WO2007041591B1 - Detecting vulnerable plaque - Google Patents

Detecting vulnerable plaque

Info

Publication number
WO2007041591B1
WO2007041591B1 PCT/US2006/038650 US2006038650W WO2007041591B1 WO 2007041591 B1 WO2007041591 B1 WO 2007041591B1 US 2006038650 W US2006038650 W US 2006038650W WO 2007041591 B1 WO2007041591 B1 WO 2007041591B1
Authority
WO
WIPO (PCT)
Prior art keywords
optical
optical waveguide
intraluminal wall
radiation
probe
Prior art date
Application number
PCT/US2006/038650
Other languages
French (fr)
Other versions
WO2007041591A3 (en
WO2007041591A2 (en
Inventor
Andres Zuluaga
Original Assignee
Infraredx Inc
Andres Zuluaga
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Infraredx Inc, Andres Zuluaga filed Critical Infraredx Inc
Priority to EP06816136A priority Critical patent/EP1928307A2/en
Priority to JP2008533782A priority patent/JP2009509694A/en
Publication of WO2007041591A2 publication Critical patent/WO2007041591A2/en
Publication of WO2007041591A3 publication Critical patent/WO2007041591A3/en
Publication of WO2007041591B1 publication Critical patent/WO2007041591B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0062—Arrangements for scanning
    • A61B5/0066—Optical coherence imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0073—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by tomography, i.e. reconstruction of 3D images from 2D projections
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
    • A61B5/0086—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters using infrared radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
    • A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
    • A61B5/6852—Catheters

Abstract

An apparatus and associated method for detecting vulnerable plaque within a lumen defined by an intraluminal wall is described. The apparatus includes a probe having a distal portion and a proximal portion. The apparatus includes an optical waveguide extending along the probe. The optical waveguide is configured to carry optical radiation between the distal and proximal portions, and has a distal end in communication with the intraluminal wall. The apparatus includes an interferometer coupled to the optical waveguide and configured to provide an interference signal for sub-surface imaging of the intraluminal wall, and a processing module configured to provide spectroscopic information from detected intensity of light collected from the intraluminal wall.

