WO2007123691A3 - Method for treating blood coagulation disorders - Google Patents

Method for treating blood coagulation disorders Download PDF

Info

Publication number
WO2007123691A3
WO2007123691A3 PCT/US2007/007924 US2007007924W WO2007123691A3 WO 2007123691 A3 WO2007123691 A3 WO 2007123691A3 US 2007007924 W US2007007924 W US 2007007924W WO 2007123691 A3 WO2007123691 A3 WO 2007123691A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood coagulation
coagulation disorders
treating blood
lipidic particles
disorders
Prior art date
Application number
PCT/US2007/007924
Other languages
French (fr)
Other versions
WO2007123691A2 (en
Inventor
Sathy V Balu-Iyer
Robert M Straubinger
Razvan Michlea
Aaron Peng
Original Assignee
Univ New York State Res Found
Sathy V Balu-Iyer
Robert M Straubinger
Razvan Michlea
Aaron Peng
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found, Sathy V Balu-Iyer, Robert M Straubinger, Razvan Michlea, Aaron Peng filed Critical Univ New York State Res Found
Publication of WO2007123691A2 publication Critical patent/WO2007123691A2/en
Publication of WO2007123691A3 publication Critical patent/WO2007123691A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

Provided is a method for treatment of blood coagulation disorders. The method comprises administering to an individual compositions comprising lipidic particles comprising phopatidylcholine, phosphatidylinositol and cholesterol. One or more peptides, polypeptides or proteins involved in the blood coagulation cascade are associated with the lipidic particles.
PCT/US2007/007924 2006-03-30 2007-03-30 Method for treating blood coagulation disorders WO2007123691A2 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78758606P 2006-03-30 2006-03-30
US78741106P 2006-03-30 2006-03-30
US60/787,586 2006-03-30
US60/787,411 2006-03-30
US86506206P 2006-11-09 2006-11-09
US60/865,062 2006-11-09

Publications (2)

Publication Number Publication Date
WO2007123691A2 WO2007123691A2 (en) 2007-11-01
WO2007123691A3 true WO2007123691A3 (en) 2008-05-29

Family

ID=38625470

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/007924 WO2007123691A2 (en) 2006-03-30 2007-03-30 Method for treating blood coagulation disorders

Country Status (1)

Country Link
WO (1) WO2007123691A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2123258A1 (en) * 2008-05-23 2009-11-25 Liplasome Pharma A/S Liposomes for drug delivery

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920016A (en) * 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
US5997864A (en) * 1995-06-07 1999-12-07 Novo Nordisk A/S Modified factor VII

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920016A (en) * 1986-12-24 1990-04-24 Linear Technology, Inc. Liposomes with enhanced circulation time
US5997864A (en) * 1995-06-07 1999-12-07 Novo Nordisk A/S Modified factor VII

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RAMANI K. ET AL.: "Passive Transfer of Polyethylene glycol to Liposomal-Recombinant Human FVIII Enhances its Efficacy in a Murine Model for Hemophilia A", J. PHARM. SCIENCES, February 2008 (2008-02-01), pages 1 - 12, XP008130854, DOI: doi:10.1002/JPS.21266 *
RAMANI K. ET AL.: "Phosphatidylserine Containing Liposomes Reduce Immunogenicity of Recombinant Human Factor VIII (rFVIII) in a Murine Model of Hemophilia A", J. PHARM. SCIENCES, vol. 97, April 2008 (2008-04-01), pages 1386 - 1398, XP008130853 *

Also Published As

Publication number Publication date
WO2007123691A2 (en) 2007-11-01

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