WO2007062387B1 - Hair grafts derived from plucked hair - Google Patents

Hair grafts derived from plucked hair

Info

Publication number
WO2007062387B1
WO2007062387B1 PCT/US2006/061193 US2006061193W WO2007062387B1 WO 2007062387 B1 WO2007062387 B1 WO 2007062387B1 US 2006061193 W US2006061193 W US 2006061193W WO 2007062387 B1 WO2007062387 B1 WO 2007062387B1
Authority
WO
WIPO (PCT)
Prior art keywords
graft
hair
protectant
cells
scaffold
Prior art date
Application number
PCT/US2006/061193
Other languages
French (fr)
Other versions
WO2007062387A3 (en
WO2007062387A2 (en
Inventor
Stephen A Cochran
Bryan Marshall
Thomas H Barrows
Yandong Su
Robyn Schlicher
Original Assignee
Aderans Res Inst Inc
Stephen A Cochran
Bryan Marshall
Thomas H Barrows
Yandong Su
Robyn Schlicher
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aderans Res Inst Inc, Stephen A Cochran, Bryan Marshall, Thomas H Barrows, Yandong Su, Robyn Schlicher filed Critical Aderans Res Inst Inc
Publication of WO2007062387A2 publication Critical patent/WO2007062387A2/en
Publication of WO2007062387A3 publication Critical patent/WO2007062387A3/en
Publication of WO2007062387B1 publication Critical patent/WO2007062387B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A61L27/3813—Epithelial cells, e.g. keratinocytes, urothelial cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3886—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells comprising two or more cell types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
    • C12N5/0627—Hair cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00752—Hair removal or transplantation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/18—Materials or treatment for tissue regeneration for hair reconstruction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts

Abstract

The present invention is a hair graft derived from a plucked hair comprising a plucked hair having adhered epidermal stem cells and associated follicular dermal cells. The present invention also includes methods of making a hair graft, methods of implanting a hair graft and methods of identifying inductive follicular dermal cells.

