barb-like connectors 24; however, more or less than two connectors 24 may extend from a single arm 20, and each of the arms 20 of a stent 18 may include the same or a different number of connectors 24.
- the stent 18 is constructed of a material that is sufficiently flexible that it can be collapsed for percutaneous insertion into a patient.
- the material is also preferably self- expanding (e.g., Nitinol) such that it can be readily compressed and re-expanded.
- the material should further be chosen so that when the stent 18 is positioned within an aorta, for example, it exerts sufficient pressure against the aortic walls that fluids cannot leak past the stent 18.
- the stent 18 should provide enough radial outward force so that the tips or ends of the fold material of a tri-lobed structure can press against the inside walls of an aorta or other structure of a patient in such a way that blood cannot flow past these tips of the replacement valve.
- the replacement valves and associated stents can be provided in a variety of sizes to accommodate the size requirements of different patients.
- Figure 6 illustrates the stent 18 of Figure 5 mounted inside a valve 16 of the type illustrated in Figure 4 to provide a completed replacement valve 26.
- the ends of the arms 20 extend beyond the ends of the valve 16 at the outflow end 14 of the valve; therefore, an area of the stent 18 relatively near the common point 22 (not visible in this figure) is positioned adjacent to the inflow end 12 of the valve 26.
- the adjacent tissue portions of the lobes at both the inflow end 12 and the outflow end 14 of the replacement valve 26 can be sewed or otherwise connected to each other, such as by sutures 10, in order to prevent or minimize the possibility of blood entering the slots 8 (see Figure 2) of the tri-lobed structure.
- the stent 18 is preferably retained in position within the slots 8 of aortic wall 4 by means of adhesive, sutures or other surgical fasteners.
- the stent 18 is positioned within the slots 8 before the tissue is sutured or attached to itself at one or both of the inflow and outflow ends 12, 14.
- the adjacent stent 18 can be sutured to the valve 26 at the same time, such that one stitching operation can serve the dual purpose of sealing the inflow end 12 of the valve 26 and also securing the stent 18 to the valve 26.
- valve 26 a replacement valve of the type generally shown as the valve 26 in Figure 6 is illustrated, as mounted in an aortic annulus 28 of a patient.
- the valve 26 is positioned so that the free edges 6 of the leaflets 2 contact the annulus 28 around at least a substantial portion of the circumference of the aortic annulus 28, and preferably contact the annulus 28 around its entire circumference.
- the valve 26 is further positioned along the length of the aorta so that the connectors 24 are above the sinuses of Valsalva 32 and adjacent to a wall 30 of the patient's aorta.
- the connectors 24 are shown here as being slightly spaced from the wall 30, such as when the valve 26 is in an at least slightly compressed or unexpanded state.
- the arms 20 will be move or be forced to move at least slightly outward toward the walls 30 until the connectors 24 are imbedded or engaged with at least a portion of the thickness of the walls 30.
- These connectors 24 will then .serve the purpose of retaining the valve 26 in its desired implant location relative to the aorta.
- the connectors 24 can be designed to extend through the entire thickness of the walls 30 such that they will basically be anchored to the outside surface of the aortic walls 30.
- the connectors may be designed to extend only through a portion of the thickness of the walls 30, which, in order to keep the valve 26 securely in place, may require a different style of connector than a connector that extends entirely through an aortic wall.
- connectors that need to engage within the thickness of a tissue can include a number of barbs or tissue engaging structures on each connector, while a connector that extends all the way through the tissue may only need to have a relatively wide base that will not easily pass backward through the hole it created when originally passing through the tissue.
- the native valve can be completely or partially removed.
- the native valve may be left in its original location; however, the replacement valve in such a circumstance should be positioned in such a way that the remaining native valve does not interfere with its operation.
- exemplary valve removal or resection devices that can be used are described, for example, in PCT Publication WO/0308809A2, which is incorporated herein by reference in its entirety.
- Figures 8-10 illustrate an end portion of one exemplary delivery device and exemplary sequential steps for using such a device for delivering a replacement valve 26 to its desired location within a patient.
- Figure 8 illustrates a tubular delivery device 34 that has been advanced to the general location where the replacement valve 26 will be implanted.
- the delivery device 34 is inserted into the body using one of a number of different approaches.
- the device 34 can reach the aorta through a retrograde approach originating at a location distal to the heart, such as the femoral artery.
- an antegrade approach could be used, which originates at a location distal to the heart, such as the femoral vein or an incision in the ventrical wall or apex.
- the device 34 is moved to the desired implantation area of the body with a replacement valve 26 being partially or entirely enclosed within an outer sheath 35.
- the portion of sheath 35 at the distal end of device 34 is at least slightly larger in diameter than the adjacent portion of the device 34, which will help to keep the valve 26 positioned near the distal end of device 34 (i.e., keep it from translating along the length of the device 34).
- the distal end of the sheath 35 may additionally or alternatively include a stop or some other configuration that keeps the valve 26 from migrating away from the distal end of device 34.
- the replacement valve 26 is shown as it is beginning to be advanced out of the end of a tubular delivery device 34 by pulling back the sheath 35, thereby releasing or exposing one end of the replacement valve 26.
- the valve 26 is delivered in a radially compressed configuration to ease passage of the device 34 through the vascular system; however, the valve 26 will be able to expand after it is released from the end of the device 34.
- the leaflets 2 of the valve 26 are first are advanced distally out of the end of the device 34, as illustrated in Figure 8, so that they can be properly located relative to the aortic annulus 28.
- Figure 9 illustrates the replacement valve 26 as it is further released from the device 34 by further retraction of the sheath 35. As the delivery device 34 is withdrawn, the stent 18 of the valve 26 is allowed to expand and seat the replacement valve 26 in its desired location.
- Figure 10 illustrates the stent of the replacement valve 26 after the delivery device 34 has been retracted a sufficient amount that it is completely separated from the valve 26.
- the arms 20 are configured so that they tend to expand radially outwardly once they are released from the sheath 35. The outward radial force causes the barbs or connectors 24 to embed or otherwise engage with the wall 30 of the patient's aorta to anchor the replacement valve 26.
- the stents of the invention may be shaped and/or positioned differently than previously described.
- the stent arms could instead be curved outwardly (i.e., convex) to conform at least somewhat to the location of the body in which it will be positioned (e.g., aorta for aortic valve, pulmonary trunk for the pulmonic vein, vein for venous valve, and ventricle of mitral/tricuspid valve).
- This outward curvature of the stent arms can help to secure or anchor the valve in place and thus can have different degrees or amounts of curvature depending on the configuration of the particular replacement valve.
- the barbs or connectors that extend from the stent arms can be positioned near the distal ends of the arms (i.e., spaced relatively far from the valve, such as valve 16), as shown and described above, in order for these connectors to be positioned beyond the sinuses of Valsalva of the aortic valve of a patient.
- the barbs or connectors could alternatively or additionally be located closer to the valve, such as valve 16, which would position the connectors closer to the outflow end of the replacement valve.
- FIG 11 illustrates an optional additional use of a balloon catheter 36 on the delivery device 34 to help to anchor the valve 26 in place in the aorta or other tissue of a patient.
- balloon catheter 36 includes a balloon 38, which is located radially between the arms 20 of the stent 18 when the sheath 35 has been retracted from the valve 26.
- balloon 38 will generally be at least partially deflated in order to minimize its size and allow for easier percutaneous insertion of the valve 26.
- the balloon 38 is inflated via the balloon catheter 36.
- the inflation of balloon 38 can be carefully monitored, such as by measuring pressures of forces, to expand the arms 20 outwardly by a particular amount, thereby driving the barbs or connectors 24 toward and into the wall 30 of the patient's aorta.
- valve may be delivered to sites other than the aortic annulus.
- Figures 12 and 13 illustrate alternative replacement valves that are similar in structure to the valve 26 discussed above, but include alternative structures for anchoring the replacement valve. These replacement valves are again shown in the general location in which they will be positioned within an aortic annulus 28 of a patient.
- Figure 12 illustrates a replacement valve that includes the stent 18 having multiple arms 20, but instead of these arms 20 including barbs or connectors, the arms 20 are stent wires that are coupled to a slotted-tube type stent ring 40.
- the arms 20 of this embodiment may also be curved outwardly to conform at least somewhat to the location of the body in which it will be positioned. This outward curvature of the stent arms can help to secure or anchor the valve in place.
- stent ring 40 may be self-expanding or may be expanded by a balloon or other device that can radially expand the ring 40.
- Figure 13 illustrates a replacement valve that again includes the stent 18 having multiple arms 20.
- the arms 20 are coupled to a stent 42 that is formed of one or more zig-zag wires.
- the wires are arranged relative to each other in such a way that they provide sufficient radial strength to keep the valve in place relative to the aortic annulus 28 or other location to which the valve is delivered.
- delivery of this valve can be performed using a procedure that is similar to that described above relative to Figures 8-11, or a different method can be used.
- stent 42 may be self-expanding or may be expanded by a balloon or other device that can radially expand the stent 42.
- FIG 14 illustrates another embodiment of the replacement valve 26 of Figure 6.
- a replacement valve 43 which includes the same basic structure of the aortic valve 3 of Figure 2, and further including the stent 18 including arms 20, as in Figure 5.
- the tips of the arms 20 of stent 18 are located in the slots 8 and are visible in this top view of the valve 43.
- the valve 43 further includes optional bulbous portions 44 that extend from each of the tips of the lobes of the tri-lobed structure of the valve 43. These portions 44 are provided to further insure secure contact between the valve 43 and the aorta or other structure in the areas adjacent to the leaflets 2, thereby further minimizing or preventing leakage adjacent the val ⁇ e commissures.
- These portions 44 may be made of a tissue, fabric, or other material, as desired.
- FIG. 15 illustrates a replacement valve 48, which includes an alternative structure to provide valve leaflets.
- leaflets 50 are cut or otherwise formed from a natural or synthetic flexible material (e.g., pericardial tissue, polymeric material, fabric, and the like), and are attached to multiple arms 52 of a stent via sutures, glue, or some other attachment material or method.
- the leaflets 50 are further attached to one another by means of sutures 54 to define a generally cup-shaped structure.
- the valve leaflets 50 comprise the regions of the cup-shaped structure located between the longitudinally extending arms 52 of the stent.
- the arms 52 of the stent can correspond generally to the arms 20 of the stent of Figure 5, or can be arranged and configured differently.
- the stent and leaflets could also be constructed together using processes and materials disclosed, for example, in U.S. Patent Nos. 6,458,153; 6,652,578; and 7,018,408 (all to Bailey et al.), which are incorporated herein by reference.
- the arms 52 are coupled to an expandable slotted tube type stent 56, which may be self-expanding or balloon-expandable similar to the stent 40 of Figure 12.
- Other forms of circumferential stents, barbs, or other structures may be used in addition to or as an alternative to the slotted tube type stent structure 56 shown in this figure. Delivery of the valve can correspond generally to the procedure described above relative to Figures 8 - 11, although other delivery devices and methods can be used.
- FIG 16 illustrates another embodiment of a replacement valve 57, which uses the valve leaflet structure of Figure 15 with a different anchoring embodiment in place of the stent 56.
- replacement valve 57 includes stent arms 56a that correspond generally to those of the stent 18 described above, but do not extend as far past the outflow end of the replacement valve as the stent arms of the replacement valve 26 of Figure 6. Because the valve leaflets 50 of this embodiment present an essentially planar circular free edge, the stent may be anchored to tissue closely adjacent the aortic valve annulus. Barbs, connectors, and/or various forms of circumferential stents may be used in combination with the stent arms 56a to anchor the replacement valve 57 in place. Delivery of the valve 57 can correspond generally to the procedure described above relative to Figures 8 - 11, although other delivery devices and methods can be used.
- the stent arms are illustrated as being positioned in the interior portion of the cup-shaped structure; however, the arms could alternatively be positioned and attached on the outside of the cup-shaped structure. Attachment of the stent to the valve structure could be accomplished by suturing, perforating the wire through the leaflets, adhering, welding, and the like. In any of these embodiments, the method used to attach the leaflets to each other in a cup-shaped structure may be the same or different than the method used to attach a stent either to the inside or outside of this cup-shaped structure
- Figure 18 illustrates another embodiment of a replacement valve 100, which can be fabricated from a piece of flexible tubing, such as is shown in Figure 17 as a flexible tube 102.
- Flexible tube 102 may be a natural or synthetic material, such as pericardial tissue, for example (which is discussed, for example, in U.S. Patent No. 5,482,424, the contents of which are incorporated herein by reference).
- Replacement valve 100 utilized the flexible tube 102, which is sutured to itself by sutures 60 at an inflow end 104, although other attachment methods may additionally or alternatively be used, such as adhesive or other surgical fasteners.
- the attachment of the tube 102 to itself produces a tri-lobed structure much like that of the inflow end of the aortic wall 4 of the replacement valve 26 of Figure 6.
- the flexible tube 102 is not sutured or attached to itself at an outflow end 106.
- the valve 100 further includes a stent that is similar to the stent 18 illustrated in Figures 5 and 6, which includes multiple extending arms 20.
- the tube 102 is mounted so that the arms 20 extend through slots in the tri-lobed structure and can be attached thereto by sutures, adhesives or other means.
- other stent configurations can also be used, such as using three separate straight wires in substitution for arms 20, which wires can be mounted within the lobes of the tube 102 in its tri-lobed configuration.
- the arms 20 or other stent structures can include barbs or connectors 24 for attachment to the walls of an aortic annulus or other tissue structure.
- self- expanding or balloon expandable stents may alternatively or additionally be attached to or extend from arms 20 for attachment to tissue of a patient.
- the outflow end 106 is not sealed to itself, allowing the downstream portion of the tube located between the arms 20 of the stent 18 to serve as the leaflets of the valve. That is, the replacement valve 100 is illustrated in Figure 18 in its open position, where blood can flow past the outer surfaces of the valve from the inflow end 104 toward the outflow end 106. Delivery of the valve corresponds to the procedure illustrated in figures 8 - 11.
- the outflow end 106 When the replacement valve 100 is in its closed, position, the outflow end 106 essentially flares outwardly toward the walls of the aorta or other structure in which it is positioned, as will be discussed in further detail below.
- Figure 19 is a top view of the replacement valve 100 of Figure 18, as located within a patient's aortic annulus 62.
- the free end of the tube, in conjunction with the arms 20 of the stent 18, define three leaflets 64.
- the stent and leaflets of this embodiment can be sized so that a small central opening 66 remains open to the interior of the tube, even when the valve is open as illustrated.
- the same construction may be applied to valves 48 and 57 described above and illustrated in Figures 15 and 16.
- Figures 20-22 illustrate additional exemplary embodiments of the replacement valve of Figures 18 and 19.
- Figure 20 is a top view of a replacement valve 110 that allows for fluid entry into the interior of the tube facilitated by a small cylindrical or conical lumen 69, which is mounted in the interior portion of the stent.
- Lumen 69 acts as a type of a spacer to keep the leaflets 64 freely moveable relative to each other, thereby facilitating closing of the valve 110 with sufficient pressure from blood flow. That is, when the blood flow moves in a "backward direction relative to the pumping blood flow, it should move the leaflets 64 apart from each other and toward the aortic annulus or other structure in which it is positioned, thereby closing the valve 110.
- Figure 21 is a top view of a replacement valve 120 that allows for fluid entry into the interior portion of the tube at the commissures of leaflets 64 to facilitate closing of the valve 120.
- Small openings between the lobes of the structure are provided by means of enlarged segments on the arms 20a of the stent.
- Figure 22 illustrates an enlarged detail of a portion of the embodiment of Figure 21. In this view, an enlarged cross section portion of arm 20a of the stent and the associated small opening 68 are visible. All of these alternative constructions of Figures 20-22 may be applied to valves 48 and 57 described
- FIG 23 illustrates a replacement valve 130 that can be fabricated from the tube 102 of Figure 17, for example.
- Valve 130 has its inflow end 122 sutured to itself to produce a flattened structure and is mounted to a stent.
- the stent may be a self- expanding stent taking the form of a u-shaped wire 70 having laterally extending barbs 72. The contours of the wires 70 can also be used to further secure the valve into its position within the patient.
- the stent may comprise two separate straight wires.
- the free end of the tube in conjunction with the stent defines two valve leaflets 74 which, when open, expand against the vessel or orifice in which the replacement valve is mounted. Delivery of the valve corresponds to the procedure illustrated in figures 8 - 11, although other delivery devices and methods can instead be used.
- Figure 24 illustrates a detail of the replacement valve 130 of Figure 23.
- an inflow opening into the interior of the valve may be desirable to facilitate separation of the valve portions from each other to close the valve 130. In some embodiments, this might be provided by enlarged cross section portions of the wire 70.
- a simple staple 78 may be substituted, also providing an opening into the valve 130. Staple 78 may be attached to the stent and may self expand into the tissue of the annulus or may be balloon expanded, for example.
- Figure 25 illustrates the replacement valve 130 of Figure 23, which is folded to allow passage through a catheter or other tubular delivery device. In this embodiment, the u-shaped stent wire 70 or other stent configuration is coupled to an expandable stent 80. By folding the replacement valve 130 rather than circumferentially compressing it, stress on the valve 130 is reduced.
- Figure 26 illustrates an alternative stent configuration 79 for use with the leaflets of the above Figures 15 - 24.
- a single longitudinally extending wire 86 is used.
- Wire 86 includes an enlarged base 88 against which the inflow end of the valve leaflets rest.
- the commissures and thus the valve leaflets 80 are defined by two or three laterally extending wires 82, which are attached to the edges of the valve leaflets 80.
- the laterally extending wires 82 are provided with barbs or connectors 84 which anchor the replacement valve in place within the vessel or orifice in which it is implanted.
- FIGs 27 and 28 illustrate additional features that can be used with a replacement valve of the type described relative to valve 130.
- a replacement valve 140 is formed from a tube of material to create a bicuspid valve structure, as in Figure 23.
- the valve has its inflow end sutured to itself to produce a flattened structure with a central longitudinal opening 148 in which a stent 146 is positioned.
- the stent 146 may take the shape of a u-shaped wire with laterally extending barbs or connectors, or another stent configuration can be used.
- the stent 146 of this embodiment works in conjunction with the size of the slot 148 to provide at least a slight gap between the opposing leaflets 144.
- the slot 148 helps to facilitate opening of the leaflets 144 when the blood flows from the outflow end of the valve toward the inflow end, thereby closing the valve 140.
- FIG 28 illustrates a replacement valve 150 that is similar to valve 140, except that valve 150 includes a slot 152 that is not particularly designed to include a space between opposing leaflets 154.
- this valve 150 includes pockets 156 at both ends, which can be formed by the ends 158 of a stent positioned therein. For example, these ends 158 may be enlarged relative to the stent wire so that the stent can operate in its normal manner while the enlarged ends operate to form the pockets 156.
- valves described above are shown as having fixation barbs located downstream of the free edges of the valve leaflets, this need not necessarily be so. In fact, the planar, generally circular configuration of the free edges of the valve leaflets in the closed position would in some cases allow the barbs or connectors to extend outward through or adjacent to the free edges of the valves. Further, while the discussion of the valves above focuses mainly on placement in the aortic annulus, the valves may be employed in other locations including replacement of other heart valves and peripheral venous valves. Finally, while the valves as disclosed are described mainly in the context of percutaneously or minimally invasively delivered valves, they could also be placed surgically.
Abstract
A prosthetic heart or venous valve (16), the valve including a central tissue structure with multiple tissue lobes extending from a common central area, wherein each of the lobes includes a longitudinal slot (8). The valve further includes a plurality of leaflets (2), each extending from the central tissue structure and positioned between two adjacent lobes, wherein each of the leaflets has a free end (6) spaced from the central tissue structure, and also has a compressible and expandable stent (18) frame with a plurality of extending arms (20), wherein each of the extending arms of the stent frame is positioned at least partially within one of the longitudinal slots of the central tissue structure.
Description
PROSTHETIC CARDIAC AND VENOUS VALVES Priority Claim
This application claims the benefit of United States Provisional Patent Application having Serial No. 60/720,398 filed on September 26, 2005, entitled "Prosthetic Cardiac Valves", the entire disclosure of which is incorporated herein by reference for all purposes. Technical Field
The present invention relates to prosthetic heart and venous valves used in the treatment of cardiac and venous valve disease. More particularly, it relates to minimally invasive and percutaneous replacement of cardiac and venous valves. Background
Recently, there has been a substantial level of interest in minimally invasive and percutaneous replacement of cardiac valves. In the specific context of pulmonary valve replacement, U.S. Patent Application Publication Nos. 2003/0199971 Al and 2003/0199963 Al, (Tower et al.), which are incorporated herein by reference in their entireties, describe a valved segment of bovine jugular vein mounted within an expandable stent, for use as a replacement pulmonary valve. The replacement valve is mounted on a balloon catheter and delivered percutaneously via the vascular system to the location of the failed pulmonary valve and expanded by the balloon to compress the valve leaflets against the right ventricular outflow tract, anchoring and sealing the replacement valve. The valve is also useful to replace failed pulmonary valves located in valved conduits.
