WO2007044471A3 - Methods and products related to the improved analysis of carbohydrates - Google Patents

Methods and products related to the improved analysis of carbohydrates Download PDF

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Publication number
WO2007044471A3
WO2007044471A3 PCT/US2006/038988 US2006038988W WO2007044471A3 WO 2007044471 A3 WO2007044471 A3 WO 2007044471A3 US 2006038988 W US2006038988 W US 2006038988W WO 2007044471 A3 WO2007044471 A3 WO 2007044471A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
carbohydrates
glycosylation
analysis
glycans
Prior art date
Application number
PCT/US2006/038988
Other languages
French (fr)
Other versions
WO2007044471A2 (en
Inventor
Carlos Bosques
Nishla Keiser
Aravind Srinivasan
Rahul Raman
Karthik Viswanathan
Ram Sasisekharan
Pankaj Gandhe
Sasi Raguram
Original Assignee
Massachusetts Inst Technology
Parivid Llc
Carlos Bosques
Nishla Keiser
Aravind Srinivasan
Rahul Raman
Karthik Viswanathan
Ram Sasisekharan
Pankaj Gandhe
Sasi Raguram
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Parivid Llc, Carlos Bosques, Nishla Keiser, Aravind Srinivasan, Rahul Raman, Karthik Viswanathan, Ram Sasisekharan, Pankaj Gandhe, Sasi Raguram filed Critical Massachusetts Inst Technology
Publication of WO2007044471A2 publication Critical patent/WO2007044471A2/en
Publication of WO2007044471A3 publication Critical patent/WO2007044471A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/20—Identification of molecular entities, parts thereof or of chemical compositions

Abstract

The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O- glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycocoηjugates with the desired glycosylation.
PCT/US2006/038988 2005-10-06 2006-10-05 Methods and products related to the improved analysis of carbohydrates WO2007044471A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/244,826 2005-10-06
US11/244,826 US20060127950A1 (en) 2004-04-15 2005-10-06 Methods and products related to the improved analysis of carbohydrates

Publications (2)

Publication Number Publication Date
WO2007044471A2 WO2007044471A2 (en) 2007-04-19
WO2007044471A3 true WO2007044471A3 (en) 2008-02-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/038988 WO2007044471A2 (en) 2005-10-06 2006-10-05 Methods and products related to the improved analysis of carbohydrates

Country Status (2)

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US (3) US20060127950A1 (en)
WO (1) WO2007044471A2 (en)

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CN110987661B (en) * 2019-11-25 2021-08-27 中南大学 Method for improving Harris distributed structural surface shear damage constitutive model

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