WO2007130493A3 - Cd40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity - Google Patents

Cd40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity Download PDF

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Publication number
WO2007130493A3
WO2007130493A3 PCT/US2007/010690 US2007010690W WO2007130493A3 WO 2007130493 A3 WO2007130493 A3 WO 2007130493A3 US 2007010690 W US2007010690 W US 2007010690W WO 2007130493 A3 WO2007130493 A3 WO 2007130493A3
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WO
WIPO (PCT)
Prior art keywords
therapeutic
interferon
type1
cellular immunity
agonist antibody
Prior art date
Application number
PCT/US2007/010690
Other languages
French (fr)
Other versions
WO2007130493A2 (en
Inventor
Ross Kedl
Phillip J Sanchez
Catherine Haluszczak
Original Assignee
Univ Colorado
Ross Kedl
Phillip J Sanchez
Catherine Haluszczak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Colorado, Ross Kedl, Phillip J Sanchez, Catherine Haluszczak filed Critical Univ Colorado
Priority to CA2652599A priority Critical patent/CA2652599C/en
Priority to EP07776657.4A priority patent/EP2019857B1/en
Priority to AU2007248628A priority patent/AU2007248628B2/en
Priority to JP2009509701A priority patent/JP5427027B2/en
Priority to CN200780024076.6A priority patent/CN101479375B/en
Priority to MX2008013993A priority patent/MX2008013993A/en
Publication of WO2007130493A2 publication Critical patent/WO2007130493A2/en
Publication of WO2007130493A3 publication Critical patent/WO2007130493A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
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    • A61K39/285—Vaccinia virus or variola virus
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    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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    • A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
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    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

A synergistic adjuvant is provided comprising synergistically effective amounts of at least one type 1 interferon and at least one CD40 agonist, wherein these moieties may be in the same or separate compositions. In addition, fusion proteins and DNA conjugates which contain a type 1 interferon/CD40 agonist/ antigen combination are provided. The use of these compositions, protein and DNA conjugates as immune adjuvants for treatment of various chronic diseases such as HIV infection and for enhancing the efficacy of vaccines (prophylactic and therapeutic) is also provided.
PCT/US2007/010690 2006-05-03 2007-05-03 Cd40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity WO2007130493A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2652599A CA2652599C (en) 2006-05-03 2007-05-03 Cd40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity
EP07776657.4A EP2019857B1 (en) 2006-05-03 2007-05-03 Cd40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity
AU2007248628A AU2007248628B2 (en) 2006-05-03 2007-05-03 CD40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity
JP2009509701A JP5427027B2 (en) 2006-05-03 2007-05-03 CD40 agonist antibody / type I interferon synergistic adjuvant conjugates, conjugates comprising the same, and their use as therapeutics to enhance cellular immunity
CN200780024076.6A CN101479375B (en) 2006-05-03 2007-05-03 CD40 agonist antibody/type 1 interferon synergistic adjuvant combines, comprise the purposes of aforesaid binding substances and the therapeutical agent as enhancing cellular immunization thereof
MX2008013993A MX2008013993A (en) 2006-05-03 2007-05-03 Cd40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity.

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US79686706P 2006-05-03 2006-05-03
US60/796,867 2006-05-03
US80982106P 2006-06-01 2006-06-01
US60/809,821 2006-06-01
US84200906P 2006-09-05 2006-09-05
US60/842,009 2006-09-05

Publications (2)

Publication Number Publication Date
WO2007130493A2 WO2007130493A2 (en) 2007-11-15
WO2007130493A3 true WO2007130493A3 (en) 2008-01-03

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PCT/US2007/010690 WO2007130493A2 (en) 2006-05-03 2007-05-03 Cd40 agonist antibody/type1 interferon synergistic adjuvant combination, conjugates containing and use thereof as a therapeutic to enhance cellular immunity

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US (6) US7993648B2 (en)
EP (2) EP2589654A1 (en)
CN (2) CN104357469B (en)
AU (1) AU2007248628B2 (en)
CA (1) CA2652599C (en)
MX (1) MX2008013993A (en)
WO (1) WO2007130493A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10117915B2 (en) 2009-09-14 2018-11-06 The Regents Of The University Of Colorado, A Body Corporate Modulation of yeast-based immunotherapy products and responses

