WO2007100807A8 - Npc1l1 orthologues - Google Patents

Npc1l1 orthologues Download PDF

Info

Publication number
WO2007100807A8
WO2007100807A8 PCT/US2007/005037 US2007005037W WO2007100807A8 WO 2007100807 A8 WO2007100807 A8 WO 2007100807A8 US 2007005037 W US2007005037 W US 2007005037W WO 2007100807 A8 WO2007100807 A8 WO 2007100807A8
Authority
WO
WIPO (PCT)
Prior art keywords
npc1l1
orthologues
set forth
methods
provides
Prior art date
Application number
PCT/US2007/005037
Other languages
French (fr)
Other versions
WO2007100807A2 (en
WO2007100807A3 (en
Inventor
Scott W Altmann
Xiaorui Yao
Kim A O'neill
Brian E Hawes
Original Assignee
Schering Corp
Scott W Altmann
Xiaorui Yao
Kim A O'neill
Brian E Hawes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Scott W Altmann, Xiaorui Yao, Kim A O'neill, Brian E Hawes filed Critical Schering Corp
Priority to EP07751771A priority Critical patent/EP1986489A2/en
Publication of WO2007100807A2 publication Critical patent/WO2007100807A2/en
Publication of WO2007100807A3 publication Critical patent/WO2007100807A3/en
Publication of WO2007100807A8 publication Critical patent/WO2007100807A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

The present invention provides, in part, NPC1L1 from various species. Methods of using the NPC1L1 polypeptides and polynucleotide set forth herein, e.g., in screening assays, are also set forth.
PCT/US2007/005037 2006-02-24 2007-02-22 Npc1l1 orthologues WO2007100807A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07751771A EP1986489A2 (en) 2006-02-24 2007-02-22 Npc1l1 orthologues

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77639406P 2006-02-24 2006-02-24
US60/776,394 2006-02-24

Publications (3)

Publication Number Publication Date
WO2007100807A2 WO2007100807A2 (en) 2007-09-07
WO2007100807A3 WO2007100807A3 (en) 2007-12-27
WO2007100807A8 true WO2007100807A8 (en) 2009-07-23

Family

ID=38220019

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/005037 WO2007100807A2 (en) 2006-02-24 2007-02-22 Npc1l1 orthologues

Country Status (3)

Country Link
US (2) US7910698B2 (en)
EP (1) EP1986489A2 (en)
WO (1) WO2007100807A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7135556B2 (en) * 2002-07-19 2006-11-14 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
US9458422B2 (en) * 2008-01-25 2016-10-04 University Of Maryland Composition of matter and method for stimulating the growth of beneficial microorganisms
WO2009138035A1 (en) * 2008-05-13 2009-11-19 中国科学院上海生命科学研究院 Screening method for medicine of blocking cholesterol absorption based on analyzing subcellular localization of npc1l1 protein