Claims

19 November 2007 (19.11.2007)CLAIMSWhat is claimed is:
1. A hair graft comprising at least one plucked hair having adhered epidermal stem cells and follicular dermal cells associated with the epidermal stem cells.
2. The graft of claim 1, wherein the follicular dermal cells are dermal papilla or dermal sheath cells.
3. The graft of claim 13 further comprising a bioabsorbable scaffold.
4. The graft of claim 3, wherein the bioabsorbable scaffold is a hollow filament having an inner lumen,
5. The graft of claim 4, wherein the plucked hair is located within the inner lumen.
6. The graft of claim 4, wherein the hollow filament has one closed end.
7. The graft of claim 4, wherein the hollow filament has two open ends.
8. The graft of claim 4, further comprising a protectant contained within the inner lumen of the filament.
9. The graft of claim 8, wherein the protectant is a fibrous material, a gel-forming material or a porous material.
10. The graft of claim 8, wherein the protectant is selected from the group consisting of collagen;, gelatin, cellulose derivatives, starch, dextrin, chitosan, lipoproteins, recombinant human forms of collagen and gelatin, fibrinogen, fibrin, fibronectin, laminin, albumin, serum, polysaccharides, mucopαlysaccarides, and combinations thereof.
11. The graft of claim 9, wherein the gel-forming material is selected from die group consisting of collagen, gelatin, albumin, laminin, heparin sulfate proteoglycans,
AMENDED SHEET (ARTICLE 19) 23 entactin, ethylene oxide, propylene oxide, polyethylene glycol molecules with end groups that covalently react to form gel networks and combinations thereof.
12. The graft of claim 10, wherein the gel-forming material comprises a copolymer of ethylene and propylene oxide, wherein the copolymer hydrophilically coats the inner surface to form a gel when the graft is placed in a warm environment,
13. The graft of claim 105 wherein the protectant is crosslinked.
14. The graft of claim 3, wherein the bioabsorbable scaffold further comprises at least one moiety associated with the scaffold.
15. The graft of claim 14, wherein the moiety is selected from the group consisting of a growth factor, an angiogenesis factor, a cell attachment binding site moiety, a cell signaling molecule, a small molecule, a glycoprotein, a bioactive molecule and combinations thereof,
16. A hair graft comprising at least one plucked hair having adhered epidermal stem cells, the at least one plucked hair located within a bioabsorbable scaffold, wherein the bioabsorbable scaffold contains a protectant and a plurality of follicular dermal cells,
17. A method of making a hair graft comprising at least one plucked hair from at least one hair follicle and incubating the at least one plucked hair with follicular dermal cells to form a hair graft, wherein the at least one plucked hair has adhered epidermal stem cells.
18. The method of claim 17, wherein the follicular dermal cells are dermal papilla cells.
19. The method of claim 17, wherein the at least one plucked hair and follicular dermal cells are incubated in a scaffold having an inner lumen.
20. The method of claim 19, wherein the scaffold is bioabsorbable.
AMENDED SHEET (ARTICLE 19)
21. The method of claim 19, further comprising a protectant located within the scaffold.
22. The method of claim 21, wherein the follicular dermal cells are located within the protectant,
23. A method of implanting a hair graft comprising creating a wound in skin of a subject and implanting the hair graft of claim 1 into the wound.
24. The method of claim 23, further comprising placing a protectant into the wound.
25. The method of claim 24, wherein the protectant is serum, plasma or a combination thereof.
26. The method of claim 23, wherein the hair graft further comprises a bioabsorbable scaffold.
27. The method of claim 23, wherein the bioabsorbable scaffold further comprises a moiety associated with the scaffold.
28. The method of claim 27, wherein the moiety is a selected from the group consisting of a growth factor, an angiogenesis factor, a cell attachment binding site moiety 5 a cell signaling molecule, a small molecule, a polypeptide, a glycoprotein, a bioactive molecule and combinations thereof.
29. The method of claim 23, wherein the at least one plucked hair is from the subject
30. The method of claim 26, wherein the follicular dermal cells are from the subject,
31. A method of implanting a hair graft comprising a) loading a syringe with a protectant; b) loading the hair graft of claim 1 into a hypodermic needle; and c) injecting the hair graft and the protectant into the subject.
32. The method of claim 313 wherein the hair graft and the protectant is injected into the uppermost fat layer of the skin.
AMENDED SHEET (ARTICLE 19)
25
3. A method for identifying inductive follicular dermal cells comprising incubating at least one plucked hair having adhered epidermal stem cells in follicular dermal cells, wherein the epidermal stem cells selectively attract follicular dermal cells capable of inducing follicular neogenesis.
AMENDED SHEET (ARTICLE 19)
26
PCT/US2006/061193 2005-11-22 2006-11-22 Hair grafts derived from plucked hair WO2007062387A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73888105P 2005-11-22 2005-11-22
US60/738,881 2005-11-22

Publications (3)

Publication Number Publication Date
WO2007062387A2 WO2007062387A2 (en) 2007-05-31
WO2007062387A3 WO2007062387A3 (en) 2007-11-22
WO2007062387B1 true WO2007062387B1 (en) 2008-01-24

Family

ID=38068048

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/061193 WO2007062387A2 (en) 2005-11-22 2006-11-22 Hair grafts derived from plucked hair

Country Status (4)