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6977245B2 (en) * 1999-04-12 2005-12-20 The United States Of America As Represented By The Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
WO2000061151A2 (en) * 1999-04-12 2000-10-19 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Oligodeoxynucleotide and its use to induce an immune response
US20030129251A1 (en) 2000-03-10 2003-07-10 Gary Van Nest Biodegradable immunomodulatory formulations and methods for use thereof
CN104357469B (en) * 2006-05-03 2018-10-26 科罗拉多州立大学董事会 The combination of CD40 agonist antibody/type 1 interferon synergistic adjuvants includes conjugate above-mentioned and application thereof
EP2066348A1 (en) * 2006-09-26 2009-06-10 Alexion Pharmaceuticals, Inc. Compositions and methods for enhancing an adjuvant
US20130149330A1 (en) * 2006-11-06 2013-06-13 Microvax, Llc Pharmaceutical compositions and methods of blocking bacillus anthracis
US10293040B1 (en) * 2006-11-06 2019-05-21 Microvax, Llc Pharmaceutical compositions and methods of blocking Bacillus anthracis
WO2008157473A1 (en) * 2007-06-15 2008-12-24 Immurx, Inc. Use of tlr agonists and/or type 1 interferons to alleviate toxicity of tnf-r agonist therapeutic regimens
CA2736030A1 (en) * 2008-09-05 2010-03-11 Barton F. Haynes Method of inducing an anti-viral immune response
PT2376107E (en) 2008-12-09 2014-07-25 Coley Pharm Group Inc Immunostimulatory oligonucleotides
US8552165B2 (en) * 2008-12-09 2013-10-08 Heather Davis Immunostimulatory oligonucleotides
CN105884903B (en) * 2009-03-10 2019-12-06 贝勒研究院 Antigen presenting cell targeted vaccines
CN106432493B (en) * 2009-03-10 2020-01-31 贝勒研究院 anti-CD40 antibodies and uses thereof
CA2754906C (en) 2009-03-10 2021-02-09 Baylor Research Institute Antigen presenting cell targeted fusion proteins comprising a linker for increased stability
EP2621951A1 (en) * 2010-09-29 2013-08-07 Université de Liège Combination of an agonistic anti-cd40 monoclonal antibody or a cd40 ligand and inactivated or attenuated bacteria for use in the treatment and/or prevention of mastitis
SG11201501195RA (en) 2012-08-15 2015-05-28 Neostem Oncology Llc Rapid method production high purity cancer stem cells and population of high purity cancer stem cells
TWI666026B (en) 2013-03-29 2019-07-21 日商大日本住友製藥股份有限公司 WT1 antigen peptide-binding vaccine
JP7037884B2 (en) 2014-01-13 2022-03-17 ベイラー リサーチ インスティテュート New vaccines for HPV and HPV-related diseases
CA2937499A1 (en) * 2014-01-22 2015-07-30 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for antibody and antibody-loaded dendritic cell mediated therapy
EP3233914A1 (en) 2014-12-19 2017-10-25 Mabtech Ab Composition, kit and method for inhibition of il-21 mediated activation of human cells
PL3240801T3 (en) * 2014-12-31 2021-06-14 Checkmate Pharmaceuticals, Inc. Combination tumor immunotherapy
RU2714157C2 (en) * 2015-02-06 2020-02-12 Хит Байолоджикс, Инк. Vector, co-expressing molecules for vaccination and costimulatory molecules
JP6515182B2 (en) * 2015-05-20 2019-05-15 大日本住友製薬株式会社 Combination of WT1 antigenic peptide and immunomodulator
US20200079860A1 (en) * 2015-08-06 2020-03-12 Memorial Sloan Kettering Cancer Center Methods and compositions for tumor therapy
KR102632796B1 (en) 2016-03-10 2024-02-02 비엘라 바이오, 인크. Ilt7 binding molecules and methods of using the same
MA44723A (en) * 2016-04-18 2019-02-27 Celldex Therapeutics Inc HUMAN CD40 BINDING AGONIST ANTIBODIES AND THEIR USES
WO2017220989A1 (en) 2016-06-20 2017-12-28 Kymab Limited Anti-pd-l1 and il-2 cytokines
KR20230149857A (en) 2016-07-07 2023-10-27 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 Antibody adjuvant conjugates
US20200353044A1 (en) * 2017-04-12 2020-11-12 Memgen, Llc Methods of cd40 and toll like receptor immune activation
US10610585B2 (en) 2017-09-26 2020-04-07 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for treating and preventing HIV
WO2019229264A1 (en) * 2018-06-01 2019-12-05 Sanofi Combination therapy for treating hepatitis b virus infection
WO2019246111A1 (en) * 2018-06-19 2019-12-26 H. Lee Moffitt Cancer Center And Research Institute, Inc. Oncolytic virus or antigen presenting cell mediated cancer therapy using type i interferon and cd40-ligand
AU2020241686A1 (en) 2019-03-15 2021-11-04 Bolt Biotherapeutics, Inc. Immunoconjugates targeting HER2
US20230242655A1 (en) * 2019-12-03 2023-08-03 Evotec International Gmbh Interferon-associated antigen binding proteins and uses thereof
CN115052626A (en) * 2019-12-03 2022-09-13 埃沃特克国际有限责任公司 Interferon-associated antigen binding proteins for the treatment of hepatitis B infection
WO2021203013A2 (en) * 2020-04-03 2021-10-07 Viela Bio, Inc. Methods of treating immune mediated pulmonary injury
US20210393743A1 (en) * 2020-06-21 2021-12-23 Ketan Desai Use of IL13 for prevention and treatment of COVID19
CN112370524A (en) * 2020-12-11 2021-02-19 北京大伟嘉生物技术股份有限公司 Antiviral composition and preparation method and application thereof
CN112426523A (en) * 2020-12-11 2021-03-02 北京大伟嘉生物技术股份有限公司 Pig vaccine containing antiviral composition and application
CN112972688A (en) * 2021-02-08 2021-06-18 吉林大学第一医院 Application of PPAR delta inhibitor and immunotherapy drug in preparation of antitumor drugs
EP4351732A1 (en) * 2021-06-09 2024-04-17 Evotec International GmbH Interferon-associated antigen binding proteins for use for the treatment or prevention of coronavirus infection
CN114794017B (en) * 2022-05-13 2022-11-22 中国医学科学院皮肤病医院(中国医学科学院皮肤病研究所) Construction method of pemphigus vulgaris animal model

