WO2007103734A3 - Method for quantifying an analyte in a biological sample using mass spectrometry - Google Patents

Method for quantifying an analyte in a biological sample using mass spectrometry Download PDF

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Publication number
WO2007103734A3
WO2007103734A3 PCT/US2007/063078 US2007063078W WO2007103734A3 WO 2007103734 A3 WO2007103734 A3 WO 2007103734A3 US 2007063078 W US2007063078 W US 2007063078W WO 2007103734 A3 WO2007103734 A3 WO 2007103734A3
Authority
WO
WIPO (PCT)
Prior art keywords
analyte
biological sample
quantifying
mass spectrometry
proteins
Prior art date
Application number
PCT/US2007/063078
Other languages
French (fr)
Other versions
WO2007103734A2 (en
Inventor
Lee Lomas
Egisto Boschetti
Original Assignee
Ciphergen Biosystems Inc
Lee Lomas
Egisto Boschetti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciphergen Biosystems Inc, Lee Lomas, Egisto Boschetti filed Critical Ciphergen Biosystems Inc
Publication of WO2007103734A2 publication Critical patent/WO2007103734A2/en
Publication of WO2007103734A3 publication Critical patent/WO2007103734A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/96—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood or serum control standard

Abstract

This invention provides methods for quantifying the amount of analyte in a biological sample, e.g., a clinical sample. The methods comprise creating a calibration series using a complex milieu of proteins comprising a large number of standard proteins and the analyte of interest. The calibration series is used to generate a standard curve for quantification of the analytes in a test biological sample.
PCT/US2007/063078 2006-03-03 2007-03-01 Method for quantifying an analyte in a biological sample using mass spectrometry WO2007103734A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77924606P 2006-03-03 2006-03-03
US60/779,246 2006-03-03

Publications (2)

Publication Number Publication Date
WO2007103734A2 WO2007103734A2 (en) 2007-09-13
WO2007103734A3 true WO2007103734A3 (en) 2007-12-06

Family

ID=38475687

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/063078 WO2007103734A2 (en) 2006-03-03 2007-03-01 Method for quantifying an analyte in a biological sample using mass spectrometry

Country Status (1)

Country Link
WO (1) WO2007103734A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2780690A4 (en) * 2011-11-18 2015-12-09 Alnylam Pharmaceuticals Inc Quantification of transthyretin and its isoforms
CN112540139B (en) * 2020-12-16 2022-07-15 杭州汇健科技有限公司 Molecular weight calibrator kit for metabolic profiling detection, and preparation method and use method thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5554539A (en) * 1993-12-22 1996-09-10 Johnson & Johnson Clinical Diagnostics, Inc. Determination of an analyte
US5643800A (en) * 1993-10-04 1997-07-01 Hewlett-Packard Company Method of preparing a sample for analysis by laser desorption ionization mass spectrometry
US5846738A (en) * 1993-10-20 1998-12-08 Boehringer Mannheim Gmbh Synthetic standard for immunoassays
US6437325B1 (en) * 1999-05-18 2002-08-20 Advanced Research And Technology Institute, Inc. System and method for calibrating time-of-flight mass spectra
US20050287679A1 (en) * 2002-03-11 2005-12-29 Pawliszyn Janusz B Calibration procedure for investigating biological systems

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643800A (en) * 1993-10-04 1997-07-01 Hewlett-Packard Company Method of preparing a sample for analysis by laser desorption ionization mass spectrometry
US5846738A (en) * 1993-10-20 1998-12-08 Boehringer Mannheim Gmbh Synthetic standard for immunoassays
US5554539A (en) * 1993-12-22 1996-09-10 Johnson & Johnson Clinical Diagnostics, Inc. Determination of an analyte
US6437325B1 (en) * 1999-05-18 2002-08-20 Advanced Research And Technology Institute, Inc. System and method for calibrating time-of-flight mass spectra
US20050287679A1 (en) * 2002-03-11 2005-12-29 Pawliszyn Janusz B Calibration procedure for investigating biological systems

Also Published As

Publication number Publication date
WO2007103734A2 (en) 2007-09-13

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