WO2007079053A3 - Light-curable bone growth material for treating dental bone defects - Google Patents

Light-curable bone growth material for treating dental bone defects Download PDF

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Publication number
WO2007079053A3
WO2007079053A3 PCT/US2006/049198 US2006049198W WO2007079053A3 WO 2007079053 A3 WO2007079053 A3 WO 2007079053A3 US 2006049198 W US2006049198 W US 2006049198W WO 2007079053 A3 WO2007079053 A3 WO 2007079053A3
Authority
WO
WIPO (PCT)
Prior art keywords
bone
growth material
light
particulate
carrier
Prior art date
Application number
PCT/US2006/049198
Other languages
French (fr)
Other versions
WO2007079053A2 (en
Inventor
Katherine Suzanne Walline
Brent Lee Atkinson
Original Assignee
Dentsply Int Inc
Katherine Suzanne Walline
Brent Lee Atkinson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dentsply Int Inc, Katherine Suzanne Walline, Brent Lee Atkinson filed Critical Dentsply Int Inc
Priority to DE602006018196T priority Critical patent/DE602006018196D1/en
Priority to EP06848115A priority patent/EP1973513B1/en
Priority to CA2634245A priority patent/CA2634245C/en
Priority to AT06848115T priority patent/ATE487459T1/en
Priority to JP2008548665A priority patent/JP2009522001A/en
Publication of WO2007079053A2 publication Critical patent/WO2007079053A2/en
Publication of WO2007079053A3 publication Critical patent/WO2007079053A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
    • A61L27/3608—Bone, e.g. demineralised bone matrix [DBM], bone powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
    • A61K6/62—Photochemical radical initiators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/891—Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K6/00—Preparations for dentistry
    • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
    • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
    • A61K6/898—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/3641—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the site of application in the body
    • A61L27/3645—Connective tissue
    • A61L27/365—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Abstract

Improved compositions comprising a mixture of particulate bone growth material and polymeric carrier are provided. The particulate is preferably porous, resorbable, anorganic bone material. The polymeric carrier can be light-cured to form a cross-linked, biodegradable hydrogel. In one version, the bone growth material is a synthetic peptide bound to anorganic bone matrix particles and the carrier is methacrylated sodium hyaluronate (MHy) or methacrylated hydroxyethylcellulose (MHEC). The composition is particularly suitable for repairing defective dental and orthopedic bone tissue. The particulate and hydrogel carrier are biodegradable so the composition can be replaced by new bone formation over time.
PCT/US2006/049198 2005-12-28 2006-12-22 Light-curable bone growth material for treating dental bone defects WO2007079053A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE602006018196T DE602006018196D1 (en) 2005-12-28 2006-12-22 LIGHT-CURABLE BONE GROWTH MATERIAL FOR THE TREATMENT OF TOOTH BONE DEFECTS
EP06848115A EP1973513B1 (en) 2005-12-28 2006-12-22 Light-curable bone growth material for treating dental bone defects
CA2634245A CA2634245C (en) 2005-12-28 2006-12-22 Light-curable bone growth material for treating dental bone defects
AT06848115T ATE487459T1 (en) 2005-12-28 2006-12-22 LIGHT CURED BONE GROWTH MATERIAL FOR THE TREATMENT OF TOOTH BONE DEFECTS
JP2008548665A JP2009522001A (en) 2005-12-28 2006-12-22 Photocurable bone growth material for treating dental bone defects

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75445305P 2005-12-28 2005-12-28
US60/754,453 2005-12-28

Publications (2)

Publication Number Publication Date
WO2007079053A2 WO2007079053A2 (en) 2007-07-12
WO2007079053A3 true WO2007079053A3 (en) 2008-07-31

Family

ID=38228802

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/049198 WO2007079053A2 (en) 2005-12-28 2006-12-22 Light-curable bone growth material for treating dental bone defects

Country Status (7)

Country Link
US (4) US20070269518A1 (en)
EP (1) EP1973513B1 (en)
JP (1) JP2009522001A (en)
AT (1) ATE487459T1 (en)
CA (1) CA2634245C (en)
DE (1) DE602006018196D1 (en)
WO (1) WO2007079053A2 (en)