Country Link
US (1) US20070122387A1 (en)
AR (1) AR057628A1 (en)
TW (1) TW200803877A (en)
WO (1) WO2007062387A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9023380B2 (en) 2005-11-22 2015-05-05 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7597885B2 (en) * 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
MX2008004928A (en) * 2005-10-17 2008-09-12 Aderans Res Inst Inc Method of delivering hair follicle progenitor cells to the skin.
WO2007092929A2 (en) 2006-02-09 2007-08-16 Aderans Research Institute, Inc. Apparatus and methods for delivering fluid and material to a subject
CA2664697A1 (en) * 2006-09-28 2008-04-10 Follica, Inc. Methods, kits, and compositions for generating new hair follicles and growing hair
US7985537B2 (en) * 2007-06-12 2011-07-26 Aderans Research Institute, Inc. Methods for determining the hair follicle inductive properties of a composition
US8871711B2 (en) 2008-11-12 2014-10-28 The Trustees Of The University Of Pennsylvania Fibroblast growth factor-9 promotes hair follicle regeneration after wounding
US20100179492A1 (en) * 2009-01-14 2010-07-15 Aderans Research Institute, Inc., Methods for increasing trichogenicity of dermal cells
US9693799B2 (en) 2009-09-17 2017-07-04 Pilofocus, Inc. System and method for aligning hair follicle
WO2011035125A1 (en) 2009-09-17 2011-03-24 Wesley Carlos K Hair restoration surgery
US9314082B2 (en) 2009-09-17 2016-04-19 Pilofocus, Inc. System and method for extraction of hair follicle
DE102010009571A1 (en) * 2010-02-26 2011-09-01 Euroderm Gmbh A method of promoting the restoration of bodily function using cells of the hair root sheath, preparation and manufacturing method
KR101087654B1 (en) 2010-04-22 2011-11-30 이희영 Hair transplanting material
US20120003300A1 (en) * 2010-06-30 2012-01-05 Pangaea Laboratories Ltd Composition Comprising Vascular Endothelial Growth Factor (VEGF) for the Treatment of Hair Loss
CN103476360B (en) * 2011-04-26 2015-09-23 李喜永 Hair transplant material
AU2012326209B2 (en) 2011-10-17 2015-12-17 Pilofocus, Inc. Hair restoration
USD690004S1 (en) 2012-03-16 2013-09-17 Aderans Research Institute, Inc. Holder for a device for delivering cellular material and physiologic fluids
CN108525007B (en) * 2018-05-15 2020-10-27 北京航空航天大学 Keratin fiber-nerve growth factor composite scaffold for nerve tissue engineering
TW202233160A (en) * 2020-10-20 2022-09-01 喬治 史特勞赫 Coated hair and use thereof
CN116173300B (en) * 2022-11-21 2023-08-22 郑州大学第一附属医院 Plant decellularized artificial blood vessel and preparation method thereof

