WO2007130725A3 - Use of hmgb1 for protection against ischemia reperfusion injury - Google Patents
Use of hmgb1 for protection against ischemia reperfusion injury Download PDFInfo
- Publication number
- WO2007130725A3 WO2007130725A3 PCT/US2007/061709 US2007061709W WO2007130725A3 WO 2007130725 A3 WO2007130725 A3 WO 2007130725A3 US 2007061709 W US2007061709 W US 2007061709W WO 2007130725 A3 WO2007130725 A3 WO 2007130725A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hmgb1
- protection against
- reperfusion injury
- ischemia reperfusion
- against ischemia
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Methods and compositions are disclosed for protecting an organ or tissue from inflammation and organ injury following ischemia, reperfusion, and trauma through the administration of an HMGB1 protein within a time period sufficient to protect the organ or tissue from injury.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76554506P | 2006-02-06 | 2006-02-06 | |
US60/765,545 | 2006-02-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007130725A2 WO2007130725A2 (en) | 2007-11-15 |
WO2007130725A3 true WO2007130725A3 (en) | 2008-04-10 |
Family
ID=38668413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/061709 WO2007130725A2 (en) | 2006-02-06 | 2007-02-06 | Use of hmgb1 for protection against ischemia reperfusion injury |
Country Status (2)
Country | Link |
---|---|
US (1) | US7829097B2 (en) |
WO (1) | WO2007130725A2 (en) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2004266654B2 (en) | 2003-08-12 | 2011-07-21 | Loma Linda University Medical Center | Modular patient support system |
DK2055308T3 (en) * | 2006-10-30 | 2017-07-17 | Genomix Co Ltd | PHARMACEUTICALS FOR PROMOTING FUNCTIONAL REGENERATION OF DAMAGED TISSUE |
BRPI0911513A2 (en) | 2008-04-30 | 2016-07-12 | Genomix Co Ltd | Methods and Agents for High-Efficiency In vivo Functional Bone Marrow Stem Cell Collection |
WO2011052668A1 (en) | 2009-10-28 | 2011-05-05 | 株式会社ジェノミックス | Tissue-regeneration promoter using recruitment of bone marrow mesenchymal stem cells and/or pluripotent stem cells in blood |
EA023058B1 (en) | 2010-01-21 | 2016-04-29 | Дзе Борд Оф Трастиз Оф Дзе Юниверсити Оф Арканзас | Vaccine vectors and methods of enhancing immune responses |
CA2800830C (en) | 2010-06-09 | 2020-09-08 | The Board Of Trustees Of The University Of Arkansas | Vaccine and methods to reduce campylobacter infection |
JP6069191B2 (en) * | 2011-04-26 | 2017-02-01 | 株式会社ジェノミックス | Peptides and their use to induce tissue regeneration |
US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
CN104884076B (en) * | 2012-10-25 | 2017-10-03 | 吉诺米克斯股份有限公司 | It make use of the treatment method of the miocardial infarction of HMGB1 fragments |
AU2013335685B2 (en) | 2012-10-25 | 2017-10-12 | Osaka University | Novel method for treating spinal cord injury using HMGB1 fragment |
PT2956165T (en) | 2013-02-14 | 2019-11-29 | Texas A & M Univ Sys | Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection |
US10376571B2 (en) | 2013-03-15 | 2019-08-13 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses to enteric pathogens |
KR20190015712A (en) | 2016-05-03 | 2019-02-14 | 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 | Yeast vaccine vectors comprising immunostimulatory and antigenic polypeptides, and methods of using the same |
WO2018139562A1 (en) * | 2017-01-27 | 2018-08-02 | 株式会社ジェノミックス | Therapeutic agent for cardiomyopathy, old myocardial infarction and chronic heart failure |
US20210163552A1 (en) * | 2017-04-25 | 2021-06-03 | Shionogi & Co., Ltd. | Peptide for inducing regeneration of tissue, and use thereof |
CN111542335A (en) | 2017-12-01 | 2020-08-14 | 斯特姆里姆有限公司 | Therapeutic agent for inflammatory bowel disease |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003026691A2 (en) * | 2001-09-25 | 2003-04-03 | Fondazione Centro San Raffaele Del Monte Tabor | Use of hmgb1 for the activation of dendritic cells |
WO2004004763A2 (en) * | 2002-07-03 | 2004-01-15 | Fondazione Centro San Raffaele Del Monte Tabor | Use of hmgb1 in the treatment of tissue damage and/or to promote tissue repair |
WO2004061456A2 (en) * | 2003-01-03 | 2004-07-22 | Alcedo Biotech Gmbh | Uses of hmgb, hmgn, hmga proteins |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
US6656452B1 (en) | 1997-10-21 | 2003-12-02 | The General Hospital Corporation | Use of inhaled NO as anti-inflammatory agent |
US6303321B1 (en) | 1999-02-11 | 2001-10-16 | North Shore-Long Island Jewish Research Institute | Methods for diagnosing sepsis |
ITMI20010562A1 (en) | 2001-03-16 | 2002-09-16 | Marco E Bianchi | HMG1 PROTEIN INHIBITORS OR ANTAGONISTS FOR THE TREATMENT OF VASCULAR DISORDERS |
CA2447576C (en) | 2001-05-15 | 2014-04-08 | North Shore-Long Island Jewish Research Institute | Use of hmg fragments as anti-inflammatory agents |
-
2007
- 2007-02-06 US US11/671,932 patent/US7829097B2/en active Active
- 2007-02-06 WO PCT/US2007/061709 patent/WO2007130725A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003026691A2 (en) * | 2001-09-25 | 2003-04-03 | Fondazione Centro San Raffaele Del Monte Tabor | Use of hmgb1 for the activation of dendritic cells |
WO2004004763A2 (en) * | 2002-07-03 | 2004-01-15 | Fondazione Centro San Raffaele Del Monte Tabor | Use of hmgb1 in the treatment of tissue damage and/or to promote tissue repair |
WO2004061456A2 (en) * | 2003-01-03 | 2004-07-22 | Alcedo Biotech Gmbh | Uses of hmgb, hmgn, hmga proteins |
Also Published As
Publication number | Publication date |
---|---|
US7829097B2 (en) | 2010-11-09 |
US20080004207A1 (en) | 2008-01-03 |
WO2007130725A2 (en) | 2007-11-15 |
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