U.S. Patent No. 5,411,552 (Andersen et al.) discloses a percutaneously deliverable valve for aortic valve replacement. Like the Tower et al. valve, this valve system employs a stent external to the valve to exert pressure against the vessel at the
implant site to provide a seal. This pressure of the stent against the vessel also helps to keep the valve from becoming displaced once it has been implanted. With these and other percutaneously delivered valves, the stent or other expandable member is typically designed to surround at least the valve orifice. This basic configuration allows blood to flow through the center of the valve when the valve is open, with the multiple valve leaflets sealing against themselves to close the valve. Because the native aortic valve annulus in which the replacement is to be implanted may be calcified and have an irregular perimeter, this basic configuration can be problematic, particularly in the context of replacement aortic valves. For example, a valve annulus with an irregular perimeter can make it difficult for an expanded stent to accurately follow the contours of the native annulus, which can result in peripheral fluid leakage. This problem is typically not present in traditional surgically implanted valves, since their relatively rigid stents are typically sealed to the valve annulus with a sealing ring that is attached to the annulus by means of numerous sutures.
Other procedures and devices that have been developed include, for example, surgically implantable valves disclosed in U.S. Patent Nos. 4,339,831 (Johnson) and 5,449,384 (Johnson), both of which are incorporated herein in their entireties. These valves have a configuration that is essentially the opposite of the natural configuration, such that the valve leaflets open inwardly and close by expanding outwardly to contact the native aortic valve annulus. These valves further include a framework comprising a plurality of struts that are sutured to the patient's annulus or an artificial annulus reconstruction ring and a flexible membrane attached to the framework to allow the membrane segments or leaflets to freely open inward to allow forward blood flow through the valve. Although the struts are described as being flexible, these valves are not contemplated to be implanted percutaneously due to the need to physically suture these implantable valves to the annulus of a patient. Another type of valve that was
developed is described in U.S. Patent No. 3,671,979 (Moulopoulos). This reference discloses a valve that can be inserted, withdrawn and retained relative to its desired implanted position with the use of a catheter. A membrane of the valve expands outward like an umbrella to seal against the interior of the aorta, downstream of a damaged aortic valve, and collapses and enfolds the catheter to allow flow of blood when the valve is open. However, this valve is not capable of being retained in this position and functioning as a valve without the use of its catheter.
There is a continued desire to provide cardiac valves that can be implanted in a minimally invasive and percutaneous manner, while minimizing or eliminating paravalvular leakage. Summary
The present invention is particularly directed to improvements in minimally invasive and percutaneously delivered valves for use in pulmonary and aortic positions. However, the invention may also be useful in other types of valves, including other heart valves and peripheral venous valves. In particular, a valve of the invention has leaflets that are configured to operate in an essentially an opposite manner from a typical artificial valve. Using this reverse or opposite configuration in a minimally invasively or percutaneously delivered valve with a collapsible stent can provide certain benefits. In particular, the outwardly sealing valve leaflets may adapt themselves or conform more readily to irregular configurations of the orifice in which the valve is mounted, thereby overcoming or reducing the sealing problems sometimes associated with expandable stents that are external to the valve leaflets.
The present invention also includes embodiments of a variety of outwardly sealing multi-leaflet valves, which are believed to be especially useful in conjunction with a number of different embodiments of collapsible stents.
In some embodiments of the invention, the valve leaflets are produced by inverting a section of a naturally valved vessel, such as a porcine aorta or a bovine jugular vein. In other embodiments, the valve leaflets are produced by sealing one end of a flexible tube and employing the unsealed end to define the leaflets. In yet other embodiments, the valve is produced by stitching together leaflets of flexible material such as pericardial tissue to provide a generally cup shaped structure. With any of these described embodiments, the valve leaflets are mounted to an expandable stent which is to be anchored to the orifice in which the valve is implanted. This valve implantation is positioned to be downstream of or adjacent to the free edges of the leaflets.
In some embodiments of the invention, the expandable stent may be configured with a flexible frame that is manufactured of a material consistent with being collapsed to allow delivery through a tubular percutaneous catheter or minimally invasive tubular surgical port type device. In other embodiments, the stent may include a self-expanding or balloon expandable circumferential stent that is located downstream of the free edges of the valve leaflets. In still other embodiments the stent may include outwardly extending barbs that are preferably, but not necessarily, located downstream of the free edges of the leaflets.
In one embodiment of the invention, a prosthetic heart or venous valve is provided, the valve comprising a central tissue structure comprising multiple tissue lobes extending from a common central area, wherein each of the lobes includes a longitudinal slot. The valve further comprises a plurality of leaflets extending from the central tissue structure and positioned between two adjacent lobes, wherein each of the leaflets comprises a free end spaced from the central tissue structure, and also comprises a compressible and expandable stent frame comprising a plurality of extending arms, wherein each of the extending arms of the stent frame is positioned at least partially within one of the longitudinal slots of the central tissue structure. The central tissue
structure can comprise a native valve segment that has been inverted to provide the plurality of leaflets, wherein the multiple tissue lobes can be formed by folded portions of an aortic wall of the native valve segment.
In another aspect of the invention, a prosthetic valve is provided, which comprises a flexible tube having an inflow end and a outflow end, wherein the inflow end of the tube is folded against and attached to itself and the outflow end of the tube is unattached to itself, and a stent having multiple longitudinally extending members located at least partially within the tube and extending to the open outflow end of the tube, wherein portions of the tube that are adjacent the outflow end of the tube and between the longitudinally extending members of the stent are moveable toward and away from a central area of the valve to provide a plurality of valve leaflets. Brief Description of the Drawings
The present invention will be further explained with reference to the appended Figures, wherein like structure is referred to by like numerals throughout the several views, and wherein:
Figure 1 is a top view of a natural aortic valve;
Figure 2 is a top view of the natural aortic valve of Figure 1 with the valve structure turned "inside-out" on itself such that the leaflets are positioned on the outside of the valve in a tri-lobed configuration;
Figure 3 is a side view of the natural aortic valve turned "inside-out" as in Figure 2, with the aortic wall sutured to itself at an inflow end of the valve;
Figure 4 is a side view of the natural aortic valve turned "inside-out" as in Figure 2, with the aortic wall sutured to itself at an inflow end of the valve, wherein the aortic wall is trimmed to more closely match the configuration of typical valve leaflets;
Figure 5 is a side view of one embodiment of a stent for use in conjunction with valves of the type illustrated in Figures 3 and 4;
Figure 6 is a side view of the stent of Figure 5 mounted inside a valve of the type illustrated in Figure 4 to provide one embodiment of a completed replacement valve of the invention;
Figure 7 is a side view of the replacement valve of Figure 6, as positioned within an aortic annulus, which is illustrated in cross-section;
Figure 8 is a side view of a delivery catheter or device positioned within an aortic annulus, with the replacement valve of Figure 6 partially advanced from one end of the catheter or device;
Figure 9 is a side view of the delivery catheter or device illustrated in Figure 8, with the replacement valve of Figure 6 being further advanced from one end of the catheter into the aortic annulus;
Figure 10 is a side view of the replacement valve of Figure 6 in a desired position within an aortic annulus, which is also the position it will generally be in after it has been completely advanced from the end of the delivery device of Figures 8 and 9;
Figure 11 is a side view of a delivery catheter within an aortic annulus that includes a balloon catheter that is radially expandable to anchor a replacement valve into the tissue of a patient;
Figure 12 is a side view of an alternative embodiment of a replacement valve of the type illustrated in Figure 6 as positioned within an aortic annulus, which includes an alternative embodiment for anchoring the valve;
Figure 13 is a side view of another alternative embodiment of a replacement valve of the type illustrated in Figure 6 as positioned within an aortic annulus, which includes another alternative embodiment for anchoring the valve;
Figure 14 is a top view of a replacement valve generally of the type illustrated in Figure 6, which further includes optional tissue or fabric portions to prevent leakage adjacent the valve commissures;
Figure 15 is a side view of an alternative structure to provide valve leaflets that are mounted to a stent to provide an alternative embodiment of a completed replacement valve of the invention;
Figure 16 is a side view of the alternative valve leaflet structure of Figure 15, which uses an alternative stent configuration;
Figure 17 is a side view of a flexible tube of natural or synthetic material as can be used for replacement valves of the invention;
Figure 18 is a perspective view of a replacement valve fabricated from the tube of Figure 17 and mounted to a stent, which includes having its inflow end sutured to produce a tri-Iobed structure;
Figure 19 is a top view of the replacement valve of Figure 18, as located within the aortic annulus;
Figure 20 is atop view of an alternative structure of the replacement valve of Figure 18;
Figure 21 is at top view of another alternative structure of the replacement valve of Figure 18;
Figure 22 is an enlarged top view of a portion of the replacement valve of Figure 21;
Figure 23 is a perspective view of a replacement valve fabricated from the tube of the type illustrated in Figure 17 and mounted to a stent, which includes having its inflow end sutured to create a bi-lobed structure;
Figure 24 is an enlarged top view of a portion of the replacement valve of Figure 23;
Figure 25 is a perspective view of an alternative embodiment of the replacement valve of Figure 23, which is folded onto itself to provide for passage through a catheter;
Figure 26 is a perspective view of an alternative stent configuration for use with the leaflets configured in accordance with the present invention;
Figure 27 is a top view of another embodiment of a replacement valve having a bi-lobed structure; and
Figure 28 is a top view of another embodiment of a replacement valve having a bi-lobed structure. Detailed Description
Referring now to the Figures, wherein the components are labeled with like numerals throughout the several Figures, and initially to Figure 1, a natural aortic valve 3 is illustrated, which generally comprises three leaflets 2 extending from an aortic wall 4. The leaflets 2 meet at their free edges 6 to seal the valve orifice when the valve 3 is in its closed position. The free edges 6 can move away from each other and toward the aortic wall 4, however, when the valve 3 is in its open configuration, thereby creating an open passage for blood flow. Such a natural aortic valve 3 may be a valved segment of a porcine valve, for example, which can be particularly advantageous in certain aspects of the invention due to the relatively thin aortic walls of these valves.
Figure 2 illustrates an top view of an aortic valve 16, which is basically the valve
3 of Figure 1 turned "inside-out" as compared to its natural state. That is, the aortic wall
4 is folded or rolled inwardly so that the side of the wall 4 that was previously facing in an outward direction is on the inside of the valve 16. The aortic wall 4 is further configured so that it defines a tri-lobed configuration, with the leaflets 2 on the outside of the valve 16 rather than the inside of the valve, as will be described in further detail below. In this configuration, the free edges 6 of leaflets 2 are located at the external periphery of the valve 16 such that the free edges 6 no longer will be in contact with each
other when the valve 16 is in its closed configuration, but instead will be in contact with the vessel in which it is implanted (e.g., aorta). In fact, the leaflets 2 are facing in a generally opposite direction from the direction they are facing in a valve in its natural state.
In the embodiment of Figure 2, the aortic wall 4 further defines three internal longitudinally extending slots 8 in the area where the wall 4 is folded onto or toward itself. That is, each of the lobes of the tri-lobed configuration includes a slot 8 extending through it. Because the valve 16 opens inwardly, rather than outwardly, relative to the structure in which it is positioned (e.g., an aorta), the leaflets 2 will seal against the aorta or other structure in which the valve is positioned when the valve 16 is in a closed state and will move toward the inner, tri-lobed structure when the valve 16 is in an open state. Thus, paravalvular leakage can be minimized or eliminated as compared to valves in which the radial strength of a stent is an issue.
In order to allow the free edges 6 of leaflets 2 of Figure 2 to better conform to the tissue annulus in which the valve 16 is positioned, it is desirable for the leaflets 2 to have a certain level of elasticity. This can be accomplished by fixing the valve material with glutaraldehyde, for example, using conventional high, low or zero pressure fixation techniques, although other fixing techniques and materials can be used. In some embodiments, the aortic wall 4 may be trimmed to reduce the thickness of the wall, which will provide different properties for the valve (e.g., strength, flexibility, and the like). In addition to the porcine valve material discussed above, such a valve structure can be produced, for example, starting with a valved segment of bovine jugular vein that is trimmed to make its walls thinner and thus more adaptable to at least some of the valve configurations of the invention.
Figure 3 illustrates a side view of the valve 16 of Figure 2, with adjacent portions of an inflow end 12 of the folded aortic wall 4 attached to each other by sutures 10 to seal
the end of the valve 16 and maintain the tri-lobed structure. Alternatively, adhesive or other surgical fasteners can be used to secure the inflow end 12 of the structure in such a configuration. In either case, in order to pull the sections of the wall 4 closer to each other along the slots 8, a vacuum can be pulled on the valve 16 prior to using the sutures or other material to seal the end of the valve 16. Figure 4 illustrates an alternative embodiment of the aortic valve of Figure 3, with the inflow end 12 of the aortic wall 4 being trimmed into a curved shape to more closely match the configuration of the bases of the valve leaflets 2 and to eliminate excess valve material extending beyond the leaflets 2.
Referring now to Figure 5, one embodiment of a stent 18 is shown, which can be used in conjunction with valves of the type illustrated in Figures 3 and 4. The stent 18 includes three longitudinally extending curved aπns 20 that extend from a common point 22, which will be positioned adjacent to the inflow end of a replacement valve. The arms 20 are shown as being generally the same length as each other in this figure, which will be adaptable to the implantation location of most replacement valves. It is possible, however, that at least one of the arms 20 is a different length than the other arms 20, such as in cases where particular anatomical needs of a patient need to be accommodated, when certain anchoring techniques are used, or when other considerations of the patient, the valve, or the delivery systems need to be considered, for example. The three arms 20 can be angularly displaced approximately 120 degrees from one another so that they are evenly spaced around the perimeter of the stent 18; however, it may instead be desirable to position the arms 20 at different angular spacings from each other.
In one embodiment of the invention, one or more of the arms 20 further include outwardly extending barbs or connectors 24 at an outflow end 14 of the stent 18. These connectors 24 are designed to engage with the wall of the aorta or other tissue structure in which the stent 18 may be positioned. Connectors 24 can include a wide variety of
configurations and features, such as the arrow-shaped tips shown, or other configurations that provide for engagement with tissue through a piercing or other similar motion, and further do not allow the connector to disengage from the tissue with normal movement of the stent within the tissue. Each of the arms 20 of this embodiment are shown as including two barb-like connectors 24; however, more or less than two connectors 24 may extend from a single arm 20, and each of the arms 20 of a stent 18 may include the same or a different number of connectors 24.
The stent 18 is constructed of a material that is sufficiently flexible that it can be collapsed for percutaneous insertion into a patient. The material is also preferably self- expanding (e.g., Nitinol) such that it can be readily compressed and re-expanded. The material should further be chosen so that when the stent 18 is positioned within an aorta, for example, it exerts sufficient pressure against the aortic walls that fluids cannot leak past the stent 18. In particular, the stent 18 should provide enough radial outward force so that the tips or ends of the fold material of a tri-lobed structure can press against the inside walls of an aorta or other structure of a patient in such a way that blood cannot flow past these tips of the replacement valve. In this and any of the embodiments of the invention, the replacement valves and associated stents can be provided in a variety of sizes to accommodate the size requirements of different patients.
Figure 6 illustrates the stent 18 of Figure 5 mounted inside a valve 16 of the type illustrated in Figure 4 to provide a completed replacement valve 26. As shown, the ends of the arms 20 extend beyond the ends of the valve 16 at the outflow end 14 of the valve; therefore, an area of the stent 18 relatively near the common point 22 (not visible in this figure) is positioned adjacent to the inflow end 12 of the valve 26. The adjacent tissue portions of the lobes at both the inflow end 12 and the outflow end 14 of the replacement valve 26 can be sewed or otherwise connected to each other, such as by sutures 10, in
order to prevent or minimize the possibility of blood entering the slots 8 (see Figure 2) of the tri-lobed structure.
The stent 18 is preferably retained in position within the slots 8 of aortic wall 4 by means of adhesive, sutures or other surgical fasteners. In one exemplary construction, the stent 18 is positioned within the slots 8 before the tissue is sutured or attached to itself at one or both of the inflow and outflow ends 12, 14. When the tissue at the inflow end 12 is sutured, the adjacent stent 18 can be sutured to the valve 26 at the same time, such that one stitching operation can serve the dual purpose of sealing the inflow end 12 of the valve 26 and also securing the stent 18 to the valve 26.
Referring now to Figure 7, a replacement valve of the type generally shown as the valve 26 in Figure 6 is illustrated, as mounted in an aortic annulus 28 of a patient. The valve 26 is positioned so that the free edges 6 of the leaflets 2 contact the annulus 28 around at least a substantial portion of the circumference of the aortic annulus 28, and preferably contact the annulus 28 around its entire circumference. The valve 26 is further positioned along the length of the aorta so that the connectors 24 are above the sinuses of Valsalva 32 and adjacent to a wall 30 of the patient's aorta. The connectors 24 are shown here as being slightly spaced from the wall 30, such as when the valve 26 is in an at least slightly compressed or unexpanded state. However, the arms 20 will be move or be forced to move at least slightly outward toward the walls 30 until the connectors 24 are imbedded or engaged with at least a portion of the thickness of the walls 30. These connectors 24 will then .serve the purpose of retaining the valve 26 in its desired implant location relative to the aorta. In one embodiment, the connectors 24 can be designed to extend through the entire thickness of the walls 30 such that they will basically be anchored to the outside surface of the aortic walls 30. Alternatively, the connectors may be designed to extend only through a portion of the thickness of the walls 30, which, in order to keep the valve 26 securely in place, may require a different style of connector
than a connector that extends entirely through an aortic wall. That is, connectors that need to engage within the thickness of a tissue can include a number of barbs or tissue engaging structures on each connector, while a connector that extends all the way through the tissue may only need to have a relatively wide base that will not easily pass backward through the hole it created when originally passing through the tissue.
In order to prevent possible interference between the patient's native valve and a replacement valve of the type illustrated in Figure 6, for example, the native valve can be completely or partially removed. In some cases, the native valve may be left in its original location; however, the replacement valve in such a circumstance should be positioned in such a way that the remaining native valve does not interfere with its operation. In cases where the native valve is to be removed, exemplary valve removal or resection devices that can be used are described, for example, in PCT Publication WO/0308809A2, which is incorporated herein by reference in its entirety.
Figures 8-10 illustrate an end portion of one exemplary delivery device and exemplary sequential steps for using such a device for delivering a replacement valve 26 to its desired location within a patient. In particular, Figure 8 illustrates a tubular delivery device 34 that has been advanced to the general location where the replacement valve 26 will be implanted. In order to reach this location, the delivery device 34 is inserted into the body using one of a number of different approaches. For example, the device 34 can reach the aorta through a retrograde approach originating at a location distal to the heart, such as the femoral artery. Alternatively, an antegrade approach could be used, which originates at a location distal to the heart, such as the femoral vein or an incision in the ventrical wall or apex. In any case, the device 34 is moved to the desired implantation area of the body with a replacement valve 26 being partially or entirely enclosed within an outer sheath 35. As shown in the figure, the portion of sheath 35 at the distal end of device 34 is at least slightly larger in diameter than the adjacent portion
of the device 34, which will help to keep the valve 26 positioned near the distal end of device 34 (i.e., keep it from translating along the length of the device 34). However, the distal end of the sheath 35 may additionally or alternatively include a stop or some other configuration that keeps the valve 26 from migrating away from the distal end of device 34.
With particular reference to Figure 8, the replacement valve 26 is shown as it is beginning to be advanced out of the end of a tubular delivery device 34 by pulling back the sheath 35, thereby releasing or exposing one end of the replacement valve 26. In accordance with the invention, the valve 26 is delivered in a radially compressed configuration to ease passage of the device 34 through the vascular system; however, the valve 26 will be able to expand after it is released from the end of the device 34. The leaflets 2 of the valve 26 are first are advanced distally out of the end of the device 34, as illustrated in Figure 8, so that they can be properly located relative to the aortic annulus 28. Figure 9 illustrates the replacement valve 26 as it is further released from the device 34 by further retraction of the sheath 35. As the delivery device 34 is withdrawn, the stent 18 of the valve 26 is allowed to expand and seat the replacement valve 26 in its desired location.
