WO2007131238A3 - Compounds and methods for modulating expression apob - Google Patents
Compounds and methods for modulating expression apob Download PDFInfo
- Publication number
- WO2007131238A3 WO2007131238A3 PCT/US2007/068403 US2007068403W WO2007131238A3 WO 2007131238 A3 WO2007131238 A3 WO 2007131238A3 US 2007068403 W US2007068403 W US 2007068403W WO 2007131238 A3 WO2007131238 A3 WO 2007131238A3
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- WO
- WIPO (PCT)
- Prior art keywords
- short antisense
- antisense compounds
- compounds
- reduction
- monomers
- Prior art date
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
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- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/0102—Diacylglycerol O-acyltransferase (2.3.1.20)
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- C12N2310/11—Antisense
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES07811873.4T ES2471978T3 (en) | 2006-05-05 | 2007-05-07 | Compounds and procedures to modulate ApoB expression |
DK07811873.4T DK2015758T3 (en) | 2006-05-05 | 2007-05-07 | RELATIONS AND PROCEDURES FOR MODULATING APOB EXPRESSION |
JP2009510131A JP5825754B2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating the expression of APOB |
US12/299,764 US8673871B2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression ApoB |
EP07811873.4A EP2015758B1 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression apob |
US14/216,600 US20150057329A1 (en) | 2006-05-05 | 2014-03-17 | Compounds and methods for modulating expression apob |
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74663106P | 2006-05-05 | 2006-05-05 | |
US60/746,631 | 2006-05-05 | ||
US74705906P | 2006-05-11 | 2006-05-11 | |
US60/747,059 | 2006-05-11 | ||
US80566006P | 2006-06-23 | 2006-06-23 | |
US60/805,660 | 2006-06-23 | ||
US86455406P | 2006-11-06 | 2006-11-06 | |
US60/864,554 | 2006-11-06 | ||
PCT/US2007/061183 WO2007090071A2 (en) | 2006-01-27 | 2007-01-27 | 6-modified bicyclic nucleic acid analogs |
USPCT/US2007/061183 | 2007-01-27 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/061183 Continuation-In-Part WO2007090071A2 (en) | 2006-01-27 | 2007-01-27 | 6-modified bicyclic nucleic acid analogs |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/299,764 A-371-Of-International US8673871B2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression ApoB |
US14/216,600 Continuation US20150057329A1 (en) | 2006-05-05 | 2014-03-17 | Compounds and methods for modulating expression apob |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2007131238A2 WO2007131238A2 (en) | 2007-11-15 |
WO2007131238A3 true WO2007131238A3 (en) | 2008-07-10 |
WO2007131238A8 WO2007131238A8 (en) | 2009-12-17 |
Family
ID=40134111
Family Applications (9)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/068406 WO2007143316A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of sglt2 |
PCT/US2007/068412 WO2007134014A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of gcgr |
PCT/US2007/068403 WO2007131238A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression apob |
PCT/US2007/068415 WO2007136989A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of dgat2 |
PCT/US2007/068408 WO2007143317A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of crp |
PCT/US2007/068402 WO2007131237A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of ptp1b |
PCT/US2007/068404 WO2007143315A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of pcsk9 |
PCT/US2007/068401 WO2007146511A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating gene expression |
PCT/US2007/068410 WO2007136988A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of gccr |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/068406 WO2007143316A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of sglt2 |
PCT/US2007/068412 WO2007134014A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of gcgr |
Family Applications After (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/068415 WO2007136989A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of dgat2 |
PCT/US2007/068408 WO2007143317A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of crp |
PCT/US2007/068402 WO2007131237A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of ptp1b |
PCT/US2007/068404 WO2007143315A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of pcsk9 |
PCT/US2007/068401 WO2007146511A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating gene expression |
PCT/US2007/068410 WO2007136988A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of gccr |
Country Status (16)
Country | Link |
---|---|
US (14) | US9045754B2 (en) |
EP (10) | EP2023939B1 (en) |
JP (7) | JP5372745B2 (en) |
KR (1) | KR101441700B1 (en) |
CN (1) | CN103554205A (en) |
AT (2) | ATE513912T1 (en) |
AU (4) | AU2007257093A1 (en) |
BR (1) | BRPI0711429A2 (en) |
CA (3) | CA2651309C (en) |
DK (5) | DK2021472T3 (en) |
ES (2) | ES2471978T3 (en) |
HK (1) | HK1128418A1 (en) |
MX (1) | MX2008014100A (en) |
NO (1) | NO20084738L (en) |
PT (1) | PT2015758E (en) |
WO (9) | WO2007143316A2 (en) |
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US7511131B2 (en) | 2002-11-13 | 2009-03-31 | Genzyme Corporation | Antisense modulation of apolipoprotein B expression |
JP2005244488A (en) | 2004-02-25 | 2005-09-08 | Matsushita Electric Ind Co Ltd | Composite machine |
US20050287558A1 (en) | 2004-05-05 | 2005-12-29 | Crooke Rosanne M | SNPs of apolipoprotein B and modulation of their expression |
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US7764650B2 (en) | 2006-03-02 | 2010-07-27 | Intel Corporation | Mobile station and method for fast roaming with integrity protection and source authentication using a common protocol |
US8163708B2 (en) | 2006-04-03 | 2012-04-24 | Santaris Pharma A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotide |
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JP2010503382A (en) * | 2006-07-17 | 2010-02-04 | サーナ・セラピューティクス・インコーポレイテッド | RNA interference-mediated inhibition of proprotein convertase subtilisin kexin 9 (PCSK9) gene expression using small interfering nucleic acids (siNA) |
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KR20090128494A (en) | 2007-03-24 | 2009-12-15 | 겐자임 코포레이션 | Administering antisense oligonucleotides complementary to human apolipoprotein b |
DK2152879T3 (en) | 2007-05-01 | 2013-02-18 | Santaris Pharma As | RNA antagonist compounds for modulating beta-catenin |
KR20100024410A (en) | 2007-05-11 | 2010-03-05 | 엔즌 파마슈티칼스, 인코포레이티드 | Rna antagonist compounds for the modulation of her3 |
US8278283B2 (en) † | 2007-07-05 | 2012-10-02 | Isis Pharmaceuticals, Inc. | 6-disubstituted or unsaturated bicyclic nucleic acid analogs |
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