WO2008011625A3 - Microneedle devices and methods of drug delivery or fluid withdrawal - Google Patents

Microneedle devices and methods of drug delivery or fluid withdrawal Download PDF

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Publication number
WO2008011625A3
WO2008011625A3 PCT/US2007/074123 US2007074123W WO2008011625A3 WO 2008011625 A3 WO2008011625 A3 WO 2008011625A3 US 2007074123 W US2007074123 W US 2007074123W WO 2008011625 A3 WO2008011625 A3 WO 2008011625A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
microneedle devices
drug delivery
drug
base substrate
Prior art date
Application number
PCT/US2007/074123
Other languages
French (fr)
Other versions
WO2008011625A2 (en
Inventor
Mark R Prausnitz
Jeong Woo Lee
Original Assignee
Georgia Tech Researh Corp
Mark R Prausnitz
Jeong Woo Lee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgia Tech Researh Corp, Mark R Prausnitz, Jeong Woo Lee filed Critical Georgia Tech Researh Corp
Publication of WO2008011625A2 publication Critical patent/WO2008011625A2/en
Publication of WO2008011625A3 publication Critical patent/WO2008011625A3/en
Priority to US12/357,195 priority Critical patent/US20090182306A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00111—Tips, pillars, i.e. raised structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0046—Solid microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0061—Methods for using microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C2201/00—Manufacture or treatment of microstructural devices or systems
    • B81C2201/03—Processes for manufacturing substrate-free structures
    • B81C2201/034—Moulding

Abstract

Microneedle devices and methods of manufacture and use thereof are provided. In one embodiment, a device is provided for sustained delivery of drug across or into a biological barrier, such as skin. The device may include a base substrate which comprises a drug dispersed in a matrix material; and one or more microneedles extending from the base substrate, wherein the one or more microneedles comprise a water-soluble or water-swellable material, wherein the one or more microneedles will dissolve or swell following insertion into the biological barrier, providing a transport pathway for the drug to pass from the base substrate into the biological barrier.
PCT/US2007/074123 2006-07-21 2007-07-23 Microneedle devices and methods of drug delivery or fluid withdrawal WO2008011625A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/357,195 US20090182306A1 (en) 2006-07-21 2009-01-21 Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83247906P 2006-07-21 2006-07-21
US60/832,479 2006-07-21

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/357,195 Continuation-In-Part US20090182306A1 (en) 2006-07-21 2009-01-21 Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal

Publications (2)

Publication Number Publication Date
WO2008011625A2 WO2008011625A2 (en) 2008-01-24
WO2008011625A3 true WO2008011625A3 (en) 2008-12-04

Family

ID=38957686

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/074123 WO2008011625A2 (en) 2006-07-21 2007-07-23 Microneedle devices and methods of drug delivery or fluid withdrawal

Country Status (1)

Country Link
WO (1) WO2008011625A2 (en)

Families Citing this family (43)