Finally, Figure 10 illustrates the stent of the replacement valve 26 after the delivery device 34 has been retracted a sufficient amount that it is completely separated from the valve 26. In this embodiment, the arms 20 are configured so that they tend to expand radially outwardly once they are released from the sheath 35. The outward radial force causes the barbs or connectors 24 to embed or otherwise engage with the wall 30 of the patient's aorta to anchor the replacement valve 26.
Although the arms 20 are shown as relatively straight wires in the embodiment of the replacement valve 26 described above, the stents of the invention may be shaped and/or positioned differently than previously described. For one example, the stent arms
could instead be curved outwardly (i.e., convex) to conform at least somewhat to the location of the body in which it will be positioned (e.g., aorta for aortic valve, pulmonary trunk for the pulmonic vein, vein for venous valve, and ventricle of mitral/tricuspid valve). This outward curvature of the stent arms can help to secure or anchor the valve in place and thus can have different degrees or amounts of curvature depending on the configuration of the particular replacement valve. Further, the barbs or connectors that extend from the stent arms can be positioned near the distal ends of the arms (i.e., spaced relatively far from the valve, such as valve 16), as shown and described above, in order for these connectors to be positioned beyond the sinuses of Valsalva of the aortic valve of a patient. However, the barbs or connectors could alternatively or additionally be located closer to the valve, such as valve 16, which would position the connectors closer to the outflow end of the replacement valve.
Figure 11 illustrates an optional additional use of a balloon catheter 36 on the delivery device 34 to help to anchor the valve 26 in place in the aorta or other tissue of a patient. In particular, balloon catheter 36 includes a balloon 38, which is located radially between the arms 20 of the stent 18 when the sheath 35 has been retracted from the valve 26. During the process of inserting the device 34 into the patient, balloon 38 will generally be at least partially deflated in order to minimize its size and allow for easier percutaneous insertion of the valve 26. Once the valve 26 is in its desired location relative to the walls 30 with which it will be engaged, the balloon 38 is inflated via the balloon catheter 36. The inflation of balloon 38 can be carefully monitored, such as by measuring pressures of forces, to expand the arms 20 outwardly by a particular amount, thereby driving the barbs or connectors 24 toward and into the wall 30 of the patient's aorta.
While the procedure illustrated in Figures 8 - 11 illustrates placement in the aortic annulus using a percutaneous catheter to deliver the valve retrograde to blood flow,
antegrade delivery of the valve is also within the scope of the invention. Similarly, while delivery using a catheter is illustrated, the valve could alternatively be compressed radially and delivered in a minimally invasive fashion using a tubular surgical trocar or port. In addition, as noted above and as will be discussed further below, the valve may be delivered to sites other than the aortic annulus.
Figures 12 and 13 illustrate alternative replacement valves that are similar in structure to the valve 26 discussed above, but include alternative structures for anchoring the replacement valve. These replacement valves are again shown in the general location in which they will be positioned within an aortic annulus 28 of a patient. Figure 12 illustrates a replacement valve that includes the stent 18 having multiple arms 20, but instead of these arms 20 including barbs or connectors, the arms 20 are stent wires that are coupled to a slotted-tube type stent ring 40. As is described above relative to another embodiment, the arms 20 of this embodiment may also be curved outwardly to conform at least somewhat to the location of the body in which it will be positioned. This outward curvature of the stent arms can help to secure or anchor the valve in place.
Delivery of this valve can be performed using a procedure that is similar to that described above relative to Figures 8-11, or a different method can be used. Alternatively or additionally, some type of adhesive may be applied to the stent ring or a biocompatible covering (e.g., fabric, tissue, polymer, and the like) to help to keep the stent in place. In any case, stent ring 40 may be self-expanding or may be expanded by a balloon or other device that can radially expand the ring 40.
Figure 13 illustrates a replacement valve that again includes the stent 18 having multiple arms 20. In this embodiment, the arms 20 are coupled to a stent 42 that is formed of one or more zig-zag wires. The wires are arranged relative to each other in such a way that they provide sufficient radial strength to keep the valve in place relative to the aortic annulus 28 or other location to which the valve is delivered. Again, delivery
of this valve can be performed using a procedure that is similar to that described above relative to Figures 8-11, or a different method can be used. In any case, stent 42 may be self-expanding or may be expanded by a balloon or other device that can radially expand the stent 42.
Figure 14 illustrates another embodiment of the replacement valve 26 of Figure 6. In particular, a replacement valve 43 is shown, which includes the same basic structure of the aortic valve 3 of Figure 2, and further including the stent 18 including arms 20, as in Figure 5. The tips of the arms 20 of stent 18 are located in the slots 8 and are visible in this top view of the valve 43. The valve 43 further includes optional bulbous portions 44 that extend from each of the tips of the lobes of the tri-lobed structure of the valve 43. These portions 44 are provided to further insure secure contact between the valve 43 and the aorta or other structure in the areas adjacent to the leaflets 2, thereby further minimizing or preventing leakage adjacent the valγe commissures. These portions 44 may be made of a tissue, fabric, or other material, as desired.
Figure 15 illustrates a replacement valve 48, which includes an alternative structure to provide valve leaflets. In this embodiment, leaflets 50 are cut or otherwise formed from a natural or synthetic flexible material (e.g., pericardial tissue, polymeric material, fabric, and the like), and are attached to multiple arms 52 of a stent via sutures, glue, or some other attachment material or method. The leaflets 50 are further attached to one another by means of sutures 54 to define a generally cup-shaped structure. The valve leaflets 50 comprise the regions of the cup-shaped structure located between the longitudinally extending arms 52 of the stent. The arms 52 of the stent can correspond generally to the arms 20 of the stent of Figure 5, or can be arranged and configured differently. The stent and leaflets could also be constructed together using processes and materials disclosed, for example, in U.S. Patent Nos. 6,458,153; 6,652,578; and 7,018,408 (all to Bailey et al.), which are incorporated herein by reference. In this
embodiment of Figure 15, the arms 52 are coupled to an expandable slotted tube type stent 56, which may be self-expanding or balloon-expandable similar to the stent 40 of Figure 12. Other forms of circumferential stents, barbs, or other structures may be used in addition to or as an alternative to the slotted tube type stent structure 56 shown in this figure. Delivery of the valve can correspond generally to the procedure described above relative to Figures 8 - 11, although other delivery devices and methods can be used.
Figure 16 illustrates another embodiment of a replacement valve 57, which uses the valve leaflet structure of Figure 15 with a different anchoring embodiment in place of the stent 56. In particular, replacement valve 57 includes stent arms 56a that correspond generally to those of the stent 18 described above, but do not extend as far past the outflow end of the replacement valve as the stent arms of the replacement valve 26 of Figure 6. Because the valve leaflets 50 of this embodiment present an essentially planar circular free edge, the stent may be anchored to tissue closely adjacent the aortic valve annulus. Barbs, connectors, and/or various forms of circumferential stents may be used in combination with the stent arms 56a to anchor the replacement valve 57 in place. Delivery of the valve 57 can correspond generally to the procedure described above relative to Figures 8 - 11, although other delivery devices and methods can be used.
In the embodiments of Figures 15 and 16 described above, the stent arms are illustrated as being positioned in the interior portion of the cup-shaped structure; however, the arms could alternatively be positioned and attached on the outside of the cup-shaped structure. Attachment of the stent to the valve structure could be accomplished by suturing, perforating the wire through the leaflets, adhering, welding, and the like. In any of these embodiments, the method used to attach the leaflets to each other in a cup-shaped structure may be the same or different than the method used to attach a stent either to the inside or outside of this cup-shaped structure
Figure 18 illustrates another embodiment of a replacement valve 100, which can be fabricated from a piece of flexible tubing, such as is shown in Figure 17 as a flexible tube 102. Flexible tube 102 may be a natural or synthetic material, such as pericardial tissue, for example (which is discussed, for example, in U.S. Patent No. 5,482,424, the contents of which are incorporated herein by reference). Replacement valve 100 utilized the flexible tube 102, which is sutured to itself by sutures 60 at an inflow end 104, although other attachment methods may additionally or alternatively be used, such as adhesive or other surgical fasteners. The attachment of the tube 102 to itself produces a tri-lobed structure much like that of the inflow end of the aortic wall 4 of the replacement valve 26 of Figure 6. However, in this embodiment, the flexible tube 102 is not sutured or attached to itself at an outflow end 106.
The valve 100 further includes a stent that is similar to the stent 18 illustrated in Figures 5 and 6, which includes multiple extending arms 20. In this embodiment, the tube 102 is mounted so that the arms 20 extend through slots in the tri-lobed structure and can be attached thereto by sutures, adhesives or other means. However, other stent configurations can also be used, such as using three separate straight wires in substitution for arms 20, which wires can be mounted within the lobes of the tube 102 in its tri-lobed configuration. In any case, the arms 20 or other stent structures can include barbs or connectors 24 for attachment to the walls of an aortic annulus or other tissue structure. As with other embodiments of replacement valve attachment discussed above, self- expanding or balloon expandable stents may alternatively or additionally be attached to or extend from arms 20 for attachment to tissue of a patient.
In this embodiment of a replacement valve 100, the outflow end 106 is not sealed to itself, allowing the downstream portion of the tube located between the arms 20 of the stent 18 to serve as the leaflets of the valve. That is, the replacement valve 100 is illustrated in Figure 18 in its open position, where blood can flow past the outer surfaces
of the valve from the inflow end 104 toward the outflow end 106. Delivery of the valve corresponds to the procedure illustrated in figures 8 - 11. When the replacement valve 100 is in its closed, position, the outflow end 106 essentially flares outwardly toward the walls of the aorta or other structure in which it is positioned, as will be discussed in further detail below.
Figure 19 is a top view of the replacement valve 100 of Figure 18, as located within a patient's aortic annulus 62. In this view it can be seen that the free end of the tube, in conjunction with the arms 20 of the stent 18, define three leaflets 64. In order for the leaflets 64 to properly close, it is desirable to have an entry point for backflow of blood to enter the interior of the tube to expand the leaflets 64. For this reason, the stent and leaflets of this embodiment can be sized so that a small central opening 66 remains open to the interior of the tube, even when the valve is open as illustrated. The same construction may be applied to valves 48 and 57 described above and illustrated in Figures 15 and 16.
Figures 20-22 illustrate additional exemplary embodiments of the replacement valve of Figures 18 and 19. In particular, Figure 20 is a top view of a replacement valve 110 that allows for fluid entry into the interior of the tube facilitated by a small cylindrical or conical lumen 69, which is mounted in the interior portion of the stent. Lumen 69 acts as a type of a spacer to keep the leaflets 64 freely moveable relative to each other, thereby facilitating closing of the valve 110 with sufficient pressure from blood flow. That is, when the blood flow moves in a "backward direction relative to the pumping blood flow, it should move the leaflets 64 apart from each other and toward the aortic annulus or other structure in which it is positioned, thereby closing the valve 110.
Figure 21 is a top view of a replacement valve 120 that allows for fluid entry into the interior portion of the tube at the commissures of leaflets 64 to facilitate closing of the valve 120. Small openings between the lobes of the structure are provided by means of
enlarged segments on the arms 20a of the stent. Figure 22 illustrates an enlarged detail of a portion of the embodiment of Figure 21. In this view, an enlarged cross section portion of arm 20a of the stent and the associated small opening 68 are visible. All of these alternative constructions of Figures 20-22 may be applied to valves 48 and 57 described
\ above and illustrated in Figures 15 and 16, along with other valves. Other structures may be used in addition to or instead of the devices of Figures 19-22, any of which should facilitate the closing of the valve.
Figure 23 illustrates a replacement valve 130 that can be fabricated from the tube 102 of Figure 17, for example. Valve 130 has its inflow end 122 sutured to itself to produce a flattened structure and is mounted to a stent. The stent may be a self- expanding stent taking the form of a u-shaped wire 70 having laterally extending barbs 72. The contours of the wires 70 can also be used to further secure the valve into its position within the patient. Alternatively, the stent may comprise two separate straight wires. The free end of the tube in conjunction with the stent defines two valve leaflets 74 which, when open, expand against the vessel or orifice in which the replacement valve is mounted. Delivery of the valve corresponds to the procedure illustrated in figures 8 - 11, although other delivery devices and methods can instead be used.
Figure 24 illustrates a detail of the replacement valve 130 of Figure 23. As with the valve of Figure 18, an inflow opening into the interior of the valve may be desirable to facilitate separation of the valve portions from each other to close the valve 130. In some embodiments, this might be provided by enlarged cross section portions of the wire 70. In alternative embodiments in which the free edges of leaflets are attached directly to a valve orifice 76, a simple staple 78 may be substituted, also providing an opening into the valve 130. Staple 78 may be attached to the stent and may self expand into the tissue of the annulus or may be balloon expanded, for example.
Figure 25 illustrates the replacement valve 130 of Figure 23, which is folded to allow passage through a catheter or other tubular delivery device. In this embodiment, the u-shaped stent wire 70 or other stent configuration is coupled to an expandable stent 80. By folding the replacement valve 130 rather than circumferentially compressing it, stress on the valve 130 is reduced.
Figure 26 illustrates an alternative stent configuration 79 for use with the leaflets of the above Figures 15 - 24. In this design, rather than employing multiple curved, longitudinally extending arms or wires, a single longitudinally extending wire 86 is used. Wire 86 includes an enlarged base 88 against which the inflow end of the valve leaflets rest. The commissures and thus the valve leaflets 80 are defined by two or three laterally extending wires 82, which are attached to the edges of the valve leaflets 80. The laterally extending wires 82 are provided with barbs or connectors 84 which anchor the replacement valve in place within the vessel or orifice in which it is implanted.
Figures 27 and 28 illustrate additional features that can be used with a replacement valve of the type described relative to valve 130. In particular, a replacement valve 140 is formed from a tube of material to create a bicuspid valve structure, as in Figure 23. The valve has its inflow end sutured to itself to produce a flattened structure with a central longitudinal opening 148 in which a stent 146 is positioned. Again, the stent 146 may take the shape of a u-shaped wire with laterally extending barbs or connectors, or another stent configuration can be used. In any case, the stent 146 of this embodiment works in conjunction with the size of the slot 148 to provide at least a slight gap between the opposing leaflets 144. The slot 148 helps to facilitate opening of the leaflets 144 when the blood flows from the outflow end of the valve toward the inflow end, thereby closing the valve 140.
Figure 28 illustrates a replacement valve 150 that is similar to valve 140, except that valve 150 includes a slot 152 that is not particularly designed to include a space
between opposing leaflets 154. In order to facilitate separation of the leaflets 154, this valve 150 includes pockets 156 at both ends, which can be formed by the ends 158 of a stent positioned therein. For example, these ends 158 may be enlarged relative to the stent wire so that the stent can operate in its normal manner while the enlarged ends operate to form the pockets 156.
While a number of the valves described above are shown as having fixation barbs located downstream of the free edges of the valve leaflets, this need not necessarily be so. In fact, the planar, generally circular configuration of the free edges of the valve leaflets in the closed position would in some cases allow the barbs or connectors to extend outward through or adjacent to the free edges of the valves. Further, while the discussion of the valves above focuses mainly on placement in the aortic annulus, the valves may be employed in other locations including replacement of other heart valves and peripheral venous valves. Finally, while the valves as disclosed are described mainly in the context of percutaneously or minimally invasively delivered valves, they could also be placed surgically.
The present invention has now been described with reference to several embodiments thereof. The foregoing detailed description and examples have been given for clarity of understanding only. No unnecessary limitations are to be understood therefrom. It will be apparent to those skilled in the art that many changes can be made in the embodiments described without departing from the scope of the invention. Thus, the scope of the present invention should not be limited to the structures described herein.
Claims
1. A prosthetic heart or venous valve, comprising: a central tissue structure comprising multiple tissue lobes extending from a common central area, wherein each of the lobes includes a longitudinal slot; a plurality of leaflets, each of which extends from the central tissue structure and is positioned between two adjacent lobes, wherein each of the leaflets comprises a free end spaced from the central tissue structure; and a flexible stent frame comprising a plurality of extending arms, wherein each of the extending arms of the stent frame is positioned at least partially within one of the longitudinal slots of the central tissue structure.
2. The valve of claim 1, wherein the central tissue structure comprises a native valve segment that has been inverted to provide the plurality of leaflets.
3. The valve of claim 2, wherein the multiple tissue lobes are formed by folded portions of an aortic wall of the native valve segment.
4. The valve of claim 3, wherein the native valve segment comprises a porcine valve segment.
5. The valve of claim 1, wherein the plurality of extending arms are connected to each other at a common point .that is positioned at an inflow end of the valve, wherein the stent frame comprises a distal portion that extends beyond the central tissue structure at an outflow end of the valve, and wherein the distal portion of the stent frame further comprises an anchoring mechanism.
6. The valve of claim 5, wherein the anchoring mechanism comprises at least one connector extending from each of the extending arms that is engageable with a thickness of tissue.
7. The valve of claim 5, wherein the anchoring mechanism comprises a compressible and expandable engagement structure extending from the stent frame.
8. The valve of claim 7, wherein the engagement structure comprises a self- expanding material.
9. The valve of claim 1, wherein the plurality of leaflets are moveable from a first position in which their free ends are spaced at a first distance from the central tissue structure to a second position in which their free ends are spaced at a second distance from the central tissue structure that is greater than the first distance, wherein the first position of the leaflets defines a plurality of channels between adjacent lobes of the central tissue structure and provides an open position of the valve.
10. The valve of claim 9, wherein the second position of the leaflets eliminates the plurality of channels between adjacent lobes of the central tissue structure and provides a closed position of the valve.
11. A prosthetic valve, comprising: a flexible tube having an inflow end and a outflow end, wherein the inflow end of the tube is folded against and attached to itself and the outflow end of the tube is open; and a stent having multiple longitudinally extending members located at least partially within the tube and extending to the open outflow end of the tube, wherein portions of the tube that are adjacent to the outflow end of the tube and between the longitudinally extending members of the stent are moveable toward and away from a central area of the valve to provide a plurality of valve leaflets.
12. A prosthetic valve according to claim 11, wherein the stent comprises a distal portion that extends beyond the outflow end of the tube, and wherein the distal portion of the stent further comprises an anchoring mechanism.
13. The valve of claim 12, wherein the anchoring mechanism comprises at least one connector extending from each of the extending members that is engageable with a thickness of tissue.
14. The valve of claim 12, wherein the anchoring mechanism comprises a compressible and expandable engagement structure extending from the stent.
15. The valve of claim 14, wherein the engagement structure comprises a self- expanding material.
16. The valve of claim 11 , further comprising at least one spacer positioned between portions of the tube that are adjacent the open outflow end of the tube.
17. The valve of claim 16, wherein the at least one spacer extends from and is attached to the inflow end of the tube and extends generally along a central longitudinal axis of the tube.
18. The valve of claim 11, wherein the stent comprises three longitudinally extending members and wherein the valve comprises three leaflets defined by the three extending members and the open outflow end of the tube.
19. The valve of claim 18, wherein the stent and leaflets are sized to provide a central aperture that is open to the inside of the tube at the outflow end of the tube when the valve is in its open position and when the valve is in its closed position.
