WO2008018904A3 - Systems and methods for processing samples in a closed container, and related devices - Google Patents

Systems and methods for processing samples in a closed container, and related devices Download PDF

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Publication number
WO2008018904A3
WO2008018904A3 PCT/US2007/001170 US2007001170W WO2008018904A3 WO 2008018904 A3 WO2008018904 A3 WO 2008018904A3 US 2007001170 W US2007001170 W US 2007001170W WO 2008018904 A3 WO2008018904 A3 WO 2008018904A3
Authority
WO
WIPO (PCT)
Prior art keywords
barrier
tray
samples
systems
methods
Prior art date
Application number
PCT/US2007/001170
Other languages
French (fr)
Other versions
WO2008018904A2 (en
Inventor
Simon Jonathon Spence
Richard Alexander Grant
Timothy Doyle Peele
William Samuel Hunter
Ashraf F Abdelmoteleb
David Thomas Kneen
Robert Alister Neil
Simon Harris
Original Assignee
Argos Therapeutics Inc
Kirin Pharma Kk
Simon Jonathon Spence
Richard Alexander Grant
Timothy Doyle Peele
William Samuel Hunter
Ashraf F Abdelmoteleb
David Thomas Kneen
Robert Alister Neil
Simon Harris
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES07835665T priority Critical patent/ES2892751T3/en
Priority to US12/159,748 priority patent/US8030080B2/en
Application filed by Argos Therapeutics Inc, Kirin Pharma Kk, Simon Jonathon Spence, Richard Alexander Grant, Timothy Doyle Peele, William Samuel Hunter, Ashraf F Abdelmoteleb, David Thomas Kneen, Robert Alister Neil, Simon Harris filed Critical Argos Therapeutics Inc
Priority to EP07835665.6A priority patent/EP1976670B1/en
Priority to KR1020087017409A priority patent/KR101321658B1/en
Priority to AU2007282135A priority patent/AU2007282135C1/en
Priority to JP2008551336A priority patent/JP5254040B2/en
Priority to CN2007800024979A priority patent/CN101370622B/en
Priority to CA2635268A priority patent/CA2635268C/en
Publication of WO2008018904A2 publication Critical patent/WO2008018904A2/en
Publication of WO2008018904A3 publication Critical patent/WO2008018904A3/en
Priority to US13/235,922 priority patent/US8211701B2/en
Priority to US13/490,863 priority patent/US8431404B2/en
Priority to US13/845,725 priority patent/US9040303B2/en
Priority to US14/692,131 priority patent/US9409178B2/en
Priority to US15/216,128 priority patent/US9527074B2/en
Priority to US15/357,347 priority patent/US9638707B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/021—Pipettes, i.e. with only one conduit for withdrawing and redistributing liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0289—Apparatus for withdrawing or distributing predetermined quantities of fluid
    • B01L3/0293—Apparatus for withdrawing or distributing predetermined quantities of fluid for liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/06—Test-tube stands; Test-tube holders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/523—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for multisample carriers, e.g. used for microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L1/00—Measuring force or stress, in general
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/34—Purifying; Cleaning
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00732—Identification of carriers, materials or components in automatic analysers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N35/00722—Communications; Identification
    • G01N35/00871—Communications between instruments or with remote terminals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L1/00—Enclosures; Chambers
    • B01L1/02—Air-pressure chambers; Air-locks therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/142—Preventing evaporation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0832—Geometry, shape and general structure cylindrical, tube shaped
    • B01L2300/0838—Capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0481—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure squeezing of channels or chambers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0378—Shapes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Abstract

A system and method for automated processing of nucleic acids and other samples includes a disposable container comprising a tray and a flexible barrier. The barrier is configured to seal with a top edge of the tray, providing a closed, aseptic work area within the sealed tray. A pipette head and/or other sample manipulation device can be attached to the inside of the barrier, and the barrier can include an interface for a robotic arm or other device. When the barrier is sealed over the tray, the barrier separates the contents of the tray from the robot or other manipulation device. The barrier can be flexible, and allow the robotic arm to move the pipette head throughout the work area of the tray. All samples, reagents, pipette tips and other tools or devices for processing nucleic acid samples may remain within the closed compartment provided by the container during processing.
PCT/US2007/001170 2006-01-18 2007-01-17 Systems and methods for processing samples in a closed container, and related devices WO2008018904A2 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
CN2007800024979A CN101370622B (en) 2006-01-18 2007-01-17 Systems and methods for processing samples in a closed container, and related devices
CA2635268A CA2635268C (en) 2006-01-18 2007-01-17 Systems and methods for processing samples in a closed container, and related devices
EP07835665.6A EP1976670B1 (en) 2006-01-18 2007-01-17 Systems and methods for processing samples in a closed container, and related devices
US12/159,748 US8030080B2 (en) 2006-01-18 2007-01-17 Systems and methods for processing samples in a closed container, and related devices
AU2007282135A AU2007282135C1 (en) 2006-01-18 2007-01-17 Systems and methods for processing samples in a closed container, and related devices
JP2008551336A JP5254040B2 (en) 2006-01-18 2007-01-17 System and method for processing samples in a closed container and associated apparatus
KR1020087017409A KR101321658B1 (en) 2006-01-18 2007-01-17 Systems and methods for processing samples in a closed container, and related devices
ES07835665T ES2892751T3 (en) 2006-01-18 2007-01-17 Systems and methods for the processing of samples in a closed container and related devices
US13/235,922 US8211701B2 (en) 2006-01-18 2011-09-19 Methods for processing samples in a closed container
US13/490,863 US8431404B2 (en) 2006-01-18 2012-06-07 Apparatus for transfer of liquid for processing samples
US13/845,725 US9040303B2 (en) 2006-01-18 2013-03-18 Apparatus for measuring volume of a fluid
US14/692,131 US9409178B2 (en) 2006-01-18 2015-04-21 Processing containers
US15/216,128 US9527074B2 (en) 2006-01-18 2016-07-21 Processing containers
US15/357,347 US9638707B2 (en) 2006-01-18 2016-11-21 Methods of processing samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76008706P 2006-01-18 2006-01-18
US60/760,087 2006-01-18

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/159,748 A-371-Of-International US8030080B2 (en) 2006-01-18 2007-01-17 Systems and methods for processing samples in a closed container, and related devices
US13/235,922 Division US8211701B2 (en) 2006-01-18 2011-09-19 Methods for processing samples in a closed container

Publications (2)

Publication Number Publication Date
WO2008018904A2 WO2008018904A2 (en) 2008-02-14
WO2008018904A3 true WO2008018904A3 (en) 2008-08-14

Family

ID=39033435

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/001170 WO2008018904A2 (en) 2006-01-18 2007-01-17 Systems and methods for processing samples in a closed container, and related devices

Country Status (9)

Country Link
US (7) US8030080B2 (en)
EP (1) EP1976670B1 (en)
JP (1) JP5254040B2 (en)
KR (1) KR101321658B1 (en)
CN (2) CN103499466B (en)
AU (1) AU2007282135C1 (en)
CA (1) CA2635268C (en)
ES (1) ES2892751T3 (en)
WO (1) WO2008018904A2 (en)

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