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GB0402131D0 (en) 2004-01-30 2004-03-03 Isis Innovation Delivery method
CA2612005C (en) 2005-06-17 2013-10-29 Georgia Tech Research Corporation Coated microstructures and method of manufacture thereof
US7699819B2 (en) 2006-02-21 2010-04-20 The Hong Kong University Of Science And Technology Molecular sieve and zeolite microneedles and preparation thereof
CA2676221C (en) 2007-01-22 2016-12-20 Corium International, Inc. Applicators for microneedles
EP2146689B1 (en) 2007-04-16 2020-08-12 Corium, Inc. Solvent-cast microneedle arrays containing active
AU2014200648B2 (en) * 2007-04-16 2015-09-24 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
CN101808588B (en) 2007-09-28 2012-12-19 贝尔法斯特女王大学 Delivery device and method
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US20090099427A1 (en) * 2007-10-12 2009-04-16 Arkal Medical, Inc. Microneedle array with diverse needle configurations
AU2008341030B2 (en) 2007-12-24 2014-04-17 Vaxxas Pty Limited Coating method
CA2749347C (en) 2008-02-07 2018-03-27 The University Of Queensland Patch production
US20090234322A1 (en) 2008-03-12 2009-09-17 Ultradent Products, Inc. Method of dental tissue injection using an array of micro-needles
AU2009249610B2 (en) * 2008-05-21 2014-01-16 Theraject, Inc. Method of manufacturing solid solution perforator patches and uses thereof
US9387000B2 (en) 2008-05-23 2016-07-12 The University Of Queensland Analyte detection using a needle projection patch
JP5879126B2 (en) * 2008-10-07 2016-03-08 ジン・トゥオＪＩＮ Ｔｕｏ Phase change polymer microneedle
CA2760573A1 (en) * 2008-12-22 2010-07-01 The University Of Queensland Patch production
JP6327852B2 (en) 2010-05-04 2018-05-23 コリウム インターナショナル， インコーポレイテッド Methods and devices for transdermal delivery of parathyroid hormone using microprojection arrays
WO2012006677A1 (en) 2010-07-14 2012-01-19 The University Of Queensland Patch applying apparatus
JP5770055B2 (en) * 2010-09-29 2015-08-26 富士フイルム株式会社 Method for manufacturing needle-like array transdermal absorption sheet
GB201107642D0 (en) * 2011-05-09 2011-06-22 Univ Cork Method
US11179553B2 (en) 2011-10-12 2021-11-23 Vaxxas Pty Limited Delivery device
MX2015008157A (en) * 2012-12-21 2016-02-22 Corium Int Inc Microarray for delivery of therapeutic agent and methods of use.
RU2679107C2 (en) * 2013-01-21 2019-02-05 Пхэан Эстетикс Инк. Microneedle, mould for producing same and method of producing microneedle
ES2921481T3 (en) 2013-03-12 2022-08-26 Corium Inc Microprojection applicators
EP2968751B1 (en) 2013-03-15 2022-11-30 Corium, Inc. Multiple impact microprojection applicators
ES2761580T3 (en) 2013-03-15 2020-05-20 Corium Inc Microarrays for therapeutic agent delivery, methods of use and manufacturing methods
EP2968118B1 (en) 2013-03-15 2022-02-09 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
CA2903763C (en) 2013-03-15 2021-11-16 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
KR20170023776A (en) 2014-02-26 2017-03-06 루마 세러퓨틱스 인코포레이티드 Ultraviolet phototherapy apparatuses and methods
EP3127578B1 (en) * 2014-04-03 2021-08-25 Toppan Printing Co., Ltd. Puncture injection instrument
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
WO2016123665A1 (en) 2015-02-02 2016-08-11 Vaxxas Pty Limited Microprojection array applicator and method
SG11201708509YA (en) * 2015-04-21 2017-11-29 Univ North Carolina State Glucose-responsive insulin delivery system using hyoxia-sensitive nanocomposites
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017045031A1 (en) 2015-09-18 2017-03-23 Vaxxas Pty Limited Microprojection arrays with microprojections having large surface area profiles
EP4324404A3 (en) * 2016-01-13 2024-04-24 The General Hospital Corporation DBA Massachusetts Systems and methods for removing exogenous particles from the skin of a patient
US20190168016A1 (en) 2016-02-09 2019-06-06 Luma Therapeutics, Inc. Methods, compositions and apparatuses for treating psoriasis by phototherapy
EP4306803A3 (en) 2017-03-31 2024-04-10 Vaxxas Pty Limited Device and method for coating surfaces
EP3639010A4 (en) 2017-06-13 2021-03-17 Vaxxas Pty Limited Quality control of substrate coatings
EP4218893A1 (en) 2017-08-04 2023-08-02 Vaxxas Pty Limited Compact high mechanical energy storage and low trigger force actuator for the delivery of microprojection array patches (map)
CN108837238B (en) * 2018-07-13 2023-09-01 江苏省人民医院（南京医科大学第一附属医院） Hyaluronic acid injection needle
CN111588689B (en) * 2020-06-20 2023-08-11 温州医科大学 Cornea minimally invasive soluble microneedle patch and preparation method and application thereof
WO2022183122A1 (en) * 2021-02-27 2022-09-01 The Brigham And Women's Hospital, Inc. Microneedle compositions and methods of delivery using the same

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US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US20020177839A1 (en) * 2001-04-20 2002-11-28 Cormier Michel J. N. Microprojection array having a beneficial agent containing coating

Also Published As

Publication number Publication date
WO2008011625A2 (en) 2008-01-24

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