20. The valve of claim 11, wherein the stent comprises two longitudinally extending members and the valve comprises two leaflets.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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EP06815495.4A EP1945142B1 (en) | 2005-09-26 | 2006-09-26 | Prosthetic cardiac and venous valves |
Applications Claiming Priority (2)
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US72039805P | 2005-09-26 | 2005-09-26 | |
US60/720,398 | 2005-09-26 |
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PCT/US2006/037543 WO2007038540A1 (en) | 2005-09-26 | 2006-09-26 | Prosthetic cardiac and venous valves |
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US (2) | US20070078510A1 (en) |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008264553A (en) * | 2007-04-23 | 2008-11-06 | Saint Joseph's Translational Research Inst Inc | Replacement heart valve, valve holder and methods of making and using same |
JP2011527912A (en) * | 2008-07-17 | 2011-11-10 | エヌヴェーテー アーゲー | Prosthetic heart valve system |
Families Citing this family (201)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6006134A (en) | 1998-04-30 | 1999-12-21 | Medtronic, Inc. | Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers |
US7018406B2 (en) | 1999-11-17 | 2006-03-28 | Corevalve Sa | Prosthetic valve for transluminal delivery |
US8016877B2 (en) | 1999-11-17 | 2011-09-13 | Medtronic Corevalve Llc | Prosthetic valve for transluminal delivery |
US8579966B2 (en) | 1999-11-17 | 2013-11-12 | Medtronic Corevalve Llc | Prosthetic valve for transluminal delivery |
US8241274B2 (en) | 2000-01-19 | 2012-08-14 | Medtronic, Inc. | Method for guiding a medical device |
US7749245B2 (en) | 2000-01-27 | 2010-07-06 | Medtronic, Inc. | Cardiac valve procedure methods and devices |
US8366769B2 (en) | 2000-06-01 | 2013-02-05 | Edwards Lifesciences Corporation | Low-profile, pivotable heart valve sewing ring |
WO2002005888A1 (en) | 2000-06-30 | 2002-01-24 | Viacor Incorporated | Intravascular filter with debris entrapment mechanism |
US6409758B2 (en) * | 2000-07-27 | 2002-06-25 | Edwards Lifesciences Corporation | Heart valve holder for constricting the valve commissures and methods of use |
US7544206B2 (en) | 2001-06-29 | 2009-06-09 | Medtronic, Inc. | Method and apparatus for resecting and replacing an aortic valve |
US8623077B2 (en) | 2001-06-29 | 2014-01-07 | Medtronic, Inc. | Apparatus for replacing a cardiac valve |
US8771302B2 (en) | 2001-06-29 | 2014-07-08 | Medtronic, Inc. | Method and apparatus for resecting and replacing an aortic valve |
FR2826863B1 (en) | 2001-07-04 | 2003-09-26 | Jacques Seguin | ASSEMBLY FOR PLACING A PROSTHETIC VALVE IN A BODY CONDUIT |
FR2828091B1 (en) | 2001-07-31 | 2003-11-21 | Seguin Jacques | ASSEMBLY ALLOWING THE PLACEMENT OF A PROTHETIC VALVE IN A BODY DUCT |
US7097659B2 (en) | 2001-09-07 | 2006-08-29 | Medtronic, Inc. | Fixation band for affixing a prosthetic heart valve to tissue |
US7201771B2 (en) | 2001-12-27 | 2007-04-10 | Arbor Surgical Technologies, Inc. | Bioprosthetic heart valve |
US7959674B2 (en) | 2002-07-16 | 2011-06-14 | Medtronic, Inc. | Suture locking assembly and method of use |
US8551162B2 (en) | 2002-12-20 | 2013-10-08 | Medtronic, Inc. | Biologically implantable prosthesis |
US8021421B2 (en) | 2003-08-22 | 2011-09-20 | Medtronic, Inc. | Prosthesis heart valve fixturing device |
US9579194B2 (en) | 2003-10-06 | 2017-02-28 | Medtronic ATS Medical, Inc. | Anchoring structure with concave landing zone |
US7556647B2 (en) | 2003-10-08 | 2009-07-07 | Arbor Surgical Technologies, Inc. | Attachment device and methods of using the same |
US7871435B2 (en) | 2004-01-23 | 2011-01-18 | Edwards Lifesciences Corporation | Anatomically approximate prosthetic mitral heart valve |
ITTO20040135A1 (en) | 2004-03-03 | 2004-06-03 | Sorin Biomedica Cardio Spa | CARDIAC VALVE PROSTHESIS |
US20050228494A1 (en) * | 2004-03-29 | 2005-10-13 | Salvador Marquez | Controlled separation heart valve frame |
CN101052359A (en) | 2004-04-23 | 2007-10-10 | 3F医疗有限公司 | Implantable prosthetic valve |
US20060052867A1 (en) | 2004-09-07 | 2006-03-09 | Medtronic, Inc | Replacement prosthetic heart valve, system and method of implant |
US8562672B2 (en) * | 2004-11-19 | 2013-10-22 | Medtronic, Inc. | Apparatus for treatment of cardiac valves and method of its manufacture |
DE102005003632A1 (en) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Catheter for the transvascular implantation of heart valve prostheses |
ITTO20050074A1 (en) | 2005-02-10 | 2006-08-11 | Sorin Biomedica Cardio Srl | CARDIAC VALVE PROSTHESIS |
US8574257B2 (en) * | 2005-02-10 | 2013-11-05 | Edwards Lifesciences Corporation | System, device, and method for providing access in a cardiovascular environment |
US7513909B2 (en) | 2005-04-08 | 2009-04-07 | Arbor Surgical Technologies, Inc. | Two-piece prosthetic valves with snap-in connection and methods for use |
US7914569B2 (en) | 2005-05-13 | 2011-03-29 | Medtronics Corevalve Llc | Heart valve prosthesis and methods of manufacture and use |
EP2901967B1 (en) | 2005-05-24 | 2019-10-02 | Edwards Lifesciences Corporation | Rapid deployment prosthetic heart valve |
WO2006130505A2 (en) | 2005-05-27 | 2006-12-07 | Arbor Surgical Technologies, Inc. | Gasket with collar for prosthetic heart valves and methods for using them |
US7776084B2 (en) * | 2005-07-13 | 2010-08-17 | Edwards Lifesciences Corporation | Prosthetic mitral heart valve having a contoured sewing ring |
US20070078510A1 (en) | 2005-09-26 | 2007-04-05 | Ryan Timothy R | Prosthetic cardiac and venous valves |
US7967857B2 (en) | 2006-01-27 | 2011-06-28 | Medtronic, Inc. | Gasket with spring collar for prosthetic heart valves and methods for making and using them |
US8075615B2 (en) * | 2006-03-28 | 2011-12-13 | Medtronic, Inc. | Prosthetic cardiac valve formed from pericardium material and methods of making same |
WO2007130881A2 (en) | 2006-04-29 | 2007-11-15 | Arbor Surgical Technologies, Inc. | Multiple component prosthetic heart valve assemblies and apparatus and methods for delivering them |
US8021161B2 (en) * | 2006-05-01 | 2011-09-20 | Edwards Lifesciences Corporation | Simulated heart valve root for training and testing |
US8092517B2 (en) * | 2006-05-25 | 2012-01-10 | Deep Vein Medical, Inc. | Device for regulating blood flow |
US11304800B2 (en) | 2006-09-19 | 2022-04-19 | Medtronic Ventor Technologies Ltd. | Sinus-engaging valve fixation member |
US8414643B2 (en) | 2006-09-19 | 2013-04-09 | Medtronic Ventor Technologies Ltd. | Sinus-engaging valve fixation member |
US8834564B2 (en) | 2006-09-19 | 2014-09-16 | Medtronic, Inc. | Sinus-engaging valve fixation member |
EP2083901B1 (en) | 2006-10-16 | 2017-12-27 | Medtronic Ventor Technologies Ltd. | Transapical delivery system with ventriculo-arterial overflow bypass |
JP5593545B2 (en) | 2006-12-06 | 2014-09-24 | メドトロニック シーブイ ルクセンブルク エス.アー.エール.エル. | System and method for transapical delivery of a self-expanding valve secured to an annulus |
WO2008103295A2 (en) * | 2007-02-16 | 2008-08-28 | Medtronic, Inc. | Replacement prosthetic heart valves and methods of implantation |
US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
FR2915087B1 (en) | 2007-04-20 | 2021-11-26 | Corevalve Inc | IMPLANT FOR TREATMENT OF A HEART VALVE, IN PARTICULAR OF A MITRAL VALVE, EQUIPMENT INCLUDING THIS IMPLANT AND MATERIAL FOR PLACING THIS IMPLANT. |
US8747458B2 (en) | 2007-08-20 | 2014-06-10 | Medtronic Ventor Technologies Ltd. | Stent loading tool and method for use thereof |
US10856970B2 (en) | 2007-10-10 | 2020-12-08 | Medtronic Ventor Technologies Ltd. | Prosthetic heart valve for transfemoral delivery |
US9848981B2 (en) | 2007-10-12 | 2017-12-26 | Mayo Foundation For Medical Education And Research | Expandable valve prosthesis with sealing mechanism |
US9149358B2 (en) | 2008-01-24 | 2015-10-06 | Medtronic, Inc. | Delivery systems for prosthetic heart valves |
WO2009094197A1 (en) | 2008-01-24 | 2009-07-30 | Medtronic, Inc. | Stents for prosthetic heart valves |
US9393115B2 (en) | 2008-01-24 | 2016-07-19 | Medtronic, Inc. | Delivery systems and methods of implantation for prosthetic heart valves |
US8157852B2 (en) | 2008-01-24 | 2012-04-17 | Medtronic, Inc. | Delivery systems and methods of implantation for prosthetic heart valves |
JP5687070B2 (en) | 2008-01-24 | 2015-03-18 | メドトロニック,インコーポレイテッド | Stent for prosthetic heart valve |
EP2254512B1 (en) | 2008-01-24 | 2016-01-06 | Medtronic, Inc. | Markers for prosthetic heart valves |
US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
WO2011104269A1 (en) | 2008-02-26 | 2011-09-01 | Jenavalve Technology Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
WO2009108355A1 (en) | 2008-02-28 | 2009-09-03 | Medtronic, Inc. | Prosthetic heart valve systems |
US8696689B2 (en) * | 2008-03-18 | 2014-04-15 | Medtronic Ventor Technologies Ltd. | Medical suturing device and method for use thereof |
US8313525B2 (en) | 2008-03-18 | 2012-11-20 | Medtronic Ventor Technologies, Ltd. | Valve suturing and implantation procedures |
US8430927B2 (en) | 2008-04-08 | 2013-04-30 | Medtronic, Inc. | Multiple orifice implantable heart valve and methods of implantation |
US8696743B2 (en) | 2008-04-23 | 2014-04-15 | Medtronic, Inc. | Tissue attachment devices and methods for prosthetic heart valves |
US8312825B2 (en) | 2008-04-23 | 2012-11-20 | Medtronic, Inc. | Methods and apparatuses for assembly of a pericardial prosthetic heart valve |
US9440054B2 (en) * | 2008-05-14 | 2016-09-13 | Onset Medical Corporation | Expandable transapical sheath and method of use |
US8728153B2 (en) * | 2008-05-14 | 2014-05-20 | Onset Medical Corporation | Expandable transapical sheath and method of use |
EP2119417B2 (en) | 2008-05-16 | 2020-04-29 | Sorin Group Italia S.r.l. | Atraumatic prosthetic heart valve prosthesis |
EP2358307B1 (en) | 2008-09-15 | 2021-12-15 | Medtronic Ventor Technologies Ltd. | Prosthetic heart valve having identifiers for aiding in radiographic positioning |
US8721714B2 (en) | 2008-09-17 | 2014-05-13 | Medtronic Corevalve Llc | Delivery system for deployment of medical devices |
EP2367505B1 (en) | 2008-09-29 | 2020-08-12 | Edwards Lifesciences CardiAQ LLC | Heart valve |
CA2739275C (en) | 2008-10-01 | 2017-01-17 | Impala, Inc. | Delivery system for vascular implant |
US8137398B2 (en) | 2008-10-13 | 2012-03-20 | Medtronic Ventor Technologies Ltd | Prosthetic valve having tapered tip when compressed for delivery |
NZ592283A (en) | 2008-10-17 | 2012-09-28 | Sanofi Aventis Deutschland | Combination of an insulin and the GLP-1 agonist AVE0010 |
US8449625B2 (en) * | 2009-10-27 | 2013-05-28 | Edwards Lifesciences Corporation | Methods of measuring heart valve annuluses for valve replacement |
US8986361B2 (en) | 2008-10-17 | 2015-03-24 | Medtronic Corevalve, Inc. | Delivery system for deployment of medical devices |
CA2743719C (en) | 2008-11-25 | 2019-03-19 | Edwards Lifesciences Corporation | Apparatus and method for in situ expansion of prosthetic device |
US8308798B2 (en) | 2008-12-19 | 2012-11-13 | Edwards Lifesciences Corporation | Quick-connect prosthetic heart valve and methods |
EP2201911B1 (en) | 2008-12-23 | 2015-09-30 | Sorin Group Italia S.r.l. | Expandable prosthetic valve having anchoring appendages |
US9980818B2 (en) | 2009-03-31 | 2018-05-29 | Edwards Lifesciences Corporation | Prosthetic heart valve system with positioning markers |
CA2961053C (en) | 2009-04-15 | 2019-04-30 | Edwards Lifesciences Cardiaq Llc | Vascular implant and delivery system |
US8512397B2 (en) | 2009-04-27 | 2013-08-20 | Sorin Group Italia S.R.L. | Prosthetic vascular conduit |
US8348998B2 (en) | 2009-06-26 | 2013-01-08 | Edwards Lifesciences Corporation | Unitary quick connect prosthetic heart valve and deployment system and methods |
US8808369B2 (en) | 2009-10-05 | 2014-08-19 | Mayo Foundation For Medical Education And Research | Minimally invasive aortic valve replacement |
MX2012005186A (en) | 2009-11-13 | 2012-06-08 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist, an insulin, and methionine. |
MX2012005184A (en) | 2009-11-13 | 2012-06-08 | Sanofi Aventis Deutschland | Pharmaceutical composition comprising a glp-1 agonist and methionine. |
US8870950B2 (en) | 2009-12-08 | 2014-10-28 | Mitral Tech Ltd. | Rotation-based anchoring of an implant |
US9226826B2 (en) | 2010-02-24 | 2016-01-05 | Medtronic, Inc. | Transcatheter valve structure and methods for valve delivery |
WO2011111047A2 (en) | 2010-03-10 | 2011-09-15 | Mitraltech Ltd. | Prosthetic mitral valve with tissue anchors |
US8652204B2 (en) | 2010-04-01 | 2014-02-18 | Medtronic, Inc. | Transcatheter valve with torsion spring fixation and related systems and methods |
US8579964B2 (en) | 2010-05-05 | 2013-11-12 | Neovasc Inc. | Transcatheter mitral valve prosthesis |
CN102883684B (en) | 2010-05-10 | 2015-04-08 | 爱德华兹生命科学公司 | Prosthetic heart valve |
US9554901B2 (en) | 2010-05-12 | 2017-01-31 | Edwards Lifesciences Corporation | Low gradient prosthetic heart valve |
AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
IT1400327B1 (en) | 2010-05-21 | 2013-05-24 | Sorin Biomedica Cardio Srl | SUPPORT DEVICE FOR VALVULAR PROSTHESIS AND CORRESPONDING CORRESPONDENT. |
JP2013526388A (en) | 2010-05-25 | 2013-06-24 | イエナバルブ テクノロジー インク | Artificial heart valve, and transcatheter delivery prosthesis comprising an artificial heart valve and a stent |
WO2012002944A1 (en) | 2010-06-29 | 2012-01-05 | Artventive Medical Group, Inc. | Reducing flow through a tubular structure |
US9247942B2 (en) | 2010-06-29 | 2016-02-02 | Artventive Medical Group, Inc. | Reversible tubal contraceptive device |
US11653910B2 (en) | 2010-07-21 | 2023-05-23 | Cardiovalve Ltd. | Helical anchor implantation |
US9763657B2 (en) | 2010-07-21 | 2017-09-19 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
JP6199186B2 (en) | 2010-08-30 | 2017-09-20 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Use of AVE0010 for the manufacture of a medicament for the treatment of type 2 diabetes |
US9918833B2 (en) | 2010-09-01 | 2018-03-20 | Medtronic Vascular Galway | Prosthetic valve support structure |
US9370418B2 (en) | 2010-09-10 | 2016-06-21 | Edwards Lifesciences Corporation | Rapidly deployable surgical heart valves |
US9125741B2 (en) | 2010-09-10 | 2015-09-08 | Edwards Lifesciences Corporation | Systems and methods for ensuring safe and rapid deployment of prosthetic heart valves |
US8641757B2 (en) | 2010-09-10 | 2014-02-04 | Edwards Lifesciences Corporation | Systems for rapidly deploying surgical heart valves |
US8845720B2 (en) | 2010-09-27 | 2014-09-30 | Edwards Lifesciences Corporation | Prosthetic heart valve frame with flexible commissures |
US9149277B2 (en) | 2010-10-18 | 2015-10-06 | Artventive Medical Group, Inc. | Expandable device delivery |
EP2486893B1 (en) | 2011-02-14 | 2017-07-05 | Sorin Group Italia S.r.l. | Sutureless anchoring device for cardiac valve prostheses |
EP2486894B1 (en) | 2011-02-14 | 2021-06-09 | Sorin Group Italia S.r.l. | Sutureless anchoring device for cardiac valve prostheses |
US9308087B2 (en) | 2011-04-28 | 2016-04-12 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US9554897B2 (en) | 2011-04-28 | 2017-01-31 | Neovasc Tiara Inc. | Methods and apparatus for engaging a valve prosthesis with tissue |
US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
US8945209B2 (en) | 2011-05-20 | 2015-02-03 | Edwards Lifesciences Corporation | Encapsulated heart valve |
US8852272B2 (en) | 2011-08-05 | 2014-10-07 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
WO2013021374A2 (en) | 2011-08-05 | 2013-02-14 | Mitraltech Ltd. | Techniques for percutaneous mitral valve replacement and sealing |
WO2013021375A2 (en) | 2011-08-05 | 2013-02-14 | Mitraltech Ltd. | Percutaneous mitral valve replacement and sealing |
SI2750699T1 (en) | 2011-08-29 | 2015-11-30 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for use in glycemic control in diabetes type 2 patients |
TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
US9078747B2 (en) | 2011-12-21 | 2015-07-14 | Edwards Lifesciences Corporation | Anchoring device for replacing or repairing a heart valve |
EP2609893B1 (en) | 2011-12-29 | 2014-09-03 | Sorin Group Italia S.r.l. | A kit for implanting prosthetic vascular conduits |
US9345573B2 (en) | 2012-05-30 | 2016-05-24 | Neovasc Tiara Inc. | Methods and apparatus for loading a prosthesis onto a delivery system |
EP2948103B1 (en) | 2013-01-24 | 2022-12-07 | Cardiovalve Ltd | Ventricularly-anchored prosthetic valves |
US9095344B2 (en) | 2013-02-05 | 2015-08-04 | Artventive Medical Group, Inc. | Methods and apparatuses for blood vessel occlusion |
US8984733B2 (en) | 2013-02-05 | 2015-03-24 | Artventive Medical Group, Inc. | Bodily lumen occlusion |
US10583002B2 (en) | 2013-03-11 | 2020-03-10 | Neovasc Tiara Inc. | Prosthetic valve with anti-pivoting mechanism |
US9681951B2 (en) | 2013-03-14 | 2017-06-20 | Edwards Lifesciences Cardiaq Llc | Prosthesis with outer skirt and anchors |
SG11201506352SA (en) | 2013-03-15 | 2015-09-29 | Edwards Lifesciences Corp | Valved aortic conduits |
US11007058B2 (en) | 2013-03-15 | 2021-05-18 | Edwards Lifesciences Corporation | Valved aortic conduits |
AU2014247167B2 (en) | 2013-04-03 | 2018-11-22 | Sanofi | Treatment of diabetes mellitus by long–acting formulations of insulins |
US9572665B2 (en) | 2013-04-04 | 2017-02-21 | Neovasc Tiara Inc. | Methods and apparatus for delivering a prosthetic valve to a beating heart |
EP2991586A1 (en) | 2013-05-03 | 2016-03-09 | Medtronic Inc. | Valve delivery tool |