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040141950A1 (en) * 2002-12-30 2004-07-22 3M Innovative Properties Company Immunostimulatory combinations
US20050043517A1 (en) * 2003-08-20 2005-02-24 Jill Giles-Komar Method for generating antibodies

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5506126A (en) 1988-02-25 1996-04-09 The General Hospital Corporation Rapid immunoselection cloning method
US5637481A (en) 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
US5961974A (en) 1991-10-25 1999-10-05 Immunex Corporation Monoclonal antibodies to CD40 ligand, pharmaceutical composition comprising the same and hybridomas producing the same
US5981724A (en) 1991-10-25 1999-11-09 Immunex Corporation DNA encoding CD40 ligand, a cytokine that binds CD40
US7405270B2 (en) 1991-10-25 2008-07-29 Immunex Corporation CD40-Ligand lacking native-pattern glycosylation
US5720163A (en) 1992-02-14 1998-02-24 Precision Combustion, Inc. Torch assembly
US5874082A (en) 1992-07-09 1999-02-23 Chiron Corporation Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation
US5397703A (en) 1992-07-09 1995-03-14 Cetus Oncology Corporation Method for generation of antibodies to cell surface molecules
JPH08507203A (en) 1992-12-04 1996-08-06 イノーバー ラボラトリーズ，インコーポレイテッド Regulatable nucleic acid therapies and methods of their use
EP0681613B1 (en) 1992-12-04 2002-05-08 Yale University Ribozyme amplified diagnostics
ATE255906T1 (en) 1993-10-01 2003-12-15 Immunex Corp ANTIBODIES AGAINST CD40
AU680102B2 (en) 1993-12-23 1997-07-17 Immunex Corporation Method of preventing or treating disease characterized by neoplastic cells expressing CD40
KR950023662A (en) 1994-01-20 1995-08-18 박홍기 Manufacturing method of high transparency polyester film excellent in winding property
US5698679A (en) 1994-09-19 1997-12-16 National Jewish Center For Immunology And Respiratory Medicine Product and process for targeting an immune response
US6132978A (en) 1995-12-19 2000-10-17 National Jewish Medical And Research Center Method to regulate CD40 signaling
NZ333607A (en) 1996-07-10 2000-08-25 Immunex Corp Method of stimulating the immune system by transfecting dendritic cells
US6017527A (en) 1996-07-10 2000-01-25 Immunex Corporation Activated dendritic cells and methods for their activation
US6653104B2 (en) 1996-10-17 2003-11-25 Immunomedics, Inc. Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
US20020086026A1 (en) 1997-06-18 2002-07-04 Heath Andrew William Novel vaccine development
US6051228A (en) 1998-02-19 2000-04-18 Bristol-Myers Squibb Co. Antibodies against human CD40
DK1082141T3 (en) 1998-05-23 2005-12-05 Univ Leiden Medical Ct CD40-binding molecules and CTL peptides for the treatment of tumors
US20030118588A1 (en) 1999-05-22 2003-06-26 Linda Diehl Induction of anti-tumor CTL immunity through in vivo triggering of 4-1BB and/or CD40
US20050255106A1 (en) 1999-05-22 2005-11-17 Linda Diehl Induction of anti-tumor ctl immunity through in vivo triggering of 4-1bb and/or cd40
US6946129B1 (en) 1999-06-08 2005-09-20 Seattle Genetics, Inc. Recombinant anti-CD40 antibody and uses thereof
AU6934600A (en) 1999-08-27 2001-03-26 Board Of Regents, The University Of Texas System Cd40 ligand and cd40 agonist compositions and methods of use
EP1253942A4 (en) 2000-02-01 2004-06-16 Tanox Inc Cd40-binding apc-activating molecules
