WO2007062039A3 - Confocal imaging methods and apparatus - Google Patents

Confocal imaging methods and apparatus Download PDF

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Publication number
WO2007062039A3
WO2007062039A3 PCT/US2006/045058 US2006045058W WO2007062039A3 WO 2007062039 A3 WO2007062039 A3 WO 2007062039A3 US 2006045058 W US2006045058 W US 2006045058W WO 2007062039 A3 WO2007062039 A3 WO 2007062039A3
Authority
WO
WIPO (PCT)
Prior art keywords
rectangular
detector array
scan
dimension
sample
Prior art date
Application number
PCT/US2006/045058
Other languages
French (fr)
Other versions
WO2007062039A2 (en
Inventor
Wenyi Feng
Theofilos Kotseroglou
Mark Wang
Alexander Triener
Diping Che
Robert Kain
Original Assignee
Illumina Inc
Wenyi Feng
Theofilos Kotseroglou
Mark Wang
Alexander Triener
Diping Che
Robert Kain
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37808340&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007062039(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Illumina Inc, Wenyi Feng, Theofilos Kotseroglou, Mark Wang, Alexander Triener, Diping Che, Robert Kain filed Critical Illumina Inc
Priority to CA2632221A priority Critical patent/CA2632221C/en
Priority to DK06838184.7T priority patent/DK1955102T3/en
Priority to CN2006800515891A priority patent/CN101361015B/en
Priority to EP06838184.7A priority patent/EP1955102B1/en
Priority to JP2008542410A priority patent/JP5055292B2/en
Priority to ES06838184T priority patent/ES2407968T3/en
Publication of WO2007062039A2 publication Critical patent/WO2007062039A2/en
Publication of WO2007062039A3 publication Critical patent/WO2007062039A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0036—Scanning details, e.g. scanning stages
    • G02B21/004—Scanning details, e.g. scanning stages fixed arrays, e.g. switchable aperture arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths

Abstract

The invention provides imaging apparatus and methods useful for obtaining a high resolution image of a sample at rapid scan rates. A rectangular detector array having a horizontal dimension that is longer than the vertical dimension can be used along with imaging optics positioned to direct a rectangular image of a portion of a sample to the rectangular detector array. A scanning device can be configured to scan the sample in a scan-axis dimension, wherein the vertical dimension for the rectangular detector array and the shorter of the two rectangular dimensions for the image are in the scan-axis dimension, and wherein the vertical dimension for the rectangular detector array is short enough to achieve confocality in a single axis.
PCT/US2006/045058 2005-11-23 2006-11-21 Confocal imaging methods and apparatus WO2007062039A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2632221A CA2632221C (en) 2005-11-23 2006-11-21 Confocal imaging methods and apparatus
DK06838184.7T DK1955102T3 (en) 2005-11-23 2006-11-21 Method and device for confocal imaging
CN2006800515891A CN101361015B (en) 2005-11-23 2006-11-21 Confocal imaging methods and apparatus
EP06838184.7A EP1955102B1 (en) 2005-11-23 2006-11-21 Confocal imaging methods and apparatus
JP2008542410A JP5055292B2 (en) 2005-11-23 2006-11-21 Confocal imaging method and apparatus
ES06838184T ES2407968T3 (en) 2005-11-23 2006-11-21 Procedures and apparatus for confocal imaging

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/286,309 US7329860B2 (en) 2005-11-23 2005-11-23 Confocal imaging methods and apparatus
US11/286,309 2005-11-23

Publications (2)

Publication Number Publication Date
WO2007062039A2 WO2007062039A2 (en) 2007-05-31
WO2007062039A3 true WO2007062039A3 (en) 2007-07-19

Family

ID=37808340

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/045058 WO2007062039A2 (en) 2005-11-23 2006-11-21 Confocal imaging methods and apparatus

Country Status (9)

Country Link
US (6) US7329860B2 (en)
EP (2) EP2594981B1 (en)
JP (1) JP5055292B2 (en)
CN (1) CN101361015B (en)
CA (1) CA2632221C (en)
DK (2) DK1955102T3 (en)
ES (2) ES2407968T3 (en)
PL (1) PL2594981T3 (en)
WO (1) WO2007062039A2 (en)

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