US9468527B2 (en) | 2013-06-12 | 2016-10-18 | Edwards Lifesciences Corporation | Cardiac implant with integrated suture fasteners |
US9636116B2 (en) | 2013-06-14 | 2017-05-02 | Artventive Medical Group, Inc. | Implantable luminal devices |
US10149968B2 (en) | 2013-06-14 | 2018-12-11 | Artventive Medical Group, Inc. | Catheter-assisted tumor treatment |
US9737308B2 (en) | 2013-06-14 | 2017-08-22 | Artventive Medical Group, Inc. | Catheter-assisted tumor treatment |
US9737306B2 (en) | 2013-06-14 | 2017-08-22 | Artventive Medical Group, Inc. | Implantable luminal devices |
US9919137B2 (en) | 2013-08-28 | 2018-03-20 | Edwards Lifesciences Corporation | Integrated balloon catheter inflation system |
CN105491978A (en) | 2013-08-30 | 2016-04-13 | 耶拿阀门科技股份有限公司 | Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame |
SG11201508895RA (en) | 2013-09-20 | 2015-11-27 | Edwards Lifesciences Corp | Heart valves with increased effective orifice area |
US9839511B2 (en) | 2013-10-05 | 2017-12-12 | Sino Medical Sciences Technology Inc. | Device and method for mitral valve regurgitation treatment |
US9393111B2 (en) | 2014-01-15 | 2016-07-19 | Sino Medical Sciences Technology Inc. | Device and method for mitral valve regurgitation treatment |
US20150122687A1 (en) | 2013-11-06 | 2015-05-07 | Edwards Lifesciences Corporation | Bioprosthetic heart valves having adaptive seals to minimize paravalvular leakage |
US9901444B2 (en) * | 2013-12-17 | 2018-02-27 | Edwards Lifesciences Corporation | Inverted valve structure |
US9549816B2 (en) | 2014-04-03 | 2017-01-24 | Edwards Lifesciences Corporation | Method for manufacturing high durability heart valve |
US9585752B2 (en) | 2014-04-30 | 2017-03-07 | Edwards Lifesciences Corporation | Holder and deployment system for surgical heart valves |
US10363043B2 (en) | 2014-05-01 | 2019-07-30 | Artventive Medical Group, Inc. | Treatment of incompetent vessels |
CA2948179C (en) | 2014-05-07 | 2023-08-15 | Baylor College Of Medicine | Artificial, flexible valves and methods of fabricating and serially expanding the same |
USD867594S1 (en) | 2015-06-19 | 2019-11-19 | Edwards Lifesciences Corporation | Prosthetic heart valve |
CA2914094C (en) | 2014-06-20 | 2021-01-05 | Edwards Lifesciences Corporation | Surgical heart valves identifiable post-implant |
CN104042374B (en) * | 2014-07-10 | 2017-02-08 | 李麟荪 | Abdominal dropsy internal-drainage one-way support |
EP4066786A1 (en) | 2014-07-30 | 2022-10-05 | Cardiovalve Ltd. | Articulatable prosthetic valve |
JP6970615B2 (en) | 2014-12-12 | 2021-11-24 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Insulin glargine / lixisenatide fixed ratio prescription |
US9974651B2 (en) | 2015-02-05 | 2018-05-22 | Mitral Tech Ltd. | Prosthetic valve with axially-sliding frames |
EP3253333B1 (en) | 2015-02-05 | 2024-04-03 | Cardiovalve Ltd | Prosthetic valve with axially-sliding frames |
US20160235525A1 (en) * | 2015-02-12 | 2016-08-18 | Medtronic, Inc. | Integrated valve assembly and method of delivering and deploying an integrated valve assembly |
TWI748945B (en) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | Treatment type 2 diabetes mellitus patients |
TW201705975A (en) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | Treatment of type 2 diabetes mellitus patients |
US10709555B2 (en) | 2015-05-01 | 2020-07-14 | Jenavalve Technology, Inc. | Device and method with reduced pacemaker rate in heart valve replacement |
CR20170597A (en) | 2015-07-02 | 2018-04-20 | Edwards Lifesciences Corp | INTEGRATED HYBRID HEART VALVES |
WO2017004369A1 (en) | 2015-07-02 | 2017-01-05 | Edwards Lifesciences Corporation | Hybrid heart valves adapted for post-implant expansion |
EP3344158B1 (en) | 2015-09-02 | 2023-03-01 | Edwards Lifesciences Corporation | Spacer for securing a transcatheter valve to a bioprosthetic cardiac structure |
US10080653B2 (en) | 2015-09-10 | 2018-09-25 | Edwards Lifesciences Corporation | Limited expansion heart valve |
WO2017065850A1 (en) | 2015-10-13 | 2017-04-20 | Venarum Medical, Llc | Implantable valve and method |
CN105496607A (en) * | 2016-01-11 | 2016-04-20 | 北京迈迪顶峰医疗科技有限公司 | Aortic valve device conveyed by catheter |
US10433952B2 (en) | 2016-01-29 | 2019-10-08 | Neovasc Tiara Inc. | Prosthetic valve for avoiding obstruction of outflow |
CN107019581B (en) * | 2016-02-02 | 2021-07-16 | 中国人民解放军第二军医大学 | Ascending aorta and aortic valve integrated intravascular stent |
US10531866B2 (en) | 2016-02-16 | 2020-01-14 | Cardiovalve Ltd. | Techniques for providing a replacement valve and transseptal communication |
US10667904B2 (en) | 2016-03-08 | 2020-06-02 | Edwards Lifesciences Corporation | Valve implant with integrated sensor and transmitter |
US10813644B2 (en) | 2016-04-01 | 2020-10-27 | Artventive Medical Group, Inc. | Occlusive implant and delivery system |
EP3454795B1 (en) | 2016-05-13 | 2023-01-11 | JenaValve Technology, Inc. | Heart valve prosthesis delivery system for delivery of heart valve prosthesis with introducer sheath and loading system |
US10456245B2 (en) | 2016-05-16 | 2019-10-29 | Edwards Lifesciences Corporation | System and method for applying material to a stent |
GB201613219D0 (en) | 2016-08-01 | 2016-09-14 | Mitraltech Ltd | Minimally-invasive delivery systems |
CN114587712A (en) | 2016-08-10 | 2022-06-07 | 卡迪尔维尔福股份有限公司 | Prosthetic valve with coaxial frame |
AU2017361296B2 (en) | 2016-11-21 | 2022-09-29 | Neovasc Tiara Inc. | Methods and systems for rapid retraction of a transcatheter heart valve delivery system |
USD846122S1 (en) | 2016-12-16 | 2019-04-16 | Edwards Lifesciences Corporation | Heart valve sizer |
CN110392557A (en) | 2017-01-27 | 2019-10-29 | 耶拿阀门科技股份有限公司 | Heart valve simulation |
US10463485B2 (en) | 2017-04-06 | 2019-11-05 | Edwards Lifesciences Corporation | Prosthetic valve holders with automatic deploying mechanisms |
CA3060663C (en) | 2017-04-28 | 2024-03-26 | Edwards Lifesciences Corporation | Prosthetic heart valve with collapsible holder |
CN110831547B (en) | 2017-06-21 | 2022-07-15 | 爱德华兹生命科学公司 | Double-wire limited expansion heart valve |
US11793633B2 (en) | 2017-08-03 | 2023-10-24 | Cardiovalve Ltd. | Prosthetic heart valve |
US10888421B2 (en) | 2017-09-19 | 2021-01-12 | Cardiovalve Ltd. | Prosthetic heart valve with pouch |
US10537426B2 (en) | 2017-08-03 | 2020-01-21 | Cardiovalve Ltd. | Prosthetic heart valve |
US11246704B2 (en) | 2017-08-03 | 2022-02-15 | Cardiovalve Ltd. | Prosthetic heart valve |
US10575948B2 (en) | 2017-08-03 | 2020-03-03 | Cardiovalve Ltd. | Prosthetic heart valve |
US10856984B2 (en) | 2017-08-25 | 2020-12-08 | Neovasc Tiara Inc. | Sequentially deployed transcatheter mitral valve prosthesis |
US10856972B2 (en) | 2017-09-19 | 2020-12-08 | Cardiovalve Ltd. | Prosthetic valve with angularly offset atrial anchoring arms and ventricular anchoring legs |
GB201720803D0 (en) | 2017-12-13 | 2018-01-24 | Mitraltech Ltd | Prosthetic Valve and delivery tool therefor |
GB201800399D0 (en) | 2018-01-10 | 2018-02-21 | Mitraltech Ltd | Temperature-control during crimping of an implant |
CN111565678B (en) | 2018-01-23 | 2023-07-07 | 爱德华兹生命科学公司 | Prosthetic valve holders, systems, and methods |
AU2018424859B2 (en) | 2018-05-23 | 2024-04-04 | Corcym S.R.L. | A cardiac valve prosthesis |
USD908874S1 (en) | 2018-07-11 | 2021-01-26 | Edwards Lifesciences Corporation | Collapsible heart valve sizer |
CA3118599A1 (en) | 2018-11-08 | 2020-05-14 | Neovasc Tiara Inc. | Ventricular deployment of a transcatheter mitral valve prosthesis |
EP3920849A1 (en) | 2019-02-04 | 2021-12-15 | Medtronic, Inc. | Balloon expandable frame for transcatheter implantation of a cardiac valve prosthesis |
US11602429B2 (en) | 2019-04-01 | 2023-03-14 | Neovasc Tiara Inc. | Controllably deployable prosthetic valve |
AU2020271896B2 (en) | 2019-04-10 | 2022-10-13 | Neovasc Tiara Inc. | Prosthetic valve with natural blood flow |
US11771554B2 (en) | 2019-05-17 | 2023-10-03 | Medtronic, Inc. | Supra annular tapered balloon expandable stent for transcatheter implantation of a cardiac valve prosthesis |
EP3972673A4 (en) | 2019-05-20 | 2023-06-07 | Neovasc Tiara Inc. | Introducer with hemostasis mechanism |
WO2020257643A1 (en) | 2019-06-20 | 2020-12-24 | Neovasc Tiara Inc. | Low profile prosthetic mitral valve |
WO2021126778A1 (en) | 2019-12-16 | 2021-06-24 | Edwards Lifesciences Corporation | Valve holder assembly with suture looping protection |
EP3973925A1 (en) * | 2020-09-23 | 2022-03-30 | Vitali Verine | Apparatus for treating cardiovascular valve dysfunction |
Citations (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3671979A (en) | 1969-09-23 | 1972-06-27 | Univ Utah | Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve |
US4339831A (en) | 1981-03-27 | 1982-07-20 | Medtronic, Inc. | Dynamic annulus heart valve and reconstruction ring |
EP0170262A2 (en) * | 1984-07-31 | 1986-02-05 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Prosthetic valve |
US5411552A (en) | 1990-05-18 | 1995-05-02 | Andersen; Henning R. | Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis |
US5449384A (en) | 1992-09-28 | 1995-09-12 | Medtronic, Inc. | Dynamic annulus heart valve employing preserved porcine valve leaflets |
US5482424A (en) | 1995-01-30 | 1996-01-09 | Mobility Plus, Inc. | Car rack for wheelchairs and the like |
US6458153B1 (en) | 1999-12-31 | 2002-10-01 | Abps Venture One, Ltd. | Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof |
WO2003008809A1 (en) | 2001-07-13 | 2003-01-30 | Knorr-Bremse | Closing device for pneumatic/hydraulic membrane actuators |
US20030199971A1 (en) | 2002-04-23 | 2003-10-23 | Numed, Inc. | Biological replacement valve assembly |
US20030199963A1 (en) | 2002-04-23 | 2003-10-23 | Numed, Inc. | System for implanting a replacement valve |
WO2003092554A1 (en) * | 2002-05-03 | 2003-11-13 | The General Hospital Corporation | Involuted endovascular valve and method of construction |
US20050096734A1 (en) * | 2003-10-31 | 2005-05-05 | Majercak David C. | Implantable valvular prosthesis |
Family Cites Families (446)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3657744A (en) | 1970-05-08 | 1972-04-25 | Univ Minnesota | Method for fixing prosthetic implants in a living body |
CA1069652A (en) | 1976-01-09 | 1980-01-15 | Alain F. Carpentier | Supported bioprosthetic heart valve with compliant orifice ring |
US4056854A (en) | 1976-09-28 | 1977-11-08 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Aortic heart valve catheter |
US4265694A (en) | 1978-12-14 | 1981-05-05 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Method of making unitized three leaflet heart valve |
US4222126A (en) | 1978-12-14 | 1980-09-16 | The United States Of America As Represented By The Secretary Of The Department Of Health, Education & Welfare | Unitized three leaflet heart valve |
US4574803A (en) | 1979-01-19 | 1986-03-11 | Karl Storz | Tissue cutter |
GB2056023B (en) | 1979-08-06 | 1983-08-10 | Ross D N Bodnar E | Stent for a cardiac valve |
US4470157A (en) | 1981-04-27 | 1984-09-11 | Love Jack W | Tricuspid prosthetic tissue heart valve |
US4501030A (en) | 1981-08-17 | 1985-02-26 | American Hospital Supply Corporation | Method of leaflet attachment for prosthetic heart valves |
FR2523810B1 (en) | 1982-03-23 | 1988-11-25 | Carpentier Alain | ORGANIC GRAFT FABRIC AND PROCESS FOR ITS PREPARATION |
IT1212547B (en) | 1982-08-09 | 1989-11-30 | Iorio Domenico | INSTRUMENT FOR SURGICAL USE INTENDED TO MAKE INTERVENTIONS FOR THE IMPLANTATION OF BIOPROTESIS IN HUMAN ORGANS EASIER AND SAFER |
US4834755A (en) | 1983-04-04 | 1989-05-30 | Pfizer Hospital Products Group, Inc. | Triaxially-braided fabric prosthesis |
US4610688A (en) | 1983-04-04 | 1986-09-09 | Pfizer Hospital Products Group, Inc. | Triaxially-braided fabric prosthesis |
US4665906A (en) | 1983-10-14 | 1987-05-19 | Raychem Corporation | Medical devices incorporating sim alloy elements |
US4681908A (en) | 1983-11-09 | 1987-07-21 | Dow Corning Corporation | Hard organopolysiloxane release coating |
US4787899A (en) | 1983-12-09 | 1988-11-29 | Lazarus Harrison M | Intraluminal graft device, system and method |
US4627436A (en) | 1984-03-01 | 1986-12-09 | Innoventions Biomedical Inc. | Angioplasty catheter and method for use thereof |
US4592340A (en) | 1984-05-02 | 1986-06-03 | Boyles Paul W | Artificial catheter means |
US5007896A (en) | 1988-12-19 | 1991-04-16 | Surgical Systems & Instruments, Inc. | Rotary-catheter for atherectomy |
US4883458A (en) | 1987-02-24 | 1989-11-28 | Surgical Systems & Instruments, Inc. | Atherectomy system and method of using the same |
US4979939A (en) | 1984-05-14 | 1990-12-25 | Surgical Systems & Instruments, Inc. | Atherectomy system with a guide wire |
DE3426300A1 (en) | 1984-07-17 | 1986-01-30 | Doguhan Dr.med. 6000 Frankfurt Baykut | TWO-WAY VALVE AND ITS USE AS A HEART VALVE PROSTHESIS |
US4580568A (en) | 1984-10-01 | 1986-04-08 | Cook, Incorporated | Percutaneous endovascular stent and method for insertion thereof |
SU1271508A1 (en) | 1984-11-29 | 1986-11-23 | Горьковский государственный медицинский институт им.С.М.Кирова | Artificial heart valve |
US4662885A (en) | 1985-09-03 | 1987-05-05 | Becton, Dickinson And Company | Percutaneously deliverable intravascular filter prosthesis |
DE3640745A1 (en) | 1985-11-30 | 1987-06-04 | Ernst Peter Prof Dr M Strecker | Catheter for producing or extending connections to or between body cavities |
US4710192A (en) | 1985-12-30 | 1987-12-01 | Liotta Domingo S | Diaphragm and method for occlusion of the descending thoracic aorta |
US4878906A (en) | 1986-03-25 | 1989-11-07 | Servetus Partnership | Endoprosthesis for repairing a damaged vessel |
US5061273A (en) | 1989-06-01 | 1991-10-29 | Yock Paul G | Angioplasty apparatus facilitating rapid exchanges |
US4878495A (en) | 1987-05-15 | 1989-11-07 | Joseph Grayzel | Valvuloplasty device with satellite expansion means |
US4872874A (en) | 1987-05-29 | 1989-10-10 | Taheri Syde A | Method and apparatus for transarterial aortic graft insertion and implantation |
US4796629A (en) | 1987-06-03 | 1989-01-10 | Joseph Grayzel | Stiffened dilation balloon catheter device |
US4909252A (en) | 1988-05-26 | 1990-03-20 | The Regents Of The Univ. Of California | Perfusion balloon catheter |
US5032128A (en) | 1988-07-07 | 1991-07-16 | Medtronic, Inc. | Heart valve prosthesis |
US4917102A (en) | 1988-09-14 | 1990-04-17 | Advanced Cardiovascular Systems, Inc. | Guidewire assembly with steerable adjustable tip |
US4856516A (en) | 1989-01-09 | 1989-08-15 | Cordis Corporation | Endovascular stent apparatus and method |
US4966604A (en) | 1989-01-23 | 1990-10-30 | Interventional Technologies Inc. | Expandable atherectomy cutter with flexibly bowed blades |
US5609626A (en) | 1989-05-31 | 1997-03-11 | Baxter International Inc. | Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts |
DK0474748T3 (en) | 1989-05-31 | 1995-05-01 | Baxter Int | Biological flap prosthesis |
US5047041A (en) | 1989-08-22 | 1991-09-10 | Samuels Peter B | Surgical apparatus for the excision of vein valves in situ |
US4986830A (en) | 1989-09-22 | 1991-01-22 | Schneider (U.S.A.) Inc. | Valvuloplasty catheter with balloon which remains stable during inflation |
US5089015A (en) | 1989-11-28 | 1992-02-18 | Promedica International | Method for implanting unstented xenografts and allografts |
US5002559A (en) | 1989-11-30 | 1991-03-26 | Numed | PTCA catheter |
US5037434A (en) | 1990-04-11 | 1991-08-06 | Carbomedics, Inc. | Bioprosthetic heart valve with elastic commissures |
US5059177A (en) | 1990-04-19 | 1991-10-22 | Cordis Corporation | Triple lumen balloon catheter |
US5085635A (en) | 1990-05-18 | 1992-02-04 | Cragg Andrew H | Valved-tip angiographic catheter |
DK124690D0 (en) | 1990-05-18 | 1990-05-18 | Henning Rud Andersen | FAT PROTECTION FOR IMPLEMENTATION IN THE BODY FOR REPLACEMENT OF NATURAL FLEET AND CATS FOR USE IN IMPLEMENTING A SUCH FAT PROTECTION |
US5217483A (en) | 1990-11-28 | 1993-06-08 | Numed, Inc. | Intravascular radially expandable stent |
US6165292A (en) | 1990-12-18 | 2000-12-26 | Advanced Cardiovascular Systems, Inc. | Superelastic guiding member |
US5152771A (en) | 1990-12-31 | 1992-10-06 | The Board Of Supervisors Of Louisiana State University | Valve cutter for arterial by-pass surgery |
US5295958A (en) | 1991-04-04 | 1994-03-22 | Shturman Cardiology Systems, Inc. | Method and apparatus for in vivo heart valve decalcification |
US5272909A (en) | 1991-04-25 | 1993-12-28 | Baxter International Inc. | Method and device for testing venous valves |
US5167628A (en) | 1991-05-02 | 1992-12-01 | Boyles Paul W | Aortic balloon catheter assembly for indirect infusion of the coronary arteries |
US5350398A (en) | 1991-05-13 | 1994-09-27 | Dusan Pavcnik | Self-expanding filter for percutaneous insertion |
US5397351A (en) | 1991-05-13 | 1995-03-14 | Pavcnik; Dusan | Prosthetic valve for percutaneous insertion |
IT1245750B (en) | 1991-05-24 | 1994-10-14 | Sorin Biomedica Emodialisi S R | CARDIAC VALVE PROSTHESIS, PARTICULARLY FOR REPLACING THE AORTIC VALVE |
US20060058775A1 (en) | 1991-07-16 | 2006-03-16 | Stevens John H | System and methods for performing endovascular procedures |
US5558644A (en) | 1991-07-16 | 1996-09-24 | Heartport, Inc. | Retrograde delivery catheter and method for inducing cardioplegic arrest |
US5584803A (en) | 1991-07-16 | 1996-12-17 | Heartport, Inc. | System for cardiac procedures |
US5766151A (en) | 1991-07-16 | 1998-06-16 | Heartport, Inc. | Endovascular system for arresting the heart |