US7063845B2 (en) 2000-04-28 2006-06-20 Gemini Science, Inc. Human anti-CD40 antibodies
US20030059427A1 (en) 2000-04-28 2003-03-27 Force Walker R. Isolation and characterization of highly active anti-CD40 antibody
ES2357051T3 (en) 2000-10-02 2011-04-15 Novartis Vaccines And Diagnostics, Inc. ANTI-CD40 HUMAN ANTIBODIES.
EP2009027B1 (en) 2001-04-27 2014-05-21 Kyowa Hakko Kirin Co., Ltd. Anti-CD40 monoclonal antibody
US7175838B2 (en) 2001-08-23 2007-02-13 The United States Of America Represented By The Department Of Health And Human Services Use of a promoter of T-cell expansion and an inducer of CD40 stimulation in the treatment or prevention of a pathologic state
AR039067A1 (en) 2001-11-09 2005-02-09 Pfizer Prod Inc ANTIBODIES FOR CD40
AU2003217912A1 (en) * 2002-03-01 2003-09-16 Xencor Antibody optimization
GB0228796D0 (en) * 2002-12-11 2003-01-15 Adjuvantix Ltd Valency
MXPA05007466A (en) * 2003-01-09 2006-03-08 Arizeke Pharmaceuticals Inc Methods of treating lung diseases.
US9259459B2 (en) * 2003-01-31 2016-02-16 Celldex Therapeutics Inc. Antibody vaccine conjugates and uses therefor
US7404950B2 (en) 2003-02-18 2008-07-29 Baylor College Of Medicine Induced activation in dendritic cell
US20040197312A1 (en) * 2003-04-02 2004-10-07 Marina Moskalenko Cytokine-expressing cellular vaccine combinations
GB0321615D0 (en) 2003-09-15 2003-10-15 Glaxo Group Ltd Improvements in vaccination
US20050136055A1 (en) 2003-12-22 2005-06-23 Pfizer Inc CD40 antibody formulation and methods
US7563443B2 (en) * 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
US20090081157A1 (en) 2006-01-09 2009-03-26 Richard Syd Kornbluth Immunostimulatory Combinations for Vaccine Adjuvants
CN104357469B (en) * 2006-05-03 2018-10-26 科罗拉多州立大学董事会 The combination of CD40 agonist antibody/type 1 interferon synergistic adjuvants includes conjugate above-mentioned and application thereof
US8734313B2 (en) * 2006-10-04 2014-05-27 Hampton University Accelerated partial breast irradiation with shielded brachytherapy applicator system and method of use

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040141950A1 (en) * 2002-12-30 2004-07-22 3M Innovative Properties Company Immunostimulatory combinations
US20050043517A1 (en) * 2003-08-20 2005-02-24 Jill Giles-Komar Method for generating antibodies

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AHONEN ET AL.: "Combined TLR and CD40 triggering induces potent CD8+ T cell expansion with variable dependence on type I IFN", J. EXPERIMENTAL MEDICINE, vol. 199, March 2004 (2004-03-01), pages 775 - 784, XP003012397 *
PUCCHIO ET AL.: "Immunizaiton of stage IV melanoma patients with Melan-A/MART-1 and gp100 peptides plus IFN-alpha results in the activation of specific CD8+ T cells and monocyte/dendritic cell precursors", CANCER RESEARCH, vol. 66, 1 May 2006 (2006-05-01), pages 4943 - 4951, XP008099533 *
TARABAN ET AL.: "Cutting edge: A critical role for CD70 in CD8 T cell priming by CD40-licensed APCs", JOURNAL OF IMMUNOLOGY, vol. 173, 2004, pages 6542 - 6546, XP008099518 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10117915B2 (en) 2009-09-14 2018-11-06 The Regents Of The University Of Colorado, A Body Corporate Modulation of yeast-based immunotherapy products and responses

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