WO2008005371A3 - Poly(orthoester) polymers, and methods of making and using same - Google Patents

Poly(orthoester) polymers, and methods of making and using same Download PDF

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Publication number
WO2008005371A3
WO2008005371A3 PCT/US2007/015197 US2007015197W WO2008005371A3 WO 2008005371 A3 WO2008005371 A3 WO 2008005371A3 US 2007015197 W US2007015197 W US 2007015197W WO 2008005371 A3 WO2008005371 A3 WO 2008005371A3
Authority
WO
WIPO (PCT)
Prior art keywords
orthoester
poly
polymers
making
methods
Prior art date
Application number
PCT/US2007/015197
Other languages
French (fr)
Other versions
WO2008005371A2 (en
Inventor
Julie A Alkatout
Michael Eric Benz
Randall V Sparer
Original Assignee
Medtronic Inc
Julie A Alkatout
Michael Eric Benz
Randall V Sparer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc, Julie A Alkatout, Michael Eric Benz, Randall V Sparer filed Critical Medtronic Inc
Priority to EP07810077A priority Critical patent/EP2044142A2/en
Publication of WO2008005371A2 publication Critical patent/WO2008005371A2/en
Publication of WO2008005371A3 publication Critical patent/WO2008005371A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/66—Polyesters containing oxygen in the form of ether groups
    • C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G64/00—Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
    • C08G64/18—Block or graft polymers
    • C08G64/183—Block or graft polymers containing polyether sequences

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Biological Depolymerization Polymers (AREA)

Abstract

Poly(orthoester) polymers, and methods of making and using such poly(orthoester) polymers are provided. The poly(orthoester) poylmers can be useful for applications including, for example, medical devices and pharmaceutical compositions. In a preferred embodiment, the poly(orthoester) polymers are biodegradable.
PCT/US2007/015197 2006-06-29 2007-06-29 Poly(orthoester) polymers, and methods of making and using same WO2008005371A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP07810077A EP2044142A2 (en) 2006-06-29 2007-06-29 Poly(orthoester) polymers, and methods of making and using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81756006P 2006-06-29 2006-06-29
US60/817,560 2006-06-29

Publications (2)

Publication Number Publication Date
WO2008005371A2 WO2008005371A2 (en) 2008-01-10
WO2008005371A3 true WO2008005371A3 (en) 2008-04-10

Family

ID=38720422

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/015197 WO2008005371A2 (en) 2006-06-29 2007-06-29 Poly(orthoester) polymers, and methods of making and using same

Country Status (3)

Country Link
US (3) US7875697B2 (en)
EP (1) EP2044142A2 (en)
WO (1) WO2008005371A2 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2044142A2 (en) * 2006-06-29 2009-04-08 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US8236923B2 (en) * 2007-01-16 2012-08-07 Fujifilm Corporation Fluorine-containing polymer and method of producing fluorine-containing polymer
US8956642B2 (en) * 2008-04-18 2015-02-17 Medtronic, Inc. Bupivacaine formulation in a polyorthoester carrier
US8940315B2 (en) 2008-04-18 2015-01-27 Medtronic, Inc. Benzodiazepine formulation in a polyorthoester carrier
US9132119B2 (en) * 2008-04-18 2015-09-15 Medtronic, Inc. Clonidine formulation in a polyorthoester carrier
DE102008037201A1 (en) * 2008-08-11 2010-04-15 Alfred Buck Artificial joint
US9410016B2 (en) 2013-07-16 2016-08-09 Dow Global Technologies Llc Aromatic polyacetals and articles comprising them
US9063420B2 (en) 2013-07-16 2015-06-23 Rohm And Haas Electronic Materials Llc Photoresist composition, coated substrate, and method of forming electronic device
US8962779B2 (en) * 2013-07-16 2015-02-24 Dow Global Technologies Llc Method of forming polyaryl polymers
US20160324798A1 (en) * 2013-12-31 2016-11-10 Heron Therapeutics, Inc. Polymer-based compositions for extended release of proteins
CN103804693B (en) * 2014-01-24 2016-03-09 中国科学院化学研究所 Dendroid polyketals and its preparation method and application
EP3134070B1 (en) 2014-04-21 2020-09-23 Heron Therapeutics, Inc. Compositions of a polyorthoester and an organic acid excipient
HRP20211612T1 (en) * 2014-04-21 2022-02-04 Heron Therapeutics, Inc. Long-acting polymeric delivery systems
CN106800651B (en) * 2017-01-22 2019-06-25 安徽大学 A kind of polymer P OEHD and preparation method thereof and its application with pH and reduction responsiveness
CN108144067B (en) * 2017-12-27 2020-11-24 安徽大学 Tetravalent platinum compound-bicyclic double-bond amphiphilic polymer prodrug, nano micelle, preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups