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FR2908775B1 (en) * 2006-11-17 2012-08-31 Biomatlante HYDROGEL AND ITS BIOMEDICAL APPLICATIONS
KR20100130178A (en) * 2008-01-09 2010-12-10 이노베이티브 헬스 테크놀로지스, 엘엘씨 Implant pellets and methods for performing bone augmentation and preservation
WO2009145813A1 (en) * 2008-03-04 2009-12-03 Qd Vision, Inc. Particles including nanoparticles, uses thereof, and methods
US20090259263A1 (en) * 2008-04-11 2009-10-15 Biomet Microfixation, Inc. Apparatus and methods of fixating bone
WO2009155583A1 (en) * 2008-06-19 2009-12-23 The Trustees Of The University Of Pennsylvania Biomaterials for tissue replacement
GB0813659D0 (en) 2008-07-25 2008-09-03 Smith & Nephew Fracture putty
US9193948B2 (en) * 2008-11-12 2015-11-24 The Trustees Of The University Of Pennsylvania Biomaterials for tissue replacement
KR101865888B1 (en) 2009-09-09 2018-06-08 삼성전자주식회사 Particles including nanoparticles, uses thereof, and methods
WO2011031876A1 (en) 2009-09-09 2011-03-17 Qd Vision, Inc. Formulations including nanoparticles
CN103002926B (en) 2010-04-16 2015-09-23 阿派泰克有限公司 Biomaterial
US11426463B2 (en) * 2012-05-30 2022-08-30 Klox Technologies Inc. Compositions and methods for biophotonic bone reconstruction
US10507178B2 (en) * 2015-05-06 2019-12-17 Research Foundation Of The City University Of New York Method for treating intervertebral disc degeneration
US10531957B2 (en) 2015-05-21 2020-01-14 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
CN108025107A (en) * 2015-05-29 2018-05-11 朗克帕德医疗有限责任公司 For being adhered to the composition and method on surface
EP3413940A4 (en) * 2016-02-08 2020-07-15 The Brigham and Women's Hospital, Inc. Bioadhesive for corneal repair
CN108676178B (en) * 2018-04-26 2021-02-09 济南大学 Preparation method of modified polysaccharide hydrogel and prepared modified polysaccharide hydrogel

Citations (3)

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US5837752A (en) * 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
WO2004011053A1 (en) * 2002-07-31 2004-02-05 Dentsply International Inc. Bone repair putty comprising porous particulate and carrier gel
WO2004075862A2 (en) * 2003-02-27 2004-09-10 Arthur Ashman Crosslinkable polymeric materials and their applications

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US5354736A (en) * 1989-08-14 1994-10-11 Regents Of The University Of California Synthetic compounds and compositions with enhanced cell binding
US5635482A (en) * 1989-08-14 1997-06-03 The Regents Of The University Of California Synthetic compounds and compositions with enhanced cell binding
US5626863A (en) * 1992-02-28 1997-05-06 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5410016A (en) * 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
JP2855307B2 (en) * 1992-02-05 1999-02-10 生化学工業株式会社 Photoreactive glycosaminoglycans, cross-linked glycosaminoglycans and methods for producing them
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US5837752A (en) * 1997-07-17 1998-11-17 Massachusetts Institute Of Technology Semi-interpenetrating polymer networks
WO2004011053A1 (en) * 2002-07-31 2004-02-05 Dentsply International Inc. Bone repair putty comprising porous particulate and carrier gel
WO2004075862A2 (en) * 2003-02-27 2004-09-10 Arthur Ashman Crosslinkable polymeric materials and their applications

Also Published As

Publication number Publication date
US20110045084A1 (en) 2011-02-24
US20070269518A1 (en) 2007-11-22
ATE487459T1 (en) 2010-11-15
CA2634245C (en) 2013-12-10
US20120129134A1 (en) 2012-05-24
WO2007079053A2 (en) 2007-07-12
JP2009522001A (en) 2009-06-11
EP1973513A2 (en) 2008-10-01
US20100034883A1 (en) 2010-02-11
EP1973513B1 (en) 2010-11-10
CA2634245A1 (en) 2007-07-12
DE602006018196D1 (en) 2010-12-23

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