US6866650B2 (en) | 1991-07-16 | 2005-03-15 | Heartport, Inc. | System for cardiac procedures |
US5795325A (en) | 1991-07-16 | 1998-08-18 | Heartport, Inc. | Methods and apparatus for anchoring an occluding member |
US5370685A (en) | 1991-07-16 | 1994-12-06 | Stanford Surgical Technologies, Inc. | Endovascular aortic valve replacement |
US6029671A (en) | 1991-07-16 | 2000-02-29 | Heartport, Inc. | System and methods for performing endovascular procedures |
US5507767A (en) | 1992-01-15 | 1996-04-16 | Cook Incorporated | Spiral stent |
US5489297A (en) | 1992-01-27 | 1996-02-06 | Duran; Carlos M. G. | Bioprosthetic heart valve with absorbable stent |
US5163953A (en) | 1992-02-10 | 1992-11-17 | Vince Dennis J | Toroidal artificial heart valve stent |
US5683448A (en) | 1992-02-21 | 1997-11-04 | Boston Scientific Technology, Inc. | Intraluminal stent and graft |
US7101392B2 (en) | 1992-03-31 | 2006-09-05 | Boston Scientific Corporation | Tubular medical endoprostheses |
ATE247435T1 (en) | 1992-05-08 | 2003-09-15 | Schneider Usa Inc | STENT FOR THE OESOPHAGUS |
US5332402A (en) | 1992-05-12 | 1994-07-26 | Teitelbaum George P | Percutaneously-inserted cardiac valve |
JPH08500757A (en) | 1992-12-30 | 1996-01-30 | シュナイダー・(ユーエスエイ)・インコーポレーテッド | Device for deploying a stent implantable in the body |
US5431676A (en) | 1993-03-05 | 1995-07-11 | Innerdyne Medical, Inc. | Trocar system having expandable port |
US5415633A (en) | 1993-07-28 | 1995-05-16 | Active Control Experts, Inc. | Remotely steered catheterization device |
KR970004845Y1 (en) | 1993-09-27 | 1997-05-21 | 주식회사 수호메디테크 | Stent for expanding a lumen |
US5545209A (en) | 1993-09-30 | 1996-08-13 | Texas Petrodet, Inc. | Controlled deployment of a medical device |
US5389106A (en) | 1993-10-29 | 1995-02-14 | Numed, Inc. | Impermeable expandable intravascular stent |
US5480424A (en) | 1993-11-01 | 1996-01-02 | Cox; James L. | Heart valve replacement using flexible tubes |
US5713950A (en) | 1993-11-01 | 1998-02-03 | Cox; James L. | Method of replacing heart valves using flexible tubes |
US5609627A (en) | 1994-02-09 | 1997-03-11 | Boston Scientific Technology, Inc. | Method for delivering a bifurcated endoluminal prosthesis |
US5549663A (en) | 1994-03-09 | 1996-08-27 | Cordis Corporation | Endoprosthesis having graft member and exposed welded end junctions, method and procedure |
US5765418A (en) | 1994-05-16 | 1998-06-16 | Medtronic, Inc. | Method for making an implantable medical device from a refractory metal |
US5824041A (en) | 1994-06-08 | 1998-10-20 | Medtronic, Inc. | Apparatus and methods for placement and repositioning of intraluminal prostheses |
JP3970341B2 (en) | 1994-06-20 | 2007-09-05 | テルモ株式会社 | Vascular catheter |
US5554185A (en) | 1994-07-18 | 1996-09-10 | Block; Peter C. | Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same |
US5674277A (en) | 1994-12-23 | 1997-10-07 | Willy Rusch Ag | Stent for placement in a body tube |
US5575818A (en) | 1995-02-14 | 1996-11-19 | Corvita Corporation | Endovascular stent with locking ring |
US6579314B1 (en) | 1995-03-10 | 2003-06-17 | C.R. Bard, Inc. | Covered stent with encapsulated ends |
US5849005A (en) | 1995-06-07 | 1998-12-15 | Heartport, Inc. | Method and apparatus for minimizing the risk of air embolism when performing a procedure in a patient's thoracic cavity |
AU708976B2 (en) | 1995-03-30 | 1999-08-19 | Edwards Lifesciences Ag | System and methods for performing endovascular procedures |
US5667523A (en) | 1995-04-28 | 1997-09-16 | Impra, Inc. | Dual supported intraluminal graft |
US5824064A (en) | 1995-05-05 | 1998-10-20 | Taheri; Syde A. | Technique for aortic valve replacement with simultaneous aortic arch graft insertion and apparatus therefor |
US5580922A (en) | 1995-06-06 | 1996-12-03 | Weyerhaeuser Company | Cellulose products treated with isocyanate compositions |
US5716417A (en) | 1995-06-07 | 1998-02-10 | St. Jude Medical, Inc. | Integral supporting structure for bioprosthetic heart valve |
DE19532846A1 (en) | 1995-09-06 | 1997-03-13 | Georg Dr Berg | Valve for use in heart |
US5591195A (en) | 1995-10-30 | 1997-01-07 | Taheri; Syde | Apparatus and method for engrafting a blood vessel |
US6348066B1 (en) | 1995-11-07 | 2002-02-19 | Corvita Corporation | Modular endoluminal stent-grafts and methods for their use |
EP0775471B1 (en) | 1995-11-27 | 2002-05-29 | Schneider (Europe) GmbH | A stent for use in a body passage way |
DE19546692C2 (en) | 1995-12-14 | 2002-11-07 | Hans-Reiner Figulla | Self-expanding heart valve prosthesis for implantation in the human body via a catheter system |
US5861028A (en) | 1996-09-09 | 1999-01-19 | Shelhigh Inc | Natural tissue heart valve and stent prosthesis and method for making the same |
US5843158A (en) | 1996-01-05 | 1998-12-01 | Medtronic, Inc. | Limited expansion endoluminal prostheses and methods for their use |
JPH09215753A (en) | 1996-02-08 | 1997-08-19 | Schneider Usa Inc | Self-expanding stent made of titanium alloy |
US5716370A (en) | 1996-02-23 | 1998-02-10 | Williamson, Iv; Warren | Means for replacing a heart valve in a minimally invasive manner |
US20020068949A1 (en) | 1996-02-23 | 2002-06-06 | Williamson Warren P. | Extremely long wire fasteners for use in minimally invasive surgery and means and method for handling those fasteners |
US5695498A (en) | 1996-02-28 | 1997-12-09 | Numed, Inc. | Stent implantation system |
US5746709A (en) | 1996-04-25 | 1998-05-05 | Medtronic, Inc. | Intravascular pump and bypass assembly and method for using the same |
US5891191A (en) | 1996-04-30 | 1999-04-06 | Schneider (Usa) Inc | Cobalt-chromium-molybdenum alloy stent and stent-graft |
WO1997042879A1 (en) | 1996-05-14 | 1997-11-20 | Embol-X, Inc. | Aortic occluder with associated filter and methods of use during cardiac surgery |
DE69719237T2 (en) | 1996-05-23 | 2003-11-27 | Samsung Electronics Co Ltd | Flexible, self-expandable stent and method for its manufacture |
US5855601A (en) | 1996-06-21 | 1999-01-05 | The Trustees Of Columbia University In The City Of New York | Artificial heart valve and method and device for implanting the same |
US6702851B1 (en) | 1996-09-06 | 2004-03-09 | Joseph A. Chinn | Prosthetic heart valve with surface modification |
US6764509B2 (en) | 1996-09-06 | 2004-07-20 | Carbomedics Inc. | Prosthetic heart valve with surface modification |
US5968068A (en) | 1996-09-12 | 1999-10-19 | Baxter International Inc. | Endovascular delivery system |
JP2000501328A (en) | 1996-10-01 | 2000-02-08 | ヌームド インコーポレーテッド | Expandable stent |
US6325826B1 (en) | 1998-01-14 | 2001-12-04 | Advanced Stent Technologies, Inc. | Extendible stent apparatus |
US5749890A (en) | 1996-12-03 | 1998-05-12 | Shaknovich; Alexander | Method and system for stent placement in ostial lesions |
NL1004827C2 (en) | 1996-12-18 | 1998-06-19 | Surgical Innovations Vof | Device for regulating blood circulation. |
EP0850607A1 (en) | 1996-12-31 | 1998-07-01 | Cordis Corporation | Valve prosthesis for implantation in body channels |
GB9701479D0 (en) | 1997-01-24 | 1997-03-12 | Aortech Europ Ltd | Heart valve |
US6241757B1 (en) | 1997-02-04 | 2001-06-05 | Solco Surgical Instrument Co., Ltd. | Stent for expanding body's lumen |
CA2281519A1 (en) | 1997-02-19 | 1998-08-27 | Condado Medical Devices Corporation | Multi-purpose catheters, catheter systems, and radiation treatment |
US5830229A (en) | 1997-03-07 | 1998-11-03 | Micro Therapeutics Inc. | Hoop stent |
US5851232A (en) | 1997-03-15 | 1998-12-22 | Lois; William A. | Venous stent |
US5817126A (en) | 1997-03-17 | 1998-10-06 | Surface Genesis, Inc. | Compound stent |
US5824053A (en) | 1997-03-18 | 1998-10-20 | Endotex Interventional Systems, Inc. | Helical mesh endoprosthesis and methods of use |
US5860966A (en) | 1997-04-16 | 1999-01-19 | Numed, Inc. | Method of securing a stent on a balloon catheter |
US5868783A (en) | 1997-04-16 | 1999-02-09 | Numed, Inc. | Intravascular stent with limited axial shrinkage |
WO1998047447A1 (en) | 1997-04-23 | 1998-10-29 | Dubrul William R | Bifurcated stent and distal protection system |
US5957949A (en) | 1997-05-01 | 1999-09-28 | World Medical Manufacturing Corp. | Percutaneous placement valve stent |
US5855597A (en) | 1997-05-07 | 1999-01-05 | Iowa-India Investments Co. Limited | Stent valve and stent graft for percutaneous surgery |
US6162245A (en) | 1997-05-07 | 2000-12-19 | Iowa-India Investments Company Limited | Stent valve and stent graft |
US6245102B1 (en) | 1997-05-07 | 2001-06-12 | Iowa-India Investments Company Ltd. | Stent, stent graft and stent valve |
US5911734A (en) | 1997-05-08 | 1999-06-15 | Embol-X, Inc. | Percutaneous catheter and guidewire having filter and medical device deployment capabilities |
US6258120B1 (en) | 1997-12-23 | 2001-07-10 | Embol-X, Inc. | Implantable cerebral protection device and methods of use |
US6855143B2 (en) | 1997-06-13 | 2005-02-15 | Arthrocare Corporation | Electrosurgical systems and methods for recanalization of occluded body lumens |
US5906619A (en) | 1997-07-24 | 1999-05-25 | Medtronic, Inc. | Disposable delivery device for endoluminal prostheses |
US5984957A (en) | 1997-08-12 | 1999-11-16 | Schneider (Usa) Inc | Radially expanded prostheses with axial diameter control |
WO1999012483A1 (en) | 1997-09-11 | 1999-03-18 | Genzyme Corporation | Articulating endoscopic implant rotator surgical apparatus and method for using same |
US5954766A (en) | 1997-09-16 | 1999-09-21 | Zadno-Azizi; Gholam-Reza | Body fluid flow control device |
US6056722A (en) | 1997-09-18 | 2000-05-02 | Iowa-India Investments Company Limited Of Douglas | Delivery mechanism for balloons, drugs, stents and other physical/mechanical agents and methods of use |
US5925063A (en) | 1997-09-26 | 1999-07-20 | Khosravi; Farhad | Coiled sheet valve, filter or occlusive device and methods of use |
US6361545B1 (en) | 1997-09-26 | 2002-03-26 | Cardeon Corporation | Perfusion filter catheter |
WO1999026559A1 (en) | 1997-11-25 | 1999-06-03 | Triad Vascular Systems, Inc. | Layered endovascular graft |
US6248116B1 (en) | 1997-12-16 | 2001-06-19 | B. Braun Celsa | Medical treatment of a diseased anatomical duct |
EP1049425B1 (en) | 1997-12-29 | 2009-11-25 | Cleveland Clinic Foundation The | System for minimally invasive insertion of a bioprosthetic heart valve |
US6530952B2 (en) | 1997-12-29 | 2003-03-11 | The Cleveland Clinic Foundation | Bioprosthetic cardiovascular valve system |
US5944738A (en) | 1998-02-06 | 1999-08-31 | Aga Medical Corporation | Percutaneous catheter directed constricting occlusion device |
JP2002502626A (en) | 1998-02-10 | 2002-01-29 | アーテミス・メディカル・インコーポレイテッド | Supplementary device and method of using the same |
EP1054635B1 (en) | 1998-02-10 | 2010-01-06 | Artemis Medical, Inc. | Occlusion, anchoring, tensioning or flow direction apparatus |
US6059809A (en) | 1998-02-16 | 2000-05-09 | Medicorp, S.A. | Protective angioplasty device |
EP0943300A1 (en) | 1998-03-17 | 1999-09-22 | Medicorp S.A. | Reversible action endoprosthesis delivery device. |
US6074418A (en) | 1998-04-20 | 2000-06-13 | St. Jude Medical, Inc. | Driver tool for heart valve prosthesis fasteners |
US6218662B1 (en) | 1998-04-23 | 2001-04-17 | Western Atlas International, Inc. | Downhole carbon dioxide gas analyzer |
US6450989B2 (en) | 1998-04-27 | 2002-09-17 | Artemis Medical, Inc. | Dilating and support apparatus with disease inhibitors and methods for use |
US7452371B2 (en) | 1999-06-02 | 2008-11-18 | Cook Incorporated | Implantable vascular device |
JP4399585B2 (en) | 1998-06-02 | 2010-01-20 | クック インコーポレイティド | Multi-sided medical device |
US6630001B2 (en) | 1998-06-24 | 2003-10-07 | International Heart Institute Of Montana Foundation | Compliant dehyrated tissue for implantation and process of making the same |
US6159239A (en) | 1998-08-14 | 2000-12-12 | Prodesco, Inc. | Woven stent/graft structure |
US6179860B1 (en) | 1998-08-19 | 2001-01-30 | Artemis Medical, Inc. | Target tissue localization device and method |
US6203550B1 (en) | 1998-09-30 | 2001-03-20 | Medtronic, Inc. | Disposable delivery device for endoluminal prostheses |
US6051014A (en) | 1998-10-13 | 2000-04-18 | Embol-X, Inc. | Percutaneous filtration catheter for valve repair surgery and methods of use |
US6475239B1 (en) | 1998-10-13 | 2002-11-05 | Sulzer Carbomedics Inc. | Method for making polymer heart valves with leaflets having uncut free edges |
US6146366A (en) | 1998-11-03 | 2000-11-14 | Ras Holding Corp | Device for the treatment of macular degeneration and other eye disorders |
DE19857887B4 (en) | 1998-12-15 | 2005-05-04 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Anchoring support for a heart valve prosthesis |
FR2788217A1 (en) | 1999-01-12 | 2000-07-13 | Brice Letac | PROSTHETIC VALVE IMPLANTABLE BY CATHETERISM, OR SURGICAL |
US6350277B1 (en) | 1999-01-15 | 2002-02-26 | Scimed Life Systems, Inc. | Stents with temporary retaining bands |
US6736845B2 (en) | 1999-01-26 | 2004-05-18 | Edwards Lifesciences Corporation | Holder for flexible heart valve |
US6896690B1 (en) | 2000-01-27 | 2005-05-24 | Viacor, Inc. | Cardiac valve procedure methods and devices |
AU772868C (en) | 1999-02-01 | 2005-08-11 | Board Of Regents, The University Of Texas System | Woven bifurcated and trifurcated stents and methods for making the same |
US7018401B1 (en) | 1999-02-01 | 2006-03-28 | Board Of Regents, The University Of Texas System | Woven intravascular devices and methods for making the same and apparatus for delivery of the same |
DE19904975A1 (en) | 1999-02-06 | 2000-09-14 | Impella Cardiotech Ag | Device for intravascular heart valve surgery |
US6425916B1 (en) | 1999-02-10 | 2002-07-30 | Michi E. Garrison | Methods and devices for implanting cardiac valves |
US6110201A (en) | 1999-02-18 | 2000-08-29 | Venpro | Bifurcated biological pulmonary valved conduit |
DE19907646A1 (en) | 1999-02-23 | 2000-08-24 | Georg Berg | Valve for blood vessels uses flap holders and counterpart holders on stent to latch together in place and all channeled for guide wire. |
US6210408B1 (en) | 1999-02-24 | 2001-04-03 | Scimed Life Systems, Inc. | Guide wire system for RF recanalization of vascular blockages |
US6673089B1 (en) | 1999-03-11 | 2004-01-06 | Mindguard Ltd. | Implantable stroke treating device |
IL128938A0 (en) | 1999-03-11 | 2000-02-17 | Mind Guard Ltd | Implantable stroke treating device |
US7147663B1 (en) | 1999-04-23 | 2006-12-12 | St. Jude Medical Atg, Inc. | Artificial heart valve attachment apparatus and methods |
US6309417B1 (en) | 1999-05-12 | 2001-10-30 | Paul A. Spence | Heart valve and apparatus for replacement thereof |
US6790229B1 (en) | 1999-05-25 | 2004-09-14 | Eric Berreklouw | Fixing device, in particular for fixing to vascular wall tissue |
EP1057459A1 (en) | 1999-06-01 | 2000-12-06 | Numed, Inc. | Radially expandable stent |
EP1057460A1 (en) | 1999-06-01 | 2000-12-06 | Numed, Inc. | Replacement valve assembly and method of implanting same |
US6241763B1 (en) | 1999-06-08 | 2001-06-05 | William J. Drasler | In situ venous valve device and method of formation |
AU6000200A (en) | 1999-07-16 | 2001-02-05 | Biocompatibles Limited | Braided stent |
US6371970B1 (en) | 1999-07-30 | 2002-04-16 | Incept Llc | Vascular filter having articulation region and methods of use in the ascending aorta |
US6299637B1 (en) | 1999-08-20 | 2001-10-09 | Samuel M. Shaolian | Transluminally implantable venous valve |
JP4409803B2 (en) | 1999-09-10 | 2010-02-03 | クック・インコーポレイテッド | Valve assembly for use in a lumen of a vessel and method for making the valve assembly |
IT1307268B1 (en) | 1999-09-30 | 2001-10-30 | Sorin Biomedica Cardio Spa | DEVICE FOR HEART VALVE REPAIR OR REPLACEMENT. |
US6371983B1 (en) | 1999-10-04 | 2002-04-16 | Ernest Lane | Bioprosthetic heart valve |
FR2799364B1 (en) | 1999-10-12 | 2001-11-23 | Jacques Seguin | MINIMALLY INVASIVE CANCELING DEVICE |
US6352708B1 (en) | 1999-10-14 | 2002-03-05 | The International Heart Institute Of Montana Foundation | Solution and method for treating autologous tissue for implant operation |
US6440164B1 (en) | 1999-10-21 | 2002-08-27 | Scimed Life Systems, Inc. | Implantable prosthetic valve |
US6585758B1 (en) | 1999-11-16 | 2003-07-01 | Scimed Life Systems, Inc. | Multi-section filamentary endoluminal stent |
US7018406B2 (en) | 1999-11-17 | 2006-03-28 | Corevalve Sa | Prosthetic valve for transluminal delivery |
US20070043435A1 (en) | 1999-11-17 | 2007-02-22 | Jacques Seguin | Non-cylindrical prosthetic valve system for transluminal delivery |
FR2800984B1 (en) | 1999-11-17 | 2001-12-14 | Jacques Seguin | DEVICE FOR REPLACING A HEART VALVE PERCUTANEOUSLY |
US8579966B2 (en) | 1999-11-17 | 2013-11-12 | Medtronic Corevalve Llc | Prosthetic valve for transluminal delivery |
US6849085B2 (en) | 1999-11-19 | 2005-02-01 | Advanced Bio Prosthetic Surfaces, Ltd. | Self-supporting laminated films, structural materials and medical devices manufactured therefrom and method of making same |
US6936066B2 (en) | 1999-11-19 | 2005-08-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Complaint implantable medical devices and methods of making same |
US7300457B2 (en) | 1999-11-19 | 2007-11-27 | Advanced Bio Prosthetic Surfaces, Ltd. | Self-supporting metallic implantable grafts, compliant implantable medical devices and methods of making same |
US6379383B1 (en) | 1999-11-19 | 2002-04-30 | Advanced Bio Prosthetic Surfaces, Ltd. | Endoluminal device exhibiting improved endothelialization and method of manufacture thereof |
US7195641B2 (en) | 1999-11-19 | 2007-03-27 | Advanced Bio Prosthetic Surfaces, Ltd. | Valvular prostheses having metal or pseudometallic construction and methods of manufacture |