Family Cites Families (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2957856A (en) * 1958-08-29 1960-10-25 Union Carbide Corp Phosphorus-containing spirobi(metadioxane) resins
US4093709A (en) 1975-01-28 1978-06-06 Alza Corporation Drug delivery devices manufactured from poly(orthoesters) and poly(orthocarbonates)
US4180646A (en) 1975-01-28 1979-12-25 Alza Corporation Novel orthoester polymers and orthocarbonate polymers
US4131648A (en) 1975-01-28 1978-12-26 Alza Corporation Structured orthoester and orthocarbonate drug delivery devices
US4079038A (en) 1976-03-05 1978-03-14 Alza Corporation Poly(carbonates)
US4066747A (en) * 1976-04-08 1978-01-03 Alza Corporation Polymeric orthoesters housing beneficial drug for controlled release therefrom
US4186185A (en) * 1976-04-08 1980-01-29 Alza Corporation Compositions comprising arylene substituted poly(orthoesters) containing useful agents
US4070347A (en) * 1976-08-16 1978-01-24 Alza Corporation Poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers having carbonyloxy functionality
US4304767A (en) 1980-05-15 1981-12-08 Sri International Polymers of di- (and higher functionality) ketene acetals and polyols
US4489056A (en) 1982-06-30 1984-12-18 Merck & Co., Inc. Acid anhydrides as rate controlling agent for the erosion of polymers which latter polymers have beneficial substances dispersed throughout their matrix or where the polymer matrix surrounds the beneficial substance
US4513143A (en) 1982-12-01 1985-04-23 Sri International Preparation of ketene acetals
US4532335A (en) 1983-03-07 1985-07-30 Sri International Preparation of ketene acetals by rearrangement of allyl and substituted allyl acetals
US4765973A (en) 1984-06-06 1988-08-23 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
US4639366A (en) 1984-06-06 1987-01-27 Merck & Co., Inc. Polymers containing pendant acid functionalities and labile backbone bonds
US4549010A (en) 1984-06-27 1985-10-22 Merck & Co., Inc. Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal
US4638045A (en) 1985-02-19 1987-01-20 Massachusetts Institute Of Technology Non-peptide polyamino acid bioerodible polymers
CA1273872A (en) 1985-05-10 1990-09-11 Larry J. Caldwell Drug delivery device which can be retained in the stomach for a controlled period of time
US4735804A (en) 1985-05-10 1988-04-05 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4758436A (en) 1985-05-29 1988-07-19 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4767627A (en) 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4780319A (en) 1985-07-08 1988-10-25 Merck & Co., Inc. Organic acids as catalysts for the erosion of polymers
CA1276556C (en) 1985-07-08 1990-11-20 Kenneth J. Himmelstein Organic acid as catalysts for the erosion of polymers
US4764364A (en) 1986-02-25 1988-08-16 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4855132A (en) 1986-02-25 1989-08-08 S R I International Method of preparing bioerodible polymers having pH sensitivity in the acid range and resulting product
US4898928A (en) 1988-03-07 1990-02-06 Sandoz Pharmaceuticals Corp. Polyacetal and polyketal hydrogels formed from acetals or ketals and polyols
US4957998A (en) 1988-08-22 1990-09-18 Pharmaceutical Delivery Systems, Inc. Polymers containing acetal, carboxy-acetal, ortho ester and carboxyortho ester linkages
US5108755A (en) 1989-04-27 1992-04-28 Sri International Biodegradable composites for internal medical use
US4946931A (en) 1989-06-14 1990-08-07 Pharmaceutical Delivery Systems, Inc. Polymers containing carboxy-ortho ester and ortho ester linkages
US5013821A (en) 1989-06-15 1991-05-07 Pharmaceutical Delivery Systems, Inc. Ortho and thio-ortho ester polymer
US5030457A (en) 1989-08-28 1991-07-09 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
EP0489843A4 (en) 1989-08-28 1992-08-12 Pharmaceutical Delivery Systems, Inc. Bioerodible polymers useful for the controlled release of therapeutic agents
US5587507A (en) 1995-03-31 1996-12-24 Rutgers, The State University Synthesis of tyrosine derived diphenol monomers
