WO2007044727A3 - Pkr activation via hybridization chain reaction - Google Patents

Pkr activation via hybridization chain reaction Download PDF

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Publication number
WO2007044727A3
WO2007044727A3 PCT/US2006/039571 US2006039571W WO2007044727A3 WO 2007044727 A3 WO2007044727 A3 WO 2007044727A3 US 2006039571 W US2006039571 W US 2006039571W WO 2007044727 A3 WO2007044727 A3 WO 2007044727A3
Authority
WO
WIPO (PCT)
Prior art keywords
chain reaction
hybridization chain
rna
pkr
activation via
Prior art date
Application number
PCT/US2006/039571
Other languages
French (fr)
Other versions
WO2007044727A2 (en
Inventor
Robert Dirks
Niles A Pierce
Original Assignee
California Inst Of Techn
Robert Dirks
Niles A Pierce
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn, Robert Dirks, Niles A Pierce filed Critical California Inst Of Techn
Priority to AT06836249T priority Critical patent/ATE526975T1/en
Priority to EP06836249A priority patent/EP1931806B1/en
Publication of WO2007044727A2 publication Critical patent/WO2007044727A2/en
Publication of WO2007044727A3 publication Critical patent/WO2007044727A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

The present application relates to the use of hybridization chain reaction (HCR) to form double stranded RNA polymers in the presence of a target, such as a nucleic acid associated with a disease or disorder. The RNA polymers are preferably able to activate the RNA-dependent kinase PKR. Activation of PKR via RNA-HCR can be used to treat a wide variety of diseases and disorders by specifically targeting diseased cells.
PCT/US2006/039571 2005-10-07 2006-10-06 Pkr activation via hybridization chain reaction WO2007044727A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AT06836249T ATE526975T1 (en) 2005-10-07 2006-10-06 PKR ACTIVATION USING HYBRIDIZATION CHAIN REACTION
EP06836249A EP1931806B1 (en) 2005-10-07 2006-10-06 Pkr activation via hybridization chain reaction

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72501105P 2005-10-07 2005-10-07
US60/725,011 2005-10-07

Publications (2)

Publication Number Publication Date
WO2007044727A2 WO2007044727A2 (en) 2007-04-19
WO2007044727A3 true WO2007044727A3 (en) 2009-05-28

Family

ID=37943474

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/039571 WO2007044727A2 (en) 2005-10-07 2006-10-06 Pkr activation via hybridization chain reaction

Country Status (4)

Country Link
US (2) US7960357B2 (en)
EP (1) EP1931806B1 (en)
AT (1) ATE526975T1 (en)
WO (1) WO2007044727A2 (en)

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ATE526975T1 (en) 2005-10-07 2011-10-15 California Inst Of Techn PKR ACTIVATION USING HYBRIDIZATION CHAIN REACTION
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JP5492901B2 (en) * 2008-10-23 2014-05-14 コーニンクレッカ フィリップス エヌ ヴェ Molecular imaging
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GB201401885D0 (en) 2014-02-04 2014-03-19 Olink Ab Proximity assay with detection based on hybridisation chain reaction (HCR)
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AU2017321492A1 (en) 2016-08-30 2019-03-14 California Institute Of Technology Immunohistochemistry via hybridization chain reaction
US11459603B2 (en) * 2017-05-23 2022-10-04 Rutgers, The State University Of New Jersey Target mediated in situ signal amplification with dual interacting hairpin probes
CN110286216B (en) * 2019-05-16 2021-10-15 中国科学院武汉物理与数学研究所 A rapidly visualized hemolytic escherichia coli O157: h7 detection method
EP4284925A1 (en) 2021-01-26 2023-12-06 California Institute of Technology Allosteric conditional guide rnas for cell-selective regulation of crispr/cas
CA3228120A1 (en) * 2021-08-04 2023-02-09 The University Of Tokyo Hairpin nucleic acid composition
WO2024005045A1 (en) * 2022-06-28 2024-01-04 国立大学法人東京大学 Hairpin nucleic acid composition

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Also Published As

Publication number Publication date
US8962582B2 (en) 2015-02-24
US20070087334A1 (en) 2007-04-19
EP1931806A4 (en) 2010-05-26
ATE526975T1 (en) 2011-10-15
WO2007044727A2 (en) 2007-04-19
US7960357B2 (en) 2011-06-14
EP1931806A2 (en) 2008-06-18
EP1931806B1 (en) 2011-10-05
US20110313030A1 (en) 2011-12-22

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