WO2007127834A3 - Compositions and methods of preparation thereof - Google Patents

Compositions and methods of preparation thereof Download PDF

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Publication number
WO2007127834A3
WO2007127834A3 PCT/US2007/067486 US2007067486W WO2007127834A3 WO 2007127834 A3 WO2007127834 A3 WO 2007127834A3 US 2007067486 W US2007067486 W US 2007067486W WO 2007127834 A3 WO2007127834 A3 WO 2007127834A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
compositions
preparation
making
same
Prior art date
Application number
PCT/US2007/067486
Other languages
French (fr)
Other versions
WO2007127834A2 (en
Inventor
Laura A. Yonce
Tessy Kanayinkal
Debra J. Mullins-Hirte
Trevor C. Huang
Rohit Cariappa
Kenneth E. Merte
James R. Keogh
Kevin D. Mcintosh
Brian J. Steffens
Asha S. Nayak
Erick L. Johnson
Original Assignee
Medtronic, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic, Inc. filed Critical Medtronic, Inc.
Publication of WO2007127834A2 publication Critical patent/WO2007127834A2/en
Publication of WO2007127834A3 publication Critical patent/WO2007127834A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0644—Platelets; Megakaryocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Abstract

The present invention provides biological compositions and methods for making the same.
PCT/US2007/067486 2006-04-26 2007-04-26 Compositions and methods of preparation thereof WO2007127834A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79497106P 2006-04-26 2006-04-26
US60/794,971 2006-04-26

Publications (2)

Publication Number Publication Date
WO2007127834A2 WO2007127834A2 (en) 2007-11-08
WO2007127834A3 true WO2007127834A3 (en) 2011-09-22

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2007/067486 WO2007127834A2 (en) 2006-04-26 2007-04-26 Compositions and methods of preparation thereof
PCT/US2007/067494 WO2007127841A2 (en) 2006-04-26 2007-04-26 Compositions and methods of preparation thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2007/067494 WO2007127841A2 (en) 2006-04-26 2007-04-26 Compositions and methods of preparation thereof

Country Status (2)

Country Link
US (1) US9096839B2 (en)
WO (2) WO2007127834A2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8293530B2 (en) 2006-10-17 2012-10-23 Carnegie Mellon University Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8529961B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8529960B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8962563B2 (en) 2009-12-21 2015-02-24 Baxter International, Inc. TFPI inhibitors and methods of use