US7749245B2 (en) | 2000-01-27 | 2010-07-06 | Medtronic, Inc. | Cardiac valve procedure methods and devices |
US6872226B2 (en) | 2001-01-29 | 2005-03-29 | 3F Therapeutics, Inc. | Method of cutting material for use in implantable medical device |
NZ520462A (en) | 2000-01-27 | 2004-08-27 | 3F Therapeutics Inc | Prosthetic heart valve |
US7507252B2 (en) | 2000-01-31 | 2009-03-24 | Edwards Lifesciences Ag | Adjustable transluminal annuloplasty system |
US6402781B1 (en) | 2000-01-31 | 2002-06-11 | Mitralife | Percutaneous mitral annuloplasty and cardiac reinforcement |
US6622604B1 (en) | 2000-01-31 | 2003-09-23 | Scimed Life Systems, Inc. | Process for manufacturing a braided bifurcated stent |
US6398807B1 (en) | 2000-01-31 | 2002-06-04 | Scimed Life Systems, Inc. | Braided branching stent, method for treating a lumen therewith, and process for manufacture therefor |
US6989028B2 (en) | 2000-01-31 | 2006-01-24 | Edwards Lifesciences Ag | Medical system and method for remodeling an extravascular tissue structure |
US6652571B1 (en) | 2000-01-31 | 2003-11-25 | Scimed Life Systems, Inc. | Braided, branched, implantable device and processes for manufacture thereof |
PL211860B1 (en) | 2000-01-31 | 2012-07-31 | Cook Biotech Inc | Valve stent system |
US6797002B2 (en) | 2000-02-02 | 2004-09-28 | Paul A. Spence | Heart valve repair apparatus and methods |
US6821297B2 (en) | 2000-02-02 | 2004-11-23 | Robert V. Snyders | Artificial heart valve, implantation instrument and method therefor |
DE10010073B4 (en) | 2000-02-28 | 2005-12-22 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Anchoring for implantable heart valve prostheses |
DE10010074B4 (en) | 2000-02-28 | 2005-04-14 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Device for fastening and anchoring heart valve prostheses |
US6454799B1 (en) | 2000-04-06 | 2002-09-24 | Edwards Lifesciences Corporation | Minimally-invasive heart valves and methods of use |
DE60136925D1 (en) | 2000-05-04 | 2009-01-22 | Univ Oregon Health & Science | ENDOVASCULAR STENT POWER |
US20030083656A1 (en) | 2000-11-07 | 2003-05-01 | George Morrison | Tissue separator assembly and method |
SE522805C2 (en) | 2000-06-22 | 2004-03-09 | Jan Otto Solem | Stent Application System |
US6527800B1 (en) | 2000-06-26 | 2003-03-04 | Rex Medical, L.P. | Vascular device and method for valve leaflet apposition |
US6676698B2 (en) | 2000-06-26 | 2004-01-13 | Rex Medicol, L.P. | Vascular device with valve for approximating vessel wall |
US6695878B2 (en) | 2000-06-26 | 2004-02-24 | Rex Medical, L.P. | Vascular device for valve leaflet apposition |
AU2001271667A1 (en) | 2000-06-30 | 2002-01-14 | Viacor Incorporated | Method and apparatus for performing a procedure on a cardiac valve |
WO2002005888A1 (en) | 2000-06-30 | 2002-01-24 | Viacor Incorporated | Intravascular filter with debris entrapment mechanism |
US6419696B1 (en) | 2000-07-06 | 2002-07-16 | Paul A. Spence | Annuloplasty devices and related heart valve repair methods |
AU2001287144A1 (en) | 2000-09-07 | 2002-03-22 | Viacor, Inc. | Fixation band for affixing a prosthetic heart valve to tissue |
US7510572B2 (en) | 2000-09-12 | 2009-03-31 | Shlomo Gabbay | Implantation system for delivery of a heart valve prosthesis |
US20060142848A1 (en) | 2000-09-12 | 2006-06-29 | Shlomo Gabbay | Extra-anatomic aortic valve placement |
US7381220B2 (en) | 2000-09-20 | 2008-06-03 | Ample Medical, Inc. | Devices, systems, and methods for supplementing, repairing, or replacing a native heart valve leaflet |
US6461382B1 (en) | 2000-09-22 | 2002-10-08 | Edwards Lifesciences Corporation | Flexible heart valve having moveable commissures |
DE10048814B4 (en) | 2000-09-29 | 2004-04-15 | Siemens Ag | Computed tomography device with a data acquisition system and method for such a computed tomography device |
DE60124285T3 (en) | 2000-09-29 | 2011-03-17 | Cordis Corp., Miami Lakes | COATED MEDICAL EQUIPMENT |
US6932838B2 (en) | 2000-09-29 | 2005-08-23 | Tricardia, Llc | Venous valvuloplasty device and method |
DE10049812B4 (en) | 2000-10-09 | 2004-06-03 | Universitätsklinikum Freiburg | Device for filtering out macroscopic particles from the bloodstream during local removal of an aortic valve on the human or animal heart |
DE10049814B4 (en) | 2000-10-09 | 2006-10-19 | Universitätsklinikum Freiburg | Device for supporting surgical procedures within a vessel, in particular for minimally invasive explantation and implantation of heart valves |
DE10049815B4 (en) | 2000-10-09 | 2005-10-13 | Universitätsklinikum Freiburg | Device for local ablation of an aortic valve on the human or animal heart |
DE10049813C1 (en) | 2000-10-09 | 2002-04-18 | Universitaetsklinikum Freiburg | Instrument for the local removal of built-up matter at an aortic valve, in a human or animal heart, is a hollow catheter with a cutting unit at the far end within a closure cap for minimum invasion |
WO2002034118A2 (en) | 2000-10-27 | 2002-05-02 | Viacor, Inc. | Intracardiovascular access (icvatm) system |
US6482228B1 (en) | 2000-11-14 | 2002-11-19 | Troy R. Norred | Percutaneous aortic valve replacement |
US6974476B2 (en) | 2003-05-05 | 2005-12-13 | Rex Medical, L.P. | Percutaneous aortic valve |
US6494909B2 (en) * | 2000-12-01 | 2002-12-17 | Prodesco, Inc. | Endovascular valve |
US20020072789A1 (en) | 2000-12-12 | 2002-06-13 | Hackett Steven S. | Soc lubricant filler port |
AU2002236640A1 (en) | 2000-12-15 | 2002-06-24 | Viacor, Inc. | Apparatus and method for replacing aortic valve |
US6562058B2 (en) | 2001-03-02 | 2003-05-13 | Jacques Seguin | Intravascular filter system |
US6488704B1 (en) | 2001-05-07 | 2002-12-03 | Biomed Solutions, Llc | Implantable particle measuring apparatus |
US6503272B2 (en) | 2001-03-21 | 2003-01-07 | Cordis Corporation | Stent-based venous valves |
US6733525B2 (en) | 2001-03-23 | 2004-05-11 | Edwards Lifesciences Corporation | Rolled minimally-invasive heart valves and methods of use |
US7556646B2 (en) | 2001-09-13 | 2009-07-07 | Edwards Lifesciences Corporation | Methods and apparatuses for deploying minimally-invasive heart valves |
US7374571B2 (en) | 2001-03-23 | 2008-05-20 | Edwards Lifesciences Corporation | Rolled minimally-invasive heart valves and methods of manufacture |
US6613077B2 (en) | 2001-03-27 | 2003-09-02 | Scimed Life Systems, Inc. | Stent with controlled expansion |
DE10121210B4 (en) | 2001-04-30 | 2005-11-17 | Universitätsklinikum Freiburg | Anchoring element for the intraluminal anchoring of a heart valve replacement and method for its production |
US6682558B2 (en) | 2001-05-10 | 2004-01-27 | 3F Therapeutics, Inc. | Delivery system for a stentless valve bioprosthesis |
US6663663B2 (en) | 2001-05-14 | 2003-12-16 | M.I. Tech Co., Ltd. | Stent |
KR100393548B1 (en) | 2001-06-05 | 2003-08-02 | 주식회사 엠아이텍 | Stent |
US7544206B2 (en) | 2001-06-29 | 2009-06-09 | Medtronic, Inc. | Method and apparatus for resecting and replacing an aortic valve |
US8771302B2 (en) | 2001-06-29 | 2014-07-08 | Medtronic, Inc. | Method and apparatus for resecting and replacing an aortic valve |
FR2826863B1 (en) | 2001-07-04 | 2003-09-26 | Jacques Seguin | ASSEMBLY FOR PLACING A PROSTHETIC VALVE IN A BODY CONDUIT |
FR2828091B1 (en) | 2001-07-31 | 2003-11-21 | Seguin Jacques | ASSEMBLY ALLOWING THE PLACEMENT OF A PROTHETIC VALVE IN A BODY DUCT |
FR2828263B1 (en) | 2001-08-03 | 2007-05-11 | Philipp Bonhoeffer | DEVICE FOR IMPLANTATION OF AN IMPLANT AND METHOD FOR IMPLANTATION OF THE DEVICE |
US6896002B2 (en) | 2001-08-21 | 2005-05-24 | Scimed Life Systems, Inc | Pressure transducer protection valve |
US7097659B2 (en) | 2001-09-07 | 2006-08-29 | Medtronic, Inc. | Fixation band for affixing a prosthetic heart valve to tissue |
US20030065386A1 (en) | 2001-09-28 | 2003-04-03 | Weadock Kevin Shaun | Radially expandable endoprosthesis device with two-stage deployment |
US6976974B2 (en) | 2002-10-23 | 2005-12-20 | Scimed Life Systems, Inc. | Rotary manifold syringe |
US7172572B2 (en) | 2001-10-04 | 2007-02-06 | Boston Scientific Scimed, Inc. | Manifold system for a medical device |
US20080021552A1 (en) | 2001-10-09 | 2008-01-24 | Shlomo Gabbay | Apparatus To Facilitate Implantation |
US6893460B2 (en) | 2001-10-11 | 2005-05-17 | Percutaneous Valve Technologies Inc. | Implantable prosthetic valve |
GB0125925D0 (en) | 2001-10-29 | 2001-12-19 | Univ Glasgow | Mitral valve prosthesis |
US8308797B2 (en) * | 2002-01-04 | 2012-11-13 | Colibri Heart Valve, LLC | Percutaneously implantable replacement heart valve device and method of making same |
US20030130729A1 (en) | 2002-01-04 | 2003-07-10 | David Paniagua | Percutaneously implantable replacement heart valve device and method of making same |
US6730377B2 (en) | 2002-01-23 | 2004-05-04 | Scimed Life Systems, Inc. | Balloons made from liquid crystal polymer blends |
US6689144B2 (en) | 2002-02-08 | 2004-02-10 | Scimed Life Systems, Inc. | Rapid exchange catheter and methods for delivery of vaso-occlusive devices |
US6752828B2 (en) | 2002-04-03 | 2004-06-22 | Scimed Life Systems, Inc. | Artificial valve |
US7125418B2 (en) | 2002-04-16 | 2006-10-24 | The International Heart Institute Of Montana Foundation | Sigmoid valve and method for its percutaneous implantation |
WO2003088809A2 (en) | 2002-04-16 | 2003-10-30 | Viacor, Inc. | Method and apparatus for resecting and replacing an aortic valve |
US7105016B2 (en) | 2002-04-23 | 2006-09-12 | Medtronic Vascular, Inc. | Integrated mechanical handle with quick slide mechanism |
US7141064B2 (en) | 2002-05-08 | 2006-11-28 | Edwards Lifesciences Corporation | Compressed tissue for heart valve leaflets |
US6830575B2 (en) | 2002-05-08 | 2004-12-14 | Scimed Life Systems, Inc. | Method and device for providing full protection to a stent |
WO2003094795A1 (en) | 2002-05-10 | 2003-11-20 | Cordis Corporation | Method of making a medical device having a thin wall tubular membrane over a structural frame |
US20030225445A1 (en) | 2002-05-14 | 2003-12-04 | Derus Patricia M. | Surgical stent delivery devices and methods |
US20040117004A1 (en) | 2002-05-16 | 2004-06-17 | Osborne Thomas A. | Stent and method of forming a stent with integral barbs |
AU2003240831A1 (en) | 2002-05-30 | 2003-12-19 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus and method for coronary sinus access |
DE20321838U1 (en) | 2002-08-13 | 2011-02-10 | JenaValve Technology Inc., Wilmington | Device for anchoring and aligning heart valve prostheses |
US7041132B2 (en) | 2002-08-16 | 2006-05-09 | 3F Therapeutics, Inc, | Percutaneously delivered heart valve and delivery means thereof |
AU2003268220B8 (en) | 2002-08-28 | 2010-01-21 | Hlt, Inc. | Method and device for treating diseased valve |
US6875231B2 (en) | 2002-09-11 | 2005-04-05 | 3F Therapeutics, Inc. | Percutaneously deliverable heart valve |
US7105013B2 (en) | 2002-09-30 | 2006-09-12 | Advanced Cardiovascular Systems, Inc. | Protective sleeve assembly for a balloon catheter |
EP1553897A1 (en) | 2002-10-24 | 2005-07-20 | Boston Scientific Limited | Venous valve apparatus and method |
DE60231843D1 (en) | 2002-11-08 | 2009-05-14 | Jacques Seguin | ENDOPROTHESIS FOR VESSEL FORKING |
WO2004043273A2 (en) | 2002-11-13 | 2004-05-27 | Rosengart Todd K | Apparatus and method for cutting a heart valve |
US6887266B2 (en) | 2002-11-14 | 2005-05-03 | Synecor, Llc | Endoprostheses and methods of manufacture |
FR2847155B1 (en) | 2002-11-20 | 2005-08-05 | Younes Boudjemline | METHOD FOR MANUFACTURING A MEDICAL IMPLANT WITH ADJUSTED STRUCTURE AND IMPLANT OBTAINED THEREBY |
WO2004050137A2 (en) | 2002-11-29 | 2004-06-17 | Mindguard Ltd. | Braided intraluminal device for stroke prevention |
US8551162B2 (en) | 2002-12-20 | 2013-10-08 | Medtronic, Inc. | Biologically implantable prosthesis |
US6830585B1 (en) | 2003-01-14 | 2004-12-14 | 3F Therapeutics, Inc. | Percutaneously deliverable heart valve and methods of implantation |
US7399315B2 (en) | 2003-03-18 | 2008-07-15 | Edwards Lifescience Corporation | Minimally-invasive heart valve with cusp positioners |
US20050107871A1 (en) | 2003-03-30 | 2005-05-19 | Fidel Realyvasquez | Apparatus and methods for valve repair |
US20060271081A1 (en) | 2003-03-30 | 2006-11-30 | Fidel Realyvasquez | Apparatus and methods for valve repair |
US7871434B2 (en) | 2003-04-01 | 2011-01-18 | Cook Incorporated | Percutaneously deployed vascular valves |
US7175656B2 (en) | 2003-04-18 | 2007-02-13 | Alexander Khairkhahan | Percutaneous transcatheter heart valve replacement |
US20040210240A1 (en) | 2003-04-21 | 2004-10-21 | Sean Saint | Method and repair device for treating mitral valve insufficiency |
EP1615595B1 (en) | 2003-04-24 | 2009-10-21 | Cook Incorporated | Artificial valve prosthesis with improved flow dynamics |
US7591832B2 (en) | 2003-04-24 | 2009-09-22 | Medtronic, Inc. | Expandable guide sheath and apparatus with distal protection and methods for use |
US20040267357A1 (en) | 2003-04-30 | 2004-12-30 | Allen Jeffrey W. | Cardiac valve modification method and device |
EP1472996B1 (en) | 2003-04-30 | 2009-09-30 | Medtronic Vascular, Inc. | Percutaneously delivered temporary valve |
EP1631218B1 (en) | 2003-05-28 | 2010-09-15 | Cook Incorporated | Prosthetic valve with vessel engaging member |
AU2003237985A1 (en) | 2003-06-09 | 2005-01-28 | 3F Therapeutics, Inc. | Atrioventricular heart valve and minimally invasive delivery systems thereof |
US20070093869A1 (en) | 2003-06-20 | 2007-04-26 | Medtronic Vascular, Inc. | Device, system, and method for contracting tissue in a mammalian body |
US20040260394A1 (en) | 2003-06-20 | 2004-12-23 | Medtronic Vascular, Inc. | Cardiac valve annulus compressor system |
US20070255396A1 (en) | 2003-06-20 | 2007-11-01 | Medtronic Vascular, Inc. | Chrodae Tendinae Girdle |
JP2007535335A (en) | 2003-06-20 | 2007-12-06 | メドトロニック ヴァスキュラー インコーポレイテッド | Annulus reduction system |
US7316706B2 (en) | 2003-06-20 | 2008-01-08 | Medtronic Vascular, Inc. | Tensioning device, system, and method for treating mitral valve regurgitation |
US7201772B2 (en) | 2003-07-08 | 2007-04-10 | Ventor Technologies, Ltd. | Fluid flow prosthetic device |
RU2006103367A (en) | 2003-07-08 | 2006-06-27 | Вентор Текнолоджиз Лтд. (Il) | IMPLANTED PROSTHETIC DEVICES, IN PARTICULAR, FOR TRANSARTHERIAL DELIVERY IN TREATMENT OF AORTAL STENOSIS AND METHODS OF IMPLANTING SUCH DEVICES |
EP1646332B1 (en) | 2003-07-18 | 2015-06-17 | Edwards Lifesciences AG | Remotely activated mitral annuloplasty system |
WO2005009285A2 (en) | 2003-07-21 | 2005-02-03 | The Trustees Of The University Of Pennsylvania | Percutaneous heart valve |
DE10334868B4 (en) | 2003-07-29 | 2013-10-17 | Pfm Medical Ag | Implantable device as a replacement organ valve, its manufacturing process and basic body and membrane element for it |
WO2005011535A2 (en) | 2003-07-31 | 2005-02-10 | Cook Incorporated | Prosthetic valve for implantation in a body vessel |
EP1659992B1 (en) | 2003-07-31 | 2013-03-27 | Cook Medical Technologies LLC | Prosthetic valve devices and methods of making such devices |
DE10340265A1 (en) | 2003-08-29 | 2005-04-07 | Sievers, Hans-Hinrich, Prof. Dr.med. | Prosthesis for the replacement of the aortic and / or mitral valve of the heart |
US20050049692A1 (en) | 2003-09-02 | 2005-03-03 | Numamoto Michael J. | Medical device for reduction of pressure effects of cardiac tricuspid valve regurgitation |
WO2005023358A1 (en) | 2003-09-03 | 2005-03-17 | Acumen Medical, Inc. | Expandable sheath for delivering instruments and agents into a body lumen |
US8535344B2 (en) | 2003-09-12 | 2013-09-17 | Rubicon Medical, Inc. | Methods, systems, and devices for providing embolic protection and removing embolic material |
WO2005032421A2 (en) | 2003-09-15 | 2005-04-14 | Medtronic Vascular, Inc. | Apparatus and method for elongation of a papillary muscle |
EG24012A (en) | 2003-09-24 | 2008-03-23 | Wael Mohamed Nabil Lotfy | Valved balloon stent |
JP3726266B2 (en) | 2003-10-02 | 2005-12-14 | 朝日インテック株式会社 | Medical guidewire tip structure |
US20060259137A1 (en) | 2003-10-06 | 2006-11-16 | Jason Artof | Minimally invasive valve replacement system |
US20050075713A1 (en) | 2003-10-06 | 2005-04-07 | Brian Biancucci | Minimally invasive valve replacement system |
US7604650B2 (en) | 2003-10-06 | 2009-10-20 | 3F Therapeutics, Inc. | Method and assembly for distal embolic protection |
WO2005046528A1 (en) | 2003-10-06 | 2005-05-26 | 3F Therapeutics, Inc. | Minimally invasive valve replacement system |
US10219899B2 (en) | 2004-04-23 | 2019-03-05 | Medtronic 3F Therapeutics, Inc. | Cardiac valve replacement systems |
EP2204141B1 (en) | 2003-10-15 | 2013-06-05 | Cook Medical Technologies LLC | Prosthesis deployment system retention device |
US7419498B2 (en) | 2003-10-21 | 2008-09-02 | Nmt Medical, Inc. | Quick release knot attachment system |
US7347869B2 (en) | 2003-10-31 | 2008-03-25 | Cordis Corporation | Implantable valvular prosthesis |
EP1689329A2 (en) | 2003-11-12 | 2006-08-16 | Medtronic Vascular, Inc. | Cardiac valve annulus reduction system |
US7473274B2 (en) | 2003-11-12 | 2009-01-06 | Medtronic Vascular, Inc. | Coronary sinus approach for repair of mitral valve regurgitation |
US7955384B2 (en) | 2003-11-12 | 2011-06-07 | Medtronic Vascular, Inc. | Coronary sinus approach for repair of mitral valve regurgitation |
WO2005048883A1 (en) | 2003-11-13 | 2005-06-02 | Fidel Realyvasquez | Methods and apparatus for valve repair |
US7186265B2 (en) | 2003-12-10 | 2007-03-06 | Medtronic, Inc. | Prosthetic cardiac valves and systems and methods for implanting thereof |