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2946769A (en) * 1954-04-23 1960-07-26 Union Carbide Corp Linear polymers containing regularly recurring ester and amide linkages
US3025323A (en) * 1957-01-18 1962-03-13 Union Carbide Corp Amide diols and their esters
US3596292A (en) * 1969-02-20 1971-08-03 Franklin Institute Hair implant structure
DE2452740A1 (en) * 1974-11-07 1976-05-13 Bayer Ag UREA-DICARBONIC ANHYDRIDE-BASED PERFORMANCE
US4052988A (en) * 1976-01-12 1977-10-11 Ethicon, Inc. Synthetic absorbable surgical devices of poly-dioxanone
US4209607A (en) * 1978-05-12 1980-06-24 Ethicon, Inc. Polyesteramides derived from bis-oxamidodiols and dicarboxylic acids
US4226243A (en) * 1979-07-27 1980-10-07 Ethicon, Inc. Surgical devices of polyesteramides derived from bis-oxamidodiols and dicarboxylic acids
US4529792A (en) * 1979-12-17 1985-07-16 Minnesota Mining And Manufacturing Company Process for preparing synthetic absorbable poly(esteramides)
US4343931A (en) * 1979-12-17 1982-08-10 Minnesota Mining And Manufacturing Company Synthetic absorbable surgical devices of poly(esteramides)
DE3037269A1 (en) * 1980-10-02 1982-06-16 Dr. Beck & Co Ag, 2000 Hamburg HEAT-CURABLE, AMID AND IMID GROUPS CONTAINING POLYCONDENSATION PRODUCTS
US4458678A (en) * 1981-10-26 1984-07-10 Massachusetts Institute Of Technology Cell-seeding procedures involving fibrous lattices
US4505266A (en) * 1981-10-26 1985-03-19 Massachusetts Institute Of Technology Method of using a fibrous lattice
US4429080A (en) * 1982-07-01 1984-01-31 American Cyanamid Company Synthetic copolymer surgical articles and method of manufacturing the same
US4643734A (en) * 1983-05-05 1987-02-17 Hexcel Corporation Lactide/caprolactone polymer, method of making the same, composites thereof, and prostheses produced therefrom
US4604097A (en) * 1985-02-19 1986-08-05 University Of Dayton Bioabsorbable glass fibers for use in the reinforcement of bioabsorbable polymers for bone fixation devices and artificial ligaments
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
GB8604360D0 (en) * 1986-02-21 1986-03-26 Univ Dundee Stimulation of hair growth
CA1340581C (en) * 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US4719917A (en) * 1987-02-17 1988-01-19 Minnesota Mining And Manufacturing Company Surgical staple
FR2612939B1 (en) * 1987-03-26 1989-06-23 Cird SKIN EQUIVALENT
US4947840A (en) * 1987-08-21 1990-08-14 Massachusetts Institute Of Technology Biodegradable templates for the regeneration of tissues
US5274074A (en) * 1987-12-17 1993-12-28 United States Surgical Corporation Medical devices fabricated from homopolymers and copolymers having recurring carbonate units
US5091176A (en) * 1988-11-02 1992-02-25 W. R. Grace & Co.-Conn. Polymer-modified peptide drugs having enhanced biological and pharmacological activities
US5147400A (en) * 1989-05-10 1992-09-15 United States Surgical Corporation Connective tissue prosthesis
JP2986509B2 (en) * 1989-05-26 1999-12-06 三井化学株式会社 Modified polyester resin composition, method for producing the same, and use thereof
US5324519A (en) * 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5423778A (en) * 1989-12-14 1995-06-13 Elof Eriksson System and method for transplantation of cells
US5661132A (en) * 1989-12-14 1997-08-26 Auragen, Inc. Wound healing
US5141522A (en) * 1990-02-06 1992-08-25 American Cyanamid Company Composite material having absorbable and non-absorbable components for use with mammalian tissue
US5133739A (en) * 1990-02-06 1992-07-28 Ethicon, Inc. Segmented copolymers of ε-caprolactone and glycolide
US5545208A (en) * 1990-02-28 1996-08-13 Medtronic, Inc. Intralumenal drug eluting prosthesis
US5061284A (en) * 1990-04-10 1991-10-29 Laghi Aldo A Silicone follicled hair implant
US5198507A (en) * 1990-06-12 1993-03-30 Rutgers, The State University Of New Jersey Synthesis of amino acid-derived bioerodible polymers
DE69121587T3 (en) * 1990-12-06 2000-05-31 Gore & Ass IMPLANTABLE BIORESORBABLE ITEMS
CA2060635A1 (en) * 1991-02-12 1992-08-13 Keith D'alessio Bioabsorbable medical implants