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030205538A1 (en) 2002-05-03 2003-11-06 Randel Dorian Methods and apparatus for isolating platelets from blood
US7832566B2 (en) 2002-05-24 2010-11-16 Biomet Biologics, Llc Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles
US7845499B2 (en) 2002-05-24 2010-12-07 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
US20060278588A1 (en) 2002-05-24 2006-12-14 Woodell-May Jennifer E Apparatus and method for separating and concentrating fluids containing multiple components
US9095818B2 (en) * 2009-06-15 2015-08-04 Biovec Transfusion, Llc Method of filtering platelets to remove antiplatelet and anticoagulant agents
US8567609B2 (en) 2006-05-25 2013-10-29 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
JP5479319B2 (en) 2007-04-12 2014-04-23 バイオメット・バイオロジックス・リミテッド・ライアビリティ・カンパニー Buoy suspension fractionation system
US8328024B2 (en) 2007-04-12 2012-12-11 Hanuman, Llc Buoy suspension fractionation system
EP2567692B1 (en) 2008-02-27 2016-04-06 Biomet Biologics, LLC Use of a device for obtaining interleukin-1 receptor antagonist rich solutions
US8337711B2 (en) 2008-02-29 2012-12-25 Biomet Biologics, Llc System and process for separating a material
CA2645937C (en) * 2008-05-22 2019-08-27 Ethicon, Inc. Thrombin and fibrinogen assay
ES2773766T3 (en) * 2008-12-19 2020-07-14 Baxalta GmbH TFPI inhibitors and methods of use
US8450275B2 (en) 2010-03-19 2013-05-28 Baxter International Inc. TFPI inhibitors and methods of use
US8187475B2 (en) 2009-03-06 2012-05-29 Biomet Biologics, Llc Method and apparatus for producing autologous thrombin
US8313954B2 (en) 2009-04-03 2012-11-20 Biomet Biologics, Llc All-in-one means of separating blood components
WO2010136588A2 (en) * 2009-05-28 2010-12-02 Profibrix B.V. Dry powder fibrin sealant
US9011800B2 (en) 2009-07-16 2015-04-21 Biomet Biologics, Llc Method and apparatus for separating biological materials
US8591391B2 (en) 2010-04-12 2013-11-26 Biomet Biologics, Llc Method and apparatus for separating a material
US20120027746A1 (en) * 2010-07-30 2012-02-02 Biomet Biologics, Llc Method for generating thrombin
EP2977054A1 (en) 2010-09-03 2016-01-27 Biomet Biologics, LLC Methods and compositions for delivering interleukin-1 receptor antagonist
US9011846B2 (en) * 2011-05-02 2015-04-21 Biomet Biologics, Llc Thrombin isolated from blood and blood fractions
CN102205147B (en) * 2011-05-16 2013-04-24 中国人民解放军第四军医大学 Transplanting material of fat granule tissues compounded with SVFs (Stromal Vascular Fractions) and PRFs (Platelet-Rich Fibrins) as well as preparation method thereof
US8586324B2 (en) 2011-08-15 2013-11-19 Biomet Biologics, Llc Method and apparatus to create autologous clotting serum
US10265388B2 (en) * 2012-02-21 2019-04-23 Cytonics Corporation Systems, compositions, and methods for transplantation
US9642956B2 (en) 2012-08-27 2017-05-09 Biomet Biologics, Llc Apparatus and method for separating and concentrating fluids containing multiple components
CN104349805B (en) 2012-09-25 2017-06-23 干细胞合伙有限责任公司 The method and apparatus for preparing single donor fibrin ferment serum
US9480716B2 (en) * 2013-02-12 2016-11-01 Lacerta Technologies Inc. Serum fraction of platelet-rich fibrin
US20140271589A1 (en) 2013-03-15 2014-09-18 Biomet Biologics, Llc Treatment of collagen defects using protein solutions
US10208095B2 (en) 2013-03-15 2019-02-19 Biomet Manufacturing, Llc Methods for making cytokine compositions from tissues using non-centrifugal methods
US9895418B2 (en) 2013-03-15 2018-02-20 Biomet Biologics, Llc Treatment of peripheral vascular disease using protein solutions
US10143725B2 (en) 2013-03-15 2018-12-04 Biomet Biologics, Llc Treatment of pain using protein solutions
US9950035B2 (en) 2013-03-15 2018-04-24 Biomet Biologics, Llc Methods and non-immunogenic compositions for treating inflammatory disorders
CN103272258A (en) * 2013-05-15 2013-09-04 中国人民解放军第四军医大学 Novel freeze-drying platelet-rich fibrin, as well as preparation and application thereof
IL231230A0 (en) * 2014-02-27 2014-08-31 Omrix Biopharmaceuticals Ltd Fibrinogen formulation
WO2016025496A1 (en) * 2014-08-11 2016-02-18 Lacerta Technologies Inc. Platelet factor 4 for use in the treatment of bone diseases
US20160264954A1 (en) * 2015-03-13 2016-09-15 Vitrum Biologies Inc. Method of stabilizing thrombin and composition thereof
WO2018212758A1 (en) * 2017-05-15 2018-11-22 Miron Richard J Liquid platelet-rich fibrin as a carrier system for biomaterials and biomolecules
CN108191968A (en) * 2018-03-12 2018-06-22 常州市蒽盗钟情生物科技有限公司 A kind of preparation method of human fibrinogen
GB2579630A (en) 2018-12-07 2020-07-01 Biotherapy Services Ltd Methods and compositions
TWI739485B (en) * 2019-08-19 2021-09-11 喜樂醫療器材股份有限公司 Hemostatic method
US20210171587A1 (en) * 2019-12-06 2021-06-10 University Of Wyoming Fibrin particles and methods of forming fibrin particles

