WO2007109733A3 - Diagnostic and prognostic markers and treatment strategies for multiple sclerosis - Google Patents

Diagnostic and prognostic markers and treatment strategies for multiple sclerosis Download PDF

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Publication number
WO2007109733A3
WO2007109733A3 PCT/US2007/064532 US2007064532W WO2007109733A3 WO 2007109733 A3 WO2007109733 A3 WO 2007109733A3 US 2007064532 W US2007064532 W US 2007064532W WO 2007109733 A3 WO2007109733 A3 WO 2007109733A3
Authority
WO
WIPO (PCT)
Prior art keywords
multiple sclerosis
diagnostic
treatment strategies
prognostic markers
markers
Prior art date
Application number
PCT/US2007/064532
Other languages
French (fr)
Other versions
WO2007109733A2 (en
Inventor
Avindra Nath
Caroline F Anderson
David N Irani
Robert J Cotter
Original Assignee
Univ Johns Hopkins
Avindra Nath
Caroline F Anderson
David N Irani
Robert J Cotter
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, Avindra Nath, Caroline F Anderson, David N Irani, Robert J Cotter filed Critical Univ Johns Hopkins
Priority to US11/857,742 priority Critical patent/US8114619B2/en
Publication of WO2007109733A2 publication Critical patent/WO2007109733A2/en
Publication of WO2007109733A3 publication Critical patent/WO2007109733A3/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/285—Demyelinating diseases; Multipel sclerosis

Abstract

Biological markers for multiple sclerosis, and their use in the diagnosis and clinical applications of the disease, are described.
PCT/US2007/064532 2006-03-21 2007-03-21 Diagnostic and prognostic markers and treatment strategies for multiple sclerosis WO2007109733A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/857,742 US8114619B2 (en) 2006-03-21 2007-09-19 Methods for diagnosis and optimizing treatment of multiple sclerosis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78442506P 2006-03-21 2006-03-21
US60/784,425 2006-03-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/857,742 Continuation-In-Part US8114619B2 (en) 2006-03-21 2007-09-19 Methods for diagnosis and optimizing treatment of multiple sclerosis

Publications (2)

Publication Number Publication Date
WO2007109733A2 WO2007109733A2 (en) 2007-09-27
WO2007109733A3 true WO2007109733A3 (en) 2008-01-24

Family

ID=38358000

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/064532 WO2007109733A2 (en) 2006-03-21 2007-03-21 Diagnostic and prognostic markers and treatment strategies for multiple sclerosis

Country Status (2)

Country Link
US (1) US8114619B2 (en)
WO (1) WO2007109733A2 (en)

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KR101313184B1 (en) * 2010-06-24 2013-09-30 한국표준과학연구원 Disease Marker Detection Kit and the Detection Method of Disease Marker
KR20140100543A (en) 2011-11-29 2014-08-14 뉴로페이지 파마슈티컬즈, 인크. Use of p3 of bacteriophage as amyloid binding agents
ES2641373T3 (en) 2012-10-02 2017-11-08 Proclara Biosciences, Inc. Use of P3 bacteriophage fusion proteins as amyloid binding agents
EP3003349B1 (en) 2013-05-28 2018-12-12 Proclara Biosciences, Inc. Polypeptides comprising a modified bacteriophage g3p amino acid sequence with reduced immunogenicity
WO2015055825A1 (en) 2013-10-18 2015-04-23 Attoquant Diagnostics Gmbh Method for diagnosis of primary hyperaldosteronism
AU2015358504A1 (en) 2014-12-03 2017-06-29 Proclara Biosciences, Inc. Polypeptides comprising a modified bacteriophage g3p amino acid sequence lacking a glycosylation signal
JP6691617B2 (en) * 2016-05-17 2020-04-28 エルディエックス・プログノスティクス・リミテッド・カンパニーＬｄｘ Ｐｒｏｇｎｏｓｔｉｃｓ Ｌｉｍｉｔｅｄ Ｃｏ． Methods and compositions for providing an assessment of preeclampsia
EP3472622B1 (en) * 2016-06-17 2020-08-05 Roche Diagnostics GmbH Circulating angiopoietin-2 (ang-2) for the prediction of recurrence of atrial fibrillation

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Also Published As

Publication number Publication date
US8114619B2 (en) 2012-02-14
US20100137420A1 (en) 2010-06-03
WO2007109733A2 (en) 2007-09-27

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