WO2007074348A3 - Multianalyte biosensors based on monolithic optoelectronic transducers - Google Patents

Multianalyte biosensors based on monolithic optoelectronic transducers Download PDF

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Publication number
WO2007074348A3
WO2007074348A3 PCT/GR2006/000069 GR2006000069W WO2007074348A3 WO 2007074348 A3 WO2007074348 A3 WO 2007074348A3 GR 2006000069 W GR2006000069 W GR 2006000069W WO 2007074348 A3 WO2007074348 A3 WO 2007074348A3
Authority
WO
WIPO (PCT)
Prior art keywords
optical
emitting element
light emitting
multianalyte
waveguide
Prior art date
Application number
PCT/GR2006/000069
Other languages
French (fr)
Other versions
WO2007074348A2 (en
Inventor
Sotirios Kakabakos
Konstantinos Misiakos
Original Assignee
Nat Ct For Scient Res Ncsr Dem
Sotirios Kakabakos
Konstantinos Misiakos
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Ct For Scient Res Ncsr Dem, Sotirios Kakabakos, Konstantinos Misiakos filed Critical Nat Ct For Scient Res Ncsr Dem
Publication of WO2007074348A2 publication Critical patent/WO2007074348A2/en
Publication of WO2007074348A3 publication Critical patent/WO2007074348A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
    • G01N2021/7706—Reagent provision
    • G01N2021/7709—Distributed reagent, e.g. over length of guide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7756—Sensor type
    • G01N2021/7763—Sample through flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N2021/7769—Measurement method of reaction-produced change in sensor
    • G01N2021/7776—Index

Abstract

Monolithic optical biosensors for sensing biomolecules are disclosed. In one aspect, the biosensors comprising a plurality of light-emitting elements and optical waveguides, each waveguide optically coupled to a light-emitting element; and an optical detector, wherein the optical biosensor is adapted to detect an analyte by binding of the analyte on a surface of one or more of the waveguides and thereby changing the optical coupling between the optical detector and one or more of the light emitting elements. In another aspect, a biosensor comprises a light emitting element, an optical waveguide optically coupled to the light emitting element and to an optical detector, the optical waveguide having a plurality of surface features adapted to effect a change in optical coupling between the light emitting element and the optical detector when biomolecules to be sensed are provided over the waveguide.
PCT/GR2006/000069 2005-12-27 2006-12-27 Multianalyte biosensors based on monolithic optoelectronic transducers WO2007074348A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GR20050100623A GR20050100623A (en) 2005-12-27 2005-12-27 Multianalyte biosensors based on monolithic optoelectronic transducers
GR20050100623 2005-12-27

Publications (2)

Publication Number Publication Date
WO2007074348A2 WO2007074348A2 (en) 2007-07-05
WO2007074348A3 true WO2007074348A3 (en) 2007-10-11

Family

ID=37875668

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GR2006/000069 WO2007074348A2 (en) 2005-12-27 2006-12-27 Multianalyte biosensors based on monolithic optoelectronic transducers

Country Status (2)

Country Link
GR (1) GR20050100623A (en)
WO (1) WO2007074348A2 (en)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4128846A1 (en) * 1991-08-30 1993-03-04 Rainer Klein Integrated optical material sensor - comprises light waveguide, coated with immobilised layer, light sources and coupling unit
US5253037A (en) * 1992-08-04 1993-10-12 Fci-Fiberchem, Inc. Optimal length for refractive index sensors
US5737457A (en) * 1994-02-25 1998-04-07 Fci - Fiberchem, Inc. Chip level waveguide sensor
US6137117A (en) * 1999-06-21 2000-10-24 The United States Of America As Represented By The Secretary Of The Navy Integrating multi-waveguide sensor
US20020110839A1 (en) * 2000-04-28 2002-08-15 David Bach Micro-array evanescent wave fluorescence detection device
GB2377492A (en) * 2001-07-14 2003-01-15 Marconi Applied Techn Ltd Detecting analytes
WO2003046527A1 (en) * 2001-11-29 2003-06-05 National Centre For Scientific Research 'demokritos' Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
WO2004044171A2 (en) * 2002-11-13 2004-05-27 Wulfman David R Waveguide system for detection of fluorescently labeled nucleic acid sequences
US20040175742A1 (en) * 2001-07-31 2004-09-09 Infineon Technologies Ag Biosensor and method for detecting macromolecular biopolymers using at least one unit for immobilizing macromolecular biopolymers

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
WO2000075644A1 (en) * 1999-06-05 2000-12-14 Zeptosens Ag Sensor platform and method for analysing multiple analytes
US20020085784A1 (en) * 2000-12-06 2002-07-04 Reimer Ernest M. Integrated lightguide-optoelectronic devices

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4128846A1 (en) * 1991-08-30 1993-03-04 Rainer Klein Integrated optical material sensor - comprises light waveguide, coated with immobilised layer, light sources and coupling unit
US5253037A (en) * 1992-08-04 1993-10-12 Fci-Fiberchem, Inc. Optimal length for refractive index sensors
US5737457A (en) * 1994-02-25 1998-04-07 Fci - Fiberchem, Inc. Chip level waveguide sensor
US6137117A (en) * 1999-06-21 2000-10-24 The United States Of America As Represented By The Secretary Of The Navy Integrating multi-waveguide sensor
US20020110839A1 (en) * 2000-04-28 2002-08-15 David Bach Micro-array evanescent wave fluorescence detection device
GB2377492A (en) * 2001-07-14 2003-01-15 Marconi Applied Techn Ltd Detecting analytes
US20040175742A1 (en) * 2001-07-31 2004-09-09 Infineon Technologies Ag Biosensor and method for detecting macromolecular biopolymers using at least one unit for immobilizing macromolecular biopolymers
WO2003046527A1 (en) * 2001-11-29 2003-06-05 National Centre For Scientific Research 'demokritos' Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
WO2004044171A2 (en) * 2002-11-13 2004-05-27 Wulfman David R Waveguide system for detection of fluorescently labeled nucleic acid sequences

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DAXHELET X ET AL: "THEORY AND PRACTICE OF LONG-PERIOD GRATINGS: WHEN A LOSS BECOMES A GAIN", OPTICS LETTERS, OSA, OPTICAL SOCIETY OF AMERICA, WASHINGTON, DC, US, vol. 28, no. 9, 1 May 2003 (2003-05-01), pages 686 - 688, XP001166521, ISSN: 0146-9592 *
ECK D ET AL: "PLASMON RESONANCE MEASUREMENTS OF THE ADSORPTION AND ADSORPTION KINETICS OF A BIOPOLYMER ONTO GOLD NANOCOLLOIDS", LANGMUIR, ACS, WASHINGTON, DC, US, vol. 17, no. 4, 18 January 2001 (2001-01-18), pages 957 - 960, XP001152488, ISSN: 0743-7463 *
ISHAQ I M ET AL: "Modification of the refractive index response of long period gratings using thin film overlays", SENSORS AND ACTUATORS B, ELSEVIER SEQUOIA S.A., LAUSANNE, CH, vol. 107, no. 2, 29 June 2005 (2005-06-29), pages 738 - 741, XP004899906, ISSN: 0925-4005 *

Also Published As

Publication number Publication date
GR1005589B (en) 2007-07-18
WO2007074348A2 (en) 2007-07-05
GR20050100623A (en) 2007-07-23

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