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5561227A (en) 1991-07-23 1996-10-01 Schering Corporation Process for the stereospecific synthesis of azetidinones
US5688787A (en) 1991-07-23 1997-11-18 Schering Corporation Substituted β-lactam compounds useful as hypochlesterolemic agents and processes for the preparation thereof
TW223059B (en) 1991-07-23 1994-05-01 Schering Corp
US5688785A (en) 1991-07-23 1997-11-18 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
LT3300B (en) 1992-12-23 1995-06-26 Schering Corp Combination of a cholesterol biosynhtesis inhibitor and a beta- lactam cholesterol absorbtion inhibitor
LT3595B (en) 1993-01-21 1995-12-27 Schering Corp Spirocycloalkyl-substituted azetidinones useful as hypocholesterolemic agents
EP0707567B1 (en) 1993-07-09 2001-09-12 Schering Corporation Process for the synthesis of azetidinones
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5627176A (en) 1994-03-25 1997-05-06 Schering Corporation Substituted azetidinone compounds useful as hypocholesterolemic agents
US5633246A (en) 1994-11-18 1997-05-27 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5624920A (en) 1994-11-18 1997-04-29 Schering Corporation Sulfur-substituted azetidinone compounds useful as hypocholesterolemic agents
US5656624A (en) 1994-12-21 1997-08-12 Schering Corporation 4-[(heterocycloalkyl or heteroaromatic)-substituted phenyl]-2-azetidinones useful as hypolipidemic agents
US5618707A (en) 1996-01-04 1997-04-08 Schering Corporation Stereoselective microbial reduction of 5-fluorophenyl-5-oxo-pentanoic acid and a phenyloxazolidinone condensation product thereof
WO1997016424A1 (en) 1995-11-02 1997-05-09 Schering Corporation Process for preparing 1-(4-fluorophenyl)-3(r)-(3(s)-hydroxy-3-([phenyl or 4-fluorophenyl])-propyl)-4(s)-(4-hydroxyphenyl)-2-azetidinone
US5739321A (en) 1996-05-31 1998-04-14 Schering Corporation 3-hydroxy γ-lactone based enantionselective synthesis of azetidinones
US5886171A (en) 1996-05-31 1999-03-23 Schering Corporation 3-hydroxy gamma-lactone based enantioselective synthesis of azetidinones
US5756470A (en) 1996-10-29 1998-05-26 Schering Corporation Sugar-substituted 2-azetidinones useful as hypocholesterolemic agents
WO1999001555A1 (en) 1997-07-03 1999-01-14 The United States Of America Represented By The Secretary, Department Of Health And Human Services Genes for niemann-pick type c disease
US6133001A (en) 1998-02-23 2000-10-17 Schering Corporation Stereoselective microbial reduction for the preparation of 1-(4-fluorophenyl)-3(R)-[3(S)-Hydroxy-3-(4-fluorophenyl)propyl)]-4(S)-(4 -hydroxyphenyl)-2-azetidinone
US5919672A (en) 1998-10-02 1999-07-06 Schering Corporation Resolution of trans-2-(alkoxycarbonylethyl)-lactams useful in the synthesis of 1-(4-fluoro-phenyl)-3(R)- (S)-hydroxy-3-(4-fluorophenyl)-propyl!-4(S)-(4-hydroxyphenyl)-2-azetidinone
CA2353981C (en) 1998-12-07 2005-04-26 Schering Corporation Process for the synthesis of azetidinones
US6207822B1 (en) 1998-12-07 2001-03-27 Schering Corporation Process for the synthesis of azetidinones
CN1249250C (en) 1999-04-05 2006-04-05 先灵公司 Stereoselective microbial reduction for prpn. of 1-(4-fluorophenyl)-3(R)-[3(s)-hydroxy-3-(4-fluorophenyl)propyl)-4(s)-(-4hydroxyphenyl)-2-azetidinone
US6593078B1 (en) 1999-04-16 2003-07-15 Schering Corporation Use of azetidinone compounds
CA2399776A1 (en) 2000-02-03 2001-08-09 Hyseq, Inc. Novel nucleic acids and polypeptides
US20030125253A1 (en) 2000-03-24 2003-07-03 Yoshio Taniyama Novel protein, process for producing the same and use therof
AU2001242750A1 (en) 2000-03-24 2001-10-03 Takeda Chemical Industries Ltd. Novel protein, process for producing the same and use thereof
US6436703B1 (en) 2000-03-31 2002-08-20 Hyseq, Inc. Nucleic acids and polypeptides
HUP0303915A3 (en) 2001-01-26 2012-12-28 Merck Sharp & Dohme Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
KR100590342B1 (en) 2001-03-28 2006-06-15 쉐링 코포레이션 Enantioselective synthesis of azetidinone intermediate compounds
WO2003100094A2 (en) 2002-05-23 2003-12-04 Devgen Nv Method for determining the influence of a compound on cholesterol transport
US7135556B2 (en) 2002-07-19 2006-11-14 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
US20040137467A1 (en) 2002-07-19 2004-07-15 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
US20040132058A1 (en) 2002-07-19 2004-07-08 Schering Corporation NPC1L1 (NPC3) and methods of use thereof
CA2492017A1 (en) * 2002-07-19 2004-01-29 Schering Corporation Npc1l1 (npc3) and methods of use thereof
CN1330667C (en) 2002-08-06 2007-08-08 塞诺菲-安万特德国有限公司 Method for isolating an intestinal cholesterol binding protein
US20040171073A1 (en) 2002-10-08 2004-09-02 Massachusetts Institute Of Technology Compounds for modulation of cholesterol transport
CA2553769C (en) 2004-01-16 2011-01-04 Merck & Co., Inc. Npc1l1 (npc3) and methods of identifying ligands thereof
EP1789437A4 (en) 2004-07-30 2008-11-05 Sinai School Medicine Npc1l1 and npc1l1 inhibitors and methods of use thereof

Also Published As

Publication number Publication date
WO2007100807A2 (en) 2007-09-07
EP1986489A2 (en) 2008-11-05
US20090098128A1 (en) 2009-04-16
US8212016B2 (en) 2012-07-03
WO2007100807A3 (en) 2007-12-27
US20120084871A1 (en) 2012-04-05
US7910698B2 (en) 2011-03-22

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