WO2007146511A8 - Compounds and methods for modulating gene expression - Google Patents
Compounds and methods for modulating gene expression Download PDFInfo
- Publication number
- WO2007146511A8 WO2007146511A8 PCT/US2007/068401 US2007068401W WO2007146511A8 WO 2007146511 A8 WO2007146511 A8 WO 2007146511A8 US 2007068401 W US2007068401 W US 2007068401W WO 2007146511 A8 WO2007146511 A8 WO 2007146511A8
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- WIPO (PCT)
- Prior art keywords
- short antisense
- antisense compounds
- compounds
- reduction
- monomers
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A61P3/04—Anorexiants; Antiobesity agents
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
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- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/0102—Diacylglycerol O-acyltransferase (2.3.1.20)
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- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
- C12N2310/3515—Lipophilic moiety, e.g. cholesterol
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT07811872T ATE514777T1 (en) | 2006-05-05 | 2007-05-07 | COMPOUNDS AND METHODS FOR MODULATING GENE EXPRESSION |
EP07811872A EP2021472B1 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating gene expression |
JP2009510130A JP5731115B2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating gene expression |
DK07811872.6T DK2021472T3 (en) | 2006-05-05 | 2007-05-07 | Compounds and Methods for Modeling Gene Expression |
AU2007258117A AU2007258117B2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating gene expression |
CA2651309A CA2651309C (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating gene expression |
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74663106P | 2006-05-05 | 2006-05-05 | |
US60/746,631 | 2006-05-05 | ||
US74705906P | 2006-05-11 | 2006-05-11 | |
US60/747,059 | 2006-05-11 | ||
US80566006P | 2006-06-23 | 2006-06-23 | |
US60/805,660 | 2006-06-23 | ||
US86455406P | 2006-11-06 | 2006-11-06 | |
US60/864,554 | 2006-11-06 | ||
PCT/US2007/061183 WO2007090071A2 (en) | 2006-01-27 | 2007-01-27 | 6-modified bicyclic nucleic acid analogs |
USPCT/US2007/061183 | 2007-01-27 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2007146511A2 WO2007146511A2 (en) | 2007-12-21 |
WO2007146511A3 WO2007146511A3 (en) | 2008-06-12 |
WO2007146511A8 true WO2007146511A8 (en) | 2009-04-02 |
Family
ID=40134111
Family Applications (9)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/068404 WO2007143315A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of pcsk9 |
PCT/US2007/068408 WO2007143317A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of crp |
PCT/US2007/068402 WO2007131237A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of ptp1b |
PCT/US2007/068403 WO2007131238A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression apob |
PCT/US2007/068412 WO2007134014A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of gcgr |
PCT/US2007/068406 WO2007143316A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of sglt2 |
PCT/US2007/068415 WO2007136989A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of dgat2 |
PCT/US2007/068410 WO2007136988A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of gccr |
PCT/US2007/068401 WO2007146511A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating gene expression |
Family Applications Before (8)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/068404 WO2007143315A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of pcsk9 |
PCT/US2007/068408 WO2007143317A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of crp |
PCT/US2007/068402 WO2007131237A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of ptp1b |
PCT/US2007/068403 WO2007131238A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression apob |
PCT/US2007/068412 WO2007134014A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of gcgr |
PCT/US2007/068406 WO2007143316A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of sglt2 |
PCT/US2007/068415 WO2007136989A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of dgat2 |
PCT/US2007/068410 WO2007136988A2 (en) | 2006-05-05 | 2007-05-07 | Compounds and methods for modulating expression of gccr |
Country Status (16)
Country | Link |
---|---|
US (14) | US8188059B2 (en) |
EP (10) | EP2363481B1 (en) |
JP (7) | JP5372745B2 (en) |
KR (1) | KR101441700B1 (en) |
CN (1) | CN103554205A (en) |
AT (2) | ATE513912T1 (en) |
AU (4) | AU2007258117B2 (en) |
BR (1) | BRPI0711429A2 (en) |
CA (3) | CA2651309C (en) |
DK (5) | DK2458006T3 (en) |
ES (2) | ES2471978T3 (en) |
HK (1) | HK1128418A1 (en) |
MX (1) | MX2008014100A (en) |
NO (1) | NO20084738L (en) |
PT (1) | PT2015758E (en) |
WO (9) | WO2007143315A2 (en) |
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US9107933B2 (en) | 2009-03-16 | 2015-08-18 | Isis Pharmaceuticals, Inc. | Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III |
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US20060009410A1 (en) * | 2002-11-13 | 2006-01-12 | Crooke Rosanne M | Effects of apolipoprotein B inhibition on gene expression profiles in animals |
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US20050287558A1 (en) | 2004-05-05 | 2005-12-29 | Crooke Rosanne M | SNPs of apolipoprotein B and modulation of their expression |
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WO2007087113A2 (en) | 2005-12-28 | 2007-08-02 | The Scripps Research Institute | Natural antisense and non-coding rna transcripts as drug targets |
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AU2007258117B2 (en) * | 2006-05-05 | 2013-05-30 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating gene expression |
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