US5756094A (en) * 1991-03-27 1998-05-26 Trustees Of The University Of Pennsylvania Methods for stimulating follicular growth
US5556783A (en) * 1991-03-27 1996-09-17 Trustees Of Univ. Of Penna Methods of culturing and modulating the growth of hair follicular stem cells
AU2605592A (en) * 1991-10-15 1993-04-22 Atrix Laboratories, Inc. Polymeric compositions useful as controlled release implants
US5286837A (en) * 1992-01-15 1994-02-15 Minnesota Mining And Manufacturing Company Process for increasing stability of poly(esteramides)
US5800537A (en) * 1992-08-07 1998-09-01 Tissue Engineering, Inc. Method and construct for producing graft tissue from an extracellular matrix
US5514378A (en) * 1993-02-01 1996-05-07 Massachusetts Institute Of Technology Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures
US5522841A (en) * 1993-05-27 1996-06-04 United States Surgical Corporation Absorbable block copolymers and surgical articles fabricated therefrom
US5403347A (en) * 1993-05-27 1995-04-04 United States Surgical Corporation Absorbable block copolymers and surgical articles fabricated therefrom
AU7564494A (en) * 1993-08-13 1995-03-14 Smith & Nephew Richards Inc. Microporous polymeric foams and microtextured surfaces
US5721049A (en) * 1993-11-15 1998-02-24 Trustees Of The University Of Pennsylvania Composite materials using bone bioactive glass and ceramic fibers
US6093200A (en) * 1994-02-10 2000-07-25 United States Surgical Composite bioabsorbable materials and surgical articles made therefrom
US5502092A (en) * 1994-02-18 1996-03-26 Minnesota Mining And Manufacturing Company Biocompatible porous matrix of bioabsorbable material
US5611811A (en) * 1994-04-29 1997-03-18 Star-Wood, Inc. Micro and mini hair transplant device
US5767152A (en) * 1995-05-04 1998-06-16 Nielsen; Thor Bagger Composition and methods for stimulating hair growth
AU6251196A (en) * 1995-06-07 1996-12-30 Gore Hybrid Technologies, Inc. An implantable containment apparatus for a therapeutical dev ice and method for loading and reloading the device therein
FR2736721B1 (en) * 1995-07-12 1997-08-14 Oreal METHOD FOR TESTING A SUBSTANCE POSSIBLE ACTIVE IN THE CAPILLARY DOMAIN
US5723508A (en) * 1996-01-25 1998-03-03 Northwestern University Method of fabricating emulsion freeze-dried scaffold bodies and resulting products
FR2745088B1 (en) * 1996-02-15 1998-04-10 Oreal METHOD FOR TESTING A SUBSTANCE POSSIBLE ACTIVE IN THE CAPILLARY DOMAIN
WO1997045532A1 (en) * 1996-05-28 1997-12-04 Brown University Research Foundation Hyaluronan based biodegradable scaffolds for tissue repair
ES2235312T3 (en) * 1997-01-28 2005-07-01 United States Surgical Corporation POLYESTERAMIDE, ITS PREPARATION AND SURGICAL DEVICES MANUFACTURED FROM THE SAME.
US5817120A (en) * 1997-02-10 1998-10-06 Rassman; William R. Hair implanting instrument
US7419661B2 (en) * 1997-04-30 2008-09-02 The Centre Of Excellence For Life Sciences Limited Dermal sheath tissue in wound healing
US5968546A (en) * 1997-05-16 1999-10-19 Baur; Marcus Keratinocyte culture from precursor cells
US6120788A (en) * 1997-10-16 2000-09-19 Bioamide, Inc. Bioabsorbable triglycolic acid poly(ester-amide)s
EP1045677A4 (en) * 1998-01-06 2005-01-12 Aderans Res Inst Inc Bioabsorbable fibers and reinforced composites produced therefrom
JP4726296B2 (en) * 1998-02-27 2011-07-20 インスティチュート ストローマン アーゲー Matrix protein composition for wound healing
US7713297B2 (en) * 1998-04-11 2010-05-11 Boston Scientific Scimed, Inc. Drug-releasing stent with ceramic-containing layer
US6027744A (en) * 1998-04-24 2000-02-22 University Of Massachusetts Medical Center Guided development and support of hydrogel-cell compositions
US6432710B1 (en) * 1998-05-22 2002-08-13 Isolagen Technologies, Inc. Compositions for regenerating tissue that has deteriorated, and methods for using such compositions
US6350284B1 (en) * 1998-09-14 2002-02-26 Bionx Implants, Oy Bioabsorbable, layered composite material for guided bone tissue regeneration
US6699287B2 (en) * 1998-09-24 2004-03-02 Korea Atomic Energy Research Institute Dermal scaffold using alkaline pre-treated chitosan matrix or alkaline pre-treated chitosan and alkaline pre-treated collagen mixed matrix
