WO2007123880B1 - Methods and kits for early stage caries detection - Google Patents

Methods and kits for early stage caries detection

Info

Publication number
WO2007123880B1
WO2007123880B1 PCT/US2007/009316 US2007009316W WO2007123880B1 WO 2007123880 B1 WO2007123880 B1 WO 2007123880B1 US 2007009316 W US2007009316 W US 2007009316W WO 2007123880 B1 WO2007123880 B1 WO 2007123880B1
Authority
WO
WIPO (PCT)
Prior art keywords
probe
detecting
caries
tooth
contacting
Prior art date
Application number
PCT/US2007/009316
Other languages
French (fr)
Other versions
WO2007123880A2 (en
WO2007123880A3 (en
Inventor
Shigemi Nagai
Original Assignee
Harvard College
Shigemi Nagai
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College, Shigemi Nagai filed Critical Harvard College
Priority to AU2007240888A priority Critical patent/AU2007240888A1/en
Priority to EP07755548.0A priority patent/EP2007307A4/en
Priority to CA002649583A priority patent/CA2649583A1/en
Priority to JP2009506536A priority patent/JP5421096B2/en
Publication of WO2007123880A2 publication Critical patent/WO2007123880A2/en
Publication of WO2007123880A3 publication Critical patent/WO2007123880A3/en
Publication of WO2007123880B1 publication Critical patent/WO2007123880B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/04—Measuring instruments specially adapted for dentistry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
    • A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances

Abstract

Methods and kits are provided for identifying very early stage carious lesions using a detectable probe that binds to the lesion.

Claims

AMENDED CLAIMS received by the International Bureau on 22 August 2008 (22.08.2008).
1. A method for detecting an early stage dental caries in a subject, the method comprising: contacting a caries lesion which is at an early stage, by selective binding of an optically detectable probe to the caries, wherein the probe comprises a molecule capable of binding the caries; and detecting the caries having bound probe using an optical device.
2. The method according to claim 1 , wherein detecting the selective binding further comprises a step selected from the group of: contacting a tooth with a fluorescent probe, wherein the fluorescent probe is selected from the group of tetracycline, Hylight Fluor, Qdot, Indocyanine Green, Doxorubicin, Riboflavin, Chlorophyll, and Porphyrin, and illuminating the tooth at an excitation wavelength, wherein diagnosing is detecting a area oflight emission at an emission wavelength; contacting the tooth with the probe, wherein Ihe probe is lucifcrase and further contacting the tooth with lxiciferin and ΛTP, wherein diagnosing is detecting a area of bioluminenesce; contacting the tooth with a colloidal gold, wherein diagnosing is detecting a area of absorbance of near infra red (NIR) light; contacting the tooth with a quantum dot composition probe, wherein diagnosing is detecting fluorescence or fluorescence-delected dichroism; contacting a tooth with a probe that is a conjugate of a quantum dot composition, wherein the conjugate is attached to a second agent selected from Ihe group of a tetracycline, bismuth, a colloidal gold or the like, followed by detecting fluorescence or fluorescence-detected dichroism; and contacting a tooth with colloidal gold, wherein diagnosing is detecting fluorescence with a HiLyte Fluor 750 hydrazide.
3. The method according to claim 1 , wherein the early stage caries is prior Io cavitation or advanced demineralization.
4. The method according to claim 2, wherein detecting the caries is observing by photometry.
5. The method according to claim 2, wherein the caries with selectively bound tetracycline probe is observing a white spot.
6. The method according to claim 2, wherein the caries with the selectively bound quantum dot probe is a spot of enamel-translucent fluorescence.
AMENDED SHEET (ARTICLE 19)
30
PCT/US2007/009316 2006-04-18 2007-04-17 Methods and kits for early stage caries detection WO2007123880A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2007240888A AU2007240888A1 (en) 2006-04-18 2007-04-17 Methods and kits for early stage caries detection
EP07755548.0A EP2007307A4 (en) 2006-04-18 2007-04-17 Methods and kits for early stage caries detection
CA002649583A CA2649583A1 (en) 2006-04-18 2007-04-17 Methods and kits for early stage caries detection
JP2009506536A JP5421096B2 (en) 2006-04-18 2007-04-17 Early stage caries detection method and kit

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US79276806P 2006-04-18 2006-04-18
US60/792,768 2006-04-18
US81913506P 2006-07-07 2006-07-07
US60/819,135 2006-07-07
US85092206P 2006-10-11 2006-10-11
US60/850,922 2006-10-11
US90142107P 2007-02-15 2007-02-15
US60/901,421 2007-02-15

Publications (3)

Publication Number Publication Date
WO2007123880A2 WO2007123880A2 (en) 2007-11-01
WO2007123880A3 WO2007123880A3 (en) 2008-08-28
WO2007123880B1 true WO2007123880B1 (en) 2008-10-16

Family

ID=38625538

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/009316 WO2007123880A2 (en) 2006-04-18 2007-04-17 Methods and kits for early stage caries detection

Country Status (7)

Country Link
US (1) US20080038686A1 (en)
EP (1) EP2007307A4 (en)
JP (1) JP5421096B2 (en)
KR (1) KR20090009856A (en)
AU (1) AU2007240888A1 (en)
CA (1) CA2649583A1 (en)
WO (1) WO2007123880A2 (en)

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Also Published As

Publication number Publication date
EP2007307A2 (en) 2008-12-31
WO2007123880A2 (en) 2007-11-01
WO2007123880A3 (en) 2008-08-28
US20080038686A1 (en) 2008-02-14
EP2007307A4 (en) 2015-04-01
JP5421096B2 (en) 2014-02-19
AU2007240888A1 (en) 2007-11-01
KR20090009856A (en) 2009-01-23
CA2649583A1 (en) 2007-11-01
JP2009534097A (en) 2009-09-24

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