WO2007136988A8 - Compounds and methods for modulating expression of gccr - Google Patents

Compounds and methods for modulating expression of gccr Download PDF

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Publication number
WO2007136988A8
WO2007136988A8 PCT/US2007/068410 US2007068410W WO2007136988A8 WO 2007136988 A8 WO2007136988 A8 WO 2007136988A8 US 2007068410 W US2007068410 W US 2007068410W WO 2007136988 A8 WO2007136988 A8 WO 2007136988A8
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WO
WIPO (PCT)
Prior art keywords
short antisense
antisense compounds
compounds
reduction
monomers
Prior art date
Application number
PCT/US2007/068410
Other languages
French (fr)
Other versions
WO2007136988A2 (en
WO2007136988A3 (en
Inventor
Sanjay Bhanot
Richard S. Geary
Robert Mckay
Brett P. Monia
Punit P. Seth
Andrew M. Siwkowski
Eric E. Swayze
Edward Wancewicz
Original Assignee
Isis Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40134111&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2007136988(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from PCT/US2007/061183 external-priority patent/WO2007090071A2/en
Priority to US12/299,583 priority Critical patent/US8372967B2/en
Priority to DK07811878.3T priority patent/DK2019692T3/en
Priority to AU2007253909A priority patent/AU2007253909B2/en
Priority to JP2009510136A priority patent/JP2009536039A/en
Application filed by Isis Pharmaceuticals, Inc. filed Critical Isis Pharmaceuticals, Inc.
Priority to BRPI0711429-0A priority patent/BRPI0711429A2/en
Priority to EP07811878.3A priority patent/EP2019692B1/en
Publication of WO2007136988A2 publication Critical patent/WO2007136988A2/en
Publication of WO2007136988A3 publication Critical patent/WO2007136988A3/en
Publication of WO2007136988A8 publication Critical patent/WO2007136988A8/en
Priority to US13/662,263 priority patent/US8969316B2/en

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol

Abstract

The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or proteins in cells, tissues, and animals with increased potency and improved therapeutic index. Thus, provided herein are short antisense compounds comprising high-affinity nucleotide modifications useful for reducing a target RNA in vivo. Such short antisense compounds are effective at lower doses than previously described antisense compounds, allowing for a reduction in toxicity and cost of treatment. In addition, the described short antisense compounds have greater potential for oral dosing.
PCT/US2007/068410 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gccr WO2007136988A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
EP07811878.3A EP2019692B1 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gccr
BRPI0711429-0A BRPI0711429A2 (en) 2006-05-05 2007-05-07 compounds and methods for gccr expression modules
DK07811878.3T DK2019692T3 (en) 2006-05-05 2007-05-07 RELATIONS AND METHODS FOR MODULATING EXPRESSION OF GCCR
AU2007253909A AU2007253909B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of GCCR
JP2009510136A JP2009536039A (en) 2006-05-05 2007-05-07 Compounds and methods for modulating the expression of GCCR
US12/299,583 US8372967B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of GCCR
US13/662,263 US8969316B2 (en) 2006-05-05 2012-10-26 Compounds and methods for modulating expression of DGAT2

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US74663106P 2006-05-05 2006-05-05
US60/746,631 2006-05-05
US74705906P 2006-05-11 2006-05-11
US60/747,059 2006-05-11
US80566006P 2006-06-23 2006-06-23
US60/805,660 2006-06-23
US86455406P 2006-11-06 2006-11-06
US60/864,554 2006-11-06
PCT/US2007/061183 WO2007090071A2 (en) 2006-01-27 2007-01-27 6-modified bicyclic nucleic acid analogs
USPCT/US2007/061183 2007-01-27

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/061183 Continuation-In-Part WO2007090071A2 (en) 2006-01-27 2007-01-27 6-modified bicyclic nucleic acid analogs

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/299,583 A-371-Of-International US8372967B2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of GCCR
US13/662,263 Continuation US8969316B2 (en) 2006-05-05 2012-10-26 Compounds and methods for modulating expression of DGAT2

Publications (3)

Publication Number Publication Date
WO2007136988A2 WO2007136988A2 (en) 2007-11-29
WO2007136988A3 WO2007136988A3 (en) 2009-05-07
WO2007136988A8 true WO2007136988A8 (en) 2009-09-24

Family

ID=40134111

Family Applications (9)

Application Number Title Priority Date Filing Date
PCT/US2007/068403 WO2007131238A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression apob
PCT/US2007/068401 WO2007146511A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression
PCT/US2007/068410 WO2007136988A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gccr
PCT/US2007/068412 WO2007134014A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gcgr
PCT/US2007/068408 WO2007143317A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of crp
PCT/US2007/068402 WO2007131237A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of ptp1b
PCT/US2007/068415 WO2007136989A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of dgat2
PCT/US2007/068406 WO2007143316A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of sglt2
PCT/US2007/068404 WO2007143315A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of pcsk9

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2007/068403 WO2007131238A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression apob
PCT/US2007/068401 WO2007146511A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating gene expression

Family Applications After (6)

Application Number Title Priority Date Filing Date
PCT/US2007/068412 WO2007134014A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of gcgr
PCT/US2007/068408 WO2007143317A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of crp
PCT/US2007/068402 WO2007131237A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of ptp1b
PCT/US2007/068415 WO2007136989A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of dgat2
PCT/US2007/068406 WO2007143316A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of sglt2
PCT/US2007/068404 WO2007143315A2 (en) 2006-05-05 2007-05-07 Compounds and methods for modulating expression of pcsk9

Country Status (16)

Country Link
US (14) US8372967B2 (en)
EP (10) EP2015758B1 (en)
JP (7) JP5372745B2 (en)
KR (1) KR101441700B1 (en)
CN (1) CN103554205A (en)
AT (2) ATE514777T1 (en)
AU (4) AU2007257094B2 (en)
BR (1) BRPI0711429A2 (en)
CA (3) CA3044969A1 (en)
DK (5) DK2015758T3 (en)
ES (2) ES2386578T3 (en)
HK (1) HK1128418A1 (en)
MX (1) MX2008014100A (en)
NO (1) NO20084738L (en)
PT (1) PT2015758E (en)
WO (9) WO2007131238A2 (en)

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