WO2007070784A3 - Fluorescent detection of cancer and fluorescent guided surgical removal - Google Patents

Fluorescent detection of cancer and fluorescent guided surgical removal Download PDF

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Publication number
WO2007070784A3
WO2007070784A3 PCT/US2006/061902 US2006061902W WO2007070784A3 WO 2007070784 A3 WO2007070784 A3 WO 2007070784A3 US 2006061902 W US2006061902 W US 2006061902W WO 2007070784 A3 WO2007070784 A3 WO 2007070784A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluorescent
cancer
surgical removal
guided surgical
surgical instruments
Prior art date
Application number
PCT/US2006/061902
Other languages
French (fr)
Other versions
WO2007070784A2 (en
Inventor
Eben Rosenthal
Original Assignee
Uab Research Foundation
Eben Rosenthal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uab Research Foundation, Eben Rosenthal filed Critical Uab Research Foundation
Publication of WO2007070784A2 publication Critical patent/WO2007070784A2/en
Publication of WO2007070784A3 publication Critical patent/WO2007070784A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A61B18/20—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser
    • A61B18/22—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using laser the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/3209—Incision instruments
    • A61B17/3211—Surgical scalpels, knives; Accessories therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1402—Probes for open surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00057—Light
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/08—Accessories or related features not otherwise provided for
    • A61B2090/0803—Counting the number of times an instrument is used
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/08—Accessories or related features not otherwise provided for
    • A61B2090/0813—Accessories designed for easy sterilising, i.e. re-usable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3937—Visible markers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/20—Surgical microscopes characterised by non-optical aspects

Abstract

The present invention provides surgical instruments that emit a detectable fluorescent signal distinct from autofluorescent signals from a tissue or instrument, and methods of using the surgical instruments, one or more fluorescently labeled and unlabeled immunoconjugates, and a visualization instrument for intraoperative immunofluorescent detection for cancerous tissue at both primary and metastatic sites, and fluorescent guided surgical manipulation and removal of such cancerous tissue. Kits comprising the surgical instruments, the fluorescently labeled and unlabeled immunoconjugates and visualization instruments for fluorescent imaging are also provided.
PCT/US2006/061902 2005-12-12 2006-12-12 Fluorescent detection of cancer and fluorescent guided surgical removal WO2007070784A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74955205P 2005-12-12 2005-12-12
US60/749,552 2005-12-12

Publications (2)

Publication Number Publication Date
WO2007070784A2 WO2007070784A2 (en) 2007-06-21
WO2007070784A3 true WO2007070784A3 (en) 2008-05-02

Family

ID=38163599

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/061902 WO2007070784A2 (en) 2005-12-12 2006-12-12 Fluorescent detection of cancer and fluorescent guided surgical removal

Country Status (1)

Country Link
WO (1) WO2007070784A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090234225A1 (en) * 2008-01-10 2009-09-17 The Ohio State University Research Foundation Fluorescence detection system
WO2010076334A2 (en) * 2008-12-31 2010-07-08 Centre Leon Berard Intraoperative diagnosis of primary tumors and secondary tumors or metastases
WO2013162502A1 (en) * 2012-04-23 2013-10-31 Empire Technology Development Llc Tissue visualization for resection
US11871988B1 (en) 2022-12-01 2024-01-16 Michael E. Starzak Mapping and endoscopic excision of a tumor using intracavity laser quenching and emission spectroscopy
CN116385337B (en) * 2022-12-15 2023-10-17 西安长空医疗科技服务有限公司 Parathyroid gland recognition device and method based on multi-light fusion

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5845639A (en) * 1990-08-10 1998-12-08 Board Of Regents Of The University Of Washington Optical imaging methods
US20020026649A1 (en) * 1997-04-28 2002-02-28 Yuying Tan Metastasis models using green fluorescent protein (GFP) as a marker
US20020029032A1 (en) * 2000-09-07 2002-03-07 Eva Arkin Fluorescent surgical hardware and surgical supplies for improved visualization
US20040006276A1 (en) * 2002-07-05 2004-01-08 The Regents Of The University Of California Autofluorescence detection and imaging of bladder cancer realized through a cystoscope
US20040015062A1 (en) * 2000-11-27 2004-01-22 Vasilis Ntziachristos Fluorescence-mediated molecular tomography
US20040241808A1 (en) * 2003-04-14 2004-12-02 Renata Pasqualini Methods for ex vivo hybridoma-free production of polyclonal and monoclonal antibodies and generation of immortalized cell populations

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5845639A (en) * 1990-08-10 1998-12-08 Board Of Regents Of The University Of Washington Optical imaging methods
US20020026649A1 (en) * 1997-04-28 2002-02-28 Yuying Tan Metastasis models using green fluorescent protein (GFP) as a marker
US20020029032A1 (en) * 2000-09-07 2002-03-07 Eva Arkin Fluorescent surgical hardware and surgical supplies for improved visualization
US20040015062A1 (en) * 2000-11-27 2004-01-22 Vasilis Ntziachristos Fluorescence-mediated molecular tomography
US20040006276A1 (en) * 2002-07-05 2004-01-08 The Regents Of The University Of California Autofluorescence detection and imaging of bladder cancer realized through a cystoscope
US20040241808A1 (en) * 2003-04-14 2004-12-02 Renata Pasqualini Methods for ex vivo hybridoma-free production of polyclonal and monoclonal antibodies and generation of immortalized cell populations

Also Published As

Publication number Publication date
WO2007070784A2 (en) 2007-06-21

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