NZ239370A (en) 1990-08-22 1994-04-27 Merck & Co Inc Bioerodible implantable controlled release dosage form comprising a poly(ortho ester) or a polyacetal with an active agent incorporated into the chain backbone
US5211951A (en) 1991-07-24 1993-05-18 Merck & Co., Inc. Process for the manufacture of bioerodible poly (orthoester)s and polyacetals
US5254345A (en) * 1991-10-11 1993-10-19 Merck & Co., Inc. Poly(orthocarbonate acetal) bioerodible polymers
DE4142130A1 (en) * 1991-12-20 1993-06-24 Basf Ag USE OF POLYACETALES BASED ON VINYL ETHERS AND DIHYDROXY COMPOUNDS IN WASHING AND CLEANING AGENTS AND POLYACETALES
DK0627911T3 (en) 1992-02-28 2000-11-20 Univ Texas Photopolymerizable biodegradable hydrogels as tissue contact materials and controlled release carriers
US5461140A (en) 1992-04-30 1995-10-24 Pharmaceutical Delivery Systems Bioerodible polymers for solid controlled release pharmaceutical compositions
CA2144407C (en) 1992-09-10 2000-05-30 Charles B. Berde Biodegradable polymer matrices for sustained delivery of local anesthetic agents
US5700485A (en) 1992-09-10 1997-12-23 Children's Medical Center Corporation Prolonged nerve blockade by the combination of local anesthetic and glucocorticoid
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US7833543B2 (en) 1995-06-07 2010-11-16 Durect Corporation High viscosity liquid controlled delivery system and medical or surgical device
US5747058A (en) 1995-06-07 1998-05-05 Southern Biosystems, Inc. High viscosity liquid controlled delivery system
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
US5968542A (en) 1995-06-07 1999-10-19 Southern Biosystems, Inc. High viscosity liquid controlled delivery system as a device
NZ311474A (en) 1995-06-09 1997-09-22 Euro Celtique Sa Formulations for providing prolonged local anesthesia
US6096344A (en) 1995-07-28 2000-08-01 Advanced Polymer Systems, Inc. Bioerodible porous compositions
US5968543A (en) 1996-01-05 1999-10-19 Advanced Polymer Systems, Inc. Polymers with controlled physical state and bioerodibility
ES2153648T3 (en) 1996-01-05 2001-03-01 Advanced Polymer Systems Inc POLYMERS WITH CONTROLLED PHYSICAL STATE AND BIOEROSIONABILITY.
NL1002427C2 (en) * 1996-02-23 1997-08-26 Akzo Nobel Nv Coating composition comprising a bicyclo or spiro-oester functional compound.
US5747060A (en) 1996-03-26 1998-05-05 Euro-Celtique, S.A. Prolonged local anesthesia with colchicine
JPH11511763A (en) 1996-06-24 1999-10-12 ユーロ―セルティーク，エス．エイ． How to provide safe local anesthesia
US6120491A (en) 1997-11-07 2000-09-19 The State University Rutgers Biodegradable, anionic polymers derived from the amino acid L-tyrosine
US5919473A (en) 1997-05-12 1999-07-06 Elkhoury; George F. Methods and devices for delivering opioid analgesics to wounds via a subdermal implant
EP1009390A4 (en) 1997-07-02 2004-05-06 Euro Celtique Sa Prolonged anesthesia in joints and body spaces
US5939453A (en) 1998-06-04 1999-08-17 Advanced Polymer Systems, Inc. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
JP2002520120A (en) 1998-07-17 2002-07-09 スカイファーマ インコーポレーテッド Biodegradable compositions for controlled release of encapsulating materials
US6133402A (en) 1998-08-04 2000-10-17 Cornell Research Foundation, Inc. Polycarbonates made using high activity catalysts
EP1225172B1 (en) * 1999-09-17 2004-07-21 Kansai Paint Co., Ltd. Polyorthoester and curable composition containing the same
EP1142596A1 (en) 2000-04-03 2001-10-10 Universiteit Gent Compositions of crosslinkable prepolymers for use in therapeutically active biodegradable implants
AU2001261516A1 (en) 2000-05-11 2001-11-20 Advanced Polymer Systems Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US20050042194A1 (en) 2000-05-11 2005-02-24 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
US6613355B2 (en) 2000-05-11 2003-09-02 A.P. Pharma, Inc. Semi-solid delivery vehicle and pharmaceutical compositions
JP2002035676A (en) * 2000-07-26 2002-02-05 Kansai Paint Co Ltd Coating finishing method
AU2002226000A1 (en) 2000-11-13 2002-05-21 Atrix Laboratories, Inc. Injectable sustained release delivery system with loperamide
