WO2007062387A3 - Hair grafts derived from plucked hair - Google Patents

Hair grafts derived from plucked hair Download PDF

Info

Publication number
WO2007062387A3
WO2007062387A3 PCT/US2006/061193 US2006061193W WO2007062387A3 WO 2007062387 A3 WO2007062387 A3 WO 2007062387A3 US 2006061193 W US2006061193 W US 2006061193W WO 2007062387 A3 WO2007062387 A3 WO 2007062387A3
Authority
WO
WIPO (PCT)
Prior art keywords
hair
plucked
grafts derived
methods
derived
Prior art date
Application number
PCT/US2006/061193
Other languages
French (fr)
Other versions
WO2007062387B1 (en
WO2007062387A2 (en
Inventor
Stephen A Cochran
Bryan Marshall
Thomas H Barrows
Yandong Su
Robyn Schlicher
Original Assignee
Aderans Res Inst Inc
Stephen A Cochran
Bryan Marshall
Thomas H Barrows
Yandong Su
Robyn Schlicher
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aderans Res Inst Inc, Stephen A Cochran, Bryan Marshall, Thomas H Barrows, Yandong Su, Robyn Schlicher filed Critical Aderans Res Inst Inc
Publication of WO2007062387A2 publication Critical patent/WO2007062387A2/en
Publication of WO2007062387A3 publication Critical patent/WO2007062387A3/en
Publication of WO2007062387B1 publication Critical patent/WO2007062387B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627—Hair cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00752—Hair removal or transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/18—Materials or treatment for tissue regeneration for hair reconstruction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts

Abstract

The present invention is a hair graft derived from a plucked hair comprising a plucked hair having adhered epidermal stem cells and associated follicular dermal cells. The present invention also includes methods of making a hair graft, methods of implanting a hair graft and methods of identifying inductive follicular dermal cells.
PCT/US2006/061193 2005-11-22 2006-11-22 Hair grafts derived from plucked hair WO2007062387A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73888105P 2005-11-22 2005-11-22
US60/738,881 2005-11-22

Publications (3)

Publication Number Publication Date
WO2007062387A2 WO2007062387A2 (en) 2007-05-31
WO2007062387A3 true WO2007062387A3 (en) 2007-11-22
WO2007062387B1 WO2007062387B1 (en) 2008-01-24

Family

ID=38068048

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/061193 WO2007062387A2 (en) 2005-11-22 2006-11-22 Hair grafts derived from plucked hair

Country Status (4)

Country Link
US (1) US20070122387A1 (en)
AR (1) AR057628A1 (en)
TW (1) TW200803877A (en)
WO (1) WO2007062387A2 (en)

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US7597885B2 (en) * 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
PL1945757T3 (en) * 2005-10-17 2018-05-30 Aderans Research Institute, Inc. Method of delivering hair follicle progenitor cells to the skin
US20070148138A1 (en) * 2005-11-22 2007-06-28 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin
US7780635B2 (en) * 2006-02-09 2010-08-24 Aderans Research Institute, Inc. Apparatus and methods for delivering fluid and material to a subject
WO2008042216A2 (en) * 2006-09-28 2008-04-10 Follica, Inc. Methods, kits, and compositions for generating new hair follicles and growing hair
US7985537B2 (en) * 2007-06-12 2011-07-26 Aderans Research Institute, Inc. Methods for determining the hair follicle inductive properties of a composition
AU2009314147B2 (en) 2008-11-12 2015-12-24 The Trustees Of The University Of Pennsylvania Fibroblast growth factor-9 promotes hair follicle regeneration after wounding
US20100179492A1 (en) * 2009-01-14 2010-07-15 Aderans Research Institute, Inc., Methods for increasing trichogenicity of dermal cells
US9693799B2 (en) 2009-09-17 2017-07-04 Pilofocus, Inc. System and method for aligning hair follicle
IN2012DN02415A (en) 2009-09-17 2015-08-21 Carlos K Weskley
US9314082B2 (en) 2009-09-17 2016-04-19 Pilofocus, Inc. System and method for extraction of hair follicle
DE102010009571A1 (en) * 2010-02-26 2011-09-01 Euroderm Gmbh A method of promoting the restoration of bodily function using cells of the hair root sheath, preparation and manufacturing method
KR101087654B1 (en) 2010-04-22 2011-11-30 이희영 Hair transplanting material
US20120003300A1 (en) * 2010-06-30 2012-01-05 Pangaea Laboratories Ltd Composition Comprising Vascular Endothelial Growth Factor (VEGF) for the Treatment of Hair Loss
US9358100B2 (en) * 2011-04-26 2016-06-07 Hee Young Lee Hair transplant material
WO2013059349A1 (en) 2011-10-17 2013-04-25 Pilofocus, Inc. Hair restoration
USD690004S1 (en) 2012-03-16 2013-09-17 Aderans Research Institute, Inc. Holder for a device for delivering cellular material and physiologic fluids
CN108525007B (en) * 2018-05-15 2020-10-27 北京航空航天大学 Keratin fiber-nerve growth factor composite scaffold for nerve tissue engineering
EP4231962A1 (en) * 2020-10-20 2023-08-30 Strauch, Georg Coated hair and use thereof
CN116173300B (en) * 2022-11-21 2023-08-22 郑州大学第一附属医院 Plant decellularized artificial blood vessel and preparation method thereof

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