US8182528B2 (en) | 2003-12-23 | 2012-05-22 | Sadra Medical, Inc. | Locking heart valve anchor |
US8840663B2 (en) | 2003-12-23 | 2014-09-23 | Sadra Medical, Inc. | Repositionable heart valve method |
US20050137686A1 (en) | 2003-12-23 | 2005-06-23 | Sadra Medical, A Delaware Corporation | Externally expandable heart valve anchor and method |
US7959666B2 (en) | 2003-12-23 | 2011-06-14 | Sadra Medical, Inc. | Methods and apparatus for endovascularly replacing a heart valve |
US9526609B2 (en) | 2003-12-23 | 2016-12-27 | Boston Scientific Scimed, Inc. | Methods and apparatus for endovascularly replacing a patient's heart valve |
WO2005070343A1 (en) * | 2003-12-23 | 2005-08-04 | Laboratoires Perouse | Kit which is intended to be implanted in a conduit |
US20050149181A1 (en) | 2004-01-07 | 2005-07-07 | Medtronic, Inc. | Bileaflet prosthetic valve and method of manufacture |
US20050228495A1 (en) | 2004-01-15 | 2005-10-13 | Macoviak John A | Suspended heart valve devices, systems, and methods for supplementing, repairing, or replacing a native heart valve |
US7470285B2 (en) | 2004-02-05 | 2008-12-30 | Children's Medical Center Corp. | Transcatheter delivery of a replacement heart valve |
ITTO20040135A1 (en) | 2004-03-03 | 2004-06-03 | Sorin Biomedica Cardio Spa | CARDIAC VALVE PROSTHESIS |
US20050203549A1 (en) | 2004-03-09 | 2005-09-15 | Fidel Realyvasquez | Methods and apparatus for off pump aortic valve replacement with a valve prosthesis |
JP2007529273A (en) | 2004-03-15 | 2007-10-25 | メドトロニック ヴァスキュラー インコーポレイテッド | Stent resistant to radial crush |
WO2005096993A1 (en) | 2004-03-31 | 2005-10-20 | Med Institute, Inc. | Endoluminal graft with a prosthetic valve |
EP1768630B1 (en) | 2004-06-16 | 2015-01-07 | Machine Solutions, Inc. | Stent crimping device |
US7462191B2 (en) | 2004-06-30 | 2008-12-09 | Edwards Lifesciences Pvt, Inc. | Device and method for assisting in the implantation of a prosthetic valve |
EP1786367B1 (en) | 2004-08-27 | 2013-04-03 | Cook Medical Technologies LLC | Placement of multiple intraluminal medical devices within a body vessel |
FR2874813B1 (en) | 2004-09-07 | 2007-06-22 | Perouse Soc Par Actions Simpli | VALVULAR PROSTHESIS |
US20060052867A1 (en) | 2004-09-07 | 2006-03-09 | Medtronic, Inc | Replacement prosthetic heart valve, system and method of implant |
US6951571B1 (en) | 2004-09-30 | 2005-10-04 | Rohit Srivastava | Valve implanting device |
US20060089711A1 (en) | 2004-10-27 | 2006-04-27 | Medtronic Vascular, Inc. | Multifilament anchor for reducing a compass of a lumen or structure in mammalian body |
US20080015671A1 (en) | 2004-11-19 | 2008-01-17 | Philipp Bonhoeffer | Method And Apparatus For Treatment Of Cardiac Valves |
US8562672B2 (en) | 2004-11-19 | 2013-10-22 | Medtronic, Inc. | Apparatus for treatment of cardiac valves and method of its manufacture |
DE102005003632A1 (en) | 2005-01-20 | 2006-08-17 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Catheter for the transvascular implantation of heart valve prostheses |
ITTO20050074A1 (en) | 2005-02-10 | 2006-08-11 | Sorin Biomedica Cardio Srl | CARDIAC VALVE PROSTHESIS |
US7955385B2 (en) | 2005-02-28 | 2011-06-07 | Medtronic Vascular, Inc. | Device, system, and method for aiding valve annuloplasty |
FR2883721B1 (en) | 2005-04-05 | 2007-06-22 | Perouse Soc Par Actions Simpli | NECESSARY TO BE IMPLANTED IN A BLOOD CIRCULATION CONDUIT, AND ASSOCIATED TUBULAR ENDOPROTHESIS |
US7914569B2 (en) | 2005-05-13 | 2011-03-29 | Medtronics Corevalve Llc | Heart valve prosthesis and methods of manufacture and use |
EP3072475B1 (en) | 2005-05-27 | 2018-10-03 | HLT, Inc. | Stentless support structure |
US8663312B2 (en) | 2005-05-27 | 2014-03-04 | Hlt, Inc. | Intravascular cuff |
US7780723B2 (en) | 2005-06-13 | 2010-08-24 | Edwards Lifesciences Corporation | Heart valve delivery system |
US20070027533A1 (en) | 2005-07-28 | 2007-02-01 | Medtronic Vascular, Inc. | Cardiac valve annulus restraining device |
US20080188928A1 (en) | 2005-09-16 | 2008-08-07 | Amr Salahieh | Medical device delivery sheath |
CA2622433A1 (en) | 2005-09-21 | 2007-04-05 | Medtronic, Inc. | Composite heart valve apparatus manufactured using techniques involving laser machining of tissue |
US20070078510A1 (en) | 2005-09-26 | 2007-04-05 | Ryan Timothy R | Prosthetic cardiac and venous valves |
US8167932B2 (en) | 2005-10-18 | 2012-05-01 | Edwards Lifesciences Corporation | Heart valve delivery system with valve catheter |
DE102005051849B4 (en) | 2005-10-28 | 2010-01-21 | JenaValve Technology Inc., Wilmington | Device for implantation and attachment of heart valve prostheses |
US20070100439A1 (en) | 2005-10-31 | 2007-05-03 | Medtronic Vascular, Inc. | Chordae tendinae restraining ring |
US20070100449A1 (en) | 2005-10-31 | 2007-05-03 | O'neil Michael | Injectable soft tissue fixation technique |
WO2007054014A1 (en) | 2005-11-09 | 2007-05-18 | Ning Wen | Delivery device for delivering a self-expanding stent |
US20070213813A1 (en) | 2005-12-22 | 2007-09-13 | Symetis Sa | Stent-valves for valve replacement and associated methods and systems for surgery |
US9078781B2 (en) | 2006-01-11 | 2015-07-14 | Medtronic, Inc. | Sterile cover for compressible stents used in percutaneous device delivery systems |
EP1991168B1 (en) | 2006-02-16 | 2016-01-27 | Transcatheter Technologies GmbH | Minimally invasive heart valve replacement |
US20070203391A1 (en) | 2006-02-24 | 2007-08-30 | Medtronic Vascular, Inc. | System for Treating Mitral Valve Regurgitation |
US20070225681A1 (en) | 2006-03-21 | 2007-09-27 | Medtronic Vascular | Catheter Having a Selectively Formable Distal Section |
US20070238979A1 (en) | 2006-03-23 | 2007-10-11 | Medtronic Vascular, Inc. | Reference Devices for Placement in Heart Structures for Visualization During Heart Valve Procedures |
US8075615B2 (en) | 2006-03-28 | 2011-12-13 | Medtronic, Inc. | Prosthetic cardiac valve formed from pericardium material and methods of making same |
US20070233238A1 (en) | 2006-03-31 | 2007-10-04 | Medtronic Vascular, Inc. | Devices for Imaging and Navigation During Minimally Invasive Non-Bypass Cardiac Procedures |
US20070232898A1 (en) | 2006-03-31 | 2007-10-04 | Medtronic Vascular, Inc. | Telescoping Catheter With Electromagnetic Coils for Imaging and Navigation During Cardiac Procedures |
US7625403B2 (en) | 2006-04-04 | 2009-12-01 | Medtronic Vascular, Inc. | Valved conduit designed for subsequent catheter delivered valve therapy |
US7524331B2 (en) | 2006-04-06 | 2009-04-28 | Medtronic Vascular, Inc. | Catheter delivered valve having a barrier to provide an enhanced seal |
US7740655B2 (en) | 2006-04-06 | 2010-06-22 | Medtronic Vascular, Inc. | Reinforced surgical conduit for implantation of a stented valve therein |
US7591848B2 (en) | 2006-04-06 | 2009-09-22 | Medtronic Vascular, Inc. | Riveted stent valve for percutaneous use |
US20070239269A1 (en) | 2006-04-07 | 2007-10-11 | Medtronic Vascular, Inc. | Stented Valve Having Dull Struts |
US20070239254A1 (en) | 2006-04-07 | 2007-10-11 | Chris Chia | System for percutaneous delivery and removal of a prosthetic valve |
US7699892B2 (en) | 2006-04-12 | 2010-04-20 | Medtronic Vascular, Inc. | Minimally invasive procedure for implanting an annuloplasty device |
EP2010102B1 (en) | 2006-04-12 | 2019-06-12 | Medtronic Vascular, Inc. | Annuloplasty device having a helical anchor |
US20070244555A1 (en) | 2006-04-12 | 2007-10-18 | Medtronic Vascular, Inc. | Annuloplasty Device Having a Helical Anchor and Methods for its Use |
US20070244544A1 (en) | 2006-04-14 | 2007-10-18 | Medtronic Vascular, Inc. | Seal for Enhanced Stented Valve Fixation |
US20070244545A1 (en) | 2006-04-14 | 2007-10-18 | Medtronic Vascular, Inc. | Prosthetic Conduit With Radiopaque Symmetry Indicators |
US20070244546A1 (en) | 2006-04-18 | 2007-10-18 | Medtronic Vascular, Inc. | Stent Foundation for Placement of a Stented Valve |
US20070288000A1 (en) | 2006-04-19 | 2007-12-13 | Medtronic Vascular, Inc. | Method for Aiding Valve Annuloplasty |
US7442207B2 (en) | 2006-04-21 | 2008-10-28 | Medtronic Vascular, Inc. | Device, system, and method for treating cardiac valve regurgitation |
WO2007127433A2 (en) | 2006-04-28 | 2007-11-08 | Medtronic, Inc. | Method and apparatus for cardiac valve replacement |
US20080004696A1 (en) | 2006-06-29 | 2008-01-03 | Valvexchange Inc. | Cardiovascular valve assembly with resizable docking station |
CN100581454C (en) | 2006-07-14 | 2010-01-20 | Ge医疗系统环球技术有限公司 | Magnetic field generator and MRI device |
CA2998123C (en) | 2006-09-08 | 2021-03-02 | Edwards Lifesciences Corporation | Integrated heart valve delivery system |
US8414643B2 (en) | 2006-09-19 | 2013-04-09 | Medtronic Ventor Technologies Ltd. | Sinus-engaging valve fixation member |
FR2906454B1 (en) | 2006-09-28 | 2009-04-10 | Perouse Soc Par Actions Simpli | IMPLANT INTENDED TO BE PLACED IN A BLOOD CIRCULATION CONDUIT. |
WO2008040014A2 (en) | 2006-09-28 | 2008-04-03 | Heart Leaflet Technologies, Inc. | Delivery tool for percutaneous delivery of a prosthesis |
EP2083901B1 (en) | 2006-10-16 | 2017-12-27 | Medtronic Ventor Technologies Ltd. | Transapical delivery system with ventriculo-arterial overflow bypass |
JP5593545B2 (en) | 2006-12-06 | 2014-09-24 | メドトロニック シーブイ ルクセンブルク エス.アー.エール.エル. | System and method for transapical delivery of a self-expanding valve secured to an annulus |
US8070799B2 (en) | 2006-12-19 | 2011-12-06 | Sorin Biomedica Cardio S.R.L. | Instrument and method for in situ deployment of cardiac valve prostheses |
EP1935378B1 (en) | 2006-12-19 | 2014-09-17 | Sorin Group Italia S.r.l. | Instrument for in situ positioning of cardiac valve prostheses |
US8236045B2 (en) | 2006-12-22 | 2012-08-07 | Edwards Lifesciences Corporation | Implantable prosthetic valve assembly and method of making the same |
EP2111190B1 (en) | 2007-01-19 | 2013-10-09 | Medtronic, Inc. | Stented heart valve devices for atrioventricular valve replacement |
US20080262593A1 (en) | 2007-02-15 | 2008-10-23 | Ryan Timothy R | Multi-layered stents and methods of implanting |
WO2008103295A2 (en) | 2007-02-16 | 2008-08-28 | Medtronic, Inc. | Replacement prosthetic heart valves and methods of implantation |
FR2913879B1 (en) | 2007-03-21 | 2009-06-12 | Perouse Soc Par Actions Simpli | DEVICE FOR LAGGING A RADIALLY EXPANSIBLE IMPLANT, NECESSARY FOR TREATMENT AND METHOD OF RELAUNCHING |
US20080255651A1 (en) | 2007-04-12 | 2008-10-16 | Medtronic Vascular, Inc. | Telescoping Stability Sheath and Method of Use |
US9138315B2 (en) | 2007-04-13 | 2015-09-22 | Jenavalve Technology Gmbh | Medical device for treating a heart valve insufficiency or stenosis |
US7896915B2 (en) | 2007-04-13 | 2011-03-01 | Jenavalve Technology, Inc. | Medical device for treating a heart valve insufficiency |
EP2150210B1 (en) | 2007-05-15 | 2016-10-12 | JenaValve Technology, Inc. | Handle for manipulating a catheter tip, catheter system and medical insertion system for inserting a self-expandable heart valve stent |
BRPI0812372A2 (en) | 2007-06-04 | 2015-02-03 | St Jude Medical | PROSTHETIC HEART VALVE. |
EP2160150B1 (en) | 2007-06-26 | 2011-10-26 | St. Jude Medical, Inc. | Apparatus for implanting collapsible/expandable prosthetic heart valves |
US8747458B2 (en) | 2007-08-20 | 2014-06-10 | Medtronic Ventor Technologies Ltd. | Stent loading tool and method for use thereof |
US8728154B2 (en) | 2007-08-24 | 2014-05-20 | St. Jude Medical, Inc. | Prosthetic aortic heart valves |
US8114154B2 (en) | 2007-09-07 | 2012-02-14 | Sorin Biomedica Cardio S.R.L. | Fluid-filled delivery system for in situ deployment of cardiac valve prostheses |
US8808367B2 (en) | 2007-09-07 | 2014-08-19 | Sorin Group Italia S.R.L. | Prosthetic valve delivery system including retrograde/antegrade approach |
DE202008018589U1 (en) | 2007-09-26 | 2016-03-14 | St. Jude Medical, Inc. | Foldable heart valve prostheses |
US9532868B2 (en) | 2007-09-28 | 2017-01-03 | St. Jude Medical, Inc. | Collapsible-expandable prosthetic heart valves with structures for clamping native tissue |
US20090138079A1 (en) | 2007-10-10 | 2009-05-28 | Vector Technologies Ltd. | Prosthetic heart valve for transfemoral delivery |
US9848981B2 (en) | 2007-10-12 | 2017-12-26 | Mayo Foundation For Medical Education And Research | Expandable valve prosthesis with sealing mechanism |
US8597349B2 (en) | 2007-11-05 | 2013-12-03 | St. Jude Medical, Inc. | Collapsible/expandable prosthetic heart valves with non-expanding stent posts and retrieval features |
EP2240121B1 (en) | 2008-01-16 | 2019-05-22 | St. Jude Medical, Inc. | Delivery and retrieval systems for collapsible/expandable prosthetic heart valves |
EP2254512B1 (en) | 2008-01-24 | 2016-01-06 | Medtronic, Inc. | Markers for prosthetic heart valves |
US9149358B2 (en) | 2008-01-24 | 2015-10-06 | Medtronic, Inc. | Delivery systems for prosthetic heart valves |
US8157852B2 (en) | 2008-01-24 | 2012-04-17 | Medtronic, Inc. | Delivery systems and methods of implantation for prosthetic heart valves |
US9168130B2 (en) | 2008-02-26 | 2015-10-27 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US8317858B2 (en) | 2008-02-26 | 2012-11-27 | Jenavalve Technology, Inc. | Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient |
US9044318B2 (en) | 2008-02-26 | 2015-06-02 | Jenavalve Technology Gmbh | Stent for the positioning and anchoring of a valvular prosthesis |
EP2247264A4 (en) | 2008-02-29 | 2011-08-31 | Florida Int Univ Board Trustees | Catheter deliverable artificial multi-leaflet heart valve prosthesis and intravascular delivery system for a catheter deliverable heart valve prosthesis |
US8313525B2 (en) | 2008-03-18 | 2012-11-20 | Medtronic Ventor Technologies, Ltd. | Valve suturing and implantation procedures |
US8696689B2 (en) | 2008-03-18 | 2014-04-15 | Medtronic Ventor Technologies Ltd. | Medical suturing device and method for use thereof |
EP2119417B2 (en) | 2008-05-16 | 2020-04-29 | Sorin Group Italia S.r.l. | Atraumatic prosthetic heart valve prosthesis |
US8137398B2 (en) | 2008-10-13 | 2012-03-20 | Medtronic Ventor Technologies Ltd | Prosthetic valve having tapered tip when compressed for delivery |
US8986361B2 (en) | 2008-10-17 | 2015-03-24 | Medtronic Corevalve, Inc. | Delivery system for deployment of medical devices |
EP2201911B1 (en) | 2008-12-23 | 2015-09-30 | Sorin Group Italia S.r.l. | Expandable prosthetic valve having anchoring appendages |
-
2006
- 2006-09-26 US US11/527,769 patent/US20070078510A1/en not_active Abandoned
- 2006-09-26 WO PCT/US2006/037543 patent/WO2007038540A1/en active Application Filing
- 2006-09-26 EP EP06815495.4A patent/EP1945142B1/en active Active
-
2009
- 2009-11-13 US US12/617,850 patent/US8506620B2/en active Active
Patent Citations (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3671979A (en) | 1969-09-23 | 1972-06-27 | Univ Utah | Catheter mounted artificial heart valve for implanting in close proximity to a defective natural heart valve |
US4339831A (en) | 1981-03-27 | 1982-07-20 | Medtronic, Inc. | Dynamic annulus heart valve and reconstruction ring |
EP0170262A2 (en) * | 1984-07-31 | 1986-02-05 | TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION | Prosthetic valve |
US5411552A (en) | 1990-05-18 | 1995-05-02 | Andersen; Henning R. | Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis |
US5449384A (en) | 1992-09-28 | 1995-09-12 | Medtronic, Inc. | Dynamic annulus heart valve employing preserved porcine valve leaflets |
US5482424A (en) | 1995-01-30 | 1996-01-09 | Mobility Plus, Inc. | Car rack for wheelchairs and the like |
US6458153B1 (en) | 1999-12-31 | 2002-10-01 | Abps Venture One, Ltd. | Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof |
US6652578B2 (en) | 1999-12-31 | 2003-11-25 | Abps Venture One, Ltd. | Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof |
US7018408B2 (en) | 1999-12-31 | 2006-03-28 | Abps Venture One, Ltd. | Endoluminal cardiac and venous valve prostheses and methods of manufacture and delivery thereof |
WO2003008809A1 (en) | 2001-07-13 | 2003-01-30 | Knorr-Bremse | Closing device for pneumatic/hydraulic membrane actuators |
US20030199971A1 (en) | 2002-04-23 | 2003-10-23 | Numed, Inc. | Biological replacement valve assembly |
US20030199963A1 (en) | 2002-04-23 | 2003-10-23 | Numed, Inc. | System for implanting a replacement valve |
WO2003092554A1 (en) * | 2002-05-03 | 2003-11-13 | The General Hospital Corporation | Involuted endovascular valve and method of construction |
US20050096734A1 (en) * | 2003-10-31 | 2005-05-05 | Majercak David C. | Implantable valvular prosthesis |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2008264553A (en) * | 2007-04-23 | 2008-11-06 | Saint Joseph's Translational Research Inst Inc | Replacement heart valve, valve holder and methods of making and using same |
EP2025306A3 (en) * | 2007-04-23 | 2009-05-20 | Saint Joseph Research Institute | Replacement heart valve, valve holder and methods of making and using same |
US7998196B2 (en) | 2007-04-23 | 2011-08-16 | Saint Joseph's Translational Research Institute, Inc. | Replacement heart valve, valve holder and methods of making and using same |
US8790397B2 (en) | 2007-04-23 | 2014-07-29 | Megumi MATHISON | Replacement heart valve, valve holder and methods of making same |
JP2011527912A (en) * | 2008-07-17 | 2011-11-10 | エヌヴェーテー アーゲー | Prosthetic heart valve system |
Also Published As
Publication number | Publication date |
---|---|
US20100057194A1 (en) | 2010-03-04 |
US20070078510A1 (en) | 2007-04-05 |
US8506620B2 (en) | 2013-08-13 |
EP1945142A1 (en) | 2008-07-23 |
EP1945142B1 (en) | 2013-12-25 |
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