WO2007130725A3 - Use of hmgb1 for protection against ischemia reperfusion injury - Google Patents

Use of hmgb1 for protection against ischemia reperfusion injury Download PDF

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Publication number
WO2007130725A3
WO2007130725A3 PCT/US2007/061709 US2007061709W WO2007130725A3 WO 2007130725 A3 WO2007130725 A3 WO 2007130725A3 US 2007061709 W US2007061709 W US 2007061709W WO 2007130725 A3 WO2007130725 A3 WO 2007130725A3
Authority
WO
WIPO (PCT)
Prior art keywords
hmgb1
protection against
reperfusion injury
ischemia reperfusion
against ischemia
Prior art date
Application number
PCT/US2007/061709
Other languages
French (fr)
Other versions
WO2007130725A2 (en
Inventor
Allan Tsung
Timothy R Billiar
Mitchell P Fink
Kevin J Tracey
Original Assignee
Univ Pittsburgh
The Feinstein Inst Medical Res
Allan Tsung
Timothy R Billiar
Mitchell P Fink
Kevin J Tracey
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pittsburgh, The Feinstein Inst Medical Res, Allan Tsung, Timothy R Billiar, Mitchell P Fink, Kevin J Tracey filed Critical Univ Pittsburgh
Publication of WO2007130725A2 publication Critical patent/WO2007130725A2/en
Publication of WO2007130725A3 publication Critical patent/WO2007130725A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02—Preservation of living parts
    • A01N1/0205—Chemical aspects
    • A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Methods and compositions are disclosed for protecting an organ or tissue from inflammation and organ injury following ischemia, reperfusion, and trauma through the administration of an HMGB1 protein within a time period sufficient to protect the organ or tissue from injury.
PCT/US2007/061709 2006-02-06 2007-02-06 Use of hmgb1 for protection against ischemia reperfusion injury WO2007130725A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76554506P 2006-02-06 2006-02-06
US60/765,545 2006-02-06

Publications (2)

Publication Number Publication Date
WO2007130725A2 WO2007130725A2 (en) 2007-11-15
WO2007130725A3 true WO2007130725A3 (en) 2008-04-10

Family

ID=38668413

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/061709 WO2007130725A2 (en) 2006-02-06 2007-02-06 Use of hmgb1 for protection against ischemia reperfusion injury

Country Status (2)

Country Link
US (1) US7829097B2 (en)
WO (1) WO2007130725A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1960780B (en) 2003-08-12 2010-11-17 洛马林达大学医学中心 Modular patient support system
KR20140115373A (en) * 2006-10-30 2014-09-30 가부시키가이샤 제노믹스 Pharmaceuticals that promote functional regeneration of damaged tissues
CA2722909A1 (en) 2008-04-30 2009-11-05 Genomix Co., Ltd. Method for collecting functional cells in vivo with high efficiency
EP2494977B1 (en) 2009-10-28 2018-06-13 Genomix Co., Ltd. Tissue-regeneration promoter using recruitment of bone marrow mesenchymal stem cells and/or pluripotent stem cells in blood
PL2525817T3 (en) 2010-01-21 2018-01-31 Univ Arkansas Vaccine vectors and methods of enhancing immune responses
UA113496C2 (en) 2010-06-09 2017-02-10 VECTOR AND METHOD OF INCREASING INFECTION RESULTING TO CAMPYLOBACTER
EP2703487B1 (en) 2011-04-26 2018-06-27 Genomix Co., Ltd. Peptide for inducing regeneration of tissue and use thereof
WO2013082458A1 (en) 2011-12-02 2013-06-06 The Regents Of The University Of California Reperfusion protection solution and uses thereof
US9623078B2 (en) * 2012-10-25 2017-04-18 Genomix Co., Ltd. Method for treating cardiac infarction using HMGB1 fragment
SG11201503215XA (en) 2012-10-25 2015-06-29 Genomix Co Ltd Novel method for treating spinal cord injury using hmgb1 fragment
JP6532407B2 (en) 2013-02-14 2019-06-19 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー Compositions and methods for enhancing the immune response to Eimeria or limiting Eimeria infection
MX2015012855A (en) 2013-03-15 2016-07-21 Univ Arkansas Compositions and methods of enhancing immune responses to enteric pathogens.
TW202224701A (en) 2016-05-03 2022-07-01 阿肯色州大學董事會 Yeast vaccine vector including immunostimulatory and antigenic polypeptides and methods of using the same
WO2018139562A1 (en) * 2017-01-27 2018-08-02 株式会社ジェノミックス Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure
EP3617222A4 (en) * 2017-04-25 2021-01-20 Shionogi & Co., Ltd Peptide for inducing regeneration of tissue, and use thereof
WO2019107530A1 (en) 2017-12-01 2019-06-06 株式会社ステムリム Therapeutic agent for inflammatory bowel disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003026691A2 (en) * 2001-09-25 2003-04-03 Fondazione Centro San Raffaele Del Monte Tabor Use of hmgb1 for the activation of dendritic cells
WO2004004763A2 (en) * 2002-07-03 2004-01-15 Fondazione Centro San Raffaele Del Monte Tabor Use of hmgb1 in the treatment of tissue damage and/or to promote tissue repair
WO2004061456A2 (en) * 2003-01-03 2004-07-22 Alcedo Biotech Gmbh Uses of hmgb, hmgn, hmga proteins

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) * 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4485045A (en) * 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) * 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) * 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
US6656452B1 (en) * 1997-10-21 2003-12-02 The General Hospital Corporation Use of inhaled NO as anti-inflammatory agent
US6303321B1 (en) 1999-02-11 2001-10-16 North Shore-Long Island Jewish Research Institute Methods for diagnosing sepsis
US7754217B2 (en) * 2001-03-16 2010-07-13 Bio3 Research Srl HMGB1 protein inhibitors and/or antagonists for the treatment of vascular diseases
WO2002092004A2 (en) * 2001-05-15 2002-11-21 North Shore-Long Island Jewish Research Institute Use of hmg fragment as anti-inflammatory agents

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003026691A2 (en) * 2001-09-25 2003-04-03 Fondazione Centro San Raffaele Del Monte Tabor Use of hmgb1 for the activation of dendritic cells
WO2004004763A2 (en) * 2002-07-03 2004-01-15 Fondazione Centro San Raffaele Del Monte Tabor Use of hmgb1 in the treatment of tissue damage and/or to promote tissue repair
WO2004061456A2 (en) * 2003-01-03 2004-07-22 Alcedo Biotech Gmbh Uses of hmgb, hmgn, hmga proteins

Also Published As

Publication number Publication date
WO2007130725A2 (en) 2007-11-15
US20080004207A1 (en) 2008-01-03
US7829097B2 (en) 2010-11-09

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