JP2004514764A (en) * 2000-11-21 2004-05-20 インペリアル・ケミカル・インダストリーズ・ピーエルシー Esterification catalysts, polyester processes, and polyester products
WO2002092661A1 (en) 2001-05-11 2002-11-21 Ap Pharma, Inc. Peg-poe, peg-poe-peg, and poe-peg-poe block copolymers
US20030152630A1 (en) 2001-05-11 2003-08-14 Ng Steven Y. PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers
US6590059B2 (en) 2001-05-11 2003-07-08 Ap Pharma, Inc. Bioerodible polyorthoesters from dioxolane-based diketene acetals
US20020176844A1 (en) 2001-05-11 2002-11-28 Ng Steven Y. Bioerodible polyorthoesters containing hydrogen bonding groups
US7649023B2 (en) 2002-06-11 2010-01-19 Novartis Ag Biodegradable block copolymeric compositions for drug delivery
US20040109893A1 (en) 2002-06-25 2004-06-10 Guohua Chen Sustained release dosage forms of anesthetics for pain management
US20040001889A1 (en) 2002-06-25 2004-01-01 Guohua Chen Short duration depot formulations
CA2494188A1 (en) 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery system including a hydrophobic cellulose derivative
JP2006502136A (en) 2002-08-13 2006-01-19 メドトロニック・インコーポレーテッド Active agent delivery system comprising a hydrophilic polymer, a medical device, and a method
AU2003258209A1 (en) 2002-08-13 2004-02-25 Medtronic, Inc. Active agent delivery systems, medical devices, and methods
DE60333566D1 (en) 2002-08-13 2010-09-09 Medtronic Inc MEDICAL DEVICE WITH IMPROVED LIABILITY BETWEEN A POLYMERIC TOUCH AND A SUBSTRATE
WO2004014449A1 (en) 2002-08-13 2004-02-19 Medtronic, Inc. Active agent delivery system including a polyurethane, medical device, and method
DE60331552D1 (en) 2002-08-13 2010-04-15 Medtronic Inc PHARMACEUTICALS COMPOSITIONS USING POLY (ETHYLENE-CO (METH) ACRYLATE, MEDICAL DEVICE AND METHOD
US7045589B2 (en) * 2002-11-15 2006-05-16 A.P. Pharma, Inc. Bioerodible poly(ortho esters) from dioxane-based di(ketene acetals), and block copolymers containing them
US6863782B2 (en) 2002-11-15 2005-03-08 A.P. Pharma, Inc. Method of preparing di(ketene acetals)
US7288609B1 (en) * 2003-03-04 2007-10-30 Advanced Cardiovascular Systems, Inc. Coatings for drug delivery devices based on poly (orthoesters)
US6982338B2 (en) * 2003-05-06 2006-01-03 National Starch And Chemical Investment Holding Corporation Oxetane compounds containing maleimide functionality
ES2379466T3 (en) * 2003-06-26 2012-04-26 Psivida Us, Inc. Bio-erasable sustained release drug delivery system
EP1660145A2 (en) 2003-08-13 2006-05-31 Medtronic, Inc. Active agent delivery systems, including a single layer of a miscible polymer blend, medical devices and methods
WO2005018702A2 (en) 2003-08-13 2005-03-03 Medtronic, Inc. Active agent delivery systems including a miscible polymer blend, medical devices, and methods
DE102004003495A1 (en) * 2004-01-23 2005-08-11 Bayer Materialscience Ag Orthoestergruppenhaltige binder
US20050209433A1 (en) * 2004-03-22 2005-09-22 Barsotti Robert J Orthoester-protected polyols for low VOC coatings
CN101426529A (en) * 2005-03-31 2009-05-06 阿帕医药有限公司 PEG-poly(ortho ester) graft copolymers and pharmaceutical compositions
DE102005018909A1 (en) * 2005-04-22 2006-10-26 Degussa Ag Process for the preparation of unsaturated, cyclic orthoesters
US7741375B2 (en) * 2006-02-17 2010-06-22 Medtronic, Inc Polyketal polymers, and methods of making and using same
EP2044142A2 (en) 2006-06-29 2009-04-08 Medtronic, Inc. Poly(orthoester) polymers, and methods of making and using same
US7927620B2 (en) * 2007-05-15 2011-04-19 Boston Scientific Scimed, Inc. Medical devices having antifouling character
US8531978B2 (en) * 2009-02-02 2013-09-10 Level 3 Communications, Llc Network cost analysis

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6524606B1 (en) * 2001-11-16 2003-02-25 Ap Pharma, Inc. Bioerodible polyorthoesters containing amine groups

Also Published As

Publication number Publication date
US20110082275A1 (en) 2011-04-07
US8133968B2 (en) 2012-03-13
WO2008005371A2 (en) 2008-01-10
US7875697B2 (en) 2011-01-25
US20120149864A1 (en) 2012-06-14
EP2044142A2 (en) 2009-04-08
US20080033140A1 (en) 2008-02-07

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