Claims

AMENDED CLAIMS received by the International Bureau on 25 June 2007 (25.06.2007)
I- An apparatus for detecting vulnerable plaque within a lumen defined by an intraluminal wall, the apparatus comprising:
a probe having a distal portion and a proximal portion; an optical waveguide extending along the probe, the optical waveguide being configured to cany optical radiation between the distal and proximal portions, and having a distal end in communication with the intraluminal wall; an interferometer coupled to the optical waveguide and configured to provide an interference signal for sub-surface imaging of the intraluminal wall; and a processing module configured to provide spectroscopic information about the intraluminal wall from detected Intensity of light collected from the intraluminal wall.
2, The apparatus of claim 1, wherein the processing module is configured to receive the detected intensity of light collected from the intraluminal wall by the optical waveguide,
3. The apparatus of claim 1, further comprising: a second optical waveguide extending along the probe, the second optical waveguide being configured to carry optical radiation between the distal and proximal portions, and having a distal end in communication with the intraluminal wall.
, 4, The apparatus of claim 3, wherein the processing module is configured to receive the detected intensity of light collected from the intraluminal wall by the second optical waveguide.
5. The apparatus of claim 1, wherein the interferometer is configured to provide an interference signal for sub-surface imaging by performing optical coherence tomography.
27
6. The apparatus of claim I5 wherein the interferometer is configured to provide an interference signal for sub-surface imaging by performing optical frequency domain reflectometry.
7. An apparatus for detecting vulnerable plaque within a lumen defined by an intraluminal wall, the apparatus comprising:
a probe having a distal portion and a proximal portion;
a first optical waveguide extending along the probe, the first optical waveguide being configured to cairy optical radiation between the distal and proximal portions, and having a distal end in communication with an area of the intraluminal wall;
a second optical waveguide extending along the probe, the second optical waveguide being configured to carry optical radiation between the distal and proximal portions, and having a distal end in communication with the area of the intraluminal wall; and
a third optical waveguide coupled to a portion of the second optical waveguide,
8. The apparatus of claim 7, further comprising: an optical coupler in optical communication with the distal end of the first optical waveguide, the optical coupler being configured to transmit optical radiation between the first optical waveguide and the intraluminal wall.
9. The apparatus of claim 7, further comprising: an optical coupler in optical communication with the distal end of the second optical waveguide, the optical coupler being configured to transmit optical radiation between the second optical waveguide and the intraluminal wall.
' 10. The apparatus of claim 7, further comprising: a fourth optical waveguide coupled to a portion ϋf the first optical waveguide,
11. The apparatus of claim 10» further comprising: a variable-delay coupler configured to couple optical radiation from the third optical waveguide into the fourth optical waveguide with a variable optical group delay,
12. The apparatus of claim 11, wherein the variable-delay coupler is configured to scan the variable optical group delay by an amount corresponding to a coherence length of a source of optical radiation.
13. The apparatus of claim 10, further comprising: an optical source configured to couple optical radiation into the second and third optical waveguides.
14. The apparatus of claim 10, further comprising: an optical detector configured to receive optical radiation from the first and fourth optical waveguides,
15. The apparatus of claim 7, further comprising: a variable-delay reflector configured to reverse the direction of propagation of optical radiation in the third optical waveguide with a variable optical group delay.
16. The apparatus of claim 15, wherein the variable-delay reflector is configured to scan the variable optical group delay by an amount corresponding to a coherence length of a source of optical radiation.
Yl. The apparatus of claim 7, further comprising: an optical source configured to couple optical radiation into the second and third optical waveguides; and
a first optical detector configured to receive optical radiation from the second and third optical waveguides.
29
18. The apparatus of claim 17, further comprising: a second optical detector configured to receive optical radiation from the first optical waveguide.
19. The apparatus of claim 8, wherein the optical coupler comprises an atraumatic light-coupler configured to atraumatically contact the intraluminal wall.
20. A method for detecting vulnerable plaque within a lumen defined by an intraluminal wall, the method comprising: inserting a distal portion of a probe into the lumen; providing optical radiation to the intraluminal wall through an optical waveguide extending along the probe; combining reference optical radiation with optical radiation scattered from the intraluminal wall, and returning through the optical waveguide, to provide an interference signal for sub-surface imaging of the intraluminal wall; and processing a detected intensity of light collected from the intraluminal wall to extract spectroscopic information.
21. The apparatus of claim I1 further comprising: an optical source configured to couple optical radiation into the optical waveguide.
22. The apparatus of claim 21, wherein the optical source is configured to emit optical radiation that provides a range of wavelengths to form the interference signal for subsurface imaging and the spectroscopic information provided from the detected intensity of light collected from the intraluminal wall.
23. The apparatus of claim 22, wherein the optical source is configured to emit narrowband radiation scanned over the range of wavelengths.
30
24. The apparatus of claim 22, wherein the optical source is configured to emit broadband radiation that includes the range of wavelengths.
31
PCT/US2006/038650 2005-09-30 2006-09-29 Detecting vulnerable plaque WO2007041591A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06816136A EP1928307A2 (en) 2005-09-30 2006-09-29 Detecting vulnerable plaque
JP2008533782A JP2009509694A (en) 2005-09-30 2006-09-29 Detection of unstable plaque

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/241,726 2005-09-30
US11/241,726 US7450241B2 (en) 2005-09-30 2005-09-30 Detecting vulnerable plaque

Publications (3)

Publication Number Publication Date
WO2007041591A2 WO2007041591A2 (en) 2007-04-12
WO2007041591A3 WO2007041591A3 (en) 2007-06-21
WO2007041591B1 true WO2007041591B1 (en) 2007-08-30

Family

ID=37728350

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/038650 WO2007041591A2 (en) 2005-09-30 2006-09-29 Detecting vulnerable plaque

Country Status (4)

Country Link
US (4) US7450241B2 (en)
EP (1) EP1928307A2 (en)
JP (1) JP2009509694A (en)
WO (1) WO2007041591A2 (en)

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WO2007041591A3 (en) 2007-06-21
US7929145B2 (en) 2011-04-19
US7450241B2 (en) 2008-11-11
US20070076212A1 (en) 2007-04-05
EP1928307A2 (en) 2008-06-11
US7679754B2 (en) 2010-03-16
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US20090051923A1 (en) 2009-02-26
US8035819B2 (en) 2011-10-11

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