WO2008011348A3 - Humanized antibody against amyloid beta - Google Patents
Humanized antibody against amyloid beta Download PDFInfo
- Publication number
- WO2008011348A3 WO2008011348A3 PCT/US2007/073504 US2007073504W WO2008011348A3 WO 2008011348 A3 WO2008011348 A3 WO 2008011348A3 US 2007073504 W US2007073504 W US 2007073504W WO 2008011348 A3 WO2008011348 A3 WO 2008011348A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- humanized antibody
- antibody against
- amyloid beta
- against amyloid
- amyloidosis
- Prior art date
Links
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 102000009091 Amyloidogenic Proteins Human genes 0.000 abstract 1
- 108010048112 Amyloidogenic Proteins Proteins 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 206010002022 amyloidosis Diseases 0.000 abstract 1
- 208000035474 group of disease Diseases 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Psychiatry (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Priority Applications (52)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES07840408T ES2436112T3 (en) | 2006-07-14 | 2007-07-13 | Humanized antibody |
EP21191801.6A EP3988566A1 (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
JP2009519711A JP2010528583A (en) | 2007-06-11 | 2007-07-13 | Humanized antibody against amyloid β |
SI200731343T SI2046833T1 (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
EP17190333.9A EP3309172B1 (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
EP07840408.4A EP2046833B9 (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
KR1020097003136A KR101605207B1 (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
CN200780033976.7A CN101516911B (en) | 2006-07-14 | 2007-07-13 | Humanized antibody for amyloid-beta |
BRPI0714713-9A BRPI0714713B1 (en) | 2006-07-14 | 2007-07-13 | HUMANIZED ANTIBODY OR AN ACTIVE FRAGMENT OF THE SAME, PHARMACEUTICAL COMPOSITION, NUCLEIC ACID MOLECULE, EXPRESSION VECTOR, NON ANIMAL NOR VEGETABLE TRANSGENIC MICRO-ORGANISM, COMPOSITION, MIXTURE, USE OF HUMANIZED ANTIBODY, ANTIBODY OR HUMANIZED METHOD ASSETS OF THE SAME, IN VITRO METHOD FOR DETECTION OF AMYLOIDOSIS, IN VITRO METHOD TO DETERMINE THE DEGREE OF AMYLOIDOGEN PLATE LOAD |
NZ574188A NZ574188A (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
PL07840408T PL2046833T3 (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
AU2007275467A AU2007275467B2 (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
CA2657681A CA2657681C (en) | 2006-07-14 | 2007-07-13 | Humanized antibodies against beta amyloid protein |
RU2009104769/10A RU2498999C2 (en) | 2006-07-14 | 2007-07-13 | Humanised antibody to beta amyloid |
MEP-2013-132A ME01758B (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
MX2009000476A MX2009000476A (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta. |
KR1020147027016A KR20140125455A (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
KR1020197000092A KR20190003862A (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
KR1020167034680A KR20160147066A (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
MEP-2010-59A ME01075B (en) | 2006-07-14 | 2007-07-13 | Antibodies |
KR1020187011457A KR20180043854A (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
RS20130515A RS53160B (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