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000074713A1 (en) * 1999-06-04 2000-12-14 Thermogenesis Corp. Autologous thrombin
US6719901B2 (en) * 1996-04-30 2004-04-13 Medtronic, Inc. System for the production of an autologous thrombin

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4627879A (en) * 1984-09-07 1986-12-09 The Trustees Of Columbia University In The City Of New York Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma
US5165938A (en) * 1984-11-29 1992-11-24 Regents Of The University Of Minnesota Wound healing agents derived from platelets
US4874368A (en) * 1988-07-25 1989-10-17 Micromedics, Inc. Fibrin glue delivery system
US5104375A (en) * 1989-10-16 1992-04-14 Johnson & Johnson Medical, Inc. Locking holder for a pair of syringes and method of use
US5030215A (en) 1990-01-03 1991-07-09 Cryolife, Inc. Preparation of fibrinogen/factor XIII precipitate
US5185001A (en) * 1990-01-18 1993-02-09 The Research Foundation Of State University Of New York Method of preparing autologous plasma fibrin and application apparatus therefor
ATE177781T1 (en) * 1990-02-20 1999-04-15 Baxter Int PURIFIED, VIRUS-FREE HUMAN THROMBIN
US6117425A (en) * 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US6197325B1 (en) * 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6054122A (en) * 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US5254350A (en) * 1991-07-22 1993-10-19 Helena Laboratories Corporation Method of preparing a thromboplastin extract
DK83092D0 (en) 1992-06-24 1992-06-24 Unes As PROCEDURE FOR THE EXTRACTION OF THROMBIN
FR2696095B1 (en) * 1992-09-30 1994-11-25 Inoteb Biological glue based on proteins coagulable by thrombin, enriched in platelet factors, its preparation and its application.
CN1091315A (en) * 1992-10-08 1994-08-31 E·R·斯奎布父子公司 Fibrin sealant compositions and using method thereof
US5795780A (en) * 1993-06-23 1998-08-18 Bristol-Myers Squibb Company Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes
CN1103815C (en) * 1993-11-12 2003-03-26 吉里德科学公司 Thrombin mutants
DE69530914T2 (en) * 1994-02-17 2004-03-11 New York Blood Center, Inc. BIOLOGICAL BIOADHESIVE PREPARATIONS CONTAINING FIBRINE ADHESIVE AND LIPOSOMES, METHODS FOR THEIR PRODUCTION AND USE
US5474540A (en) * 1994-03-25 1995-12-12 Micromedics, Inc. Fluid separation control attachment for physiologic glue applicator
WO1996016714A1 (en) * 1994-12-02 1996-06-06 Bristol-Myers Squibb Company Method and device for separating fibrin monomer from blood plasma
US5585007A (en) * 1994-12-07 1996-12-17 Plasmaseal Corporation Plasma concentrate and tissue sealant methods and apparatuses for making concentrated plasma and/or tissue sealant
US5510102A (en) * 1995-01-23 1996-04-23 The Regents Of The University Of California Plasma and polymer containing surgical hemostatic adhesives
US5733545A (en) 1995-03-03 1998-03-31 Quantic Biomedical Partners Platelet glue wound sealant
US5674394A (en) * 1995-03-24 1997-10-07 Johnson & Johnson Medical, Inc. Single use system for preparation of autologous plasma
US5643192A (en) 1995-04-06 1997-07-01 Hamilton Civic Hospitals Research Development, Inc. Autologous fibrin glue and methods for its preparation and use
US5814022A (en) * 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
EP0885020A1 (en) 1996-02-20 1998-12-23 Cohesion Corporation Tissue sealant compositions and methods of use thereof
DE19781869T1 (en) 1996-04-30 2000-03-16 Medtronic Inc Process for the production of an autologous fibrin hemostatic agent
JP3727950B2 (en) * 1996-09-10 2005-12-21 オーリクス ビオファーマソティカル エス．アー． Applicator device for supplying multi-component fluid
US7009034B2 (en) * 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US6783514B2 (en) 1997-01-31 2004-08-31 United States Surgical Corporation Fibrin sealant applicator
KR20010013413A (en) * 1997-06-05 2001-02-26 피터 지. 스트링거 Methods for treating thrombotic disorders
WO1999018931A1 (en) 1997-10-10 1999-04-22 University Of Virginia Use of fibrin sealant to maintain hemostasis, lymphostasis and prevent local accumulation of body fluids
JP3578627B2 (en) * 1998-05-15 2004-10-20 株式会社ホギメディカル Tissue sealant that promotes wound healing
WO1999066797A1 (en) 1998-06-22 1999-12-29 Worden Charles E Enriched platelet wound healant
US6274090B1 (en) 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
AU2001278122A1 (en) 2000-07-31 2002-02-13 Eliyon Technologies Corporation Method for maintaining people and organization information
WO2002080991A2 (en) 2001-04-09 2002-10-17 Medtronic, Inc. System for the production of autologous platelet gel
US6942880B1 (en) * 2001-04-09 2005-09-13 Medtronic, Inc. Autologous platelet gel having beneficial geometric shapes and methods of making the same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6719901B2 (en) * 1996-04-30 2004-04-13 Medtronic, Inc. System for the production of an autologous thrombin
WO2000074713A1 (en) * 1999-06-04 2000-12-14 Thermogenesis Corp. Autologous thrombin