CA2291312A1 (en) * 1998-11-30 2000-05-30 Isotis B.V. Artificial skin
US6970925B1 (en) * 1999-02-03 2005-11-29 William H. Gates, III Method and system for property notification
US6884427B1 (en) * 1999-02-08 2005-04-26 Aderans Research Institute, Inc. Filamentary means for introducing agents into tissue of a living host
US20020090725A1 (en) * 2000-11-17 2002-07-11 Simpson David G. Electroprocessed collagen
WO2000051662A1 (en) * 1999-03-04 2000-09-08 Tepha, Inc. Bioabsorbable, biocompatible polymers for tissue engineering
US6548058B1 (en) * 1999-07-20 2003-04-15 Epitech, S.A. Keratinocyte culture and uses thereof
US6306424B1 (en) * 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
US6569143B2 (en) * 1999-10-14 2003-05-27 Becton, Dickinson And Company Method of intradermally injecting substances
US7560275B2 (en) * 1999-12-30 2009-07-14 Vbi Technologies, L.L.C. Compositions and methods for generating skin
US6613798B1 (en) * 2000-03-30 2003-09-02 Curis, Inc. Small organic molecule regulators of cell proliferation
US6864229B2 (en) * 2000-04-21 2005-03-08 New England Medical Center Hospitals, Inc. G protein coupled receptor (GPCR) agonists and antagonists and methods of activating and inhibiting GPCR using the same
US6423252B1 (en) * 2000-06-23 2002-07-23 Ethicon, Inc. Methods of making micropatterned foams
US7198641B2 (en) * 2000-08-08 2007-04-03 Aderans Research Institute, Inc. Scaffolds for tissue engineered hair
US6673603B2 (en) * 2000-09-01 2004-01-06 Modex Therapeutiques, S.A. Cell paste comprising keratinocytes and fibroblasts
US6773713B2 (en) * 2001-02-23 2004-08-10 University Of Massachusetts Injection molding of living tissues
US6749792B2 (en) * 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
US20030011815A1 (en) * 2001-07-11 2003-01-16 Konica Corporation Image forming apparatus, image forming system and image forming method
US20030049839A1 (en) * 2001-08-01 2003-03-13 The University Of Texas System Transparent multi-channel cell scaffold that creates a cellular and/or molecular gradient
ATE534728T1 (en) * 2001-09-20 2011-12-15 Anticancer Inc NESTIN-EXPRESSING HAIR FOLLICLE STEM CELLS
AU2002343738A1 (en) * 2001-11-15 2003-05-26 University Of Medicine And Dentistry Of New Jersey A three-dimensional matrix for producing living tissue equivalents
US20050089512A1 (en) * 2001-12-19 2005-04-28 Kordula Schlotmann Skin/hair equivalent with reconstructed papillae
WO2003057152A2 (en) * 2001-12-31 2003-07-17 Isolagen Technologies, Inc Hair follicle growth
US20040068284A1 (en) * 2002-01-29 2004-04-08 Barrows Thomas H. Method for stimulating hair growth and kit for carrying out said method
US20030161815A1 (en) * 2002-02-12 2003-08-28 Intercytex Limited Cell delivery system
US20030195625A1 (en) * 2002-04-15 2003-10-16 Garcia Castro Marco A. Biodegradable follicle hair implant
US7156856B2 (en) * 2003-04-29 2007-01-02 Feller Alan S Method and apparatus for follicular extraction and transplantation
US20050233450A1 (en) * 2004-01-12 2005-10-20 Goetinck Paul F Methods of inducing hair growth
US7597885B2 (en) * 2004-03-26 2009-10-06 Aderans Research Institute, Inc. Tissue engineered biomimetic hair follicle graft
AR050212A1 (en) * 2004-08-13 2006-10-04 Aderans Res Inst Inc ORGANOGENESIS FROM DISCELLED CELLS
US20060057126A1 (en) * 2004-09-16 2006-03-16 Nikolai Tankovich Device and method for hair growth from stem cells
MX2008004928A (en) * 2005-10-17 2008-09-12 Aderans Res Inst Inc Method of delivering hair follicle progenitor cells to the skin.
TW200800240A (en) * 2005-11-22 2008-01-01 Aderans Res Inst Inc Hair follicle graft from tissue engineered skin

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9023380B2 (en) 2005-11-22 2015-05-05 Aderans Research Institute, Inc. Hair follicle graft from tissue engineered skin

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US20070122387A1 (en) 2007-05-31
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TW200803877A (en) 2008-01-16

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