UAA200900880A UA100672C2 (en) | 2006-07-14 | 2007-07-13 | HUMANIZED ANTIBODY TO b-AMYLOID PROTEIN |
PL11192705T PL2468770T3 (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta. |
KR1020167010466A KR20160049045A (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
DK07840408.4T DK2046833T5 (en) | 2006-07-14 | 2007-07-13 | HUMANIZED ANTIBODY AGAINST AMYLOID BETA |
KR1020177023161A KR20170098978A (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
EP07867188.0A EP2074145B1 (en) | 2006-10-02 | 2007-10-02 | Humanized antibody against amyloid beta |
ES07867188.0T ES2640095T3 (en) | 2006-10-02 | 2007-10-02 | Humanized antibody against beta-amyloid |
PCT/US2007/021134 WO2008060364A2 (en) | 2006-10-02 | 2007-10-02 | Humani zed antibody against amyloid beta |
KR1020147032970A KR20150002879A (en) | 2006-10-02 | 2007-10-02 | Humanized antibody against amyloid beta |
MX2009003468A MX2009003468A (en) | 2006-07-14 | 2007-10-02 | Antibodies. |
KR1020097009094A KR101535684B1 (en) | 2006-07-14 | 2007-10-02 | Humanized antibody against amyloid beta |
CN2007800445554A CN101611054B (en) | 2006-10-02 | 2007-10-02 | Humanized antibody against amyloid beta |
JP2009531414A JP5641737B2 (en) | 2006-07-14 | 2007-10-02 | Humanized antibody against amyloid β |
PL07867188T PL2074145T3 (en) | 2006-10-02 | 2007-10-02 | Humanized antibody against amyloid beta |
SI200731964T SI2074145T1 (en) | 2006-10-02 | 2007-10-02 | Humanized antibody against amyloid beta |
HUE07867188A HUE033466T2 (en) | 2006-10-02 | 2007-10-02 | Humanized antibody against amyloid beta |
DK07867188.0T DK2074145T5 (en) | 2006-10-02 | 2007-10-02 | HUMANIZED ANTIBODY AGAINST AMYLOID BETA |
BRPI0719763-2A BRPI0719763A2 (en) | 2006-10-02 | 2007-10-02 | ANTIBODY, NUCLEIC ACID MOLECULE, EXPRESSION VECTOR, CELL, COMPOSITION, MIXTURE, USE OF A CHEMICAL ANTIBODY OR A FRAGMENT OF THE SAME OR A FRAGMENT OF THE SAME AND / OR A PART OR A FUNCTION OR A PART OR A FUNCTION MIXTURE, METHODS FOR PREPARING A PHARMACEUTICAL COMPOSITION OR MIXTURE, TO PREVENT, TREAT OR RELIEVE THE EFFECTS OF A DISEASE, DIAGNOSTIC DISEASE, OR CONDITION ASSOCIATED WITH A DETERMINATION OF THE DETERMINATION OF CAROGUE DETERMINATION IN A FABRIC AND / OR BODY FLUIDS, TEST KITS FOR DISEASE AND DIAGNOSTIC TESTING AND CONDITIONS ASSOCIATED WITH AMYLOID, LIGHT CHAIN VARIABLE REGION, HEAVY CIRCLE, GENELE DESENGER, GENELE DIAGET LINES PRE-FORMED BETA-AMYLOID FIBERS TO PREVENT ABETA-INDUCED NEURON DEGRADATION, TO DIAGNOSE A PREDISPOSITION TO A DISEASE OR CO NDITION ASSOCIATED WITH AMYLOID IN A PATIENT, TO MONITOR MINIMUM RESIDUAL DISEASE IN A PATIENT, TO PROGNOSE LIABILITY OF A PATIENT WHO IS TREATED WITH AN ANTIBODY OR A COMPOSITION OF VACCINE, TO REDUCE THE CARBON LOAD TO THE CIRCLE THE NUMBER OF PLATES IN AN ANIMAL BRAIN, TO REDUCE THE TOTAL SOLUBLE OPEN QUANTITY IN AN ANIMAL BRAIN AND TO HOLD OR INCREASE COGNITIVE MEMORY CAPACITY IN A MAMMALIAN. |
NO20090156A NO344963B1 (en) | 2006-07-14 | 2009-01-12 | Humanized antibody |
IL196478A IL196478B (en) | 2006-07-14 | 2009-01-13 | Humanized antibody and fragments thereof binding to amyloid beta and nucleic acids, vectors and cells for producing them, as well as pertinent therapeutic compositions, mixtures and uses thereof |