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE MEDLINE [online] US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US; September 2003 (2003-09-01), KOLODZEISKAIA M V ET AL: "[Interrelation between thrombin structure and its stability].", XP002647001, Database accession no. NLM14681990 *
DE SOMER: "Can autologous thrombin with a rest fraction of ethanol be used safely for activation of concentrated autologous platelets applied on nerves ?", EUROPEAN SPINE JOURNAL, vol. 15, 2006, pages 501 - 505, XP019351070 *
KUMAR ET AL: "Stability of human thrombin produced from 11 ml of plasma using the thrombin processing device", THE JOURNAL OF THE AMERICAN SOCIETY OF EXTRA-CORPOREAL TECHNOLOGY, vol. 37, 2005, pages 390 - 395, XP008084221 *
KUMAR ET AL: "Whole blood thrombin: Development of a process for intra- operative production of human thrombin", THE JOURNAL OF THE AMERICAN SOCIETY OF EXTRA-CORPOREAL TECHNOLOGY, vol. 39, March 2007 (2007-03-01), pages 18 - 23, XP008084222 *
ROSENTHAL ET AL: "Use of a platelet-fibrinogen-thrombin mixture as a corneal adhesive: experiments with sutureless lamellar keratoplasty in the rabbit", INVESTIGATIVE OPHTHALMOLOGY, vol. 14, November 1975 (1975-11-01), pages 872 - 875, XP002646644 *
UKRAINSKII BIOKHIMICHESKII ZHURNAL 2003 SEP-OCT LNKD- PUBMED:14681990, vol. 75, no. 5, September 2003 (2003-09-01), pages 17 - 27, ISSN: 0201-8470 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8529960B2 (en) 2002-03-18 2013-09-10 Carnell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8293530B2 (en) 2006-10-17 2012-10-23 Carnegie Mellon University Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8529961B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8529958B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8529959B2 (en) 2006-10-17 2013-09-10 Carmell Therapeutics Corporation Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8911789B2 (en) 2006-10-17 2014-12-16 Carnegie Mellon University Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom
US8962563B2 (en) 2009-12-21 2015-02-24 Baxter International, Inc. TFPI inhibitors and methods of use

Also Published As

Publication number Publication date
US9096839B2 (en) 2015-08-04
WO2007127841A3 (en) 2011-09-29
WO2007127834A2 (en) 2007-11-08
WO2007127841A2 (en) 2007-11-08
US20080044852A1 (en) 2008-02-21

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