NO20091284A NO20091284L (en) | 2006-07-14 | 2009-03-30 | Humanized antibodies to amyloid beta |
HRP20090221AA HRP20090221B1 (en) | 2006-07-14 | 2009-04-14 | Humanized antibody |
HK10103596.0A HK1139154A1 (en) | 2006-10-02 | 2010-04-13 | Humani zed antibody against amyloid beta |
PH12012501882A PH12012501882A1 (en) | 2006-07-14 | 2012-09-21 | Humanized antibody against amyloid beta |
AU2013202799A AU2013202799C1 (en) | 2006-07-14 | 2013-04-07 | Humanized antibody against amyloid beta |
JP2014136443A JP2014223075A (en) | 2006-10-02 | 2014-07-02 | HUMANIZED ANTIBODY TO AMYLOID β |
CR20140496A CR20140496A (en) | 2006-07-14 | 2014-10-27 | HUMANIZED ANTIBODIES AGAINST BETA-AMILOIDS |
JP2016124266A JP2016179998A (en) | 2006-10-02 | 2016-06-23 | HUMANIZED ANTIBODIES AGAINST AMYLOID β |
IL254065A IL254065B (en) | 2006-07-14 | 2017-08-20 | Humanized antibody against amyloid beta |
JP2017243730A JP2018095647A (en) | 2006-10-02 | 2017-12-20 | HUMANIZED ANTIBODIES AGAINST AMYLOID β |
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06014730 | 2006-07-14 | ||
EP06014730.3 | 2006-07-14 | ||
EP06020766 | 2006-10-02 | ||
EP06020765.1 | 2006-10-02 | ||
EP06020765 | 2006-10-02 | ||
US94328907P | 2007-06-11 | 2007-06-11 | |
US60/943,289 | 2007-06-11 | ||
US94349907P | 2007-06-12 | 2007-06-12 | |
US60/943,499 | 2007-06-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008011348A2 WO2008011348A2 (en) | 2008-01-24 |
WO2008011348A3 true WO2008011348A3 (en) | 2008-07-10 |
Family
ID=43063574
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/073504 WO2008011348A2 (en) | 2006-07-14 | 2007-07-13 | Humanized antibody against amyloid beta |
Country Status (21)
Country | Link |
---|---|
US (5) | US7892544B2 (en) |
EP (2) | EP2046833B9 (en) |
JP (1) | JP5641737B2 (en) |
KR (2) | KR101605207B1 (en) |
AR (1) | AR062065A1 (en) |
AU (1) | AU2007275467B2 (en) |
CA (1) | CA2657681C (en) |
CL (1) | CL2007002070A1 (en) |
CO (1) | CO6150201A2 (en) |
CR (1) | CR10556A (en) |
HR (1) | HRP20090221B1 (en) |
IL (1) | IL196478B (en) |
MA (1) | MA30632B1 (en) |
MX (2) | MX2009000476A (en) |
NO (2) | NO344963B1 (en) |
NZ (1) | NZ574188A (en) |
PL (2) | PL2468770T3 (en) |
RU (1) | RU2498999C2 (en) |
SG (1) | SG173385A1 (en) |
TW (1) | TWI551607B (en) |
WO (1) | WO2008011348A2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8877190B2 (en) | 2006-11-30 | 2014-11-04 | Abbvie Inc. | Aβ conformer selective anti-Aβ globulomer monoclonal antibodies |
US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
US9146244B2 (en) | 2007-06-12 | 2015-09-29 | Ac Immune S.A. | Polynucleotides encoding an anti-beta-amyloid monoclonal antibody |
US9221900B2 (en) | 2010-07-30 | 2015-12-29 | Ac Immune S.A. | Methods for identifying safe and functional humanized antibodies |
US9403902B2 (en) | 2007-10-05 | 2016-08-02 | Ac Immune S.A. | Methods of treating ocular disease associated with amyloid-beta-related pathology using an anti-amyloid-beta antibody |
Families Citing this family (103)
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---|---|---|---|---|
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
DE10303974A1 (en) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid β (1-42) oligomers, process for their preparation and their use |
US8663650B2 (en) | 2003-02-21 | 2014-03-04 | Ac Immune Sa | Methods and compositions comprising supramolecular constructs |
TW200635607A (en) | 2004-12-15 | 2006-10-16 | Elan Pharm Inc | Humanized Aβ antibodies for use in improving cognition |
AU2006319358B2 (en) * | 2005-11-30 | 2012-01-19 | AbbVie Deutschland GmbH & Co. KG | Anti-Abeta globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies |
KR101439828B1 (en) | 2005-11-30 | 2014-09-17 | 애브비 인코포레이티드 | Monoclonal antibodies against amyloid beta protein and uses thereof |
RU2015111675A (en) * | 2005-12-12 | 2015-08-10 | Ац Иммуне Са | SPECIFIC IN RESPECT TO AMYLOID BETA (A BETA) 1-42 MONOCLONAL ANTIBODIES WITH THERAPEUTIC PROPERTIES |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
KR101605207B1 (en) * | 2006-07-14 | 2016-03-22 | 에이씨 이뮨 에스.에이. | Humanized antibody against amyloid beta |
KR20150002879A (en) * | 2006-10-02 | 2015-01-07 | 에이씨 이뮨 에스.에이. | Humanized antibody against amyloid beta |
EP2102165A2 (en) | 2006-11-24 | 2009-09-23 | AC Immune S.A. | N-(methyl)-1h-pyrazol-3-amine, n-(methyl)-pyridin-2-amine and n-(methyl)-thiazol-2-amine derivatives for the treatment of diseases associated with amyloid or amyloid-like proteins, like e.g. alzheimer's |
WO2008104386A2 (en) * | 2007-02-27 | 2008-09-04 | Abbott Gmbh & Co. Kg | Method for the treatment of amyloidoses |
EP2481408A3 (en) | 2007-03-01 | 2013-01-09 | Probiodrug AG | New use of glutaminyl cyclase inhibitors |
US20090022728A1 (en) * | 2007-03-09 | 2009-01-22 | Rinat Neuroscience Corporation | Methods of treating ophthalmic diseases |
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US20090232801A1 (en) * | 2007-05-30 | 2009-09-17 | Abbot Laboratories | Humanized Antibodies Which Bind To AB (1-42) Globulomer And Uses Thereof |
CN101820911B (en) * | 2007-06-12 | 2015-05-06 | Ac免疫有限公司 | Humanized antibodies to amyloid beta |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
DK2182983T3 (en) | 2007-07-27 | 2014-07-14 | Janssen Alzheimer Immunotherap | TREATMENT OF AMYLOIDOGENIC DISEASES WITH HUMANIZED ANTI-ABETA ANTIBODIES |
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SG190572A1 (en) | 2008-04-29 | 2013-06-28 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
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CA2726087A1 (en) | 2008-06-03 | 2009-12-10 | Tariq Ghayur | Dual variable domain immunoglobulins and uses thereof |
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US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
EP2403624A4 (en) | 2009-03-02 | 2012-08-22 | Dignity Health | Diagnostic devices and methods of use |
US20140024050A1 (en) * | 2009-03-10 | 2014-01-23 | Abbott Laboratories | Antibodies which detect pivkaii and methods of use thereof |
AU2010294214B2 (en) | 2009-09-11 | 2015-05-07 | Vivoryon Therapeutics N.V. | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
EP2311823A1 (en) | 2009-10-15 | 2011-04-20 | AC Immune S.A. | 2,6-Diaminopyridine compounds for treating diseases associated with amyloid proteins or for treating ocular diseases |
AU2010306677B2 (en) | 2009-10-15 | 2013-05-23 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
UY32979A (en) | 2009-10-28 | 2011-02-28 | Abbott Lab | IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME |
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